-
1
-
-
0026666057
-
Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine
-
Undrovinas AI, Fleidervish IA, Makielski JC. Inward sodium current at resting potentials in single cardiac myocytes induced by the ischemic metabolite lysophosphatidylcholine. Circ Res. 1992;71:1231-41.
-
(1992)
Circ Res
, vol.71
, pp. 1231-41
-
-
Undrovinas, A.I.1
Fleidervish, I.A.2
Makielski, J.C.3
-
2
-
-
0030882337
-
Allen d influence of stimulation frequency on [na+]i and contractile function in langendorff-perfused rat heart
-
Maier LS, Pieske B, Allen D Influence of stimulation frequency on [Na+]i and contractile function in Langendorff-perfused rat heart. Am J Physiol 1997;H1246-54
-
(1997)
Am J Physiol
-
-
Maier, L.S.1
Pieske, B.2
-
3
-
-
0037162348
-
i and contractility in nonfailing and failing human myocardium
-
DOI 10.1161/01.CIR.0000023042.50192.F4
-
Pieske B, Maier LS, Piacentino 3rd V, Weisser J, Hasenfuss G, Houser S. Rate dependence of [Na+]i and contractility in nonfailing and failing human myocardium. Circulation. 2002;106:447-53. (Pubitemid 34803689)
-
(2002)
Circulation
, vol.106
, Issue.4
, pp. 447-453
-
-
Pieske, B.1
Maier, L.S.2
Piacentino III, V.3
Weisser, J.4
Hasenfuss, G.5
Houser, S.6
-
4
-
-
42749091983
-
Late sodium current in failing heart: Friend or foe?
-
DOI 10.1016/j.pbiomolbio.2007.07.010, PII S0079610707000545
-
Maltsev VA, Undrovinas A. Late sodium current in failing heart: friend or foe? Prog Biophys Mol Biol. 2008;96:421-51. (Pubitemid 351635619)
-
(2008)
Progress in Biophysics and Molecular Biology
, vol.96
, Issue.1-3
, pp. 421-451
-
-
Maltsev, V.A.1
Undrovinas, A.2
-
5
-
-
33646010676
-
Modulation of cardiac na and ca currents by cam and camkii
-
Wagner S, Maier LS. Modulation of cardiac Na and Ca currents by CaM and CaMKII. J Cardiovasc Electrophysiol. 2006;17 Suppl 1: S26-33.
-
(2006)
J Cardiovasc Electrophysiol
, vol.17
, Issue.SUPPL. 1
-
-
Wagner, S.1
Maier, L.S.2
-
6
-
-
67749101989
-
Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model
-
Xi Y, Wu G, Yang L, Han K, Du Y, Wang T, Lei X, Bai X, Ma A. Increased late sodium currents are related to transcription of neuronal isoforms in a pressure-overload model. Eur J Heart Fail. 2009;11:749-57.
-
(2009)
Eur J Heart Fail
, vol.11
, pp. 749-57
-
-
Xi, Y.1
Wu, G.2
Yang, L.3
Han, K.4
Du, Y.5
Wang, T.6
Lei, X.7
Bai, X.8
Ma, A.9
-
7
-
-
33751337747
-
Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes
-
DOI 10.1161/01.RES.0000251305.25604.b0, PII 0000301220061124000012
-
Fredj S, Lindegger N, Sampson KJ, Carmeliet P, Kass RS. Altered Na+ channels promote pause-induced spontaneous diastolic activity in long QT syndrome type 3 myocytes. Circ Res. 2006;99:1225-32. (Pubitemid 44808659)
-
(2006)
Circulation Research
, vol.99
, Issue.11
, pp. 1225-1232
-
-
Fredj, S.1
Lindegger, N.2
Sampson, K.J.3
Carmeliet, P.4
Kass, R.S.5
-
8
-
-
0035115891
-
Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium
-
Huang B, El-Sherif T, Gidh-Jain M, Qin D, El-Sherif N. Alterations of sodium channel kinetics and gene expression in the postinfarction remodeled myocardium. J Cardiovasc Electrophysiol. 2001;12:218-25. (Pubitemid 32171514)
-
(2001)
Journal of Cardiovascular Electrophysiology
, vol.12
, Issue.2
, pp. 218-225
-
-
Huang, B.1
El-Sherif, T.2
Gidh-Jain, M.3
Qin, D.4
El-Sherif, N.5
-
9
-
-
0029952835
-
Hypoxia increases persistent sodium current in rat ventricular myocytes
-
Ju YK, Saint DA, Gage PW. Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol. 1996;497:337-47. (Pubitemid 26418103)
-
(1996)
Journal of Physiology
, vol.497
, Issue.2
, pp. 337-347
-
-
Ju, Y.-K.1
Saint, D.A.2
Gage, P.W.3
-
10
-
-
33847261532
-
Chronic heart failure slows late sodium current in human and canine ventricular myocytes: Implications for repolarization variability
-
DOI 10.1016/j.ejheart.2006.08.007, PII S1388984206002522
-
Maltsev VA, Silverman N, Sabbah HN, Undrovinas AI. Chronic heart failure slows late sodium current in human and canine ventricular myocytes: implications for repolarization variability. Eur J Heart Fail. 2007;9:219-27. (Pubitemid 46330143)
-
(2007)
European Journal of Heart Failure
, vol.9
, Issue.3
, pp. 219-227
-
-
Maltsev, V.A.1
Silverman, N.2
Sabbah, H.N.3
Undrovinas, A.I.4
-
11
-
-
77952165183
-
Altered na+ currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium
-
This is the first report in human myocardium showing altered Na currents in atrial fibrillation and the beneficial effects of ranolazine on arrhythmogenesis. The RAFFAELLO study mainly results from this report
-
Sossalla S, Kallmeyer B, Wagner S, Mazur M, Maurer U, Toischer K, Schmitto JD, Seipelt R, Schondube FA, Hasenfuss G, Belardinelli L, Maier LS. Altered Na+ currents in atrial fibrillation effects of ranolazine on arrhythmias and contractility in human atrial myocardium. J Am Coll Cardiol. 2010;55:2330-42. This is the first report in human myocardium showing altered Na currents in atrial fibrillation and the beneficial effects of ranolazine on arrhythmogenesis. The RAFFAELLO study mainly results from this report.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 2330-42
-
-
Sossalla, S.1
Kallmeyer, B.2
Wagner, S.3
Mazur, M.4
Maurer, U.5
Toischer, K.6
Schmitto, J.D.7
Seipelt, R.8
Schondube, F.A.9
Hasenfuss, G.10
Belardinelli, L.11
Maier, L.S.12
-
12
-
-
45549105581
-
Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation
-
Sossalla S, Wagner S, Rasenack EC, Ruff H, Weber SL, Schondube FA, Tirilomis T, Tenderich G, Hasenfuss G, Belardinelli L,Maier LS. Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts-role of late sodium current and intracellular ion accumulation. J Mol Cell Cardiol. 2008;45:32-43.
