Immune cells and bone: Coupling goes both ways

Immunological Investigations

Volumn 42, Issue 7, 2013, Pages 532-543

  Horwood, Nicole J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Coupling; Haemopoietic stem cell niche; Osteoblasts; Osteoclasts

Indexed keywords

ANGIOPOIETIN 1; CATHEPSIN K; CD45 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; CYCLOOXYGENASE 2; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; GAMMA INTERFERON; GLYCOPROTEIN; INTERLEUKIN 17; JAGGED1; NERVE CELL ADHESION MOLECULE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPONTIN; PARATHYROID HORMONE; PROSTAGLANDIN E2; SCLEROSTIN; STEM CELL FACTOR; STRONTIUM; STRONTIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA;

ALBERS SCHOENBERG DISEASE; ANKYLOSING SPONDYLITIS; APOPTOSIS; ARTHRITIS; ARTICLE; B LYMPHOCYTE; BONE CELL; BONE MARROW; CELL ACTIVITY; ENCHONDRAL OSSIFICATION; ENDOTHELIUM CELL; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; LYMPHOID PROGENITOR CELL; MACROPHAGE; NATURAL KILLER CELL; NONHUMAN; OSSIFICATION; OSTEOCLAST ACTIVITY; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; STEM CELL MOBILIZATION; STEM CELL NICHE; T LYMPHOCYTE ACTIVATION; TH17 CELL; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; HUMANS; IMMUNE SYSTEM;

EID: 84883592970     PISSN: 08820139     EISSN: 15324311     Source Type: Journal    
DOI: 10.3109/08820139.2013.822762     Document Type: Article

References (98)

