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Volumn 11, Issue 4, 2009, Pages 328-338

Future G protein-coupled receptor targets for treatment of heart failure

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR KINASE; BETA ARRESTIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIN 1; ENDOTHELIN RECEPTOR ANTAGONIST; FUROSEMIDE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR KINASE; METOPROLOL; PHOSPHODIESTERASE IV;

EID: 67651113673     PISSN: 10928464     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11936-009-0033-5     Document Type: Review
Times cited : (49)

References (49)
  • 3
    • 0028183015 scopus 로고
    • International Union of Pharmacology nomenclature of adrenoceptors
    • Bylund DB, Eikenberg DC, Hieble JP, et al.: International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol Rev 1994, 46:121-136.
    • (1994) Pharmacol Rev , vol.46 , pp. 121-136
    • Bylund, D.B.1    Eikenberg, D.C.2    Hieble, J.P.3
  • 4
    • 0037050009 scopus 로고    scopus 로고
    • Seven-transmembrane-spanning receptors and heart function
    • Rockman HA, Koch WJ, Lefkowitz RJ: Seven-transmembrane-spanning receptors and heart function. Nature 2002, 415:206-212.
    • (2002) Nature , vol.415 , pp. 206-212
    • Rockman, H.A.1    Koch, W.J.2    Lefkowitz, R.J.3
  • 5
    • 0021194420 scopus 로고
    • Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
    • Cohn JN, Levine TB, Olivari MT, et al.: Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. N Engl J Med 1984, 311:819-823.
    • (1984) N Engl J Med , vol.311 , pp. 819-823
    • Cohn, J.N.1    Levine, T.B.2    Olivari, M.T.3
  • 6
  • 7
    • 0034620523 scopus 로고    scopus 로고
    • b-Adrenergic receptor blockade in chronic HF
    • Bristow MR: B-Adrenergic receptor blockade in chronic HF. Circulation 2000, 101:558-569.
    • (2000) Circulation , vol.101 , pp. 558-569
    • Bristow, M.R.1
  • 8
    • 0032729995 scopus 로고    scopus 로고
    • Opposing effects of b1- and b2-adrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein
    • Communal C, Singh K, Sawyer DB, Colucci WS: Opposing effects of b1- and b2-adrenergic receptors on cardiac myocyte apoptosis: Role of a pertussis toxin-sensitive G protein. Circulation 1999, 100:2210-2212.
    • (1999) Circulation , vol.100 , pp. 2210-2212
    • Communal, C.1    Singh, K.2    Sawyer, D.B.3    Colucci, W.S.4
  • 9
    • 0035852634 scopus 로고    scopus 로고
    • Dual modulation of cell survival and cell death by b2-adrenergic signaling in adult mouse cardiac myocytes
    • Zhu WZ, Zheng M, Koch WJ, et al.: Dual modulation of cell survival and cell death by b2-adrenergic signaling in adult mouse cardiac myocytes. Proc Natl Acad Sci U S A. 2001, 98:1607-1612.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1607-1612
    • Zhu, W.Z.1    Zheng, M.2    Koch, W.J.3
  • 10
    • 0034636061 scopus 로고    scopus 로고
    • Early and delayed consequences of b2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level
    • Liggett SB, Tepe NM, Lorenz JN, et al.: Early and delayed consequences of b2-adrenergic receptor overexpression in mouse hearts: Critical role for expression level. Circulation 2000, 101:1707-1714.
    • (2000) Circulation , vol.101 , pp. 1707-1714
    • Liggett, S.B.1    Tepe, N.M.2    Lorenz, J.N.3
  • 11
    • 0033535942 scopus 로고    scopus 로고
    • Progressive hypertrophy and heart failure in b1-adrenergic receptor transgenic mice
    • Engelhardt S, Hein L, Wiesmann F, Lohse MJ: Progressive hypertrophy and heart failure in b1-adrenergic receptor transgenic mice. Proc Natl Acad Sci U S A 1999, 96:7059-7064.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 7059-7064
    • Engelhardt, S.1    Hein, L.2    Wiesmann, F.3    Lohse, M.J.4
  • 12
    • 4844228660 scopus 로고    scopus 로고
    • Beneficial effects of chronic pharmacological manipulation of b-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy
    • Ahmet I, Krawczyk M, Heller P, et al.: Beneficial effects of chronic pharmacological manipulation of b-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation 2004, 110:1083-1090.