-
(2008)
J Mol Cell Cardiol
, vol.45
, pp. 32-43
-
-
Sossalla, S.1
Wagner, S.2
Rasenack, E.C.3
Ruff, H.4
Weber, S.L.5
Schondube, F.A.6
Tirilomis, T.7
Tenderich, G.8
Hasenfuss, G.9
Belardinelli, L.10
Maier, L.S.11
-
13
-
-
33645971939
-
Na(+) current in human ventricle: Implications for sodium loading and homeostasis
-
Makielski JC, Farley AL. Na(+) current in human ventricle: implications for sodium loading and homeostasis. J Cardiovasc Electrophysiol. 2006;17 Suppl 1:S15-20.
-
(2006)
J Cardiovasc Electrophysiol
, vol.17
, Issue.SUPPL. 1
-
-
Makielski, J.C.1
Farley, A.L.2
-
14
-
-
33745368556
-
Inhibition of the late sodium current as a potential cardioprotective principle: Effects of the late sodium current inhibitor ranolazine
-
Belardinelli L, Shryock JC, Fraser H. Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine. Heart. 2006;92 Suppl 4:iv6- iv14.
-
(2006)
Heart
, vol.92
, Issue.SUPPL. 4
-
-
Belardinelli, L.1
Shryock, J.C.2
Fraser, H.3
-
15
-
-
10744223969
-
2+ exchanger overexpression predisposes to reactive oxygen species-induced injury
-
DOI 10.1016/j.cardiores.2003.08.006
-
Wagner S, Seidler T, Picht E, Maier LS, Kazanski V, Teucher N, Schillinger W, Pieske B, Isenberg G, Hasenfuss G, Kogler H. Na+- Ca2+ exchanger overexpression predisposes to reactive oxygen species-induced injury. Cardiovasc Res. 2003;60:404-12. (Pubitemid 37412374)
-
(2003)
Cardiovascular Research
, vol.60
, Issue.2
, pp. 404-412
-
-
Wagner, S.1
Seidler, T.2
Picht, E.3
Maier, L.S.4
Kazanski, V.5
Teucher, N.6
Schillinger, W.7
Pieske, B.8
Isenberg, G.9
Hasenfuss, G.10
Kogler, H.11
-
16
-
-
33947431938
-
A comparison between ranolazine and CVT-4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion
-
DOI 10.1124/jpet.106.115519
-
Wang P, Fraser H, Lloyd SG, McVeigh JJ, Belardinelli L, Chatham JC. A comparison between ranolazine and CVT- 4325, a novel inhibitor of fatty acid oxidation, on cardiac metabolism and left ventricular function in rat isolated perfused heart during ischemia and reperfusion. J Pharmacol Exp Ther. 2007;321:213-20. (Pubitemid 46456960)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.321
, Issue.1
, pp. 213-220
-
-
Wang, P.1
Fraser, H.2
Lloyd, S.G.3
McVeigh, J.J.4
Belardinelli, L.5
Chatham, J.C.6
-
17
-
-
0032526650
-
2+] and work in trabeculae from hypertrophic and normal rat hearts
-
Brandes R, Maier LS, Bers DM. Regulation of mitochondrial [NADH] by cytosolic [Ca2+] and work in trabeculae from hypertrophic and normal rat hearts. Circ Res. 1998;82:1189-98. (Pubitemid 28311126)
-
(1998)
Circulation Research
, vol.82
, Issue.11
, pp. 1189-1198
-
-
Brandes, R.1
Maier, L.S.2
Bers, D.M.3
-
18
-
-
0348129532
-
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: A randomized controlled trial
-
DOI 10.1001/jama.291.3.309
-
Chaitman BR, Pepine CJ, Parker JO, Skopal J, Chumakova G, Kuch J, Wang W, Skettino SL, Wolff AA. Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial. JAMA. 2004;291:309-16. (Pubitemid 38101603)
-
(2004)
Journal of the American Medical Association
, vol.291
, Issue.3
, pp. 309-316
-
-
Chaitman, B.R.1
Pepine, C.J.2
Parker, J.O.3
Skopal, J.4
Chumakova, G.5
Kuch, J.6
Wang, W.7
Skettino, S.L.8
Wolff, A.A.9
-
19
-
-
11144356285
-
Anti-ischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina
-
DOI 10.1016/j.jacc.2003.11.045, PII S0735109704001925
-
Chaitman BR, Skettino SL, Parker JO, Hanley P, Meluzin J, Kuch J, Pepine CJ, Wang W, Nelson JJ, Hebert DA, Wolff AA. Antiischemic effects and long-term survival during ranolazine monotherapy in patients with chronic severe angina. J Am Coll Cardiol. 2004;43:1375-82. (Pubitemid 38496341)
-
(2004)
