Comparison of human liver and small intestinal glutathione S- transferase-catalyzed busulfan conjugation in vitro

Drug Metabolism and Disposition

Volumn 26, Issue 1, 1998, Pages 52-55

  Gibbs, John P ^b   Yang, Ji Sun ^b   Slattery, John T ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BUSULFAN; GLUTATHIONE TRANSFERASE;

ARTICLE; DRUG CLEARANCE; DRUG DEGRADATION; DRUG ELIMINATION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME LOCALIZATION; HUMAN; HUMAN TISSUE; LIVER METABOLISM; PRIORITY JOURNAL; SMALL INTESTINE; TISSUE DISTRIBUTION;

BUSULFAN; CATALYSIS; CYTOSOL; DINITROBENZENES; GLUTATHIONE TRANSFERASE; HUMANS; INTESTINE, SMALL; KINETICS; LIVER; PROTEINS; THIOPHENES;

EID: 0031919721     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bradford MA (1976) A rapid and sensitive method for the quanitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
2. Czerwinski M, Gibbs JP and Slattery JT (1996) Busulfan conjugation by glutathione S-transferases α, μ, and π. Drug Metab Dispos 24:1015-1019.
3. DeWaziers I, Cugnenc PH, Yang CS, Leroux JP and Beaune BH (1989) Cytochrome P450 isoenzymes, epoxide hydrolase, and glutathione transferases in rat and human hepatic and extrahepatic tissues. J Pharmacol Exp Ther 253:387-394.
4. Dix SP, Wingard JR, Mullins RE, Jerkunica I, Davidson TG, Gilmore CE, York RC, Lin LS, devine SM, Geller RB, Heffner LT, Hillyer CD, Holland HK, Winton EF and Saral R (1996) Association of busulfan area under the curve with veno-occlusive disease following bone marrow transplantation. Bone Marrow Transplant 17:225-230.
5. Gibbs JP, Czerwinski M and Slattery JT (1996) Busulfan-glutathione conjugation catalyzed by human liver cytosolic glutathione S-transferases. Cancer Res 56:3678-3681.
6. Gibbs JP, Murray G, Risler R, Chien JY, Dev R and Slattery JT (1997) Age-dependent tetrahydrothiophenium ion formation in children and adults. Cancer Res, in press.
7. Grochow LB (1993) Busulfan disposition: The role of therapeutic drug monitoring in bone marrow transplantation induction regimens. Semin Oncol 20:18-25.
8. 14C-busulfan in isolated perfused rat liver. Eur J Drug Metab Pharmacokinet 12:71-76.
9. Hassan M, Ehrsson H and Ljungman P (1996) Aspects concerning busulfan pharmacokinetics and bioavailability. Leuk Lymphoma 22:395-407.
10. Hassan M, Ljungman P, Ringden O, Syruckova Z, Bekassy A, Stary J, Wallin I and Kallberg N (1995) Busulfan bioavailability. Blood 82:2144-2150.
11. Haves JD and Pulford DJ (1995) The glutathione S-transferase supergene family: Regulation of GST and the contribution of the isoenzymes to cancer chemoprevention and drug resistance. Crit Rev Biochem Mol Biol 30:445-600.
12. International Commission on Radiological Protection (1975) Report of the Task Group on Reference Man. New York, Permagon, p. 136.
13. Laemmli UK (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond) 227:680-685.
14. Marchand DH, Remmel RP and Abdel-Monem MM (1988) Biliary excretion of a glutathione conjugate of busulfan and 1,4-dibromobutane in the rat. Drug Metab Dispos 16:85-92.
15. Mulders TMT, van Ommen B, van Bladeren PJ, Breimer DD and Mulder GJ (1993) Stereoselectivity of human liver and intestinal cytosolic fractions as well as purified human glutathione S-transferase isoenzymes towards 2-bromoisovalerylurea enantiomers. Biochem Pharmacol 46:1775-1780.
16. Nadkarni MV, Trams EG and Smith PK (1959) Preliminary studies on the distribution and fate of TEM, TEPA, and myleran in the human. Cancer Res 19:713-718.
17. Paine MF, Khalighi M, Fisher JM, Shen DD, Kunze KL, Marsh CL, Perkins JD and Thummel KE. Characterization of inter- and intra-intestinal differences in human CYP3A-dependent metabolism. J Pharmacol Exp Ther, in press.
18. Nijhoff WA, Grubben M, Nagengast FM, Jansen J, Verhagen H, van Poppel G and Peters W (1995) Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans. Carcinogenesis 16:2125-2128.
19. Paine MF, Shen DD, Kunze KL, Perkins JD, Marsh CL, McVicar JD, Barr DM, Gillies BS and Thummel KE (1996) First-pass metabolism of midazolam by the human intestine. Clin Pharmacol Ther 60:14-24.
20. Peters WHM, Kock L, Nagengast FM and Kremers PG (1991) Biotransformation enzymes in the human intestine: Critical low levels in the colon? Gut 32:408-412.
21. Peters WHM, Nagengast FM and van Tongeren J (1989) Glutathione S-transferase, cytochrome P450, and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver. Gastroenterology 96:783-789.
22. Peters WHM, Roelofs HMJ, Nagengast FM and van Tongeren JHM (1989) Human intestinal glutathione. S-transferases. Biochem J 257:471-476.
23. Slattery JT, Clift RA, Buckner CD, Radich J, Storer B, Bensinger WI, Soll E, Anasetti C, Bowden R, Bryant E, Chauncey T, Deeg J, Doney KC, Flowers M, Gooley T, Hansen JA, Martin PJ, MacDonald GB, Nash R, Petersdorf EW, Sanders JE, Schoch G, Stewart P, Storb R, Sullivan KM, Thomas ED, Witherspoon RP and Appelbaum FR (1997) Marrow transplantation for chronic myeloid leukemia: The influence of plasma busulfan levels on the outcome of transplantation. Blood 89:3055-3060.
24. Slattery JT, Sanders JE, Buckner CD, Schaffer RL, Lambert KW, Langer FP, Anasetti C, Bensinger WI, Fisher LD, Appelbaum FR and Hansen JA (1995) Graft-rejection and toxicity following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transplant 16:31-42.
25. Thummel KE, O'Shea D, Paine MF, Shen DD, Kunze KL, Perkins JD and Wilkinson GR (1996) Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism. Clin Pharmacol Ther 59:491-502.
26. Thummel KE, Shen DD, Podoll TD, Kunze KL, Trager WF, Hartwell PS, Raisys VA, Marsh CL, McVicar JP, Barr DM, Perkins JD and Carithers RL (1994) Use of midazolam as a human cytochrome P450 3A probe: I. In vitro-in vivo correlations in liver transplant patients. J Pharmacol Exp Ther 27:549-556.
27. Tobin H, Staehelin T and Gordon J (1972) Electrophoretic transfer of protein from polyacrylamide gels to nitrocellulose sheets: Procedures and some applications. Proc Natl Acad Sci USA 76:4350-4354.
28. Vodopick H, Hamilton HE, Jackson HL, Peng CT and Sheets RF (1969) Metabolic fate of tritiated busulfan in man. J Lab Clin Med 73:266-276.