Propofol protects against nitrosative stress-induced apoptotic insults to cerebrovascular endothelial cells via an intrinsic mitochondrial mechanism

Surgery (United States)

Volumn 154, Issue 1, 2013, Pages 58-68

  Chen, Ruei Ming ^a,b,c   Tai, Yu Tyng ^b   Chen, Tyng Guey ^b   Lin, The Hin ^a   Chang, Huai Chia ^c   Chen, Ta Liang ^c   Wu, Gong Jhe ^a,c,d  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CASPASE 3; CASPASE 9; CELL DNA; CYTOCHROME C; GENOMIC DNA; NITRIC OXIDE; NITROPRUSSIDE SODIUM; PROPOFOL; PROTEIN BAK; S NITROSOGLUTATHIONE; BAK1 PROTEIN, MOUSE; CASPASE; REACTIVE NITROGEN SPECIES;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL DAMAGE; CELL DEATH; CELL DISRUPTION; CELL ISOLATION; CELL LEVEL; CELL PERMEABILIZATION; CELL PROTECTION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; DNA FRAGMENTATION; DOWN REGULATION; DRUG MECHANISM; ELECTRIC RESISTANCE; ENZYME ACTIVATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUOROMETRY; GENE TRANSLOCATION; IMMUNODETECTION; MITOCHONDRION; MONOLAYER CULTURE; MOUSE; NITROSATIVE STRESS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BRAIN; DRUG EFFECT; ENDOTHELIUM CELL; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; PHYSIOLOGY; VASCULARIZATION;

ANIMALS; APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BRAIN; CASPASES; CYTOCHROMES C; CYTOPROTECTION; ENDOTHELIAL CELLS; MICE; MICE, INBRED ICR; MITOCHONDRIA; NITRIC OXIDE; NITROPRUSSIDE; PROPOFOL; REACTIVE NITROGEN SPECIES; S-NITROSOGLUTATHIONE; STRESS, PHYSIOLOGICAL;

EID: 84883594005     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2013.02.003     Document Type: Article

References (40)