Journal of the American College of Cardiology
, vol.43
, Issue.8
, pp. 1375-1382
-
-
Chaitman, B.R.1
Skettino, S.L.2
Parker, J.O.3
Hanley, P.4
Meluzin, J.5
Kuch, J.6
Pepine, C.J.7
Wang, W.8
Nelson, J.J.9
Hebert, D.A.10
Wolff, A.A.11
-
20
-
-
4344577023
-
Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties
-
DOI 10.1161/01.CIR.0000139333.83620.5D
-
Antzelevitch C, Belardinelli L, Zygmunt AC, Burashnikov A, Di Diego JM, Fish JM, Cordeiro JM, Thomas G. Electrophysiological effects of ranolazine, a novel antianginal agent with antiarrhythmic properties. Circulation. 2004;110:904-10. (Pubitemid 39136212)
-
(2004)
Circulation
, vol.110
, Issue.8
, pp. 904-910
-
-
Antzelevitch, C.1
Belardinelli, L.2
Zygmunt, A.C.3
Burashnikov, A.4
Di Diego, J.M.5
Fish, J.M.6
Cordeiro, J.M.7
Thomas, G.8
-
21
-
-
33745251122
-
Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction
-
Song Y, Shryock JC, Wagner S, Maier LS, Belardinelli L. Blocking late sodium current reduces hydrogen peroxide-induced arrhythmogenic activity and contractile dysfunction. J Pharmacol Exp Ther. 2006;318:214-22.
-
(2006)
J Pharmacol Exp Ther
, vol.318
, pp. 214-22
-
-
Song, Y.1
Shryock, J.C.2
Wagner, S.3
Maier, L.S.4
Belardinelli, L.5
-
22
-
-
33646007982
-
Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current
-
Undrovinas AI, Belardinelli L, Undrovinas NA, Sabbah HN. Ranolazine improves abnormal repolarization and contraction in left ventricular myocytes of dogs with heart failure by inhibiting late sodium current. J Cardiovasc Electrophysiol. 2006;17 Suppl 1: S169-77.
-
(2006)
J Cardiovasc Electrophysiol
, vol.17
, Issue.SUPPL. 1
-
-
Undrovinas, A.I.1
Belardinelli, L.2
Undrovinas, N.A.3
Sabbah, H.N.4
-
23
-
-
40849140980
-
+ channel isoforms by ranolazine
-
DOI 10.1124/mol.107.041541
-
Wang GK, Calderon J, Wang SY. State- And use-dependent block of muscle Nav1.4 and neuronal Nav1.7 voltage-gated Na+ channel isoforms by ranolazine. Mol Pharmacol. 2008;73:940-8. (Pubitemid 351397898)
-
(2008)
Molecular Pharmacology
, vol.73
, Issue.3
, pp. 940-948
-
-
Ging, K.W.1
Calderon, J.2
Wang, S.-Y.3
-
24
-
-
84861867021
-
Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel nav1.5: A novel mechanism of drug action
-
This is the first report showing a novel mechanism of how Na channel scan be activated (ie, by mechanosensitivity) and how ranolazine may decrease this mechanism
-
Beyder A, Strege PR, Reyes S, Bernard CE, Terzic A, Makielski J, Ackerman MJ, Farrugia G Ranolazine decreases mechanosensitivity of the voltage-gated sodium ion channel NaV1.5: a novel mechanism of drug action. Circulation. 2012;125:2698-2706. This is the first report showing a novel mechanism of how Na channel scan be activated (ie, by mechanosensitivity) and how ranolazine may decrease this mechanism.
-
(2012)
Circulation
, vol.125
, pp. 2698-2706
-
-
Beyder, A.1
Strege, P.R.2
Reyes, S.3
Bernard, C.E.4
Terzic, A.5
Makielski, J.6
Ackerman, M.J.7
Farrugia, G.8
-
25
-
-
0037376575
-
+ dependent
-
DOI 10.1016/S0008-6363(02)00830-1
-
von Lewinski D, Stumme B, Maier LS, Luers C, Bers DM, Pieske B. Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent. Cardiovasc Res. 2003;57:1052-61. (Pubitemid 36324610)
-
(2003)
Cardiovascular Research
, vol.57
, Issue.4
, pp. 1052-1061
-
-
Von Lewinski, D.1
Stumme, B.2
Maier, L.S.3
Luers, C.4
Bers, D.M.5
Pieske, B.6
-
26
-
-
84862776882
-
Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity
-
Lovelock JD, Monasky MM, Jeong EM, Lardin HA, Liu H, Patel BG, Taglieri DM, Gu L, Kumar P, Pokhrel N, Zeng D, Belardinelli L, Sorescu D, Solaro RJ, Dudley Jr. SC. Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res. 2012;110(6):841-50.