1. Alexander KA, Chang MK, Maylin ER, et al. (2011). Osteal macrophages promote in vivo intramembranous bone healing in a mouse tibial injury model. J Bone Miner Res, 26, 1517-32
2. Bar-Shavit Z. (2007). The osteoclast: A multinucleated, hematopoietic-origin, boneresorbing osteoimmune cell. J Cell Biochem, 102, 1130-9
3. Barbier V, Winkler IG, Levesque JP. (2012). Mobilization of hematopoietic stem cells by depleting bone marrow macrophages. Meth Mol Biol, 904, 117-38
4. Bedi B, Li JY, Tawfeek H, et al
5. receptor 1 in T cells blunts the bone anabolic activity of PTH. Proc Natl Acad Sci USA, 109, E725-33
6. Bluml S, McKeever K, Ettinger R, et al. (2013). B-cell targeted therapeutics in clinical development. Arthr Res Ther, 15, S4
7. Bowness P, Ridley A, Shaw J, et al. (2011). Th17 cells expressing KIR3DL2 and responsive to HLA-B27 homodimers are increased in ankylosing spondylitis. J Immunol, 186, 2672-80
8. Bromberg O, Frisch BJ,Weber JM, et al. (2012). Osteoblastic N-cadherin is not required for microenvironmental support and regulation of hematopoietic stem and progenitor cells. Blood, 120, 303-13
9. Calvi LM, Adams GB, Weibrecht KW, et al. (2003). Osteoblastic cells regulate the haematopoietic stem cell niche. Nature, 425, 841-6
10. Calvi LM, Bromberg O, Rhee Y, et al. (2012). Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells. Blood, 119, 2489-99
11. Champagne CM, Takebe J, Offenbacher S, Cooper LF. (2002). Macrophage cell lines produce osteoinductive signals that include bone morphogenetic protein-2. Bone, 30, 26-31
12. Chang MK, Raggatt LJ, Alexander KA, et al. (2008). Osteal tissue macrophages are intercalated throughout human and mouse bone lining tissues and regulate osteoblast function in vitro and in vivo. J Immunol, 181, 1232-44
13. Choudhary S, Blackwell K, Voznesensky O, et al. (2013). Prostaglandin E acts via bone marrow macrophages to block PTH-stimulated osteoblast differentiation in vitro. Bone, 56, 31-41
14. Colonna M. (2003). DAP12 signaling: From immune cells to bone modeling and brain myelination. J Clin Invest, 111, 313-14
15. Dalbeth N, Callan MF. (2002). A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheumat, 46, 1763-72
16. Dalbeth N, Gundle R, Davies RJ, et al. (2004). CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation. J Immunol, 173, 6418-26
17. Despars G, Pandruvada SN, Anginot A, et al. (2013). DAP12 Overexpression induces osteopenia and impaired early hematopoiesis. PloS one, 8, e65297
18. Ding L, Morrison SJ. (2013). Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches. Nature, 495, 231-5
19. Dougall WC, Glaccum M, Charrier K, et al. (1999). RANK is essential for osteoclast and lymph node development. Genes & Develop, 13, 2412-24
20. Duque G, Huang DC, Dion N, et al. (2011). Interferon-gamma plays a role in bone formation in vivo and rescues osteoporosis in ovariectomized mice. J Bone Miner Res, 26, 1472-83
21. Flanagan AM, Chambers TJ. (1992). Stimulation of bone nodule formation in vitro by prostaglandins E1 and E2. Endocrinology, 130, 443-8
22. Frisch BJ, Porter RL, Gigliotti BJ, et al. (2009). In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. Blood, 114, 4054-63
23. Gao Y, Grassi F, Ryan MR, et al. (2007). IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest, 117, 122-32
24. Genetos DC, Yellowley CE, Loots GG. (2011). Prostaglandin E2 signals through PTGER2 to regulate sclerostin expression. PloS one, 6, e17772
25. Gough AK, Lilley J, Eyre S, et al. (1994). Generalised bone loss in patients with early rheumatoid arthritis. Lancet, 344, 23-7
26. Greenbaum A, Hsu YM, Day RB, et al. (2013). CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature, 495, 227-30
27. Guihard P, Danger Y, Brounais B, et al. (2012). Induction of osteogenesis in mesenchymal stem cells by activated monocytes/macrophages depends on oncostatin M signaling. Stem Cells, 30, 762-72
28. Henriksen K, Karsdal MA, Martin TJ. (2013). Osteoclast-derived coupling factors in bone remodeling. Calcified Tissue Inter, May 23. [Epub ahead of print].
29. Horowitz MC, Xi Y, Pflugh DL, et al. (2004). Pax5-deficient mice exhibit early onset osteopenia with increased osteoclast progenitors. J Immunol, 173, 6583-91
30. Horwood NJ, Elliott J, Martin TJ, Gillespie MT. (1998). Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells. Endocrinology, 139, 4743-6
31. Horwood NJ, Urbaniak AM, Danks L. (2012). Tec family kinases in inflammation and disease. Inter Rev Immunol, 31, 87-103
32. Horwood NJ, Kartsogiannis V, Quinn JM, et al. (1999). Activated T lymphocytes support osteoclast formation in vitro. Biochem Biophys Res Commun, 265, 144-50
33. Howard GA, Bottemiller BL, Turner RT, et al. (1981). Parathyroid hormone stimulates bone formation and resorption in organ culture: Evidence for a coupling mechanism. Proc Natl Acad Sci USA, 78, 3204-8
34. Jandus C, Bioley G, Rivals JP, et al. (2008). Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides. Arthritis Rheum, 58, 2307-17
