Improved supersaturation and oral absorption of dutasteride by amorphous solid dispersions

Chemical and Pharmaceutical Bulletin

Volumn 60, Issue 11, 2012, Pages 1468-1473

  Beak, In Hwan ^a   Kim, Min Soo ^b  

^a Chungnam National University   (South Korea)

^b Inje University   (South Korea)

Author keywords

Amorphous; Dutasteride; Poorly water soluble drug; Solid dispersion; Supersaturation

Indexed keywords

DUTASTERIDE; EUDRAGIT; EXCIPIENT; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; POVIDONE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION (PARAMETERS); CRYSTALLIZATION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG SOLUBILITY; HYDROGEN BOND; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PLASMA CONCENTRATION-TIME CURVE; RAT; SPRAY DRYING; STATIC ELECTRICITY;

5-ALPHA REDUCTASE INHIBITORS; ADMINISTRATION, ORAL; ANIMALS; AZASTEROIDS; BETA-CYCLODEXTRINS; CELLULOSE; EXCIPIENTS; MALE; METHYLCELLULOSE; METHYLMETHACRYLATES; POVIDONE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY;

EID: 84868590237     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c12-00563     Document Type: Article

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