-
(2012)
Circ Res
, vol.110
, Issue.6
, pp. 841-50
-
-
Lovelock, J.D.1
Monasky, M.M.2
Jeong, E.M.3
Lardin, H.A.4
Liu, H.5
Patel, B.G.6
Taglieri, D.M.7
Gu, L.8
Kumar, P.9
Pokhrel, N.10
Zeng, D.11
Belardinelli, L.12
Sorescu, D.13
Solaro, R.J.14
Dudley Jr., S.C.15
-
27
-
-
0028134824
-
Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease
-
DOI 10.1007/BF00877121
-
Hayashida W, van Eyll C, Rousseau MF, Pouleur H. Effects of ranolazine on left ventricular regional diastolic function in patients with ischemic heart disease. Cardiovasc Drugs Ther. 1994;8:741- 7. (Pubitemid 24376754)
-
(1994)
Cardiovascular Drugs and Therapy
, vol.8
, Issue.5
, pp. 741-747
-
-
Hayashida, W.1
Van Eyll, C.2
Rousseau, M.F.3
Pouleur, H.4
-
28
-
-
53049104215
-
Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-qt syndrome
-
Moss AJ, Zareba W, Schwarz KQ, Rosero S, McNitt S, Robinson JL. Ranolazine shortens repolarization in patients with sustained inward sodium current due to type-3 long-QT syndrome. J Cardiovasc Electrophysiol. 2008;19:1289-93.
-
(2008)
J Cardiovasc Electrophysiol
, vol.19
, pp. 1289-93
-
-
Moss, A.J.1
Zareba, W.2
Schwarz, K.Q.3
Rosero, S.4
McNitt, S.5
Robinson, J.L.6
-
29
-
-
79960175880
-
Improvement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable angina
-
This is the first clinical report in patients showing improved echocardiographic parameters of left ventricular function in response to ranolazine
-
Figueredo VM, Pressman GS, Romero-Corral A, Murdock E, Holderbach P, Morris DL. Improvement in left ventricular systolic and diastolic performance during ranolazine treatment in patients with stable angina. J Cardiovasc Pharmacol Ther. 2011;16:168-72. This is the first clinical report in patients showing improved echocardiographic parameters of left ventricular function in response to ranolazine.
-
(2011)
J Cardiovasc Pharmacol Ther
, vol.16
, pp. 168-72
-
-
Figueredo, V.M.1
Pressman, G.S.2
Romero-Corral, A.3
Murdock, E.4
Holderbach, P.5
Morris, D.L.6
-
30
-
-
77949286901
-
B-type natriuretic peptide and the effect of ranolazine in patients with non-st-segment elevation acute coronary syndromes: Observations from the merlin-timi 36 (metabolic efficiency with ranolazine for less ischemia in non-st elevation acute coronary-thrombolysis in myocardial infarction 36) trial
-
Morrow DA, Scirica BM, Sabatine MS, de Lemos JA, Murphy SA, Jarolim P, Theroux P, Bode C, Braunwald E. B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial. J Am Coll Cardiol. 2010;55:1189-96.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 1189-96
-
-
Morrow, D.A.1
Scirica, B.M.2
Sabatine, M.S.3
De Lemos, J.A.4
Murphy, S.A.5
Jarolim, P.6
Theroux, P.7
Bode, C.8
Braunwald, E.9
-
31
-
-
0036936426
-
Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure
-
DOI 10.1054/jcaf.2002.129232
-
Sabbah HN, Chandler MP, Mishima T, Suzuki G, Chaudhry P, Nass O, Biesiadecki BJ, Blackburn B, Wolff A, Stanley WC. Ranolazine, a partial fatty acid oxidation (pFOX) inhibitor, improves left ventricular function in dogs with chronic heart failure. J Card Fail. 2002;8:416-22. (Pubitemid 36055744)
-
(2002)
Journal of Cardiac Failure
, vol.8
, Issue.6
, pp. 416-422
-
-
Sabbah, H.N.1
Chandler, M.P.2
Mishima, T.3
Suzuki, G.4
Chaudhry, P.5
Nass, O.6
Biesiadecki, B.J.7
Blackburn, B.8
Wolff, A.9
Stanley, W.C.10
-
32
-
-
57049182027
-
Ranolazine combined with enalapril or metoprolol prevents progressive lv dysfunction and remodeling in dogs with moderate heart failure
-
Rastogi S, Sharov VG, Mishra S, Gupta RC, Blackburn B, Belardinelli L, Stanley WC, Sabbah HN. Ranolazine combined with enalapril or metoprolol prevents progressive LV dysfunction and remodeling in dogs with moderate heart failure. Am J Physiol Heart Circ Physiol. 2008;295:H2149-55.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.295
-
-
Rastogi, S.1
Sharov, V.G.2
Mishra, S.3
Gupta, R.C.4
Blackburn, B.5
Belardinelli, L.6
Stanley, W.C.7
Sabbah, H.N.8
-
33
-
-
79960430593
-
Ranolazine for the treatment of heart failure with preserved ejection fraction: Background, aims, and design of the rali-dhf study
-
Jacobshagen C, Belardinelli L, Hasenfuss G, Maier LS. Ranolazine for the treatment of heart failure with preserved ejection fraction: Background, aims, and design of the RALI-DHF study. Clin Cardiol. 2011;34:426-32.