    • (2004) Circulation , vol.110 , pp. 1083-1090
    • Ahmet, I.1    Krawczyk, M.2    Heller, P.3
  • 13
    • 0032745831 scopus 로고    scopus 로고
    • Enhancement of cardiac function after adenoviral-mediated in vivo intra-coronary b2-adrenergic receptor gene delivery
    • Maurice JP, Hata JA, Shah AS, et al.: Enhancement of cardiac function after adenoviral-mediated in vivo intra-coronary b2-adrenergic receptor gene delivery. J Clin Invest 1999, 104:21-29.
    • (1999) J Clin Invest , vol.104 , pp. 21-29
    • Maurice, J.P.1    Hata, J.A.2    Shah, A.S.3
  • 14
    • 41649114019 scopus 로고    scopus 로고
    • Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress
    • DeGeorge BR Jr, Gao E, Boucher M, et al.: Targeted inhibition of cardiomyocyte Gi signaling enhances susceptibility to apoptotic cell death in response to ischemic stress. Circulation 2008, 117:1378-1387.
    • (2008) Circulation , vol.117 , pp. 1378-1387
    • DeGeorge Jr., B.R.1    Gao, E.2    Boucher, M.3
  • 15
    • 0141457810 scopus 로고    scopus 로고
    • The b-adrenergic receptor kinase (bARK1) in heart failure
    • Petrofski JA, Koch WJ: The b-adrenergic receptor kinase (bARK1) in heart failure. J Mol Cell Cardiol 2003, 35:1167-1174.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 1167-1174
    • Petrofski, J.A.1    Koch, W.J.2
  • 16
    • 17644402459 scopus 로고    scopus 로고
    • Transduction of receptor signals by b-arrestins
    • Lefkowitz RJ, Shenoy SK: Transduction of receptor signals by b-arrestins. Science 2005, 308:512-517.
    • (2005) Science , vol.308 , pp. 512-517
    • Lefkowitz, R.J.1    Shenoy, S.K.2
  • 17
    • 48249116367 scopus 로고    scopus 로고
    • Gene therapy in heart failure
    • Vinge LE, Raake PW, Koch WJ: Gene therapy in heart failure. Circ Res 2008, 102:1458-1470.
    • (2008) Circ Res , vol.102 , pp. 1458-1470
    • Vinge, L.E.1    Raake, P.W.2    Koch, W.J.3
  • 18
    • 0027481032 scopus 로고
    • The binding site for the bg subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase
    • Koch WJ, Inglese J, Stone WC, Lefkowitz RJ: The binding site for the bg subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase. J Biol Chem 1993, 268:8256-8260.
    • (1993) J Biol Chem , vol.268 , pp. 8256-8260
    • Koch, W.J.1    Inglese, J.2    Stone, W.C.3    Lefkowitz, R.J.4
  • 19
    • 0029061324 scopus 로고
    • Cardiac function in mice overexpressing the b-adrenergic receptor kinase or a bARK inhibitor
    • Koch WJ, Rockman HA, Samama P, et al.: Cardiac function in mice overexpressing the b-adrenergic receptor kinase or a bARK inhibitor. Science 1995, 268:1350-1353.
    • (1995) Science , vol.268 , pp. 1350-1353
    • Koch, W.J.1    Rockman, H.A.2    Samama, P.3
  • 20
    • 0035814968 scopus 로고    scopus 로고
    • In vivo ventricular gene delivery of a b-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction
    • Shah AS, White DC, Emani S, et al.: In vivo ventricular gene delivery of a b-adrenergic receptor kinase inhibitor to the failing heart reverses cardiac dysfunction. Circulation 2001, 103:1311-1316.