35. Kawaguchi H, Raisz LG, Voznesensky OS, et al. (1994). Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae. Endocrinology, 135, 1157-64
36. Kawaguchi H, Pilbeam CC, Harrison JR, Raisz LG. (1995). The role of prostaglandins in the regulation of bone metabolism. Clin Orthop Relat Res, 1995, 36-46
37. Kim YG, Lee CK, Nah SS, et al. (2007). Human CD4CD25 regulatory T cells inhibit the differentiation of osteoclasts from peripheral blood mononuclear cells. Biochem Biophys Res Commun, 357, 1046-52
38. Kollet O, Dar A, Shivtiel S, et al. (2006). Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells. Nature Med, 12, 657-64
39. Kong YY, Feige U, Sarosi I, et al. (1999a). Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature, 402, 304-9
40. Kong YY, Yoshida H, Sarosi I, et al. (1999b). OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature, 397, 315-23
41. Kotake S, Udagawa N, Takahashi N, et al. (1999). IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest, 103, 1345-52
42. Levesque JP, Helwani FM, Winkler IG. (2003). Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilization induced by GCSF or cyclophosphamide. J Clin Investig, 111, 187-96
43. Levesque JP, Helwani FM, Winkler IG. (2010). The endosteal 'osteoblastic' niche and its role in hematopoietic stem cell homing and mobilization. Leukemia, 24, 1979-92
44. Li L, Pettit AR, Gregory LS, Forwood MR. (2006). Regulation of bone biology by prostaglandin endoperoxide H synthases (PGHS): A rose by any other name. Cytokine Growth Factor Rev, 17, 203-16
45. Li Y, Li A, Yang X, Weitzmann MN. (2007a). B cells and T cells are critical for the preservation of bone homeostasis and attainment of peak bone mass in vivo. Blood, 109, 3839-48
46. Li Y, Toraldo G, Li A, et al. (2007b). Ovariectomy-induced bone loss occurs independently of B cells. J Cell Biochem, 100, 1370-5
47. Lo CK, Lam QL, Sun L, et al. (2008). Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production. Arthritis Rheum, 58, 2700-11
48. Loftus Jr EV, Achenbach SJ, Sandborn WJ, et al. (2003). Risk of fracture in ulcerative colitis: A population-based study from Olmsted County, Minnesota. Clin Gastroenterol Hepatol, 1, 465-73
49. Lymperi S, Horwood N, Marley S, et al. (2008). Strontium can increase some osteoblasts without increasing hematopoietic stem cells. Blood, 111, 1173-81
50. Lymperi S, Ersek A, Ferraro F, et al. (2011). Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo. Blood, 117, 1540-9
51. Lymperi S, Ferraro F, Scadden DT (2010). The HSC niche concept has turned 31 Has our knowledge matured? Ann NY Acad Sci, 1192, 12-18
52. Madyastha PR, Yang S, Ries WL, Key Jr LL. (2000). IFN-gamma enhances osteoclast generation in cultures of peripheral blood from osteopetrotic patients and normalizes superoxide production. J Inter Soc Interferon Cytok Res, 20, 645-52
53. Magrey M, Khan MA. (2010). Osteoporosis in ankylosing spondylitis. Curr Rheumatol Rep, 12, 332-6
54. Mansour A, Abou-Ezzi G, Sitnicka E, et al. (2012). Osteoclasts promote the formation of hematopoietic stem cell niches in the bone marrow. J Exper Med, 209, 537-49
55. Mei HE, Schmidt S, Dorner T. (2012). Rationale of anti-CD19 immunotherapy: An option to target autoreactive plasma cells in autoimmunity. Arthritis Res Ther, 14, S1
56. Miyamoto K, Yoshida S, Kawasumi M, et al. (2011). Osteoclasts are dispensable for hematopoietic stem cell maintenance and mobilization. J Exper Med, 208, 2175-81
57. Moore J, Ma D, Will R, et al. (2004). A phase II study of Rituximab in rheumatoid arthritis patients with recurrent disease following haematopoietic stem cell transplantation. Bone Marrow Transplant, 34, 241-7
58. Nagata T, Kaho K, Nishikawa S, et al. (1994). Effect of prostaglandin E2 on mineralization of bone nodules formed by fetal rat calvarial cells. Calcif Tissue Int, 55, 451-7
59. Nakagawa H, Takagi K, Kitaoka M, et al. (1993). Influence of monocyte-macrophage lineage cells on alkaline phosphatase activity of developing osteoblasts derived from rat bone marrow stromal cells. Nippon Seikeigeka Gakkai Zasshi, 67, 480-9
60. Nakashima T, Takayanagi H. (2011). New regulation mechanisms of osteoclast differentiation. Ann NY Acad Sci, 1240, E13-18
61. Nam D, Mau E, Wang Y, et al. (2012). T-lymphocytes enable osteoblast maturation via IL-17F during the early phase of fracture repair. PloS one, 7, e40044
62. Nicolaidou V, Wong MM, Redpath AN, et al. (2012). Monocytes induce STAT3 activation in human mesenchymal stem cells to promote osteoblast formation. PLoS One, 7, e39871
63. Nie H, Zheng Y, Li R, et al. (2013). Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. Nat Med, 19, 322-8
64. Ninomiya T, Hosoya A, Hiraga T, et al. (2011). Prostaglandin E(2) receptor EP(4)- selective agonist (ONO-4819) increases bone formation by modulating mesenchymal cell differentiation. Eur J Pharmacol, 650, 396-402
65. Nutt SL, Heavey B, Rolink AG, Busslinger M. (1999). Commitment to the B-lymphoid lineage depends on the transcription factor Pax5. Nature, 401, 556-62