-
(2011)
Clin Cardiol
, vol.34
, pp. 426-32
-
-
Jacobshagen, C.1
Belardinelli, L.2
Hasenfuss, G.3
Maier, L.S.4
-
34
-
-
78349303787
-
Inhibition of elevated ca2+/calmodulin- dependent protein kinase ii improves contractility in human failing myocardium
-
Sossalla S, Fluschnik N, Schotola H, Ort KR, Neef S, Schulte T, Wittkopper K, Renner A, Schmitto JD, Gummert J, El-Armouche A, Hasenfuss G, Maier LS. Inhibition of elevated Ca2+/calmodulin- dependent protein kinase II improves contractility in human failing myocardium. Circ Res. 2010;107:1150-61.
-
(2010)
Circ Res
, vol.107
, pp. 1150-61
-
-
Sossalla, S.1
Fluschnik, N.2
Schotola, H.3
Ort, K.R.4
Neef, S.5
Schulte, T.6
Wittkopper, K.7
Renner, A.8
Schmitto, J.D.9
Gummert, J.10
El-Armouche, A.11
Hasenfuss, G.12
Maier, L.S.13
-
35
-
-
79957795565
-
Diastolic dysfunction and arrhythmias caused by overexpression of camkiidc can be reversed by inhibition of late na+ current
-
Sossalla S, Maurer U, Schotola H, Hartmann N, DidieM, Zimmermann W, Jacobshagen C, Wagner S, Maier LS (2011) Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIdC can be reversed by inhibition of late Na+ current. Basic Res Cardiol 263-272
-
(2011)
Basic Res Cardiol
, pp. 263-272
-
-
Sossalla, S.1
Maurer, U.2
Schotola, H.3
Hartmann, N.4
DidieM Zimmermann, W.5
Jacobshagen, C.6
Wagner, S.7
Maier, L.S.8
-
36
-
-
33845284849
-
+ channels
-
DOI 10.1172/JCI26620
-
Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS. Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest. 2006;116:3127-38. (Pubitemid 44878627)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.12
, pp. 3127-3138
-
-
Wagner, S.1
Dybkova, N.2
Rasenack, E.C.L.3
Jacobshagen, C.4
Fabritz, L.5
Kirchhof, P.6
Maier, S.K.G.7
Zhang, T.8
Hasenfuss, G.9
Brown, J.H.10
Bers, D.M.11
Maier, L.S.12
-
37
-
-
36849057068
-
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials
-
DOI 10.1529/biophysj.107.114868
-
Grandi E, Puglisi JL, Wagner S, Maier LS, Severi S, Bers DM. Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials. Biophys J. 2007;93:3835-47. (Pubitemid 350223802)
-
(2007)
Biophysical Journal
, vol.93
, Issue.11
, pp. 3835-3847
-
-
Grandi, E.1
Puglisi, J.L.2
Wagner, S.3
Maier, L.S.4
Severi, S.5
Bers, D.M.6
-
38
-
-
79952772425
-
Reactive oxygen species-Activated ca/calmodulin kinase iid is required for late ina augmentation leading to cellular na and ca overload
-
Wagner S, Ruff HM, Weber SL, Bellmann S, Sowa T, Schulte T, Grandi E, Bers DM, Backs J, Belardinelli L, Maier LS. Reactive oxygen species-Activated Ca/Calmodulin Kinase IId is required for late INa augmentation leading to cellular Na and Ca overload. Circ Res. 2011;108:555-65.
-
(2011)
Circ Res
, vol.108
, pp. 555-65
-
-
Wagner, S.1
Ruff, H.M.2
Weber, S.L.3
Bellmann, S.4
Sowa, T.5
Schulte, T.6
Grandi, E.7
Bers, D.M.8
Backs, J.9
Belardinelli, L.10
Maier, L.S.11
-
39
-
-
33751214195
-
Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts
-
DOI 10.1016/j.yjmcc.2006.08.012, PII S0022282806007711
-
Fraser H, Belardinelli L, Wang L, Light PE, McVeigh JJ, Clanachan AS. Ranolazine decreases diastolic calcium accumulation caused by ATX-II or ischemia in rat hearts. J Mol Cell Cardiol. 2006;41:1031- 8. (Pubitemid 44791334)
-
(2006)
Journal of Molecular and Cellular Cardiology
, vol.41
, Issue.6
, pp. 1031-1038
-
-
Fraser, H.1
Belardinelli, L.2
Wang, L.3
Light, P.E.4
McVeigh, J.J.5
Clanachan, A.S.6
-
40
-
-
0028030471
-
Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart
-
Gralinski MR, Black SC, Kilgore KS, Chou AY, McCormack JG, Lucchesi BR. Cardioprotective effects of ranolazine (RS-43285) in the isolated perfused rabbit heart. Cardiovasc Res. 1994;28:1231- 7. (Pubitemid 24264731)
-
(1994)
Cardiovascular Research
, vol.28
, Issue.8
, pp. 1231-1237
-
-
Gralinski, M.R.1
Black, S.C.2
Kilgore, K.S.3
Chou, A.Y.4
McCormack, J.G.5
Lucchesi, B.R.6
-
41
-
-
67651067954
-
The late na+ current (ina) inhibitor ranolazine attenuates effects of palmitoyl-lcarnitine to increase late ina and cause ventricular diastolic dysfunction
-
Wu Y, Song Y, Belardinelli L, Shryock JC. The late Na+ current (INa) inhibitor ranolazine attenuates effects of palmitoyl-Lcarnitine to increase late INa and cause ventricular diastolic dysfunction. J Pharmacol Exp Ther. 2009;330:550-7.