    • (2001) Circulation , vol.103 , pp. 1311-1316
    • Shah, A.S.1    White, D.C.2    Emani, S.3
  • 21
    • 0034625008 scopus 로고    scopus 로고
    • Preservation of myocardial b-adrenergic receptor delays the development of heart failure following myocardial infarction
    • White DC, Hata JA, Shah AS, et al.: Preservation of myocardial b-adrenergic receptor delays the development of heart failure following myocardial infarction. Proc Natl Acad Sci U S A 2000, 97:5428-5433.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 5428-5433
    • White, D.C.1    Hata, J.A.2    Shah, A.S.3
  • 22
    • 1842526833 scopus 로고    scopus 로고
    • Targeted b-adrenergic receptor kinase (bARK1) inhibition by gene transfer in failing human hearts
    • Williams ML, Hata JA, Schroder J, et al.: Targeted b-adrenergic receptor kinase (bARK1) inhibition by gene transfer in failing human hearts. Circulation 2004, 109:1590-1593.
    • (2004) Circulation , vol.109 , pp. 1590-1593
    • Williams, M.L.1    Hata, J.A.2    Schroder, J.3
  • 23
    • 59049097977 scopus 로고    scopus 로고
    • Myocardial adeno-associated virus serotype 6-bARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure
    • Rengo G, Lymperopoulos A, Zincarelli C, et al.: Myocardial adeno-associated virus serotype 6-bARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure. Circulation 2009, 119:89-98.
    • (2009) Circulation , vol.119 , pp. 89-98
    • Rengo, G.1    Lymperopoulos, A.2    Zincarelli, C.3
  • 24
    • 0032540893 scopus 로고    scopus 로고
    • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice
    • Rockman HA, Choi DJ, Akhter SA, et al.: Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. J Biol Chem 1998, 273:18180-18184.
    • (1998) J Biol Chem , vol.273 , pp. 18180-18184
    • Rockman, H.A.1    Choi, D.J.2    Akhter, S.A.3
  • 25
    • 50949099098 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure
    • Raake PW, Vinge LE, Gao E, et al.: G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure. Circ Res 2008, 103:413-422.
    • (2008) Circ Res , vol.103 , pp. 413-422
    • Raake, P.W.1    Vinge, L.E.2    Gao, E.3
  • 26
    • 1942453389 scopus 로고    scopus 로고
    • Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases
    • Dzimiri N, Muiya P, Andres E, Al-Halees Z: Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases. Eur J Pharmacol 2004, 489:167-177.
    • (2004) Eur J Pharmacol , vol.489 , pp. 167-177
    • Dzimiri, N.1    Muiya, P.2    Andres, E.3    Al-Halees, Z.4
  • 27
    • 0033982570 scopus 로고    scopus 로고
    • Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart
    • Eckhart AD, Duncan SJ, Penn RB, et al.: Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Circ Res 2000, 86:43-50.
    • (2000) Circ Res , vol.86 , pp. 43-50
    • Eckhart, A.D.1    Duncan, S.J.2    Penn, R.B.3
  • 28
    • 43249124512 scopus 로고    scopus 로고
    • A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure
    • Liggett SB, Cresci S, Kelly RJ, et al.: A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure. Nat Med 2008, 14:510-517.
    • (2008) Nat Med , vol.14 , pp. 510-517
    • Liggett, S.B.1    Cresci, S.2    Kelly, R.J.3
  • 29
    • 34848820302 scopus 로고    scopus 로고
    • Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection
    • Noma T, Lemaire A, Naga Prasad SV, et al.: Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. J Clin Invest 2007, 117:2396-2398.
    • (2007) J Clin Invest , vol.117 , pp. 2396-2398
    • Noma, T.1    Lemaire, A.2    Naga Prasad, S.V.3
  • 30
    • 50449087071 scopus 로고    scopus 로고
    • Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes
    • Martini JS, Raake P, Vinge LE, et al.: Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A 2008, 105:12457-12462.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 12457-12462
    • Martini, J.S.1    Raake, P.2    Vinge, L.E.3
  • 31
    • 33750802401 scopus 로고    scopus 로고
    • b-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes
    • Rajagopal K, Whalen EJ, Violin JD et al.: B-Arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. Proc Natl Acad Sci U S A 2006, 103:16284-16289.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 16284-16289
    • Rajagopal, K.1    Whalen, E.J.2    Violin, J.D.3
  • 32
    • 38549107922 scopus 로고    scopus 로고
    • Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4
    • Richter W, Day P, Agrawal R, et al.: Signaling from beta1- and beta2-adrenergic receptors is defined by differential interactions with PDE4. EMBO J 2008, 27:384-393.