66. Olson TS, Caselli A, Otsuru S, et al. (2013). Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning. Blood, 121, 5238-49
67. Pollinger B, Junt T, Metzler B, et al. (2011). Th17 cells, not IL-17 gammadelta T cells, drive arthritic bone destruction in mice and humans. J Immunol, 186, 2602-12
68. Porter RL, Georger MA, Bromberg O, et al. (2013). Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury. Stem Cells, 31, 372-83
69. Quinn JM, Neale S, Fujikawa Y, et al. (1998). Human osteoclast formation from blood monocytes, peritoneal macrophages, and bone marrow cells. Calcified Tissue Inter, 62, 527-31
70. Quinn JM, Horwood NJ, Elliott J, et al. (2000). Fibroblastic stromal cells express receptor activator of NF-kappa B ligand and support osteoclast differentiation. J Amer Soc Bone Miner Res, 15, 1459-66
71. Raggatt LJ, Alexander KA, Kaur S, et al. (2013). Absence of B cells does not compromise intramembranous bone formation during healing in a tibial injury model. Amer J Pathol, 182, 1501-8
72. Repovic P, Benveniste EN. (2002). Prostaglandin E2 is a novel inducer of oncostatin-M expression in macrophages and microglia. J Neurosci, 22, 5334-43
73. Rifas L, Arackal S, Weitzmann MN. (2003). Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. J Cell Biochem, 88, 650-9
74. Rifas L, Cheng SL, Shen V, Peck WA. (1989). Monokines produced by macrophages stimulate the growth of osteoblasts. Connect Tissue Res, 23, 163-78
75. Ruutu M, Thomas G, Steck R, et al. (2012). Beta-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis Rheum, 64, 2211-22
76. Sato K, Takayanagi H. (2006). Osteoclasts, rheumatoid arthritis, and osteoimmunology. Curr Opin Rheumatol, 18, 419-26
77. Shinoda K, Sugiyama E, Taki H, et al. (2003). Resting T cells negatively regulate osteoclast generation from peripheral blood monocytes. Bone, 33, 711-20
78. Soderstrom K, Stein E, Colmenero P, et al. (2010). Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. Proc Natl Acad Sci USA, 107, 13028-33
79. Spector TD, Hall GM, McCloskey EV, Kanis JA. (1993). Risk of vertebral fracture in women with rheumatoid arthritis. BMJ, 306, 558
80. Stier S, Ko Y, Forkert R, et al. (2005). Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exper Med, 201, 1781-91
81. Sugiyama T, Kohara H, Noda M, Nagasawa T. (2006). Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches. Immunity, 25, 977-88
82. Takayanagi, H. (2012). New developments in osteoimmunology. Nat Rev Rheumatol, 8, 684-9
83. Takayanagi H, Ogasawara K, Hida S, et al. (2000). T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma. Nature, 408, 600-5
84. Tian XY, Zhang Q, Zhao R, et al. (2008). Continuous PGE2 leads to net bone loss while intermittent PGE2 leads to net bone gain in lumbar vertebral bodies of adult female rats. Bone, 42, 914-20
85. Toraldo G, Roggia C, Qian WP, et al. (2003). IL-7 induces bone loss in vivo by induction of receptor activator of nuclear factor kappa B ligand and tumor necrosis factor alpha from T cells. Proc Natl Acad Sci USA, 100, 125-30
86. Tsukii K, Shima N, Mochizuki S, et al. (1998). Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of bone. Biochem Biophys Res Commun, 246, 337-41
87. Tyagi AM, Srivastava K, Mansoori MN, et al. (2012). Estrogen deficiency induces the differentiation of IL-17 secreting Th17 cells: A new candidate in the pathogenesis of osteoporosis. PLoS One, 7, e44552
88. Walker EC, McGregor NE, Poulton IJ, et al. (2010). Oncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in mice. J Clin Invest, 120, 582-92
89. Weber JM, Forsythe SR, Christianson CA, et al. (2006). Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells. Bone, 39, 485-93
90. Weinreb M, Suponitzky I, Keila S. (1997). Systemic administration of an anabolic dose of PGE2 in young rats increases the osteogenic capacity of bone marrow. Bone, 20, 521-6
91. Weitzmann MN, Cenci S, Haug J, et al. (2000). B lymphocytes inhibit human osteoclastogenesis by secretion of TGFbeta. J Cell Biochem, 78, 318-24
92. Winkler IG, et al. (2010). Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs. Blood, 116, 4815-28
93. Winkler IG, Sims NA, Pettit AR, et al. (2012). Vascular niche E-selectin regulates hematopoietic stem cell dormancy, self renewal and chemoresistance. Nature Med, 18, 1651-7
94. Xie C, Ming X, Wang Q, et al. (2008). COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone, 43, 1075-83
95. Yun TJ, Tallquist MD, Aicher A, et al. (2001). Osteoprotegerin, a crucial regulator of bone metabolism, also regulates B cell development and function. J Immunol, 166, 1482-91
96. Zaiss MM, Frey B, Hess A, et al. (2010). Regulatory T cells protect from local and systemic bone destruction in arthritis. J Immunol, 184, 7238-46
97. Zarling JM, Shoyab M, Marquardt H, et al. (1986). Oncostatin M: A growth regulator produced by differentiated histiocytic lymphoma cells. Proc Natl Acad Sci USA, 83, 9739-43
98. Zhang J, Niu C, Ye L, et al. (2003). Identification of the haematopoietic stem cell niche and control of the niche size. Nature, 425, 836-41