-
(2009)
J Pharmacol Exp Ther
, vol.330
, pp. 550-7
-
-
Wu, Y.1
Song, Y.2
Belardinelli, L.3
Shryock, J.C.4
-
42
-
-
0034126801
-
Ranolazine attenuates palmitoyl-L-carnitine-induced mechanical and metabolic derangement in the isolated, perfused rat heart
-
Maruyama K, Hara A, Hashizume H, Ushikubi F, Abiko Y. Ranolazine attenuates palmitoyl-L-carnitine-induced mechanical and metabolic derangement in the isolated, perfused rat heart. J Pharm Pharmacol. 2000;52:709-15. (Pubitemid 30410085)
-
(2000)
Journal of Pharmacy and Pharmacology
, vol.52
, Issue.6
, pp. 709-715
-
-
Maruyama, K.1
Hara, A.2
Hashizume, H.3
Ushikubi, F.4
Abiko, Y.5
-
43
-
-
74249087588
-
Calcium/calmodulin-dependent protein kinase ii contributes to cardi-Ac arrhythmogenesis in heart failure
-
Sag CM, Wadsack DP, Khabbazzadeh S, Abesser M, Grefe C, Neumann K, Opiela MK, Backs J, Olson EN, Brown JH, Neef S, Maier SK, Maier LS. Calcium/calmodulin-dependent protein kinase II contributes to cardi-Ac arrhythmogenesis in heart failure. Circ Heart Fail. 2009;2:664-75.
-
(2009)
Circ Heart Fail
, vol.2
, pp. 664-75
-
-
Sag, C.M.1
Wadsack, D.P.2
Khabbazzadeh, S.3
Abesser, M.4
Grefe, C.5
Neumann, K.6
Opiela, M.K.7
Backs, J.8
Olson, E.N.9
Brown, J.H.10
Neef, S.11
Maier, S.K.12
Maier, L.S.13
-
45
-
-
44949176560
-
An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes
-
Song Y, Shryock JC, Belardinelli L. An increase of late sodium current induces delayed afterdepolarizations and sustained triggered activity in atrial myocytes. Am J Physiol Heart Circ Physiol. 2008;294:H2031-9.
-
(2008)
Am J Physiol Heart Circ Physiol
, vol.294
-
-
Song, Y.1
Shryock, J.C.2
Belardinelli, L.3
-
46
-
-
3342882854
-
Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome
-
DOI 10.1124/jpet.104.066100
-
Wu L, Shryock JC, Song Y, Li Y, Antzelevitch C, Belardinelli L. Antiarrhythmic effects of ranolazine in a guinea pig in vitro model of long-QT syndrome. J Pharmacol Exp Ther. 2004;310:599-605. (Pubitemid 38992327)
-
(2004)
Journal of Pharmacology and Experimental Therapeutics
, vol.310
, Issue.2
, pp. 599-605
-
-
Wu, L.1
Shryock, J.C.2
Song, Y.3
Li, Y.4
Antzelevitch, C.5
Belardinelli, L.6
-
47
-
-
3242778566
-
Na in guinea pig ventricular myocytes
-
DOI 10.1097/00005344-200408000-00008
-
Song Y, Shryock JC, Wu L, Belardinelli L. Antagonism by ranolazine of the pro-Arrhythmic effects of increasing late INa in guinea pig ventricular myocytes. J Cardiovasc Pharmacol. 2004;44:192- 9. (Pubitemid 38982162)
-
(2004)
Journal of Cardiovascular Pharmacology
, vol.44
, Issue.2
, pp. 192-199
-
-
Song, Y.1
Shryock, J.C.2
Wu, L.3
Belardinelli, L.4
-
48
-
-
70449090162
-
Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion
-
Dhalla AK, Wang WQ, Dow J, Shryock JC, Belardinelli L, Bhandari A, Kloner RA. Ranolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion. Am J Physiol Heart Circ Physiol. 2009;297:H1923-9.
-
(2009)
Am J Physiol Heart Circ Physiol
, vol.297
-
-
Dhalla, A.K.1
Wang, W.Q.2
Dow, J.3
Shryock, J.C.4
Belardinelli, L.5
Bhandari, A.6
Kloner, R.A.7
-
49
-
-
78651326450
-
Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine
-
In this report, pacing-induced re-entrant ventricular fibrillation and early afterdepolarization-mediated multifocal ventricular fibrillation was shown in perfused rat hearts
-
Morita N, Lee JH, Xie Y, Sovari A, Qu Z, Weiss JN, Karagueuzian HS. Suppression of re-entrant and multifocal ventricular fibrillation by the late sodium current blocker ranolazine. J Am Coll Cardiol. 2011;57:366-75. In this report, pacing-induced re-entrant ventricular fibrillation and early afterdepolarization-mediated multifocal ventricular fibrillation was shown in perfused rat hearts.