1. Sebel PS, Lowdon JD. Propofol: a new intravenous anesthetic. Anesthesiology 1989;71:260-77. (Pubitemid 19203342)
2. Bryson HM, Fulton BR, Faulds D. Propofol: an update of its use in anaesthesia and conscious sedation. Drugs 1995;50:513-59.
3. Young C, Knudsen N, Andrew H, Reves JG. Sedation in the intensive care unit. Crit Care Med 2000;28:854-66. (Pubitemid 30174290)
4. Johnston AJ, Steiner LA, Chatfield DA, et al. Effects of propofol on cerebral oxygenation and metabolism after head injury. Br J Anaesth 2003;91:781-6. (Pubitemid 37508816)
5. Weiss M, Frei M, Buehrer S, Feurer R, Goitein G, Timmermann B. Deep propofol sedation for vacuum-assisted bite-block immobilization in children undergoing proton radiation therapy of cranial tumors. Paediatr Anaesth 2007;17:867-73. (Pubitemid 47221155)
6. Demiryurek AT, Cinel I, Kahraman S, et al. Propofol and intralipid interact with reactive oxygen species: a chemiluminescence study. Br J Anaesth 1998;80:649-54. (Pubitemid 28224927)
7. Chen RM, Wu CH, Chang HC, et al. Propofol suppresses macrophage functions through modulating mitochondrial membrane potential and cellular adenosine triphosphate levels. Anesthesiology 2003;98:1178-85. (Pubitemid 36520205)
8. Wu GJ, Chen TL, Chang CC, Chen RM. Propofol suppresses tumor necrosis factor-a biosynthesis in lipopolysaccharide-stimulated macrophages possibly through downregulation of nuclear factor-kappa B-mediated toll-like receptor 4 gene expression. Chem Biol Interact 2009;180:465-71.
9. Chen RM, Wu GJ, Tai YT, et al. Propofol downregulates nitric oxide biosynthesis through inhibiting inducible nitric oxide synthase in lipopolysaccharide-activated macrophages. Arch Toxicol 2003;77:418-23.
10. Chang HC, Lin KH, Tai YT, Chen JT, Chen RM. Lipoteichoic acid-induced TNF-a and IL-6 gene expressions and oxidative stress production in macrophages are suppressed by ketamine through downregulating toll-like receptor 2-mediated activation of ERK1/2 and NFkB. Shock 2010; 33:485-92.
11. Lee CJ, Tai YT, Lin YL, Chen RM. Molecular mechanisms of propofol-involved suppression of nitric oxide biosynthesis and inducible nitric oxide synthase gene expression in lipopolysaccharide-stimulated macrophage-like Raw 264.7 cells. Shock 2010;33:93-100.
12. Abbott NJ. Astrocyte-endothelial interactions and blood-brain barrier permeability. J Anat 2002;200:629-38. (Pubitemid 34823054)
13. Lin YL, Chang HC, Chen TL, et al. Resveratrol protects against oxidized LDL-induced breakage of the blood-brain barrier by lessening disruption of tight junctions and apoptotic insults to mouse cerebrovascular endothelial cells. J Nutr 2010;140:2187-92.
14. Pun PB, Lu J, Moochhala S. Involvement of ROS in BBB dysfunction. Free Rad Res 2009;43:348-64.
15. Rubin LL. Endothelial cells: adhesion and tight junctions. Curr Opin Cell Biol 1992;4:830-3.
16. Chen TG, Chen TL, Chang HC, et al. Oxidized low-density lipoprotein induces apoptotic insults to mouse cerebral endothelial cells via a Bax-mitochondria-caspase protease pathway. Toxicol Appl Pharmacol 2007;219:42-53.
17. Chang HC, Chen TG, Tai YT, Chen TL, Chiu WT, Chen RM. Resveratrol attenuates oxidized LDL-evoked Lox-1 signaling and consequently protects against apoptotic insults to cerebrovascular endothelial cells. J Cereb Blood Flow Metab 2011;31:842-54.
18. de Vries HE, Blom-Roosemalen MC, de Boer AG, van Berkel TJ, Breimer DD, Kuiper J. Effect of endotoxin on permeability of bovine cerebral endothelial cell layers in vitro. J Pharmacol Exp Ther 1996;277:1418-23. (Pubitemid 27167154)
19. Sharp CD, Hines I, Houghton J, et al. Glutamate causes a loss in human cerebral endothelial barrier integrity through activation of NMDA receptor. Am J Physiol Heart Circ Physiol 2003;285:2592-8.
20. Betz AL. Alterations in cerebral endothelial cell function in ischemia. Adv Neurol 1996;71:301-11.
21. Cobb JP, Hotchkiss RS, Karl IE, Buchman TG. Mechanisms of cell injury and death. Br J Anaesth 1996;77:3-10. (Pubitemid 26229908)
22. Saikumar P, Dong Z, Patel Y, et al. Role of hypoxia-induced Bax translocation and cytochrome c release in reoxygenation injury. Oncogene 1998;17:3401-15. (Pubitemid 29050675)
23. Antignani A, Youle RJ. How do Bax and Bak lead to permeabilization of the outer mitochondrial membrane? Curr Opin Cell Biol 2006;18:685-9. (Pubitemid 44692478)
24. Rao L, Perez D, White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 1996;135:1441-55. (Pubitemid 26427643)
25. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 1991; 43:109-42.
26. Chen RM, Lin YL, Chou CW. GATA-3 transduces survival signals in osteoblasts through upregulation of bcl-xL gene expression. J Bone Min Res 2010;25:2193-204.
27. Xu J, He L, Ahmed SH, Goldberg MP, Beckman JS, Hsu CY. Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells. Stroke 2000;31:1744-51. (Pubitemid 30437532)
28. Chang H, Tsai SY, Chen TL, Chen TL, Chen RM. Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosis. Can J Anesth 2002;49:477-80. (Pubitemid 34692922)
29. Chen RM, Chen TG, Chen TL, et al. Anti-inflammatory and antioxidative effects of propofol on lipopolysaccharide-activated macrophages. Ann NY Acad Sci 2005;1042:262-71.
30. Gepts E, Camu F, Cockshott ID, Douglas EJ. Disposition of propofol administered as constant rate intravenous infusions in humans. Anesth Analg 1987;66:1256-63. (Pubitemid 18024603)
31. Ho WP, Chan WP, Hsieh MS, Chen RM. Runx2-mediated Bcl-2 gene expression contributes to nitric oxide protection against oxidative stress-induced osteoblast apoptosis. J Cell Biochem 2009;108:1084-93.
32. Chang CC, Liao YS, Lin YL, Chen RM. Nitric oxide protects osteoblasts from oxidative stress-induced apoptotic insults via a mitochondria-dependent mechanism. J Orthop Res 2006;24:1917-25.
33. Chen RM, Chen TL, Chiu WT, Chang CC. Molecular mechanism of nitric oxide-induced osteoblast apoptosis. J Orthop Res 2005;23:462-8.
34. Tai YT, Chen TL, Cherng YG, Hwang YP, Chen JT, Chen RM. Pretreatment with low nitric oxide protects osteoblasts from highnitricoxide-induced apoptotic insults throughregulation of c-Jun N-terminal kinase/c-Jun-mediated Bcl-2 gene expression and protein translocation. J Orthop Res 2007;25:625-35.
35. Kowaluk EA, Seth P, Fung HL. Metabolic activation of sodium nitroprusside to nitric oxide in vascular smooth muscle. J Pharmacol Exp Ther 1992;262:916-22.
36. Erusalimsky JD, Moncada S. Nitric oxide and mitochondrial signaling: from physiology to pathophysiology. Arterioscl Throm Vas Biol 2007;27:2524-31. (Pubitemid 350158901)
37. Autret A, Martin SJ. Emerging role for members of the Bcl-2 family in mitochondrial morphogenesis. Mol Cell 2009;36:355-63.
38. Chen RM, Wu GJ, Chang HC, et al. 2,6-Diisopropylphenol protects osteoblasts from oxidative stress-induced apoptosis through suppression of caspase-3 activation. Ann NY Acad Sci 2005;1042:448-59.
39. Sheridan C, Martin SJ. Mitochondrial fission/fusion dynamics and apoptosis. Mitochondrion 2010;10:640-8.
40. Goyal L. Cell death inhibition: keeping caspases in check. Cell 2001;104:805-8. (Pubitemid 32289272)