-
(2011)
J Am Coll Cardiol
, vol.57
, pp. 366-75
-
-
Morita, N.1
Lee, J.H.2
Xie, Y.3
Sovari, A.4
Qu, Z.5
Weiss, J.N.6
Karagueuzian, H.S.7
-
50
-
-
80052884048
-
Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long qt syndrome model
-
This report shows for the first time in a genetic mouse model of long QT 3 atrial fibrillation and how ranolazine improves arrhythmogenesis
-
Lemoine MD, Duverger JE, Naud P, Chartier D, Qi XY, Comtois P, Fabritz L, Kirchhof P, Nattel S. Arrhythmogenic left atrial cellular electrophysiology in a murine genetic long QT syndrome model. Cardiovasc Res. 2011;92:67-72. This report shows for the first time in a genetic mouse model of long QT 3 atrial fibrillation and how ranolazine improves arrhythmogenesis.
-
(2011)
Cardiovasc Res
, vol.92
, pp. 67-72
-
-
Lemoine, M.D.1
Duverger, J.E.2
Naud, P.3
Chartier, D.4
Qi, X.Y.5
Comtois, P.6
Fabritz, L.7
Kirchhof, P.8
Nattel, S.9
-
51
-
-
0025748631
-
Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and m cells
-
Antzelevitch C, Sicouri S, Litovsky SH, Lukas A, Krishnan SC, Di Diego JM, Gintant GA, Liu DW. Heterogeneity within the ventricular wall. Electrophysiology and pharmacology of epicardial, endocardial, and M cells. Circ Res. 1991;69:1427- 49.
-
(1991)
Circ Res
, vol.69
, pp. 1427-1449
-
-
Antzelevitch, C.1
Sicouri, S.2
Litovsky, S.H.3
Lukas, A.4
Krishnan, S.C.5
Di Diego, J.M.6
Gintant, G.A.7
Liu, D.W.8
-
53
-
-
76449092876
-
Late Na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model
-
Antoons G, Oros A, Beekman JD, Engelen MA, Houtman MJ, Belardinelli L, Stengl M, Vos MA. Late Na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model. J Am Coll Cardiol. 2010;55:801-9.
-
(2010)
J Am Coll Cardiol
, vol.55
, pp. 801-9
-
-
Antoons, G.1
Oros, A.2
Beekman, J.D.3
Engelen, M.A.4
Houtman, M.J.5
Belardinelli, L.6
Stengl, M.7
Vos, M.A.8
-
54
-
-
31144473292
-
An increase in late sodium current potentiates the proarrhythmic activities of low-risk QT-prolonging drugs in female rabbit hearts
-
DOI 10.1124/jpet.105.094862
-
Wu L, Shryock J, Song Y, Belardinelli L. An increase in late sodium current potentiates the proarrhythmic activities of lowrisk QT-prolonging drugs in female rabbit hearts. J Pharmacol Exp Ther. 2006;316:718-26. (Pubitemid 43130999)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.316
, Issue.2
, pp. 718-726
-
-
Wu, L.1
Shryock, J.C.2
Song, Y.3
Belardinelli, L.4
-
55
-
-
73249135820
-
The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: A review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation
-
Murdock DK, Kersten M, Kaliebe J, Larrain G. The use of oral ranolazine to convert new or paroxysmal atrial fibrillation: a review of experience with implications for possible "pill in the pocket" approach to atrial fibrillation. Indian Pacing Electrophysiol J. 2009;9:260-7.
-
(2009)
Indian Pacing Electrophysiol J
, vol.9
, pp. 260-7
-
-
Murdock, D.K.1
Kersten, M.2
Kaliebe, J.3
Larrain, G.4
-
56
-
-
55849135767
-
The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation
-
Murdock DK, Overton N, Kersten M, Kaliebe J, Devecchi F. The effect of ranolazine on maintaining sinus rhythm in patients with resistant atrial fibrillation. Indian Pacing Electrophysiol J. 2008;8:175-81.
-
(2008)
Indian Pacing Electrophysiol J
, vol.8
, pp. 175-81
-
-
Murdock, D.K.1
Overton, N.2
Kersten, M.3
Kaliebe, J.4
Devecchi, F.5
-
57
-
-
79960783503
-
Ranolazine verses amiodarone for prophylaxis against atrial fibrillation following coronary artery bypass surgery
-
Miles RH, Murdock DK. Ranolazine verses amiodarone for prophylaxis against atrial fibrillation following coronary artery bypass surgery. Heart Rhythm. 2010;7:258.
-
(2010)
Heart Rhythm
, vol.7
, pp. 258
-
-
Miles, R.H.1
Murdock, D.K.2
-
58
-
-
0028821910
-
Proarrhythmia with class iii antiarrhythmic drugs: Definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications
-
Hohnloser SH, Singh BN. Proarrhythmia with class III antiarrhythmic drugs: definition, electrophysiologic mechanisms, incidence, predisposing factors, and clinical implications. J Cardiovasc Electrophysiol. 1995;6:920-36.
-
(1995)
J Cardiovasc Electrophysiol
, vol.6
, pp. 920-36
-
-
Hohnloser, S.H.1
Singh, B.N.2
-
59
-
-
34748873780
-
Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: Differences in sodium channel inactivation between atria and ventricles and the role of ranolazine
-
DOI 10.1161/CIRCULATIONAHA.107.704890
-
Burashnikov A, Di Diego JM, Zygmunt AC, Belardinelli L, Antzelevitch C. Atrium-selective sodium channel block as a strategy for suppression of atrial fibrillation: differences in sodium channel inactivation between atria and ventricles and the role of ranolazine. Circulation. 2007;116:1449-57. (Pubitemid 47480635)
-
(2007)
Circulation
, vol.116
, Issue.13
, pp. 1449-1457
-
-
Burashnikov, A.1
Di Diego, J.M.2
Zygmunt, A.C.3
Belardinelli, L.4
Antzelevitch, C.5
-
60
-
-
64149119680
-
Block of tetrodotoxinsensitive, na (v)1.7 and tetrodotoxin-resistant, na(v)1.8, na+ channels by ranolazine
-
Rajamani S, Shryock JC, Belardinelli L. Block of tetrodotoxinsensitive, Na(V)1.7 and tetrodotoxin-resistant, Na(V)1.8, Na+ channels by ranolazine. Channels (Austin). 2008;2:449-60.
-
(2008)
Channels (Austin)
, vol.2
, pp. 449-60
-
-
Rajamani, S.1
Shryock, J.C.2
Belardinelli, L.3
-
61
-
-
77949641112
-
Camkiidependent diastolic sr ca2+ leak and elevated diastolic ca2+ levels in right atrial myocardium of patients with atrial fibrillation
-
Neef S, Dybkova N, Sossalla S, Ort KR, Fluschnik N, Neumann K, Seipelt R, Schondube FA, Hasenfuss G, Maier LS. CaMKIIdependent diastolic SR Ca2+ leak and elevated diastolic Ca2+ levels in right atrial myocardium of patients with atrial fibrillation. Circ Res. 2010;106:1134-44.
-
(2010)
Circ Res
, vol.106
, pp. 1134-44
-
-
Neef, S.1
Dybkova, N.2
Sossalla, S.3
Ort, K.R.4
Fluschnik, N.5
Neumann, K.6
Seipelt, R.7
Schondube, F.A.8
Hasenfuss, G.9
Maier, L.S.10
-
62
-
-
52149109259
-
Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart
-
Kumar K, Nearing BD, Bartoli CR, Kwaku KF, Belardinelli L, Verrier RL. Effect of ranolazine on ventricular vulnerability and defibrillation threshold in the intact porcine heart. J Cardiovasc Electrophysiol. 2008;19:1073-9.
-
(2008)
J Cardiovasc Electrophysiol
, vol.19
, pp. 1073-9
-
-
Kumar, K.1
Nearing, B.D.2
Bartoli, C.R.3
Kwaku, K.F.4
Belardinelli, L.5
Verrier, R.L.6
-
63
-
-
67649795769
-
Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart
-
Kumar K, Nearing BD, Carvas M, Nascimento BC, Acar M, Belardinelli L, Verrier RL. Ranolazine exerts potent effects on atrial electrical properties and abbreviates atrial fibrillation duration in the intact porcine heart. J Cardiovasc Electrophysiol. 2009;20:796-802.
-
(2009)
J Cardiovasc Electrophysiol
, vol.20
, pp. 796-802
-
-
Kumar, K.1
Nearing, B.D.2
Carvas, M.3
Nascimento, B.C.4
Acar, M.5
Belardinelli, L.6
Verrier, R.L.7
-
64
-
-
77949596392
-
Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart
-
Carvas M, Nascimento BC, Acar M, Nearing BD, Belardinelli L, Verrier RL. Intrapericardial ranolazine prolongs atrial refractory period and markedly reduces atrial fibrillation inducibility in the intact porcine heart. J Cardiovasc Pharmacol. 2010;55:286-91.
-
(2010)
J Cardiovasc Pharmacol
, vol.55
, pp. 286-91
-
-
Carvas, M.1
Nascimento, B.C.2
Acar, M.3
Nearing, B.D.4
Belardinelli, L.5
Verrier, R.L.6
-
65
-
-
77649299995
-
Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria
-
Sicouri S, Burashnikov A, Belardinelli L, Antzelevitch C. Synergistic electrophysiologic and antiarrhythmic effects of the combination of ranolazine and chronic amiodarone in canine atria. Circ Arrhythm Electrophysiol. 2010;3:88-95.
-
(2010)
Circ Arrhythm Electrophysiol
, vol.3
, pp. 88-95
-
-
Sicouri, S.1
Burashnikov, A.2
Belardinelli, L.3
Antzelevitch, C.4
-
66
-
-
77957571615
-
Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation
-
The study nicely shows that a combination therapy of ranolazine with dronedarone may be a novel antiarrhythmic approach on which the HARMONY study is based
-
BurashnikovA, Sicouri S,DiDiego JM, Belardinelli L, Antzelevitch C. Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation. J Am Coll Cardiol. 2010;56:1216-24. The study nicely shows that a combination therapy of ranolazine with dronedarone may be a novel antiarrhythmic approach on which the HARMONY study is based.
-
(2010)
J Am Coll Cardiol
, vol.56
, pp. 1216-24
-
-
Burashnikov, A.1
Sicouri, S.2
DiDiego, J.M.3
Belardinelli, L.4
Antzelevitch, C.5
-
67
-
-
46349111138
-
Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
-
Sicouri S, Glass A, Belardinelli L, Antzelevitch C. Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations. Heart Rhythm. 2008;5:1019-26.
-
(2008)
Heart Rhythm
, vol.5
, pp. 1019-26
-
-
Sicouri, S.1
Glass, A.2
Belardinelli, L.3
Antzelevitch, C.4
-
68
-
-
84857207640
-
Second chance for dronedarone after recent setback?
-
Mullard A. Second chance for dronedarone after recent setback? Lancet. 2012;379:601.
-
(2012)
Lancet
, vol.379
, pp. 601
-
-
Mullard, A.1
|