    • (2008) EMBO J , vol.27 , pp. 384-393
    • Richter, W.1    Day, P.2    Agrawal, R.3
  • 33
    • 0041765759 scopus 로고    scopus 로고
    • Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes
    • Brede M, Nagy G, Philipp M, et al.: Differential control of adrenal and sympathetic catecholamine release by alpha 2-adrenoceptor subtypes. Mol Endocrinol 2003, 17:1640-1646.
    • (2003) Mol Endocrinol , vol.17 , pp. 1640-1646
    • Brede, M.1    Nagy, G.2    Philipp, M.3
  • 34
    • 33847728682 scopus 로고    scopus 로고
    • Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure
    • Lymperopoulos A, Rengo G, Funakoshi H, et al.: Adrenal GRK2 upregulation mediates sympathetic overdrive in heart failure. Nat Med 2007, 13:315-323.
    • (2007) Nat Med , vol.13 , pp. 315-323
    • Lymperopoulos, A.1    Rengo, G.2    Funakoshi, H.3
  • 35
    • 38649085669 scopus 로고    scopus 로고
    • Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity
    • Lymperopoulos A, Rengo G, Zincarelli C, et al.: Modulation of adrenal catecholamine secretion by in vivo gene transfer and manipulation of G protein-coupled receptor kinase-2 activity. Mol Ther 2008, 16:302-307.
    • (2008) Mol Ther , vol.16 , pp. 302-307
    • Lymperopoulos, A.1    Rengo, G.2    Zincarelli, C.3
  • 37
    • 0038050389 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor (AT2R): A challenging twin
    • Berk BC: Angiotensin type 2 reAeptor (AT2R): a challenging twin. Sci STKE 2003, 181:PE16.
    • (2003) Sci STKE , vol.181
    • Berk, B.C.1
  • 38
    • 0037512313 scopus 로고    scopus 로고
    • Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure
    • Matsumoto T, Wada A, Tsutamoto T, et al.: Chymase inhibition prevents cardiac fibrosis and improves diastolic dysfunction in the progression of heart failure. Circulation 2003, 107:2555-2558.
    • (2003) Circulation , vol.107 , pp. 2555-2558
    • Matsumoto, T.1    Wada, A.2    Tsutamoto, T.3
  • 39
    • 0242490542 scopus 로고    scopus 로고
    • Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both
    • Pfeffer MA, McMurray JJV, Velazquez EJ, et al.: Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both. N Engl J Med 2003, 349:1893-1906.
    • (2003) N Engl J Med , vol.349 , pp. 1893-1906
    • Pfeffer, M.A.1    McMurray, J.J.V.2    Velazquez, E.J.3
  • 40
    • 2942516035 scopus 로고    scopus 로고
    • Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure
    • Cruden NL, Witherow FN, Webb DJ, et al.: Bradykinin contributes to the systemic hemodynamic effects of chronic angiotensin-converting enzyme inhibition in patients with heart failure. Arterioscler Thromb Vasc Biol 2004, 24:1043-1048.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1043-1048
    • Cruden, N.L.1    Witherow, F.N.2    Webb, D.J.3
  • 41
    • 34447649922 scopus 로고    scopus 로고
    • Beta-arrestin-biased ligands at seven-transmembrane receptors
    • Violin JD, Lefkowitz RJ: Beta-arrestin-biased ligands at seven-transmembrane receptors. Trends Pharmacol Sci 2007, 28:416-422.
    • (2007) Trends Pharmacol Sci , vol.28 , pp. 416-422
    • Violin, J.D.1    Lefkowitz, R.J.2
  • 43
    • 0037133628 scopus 로고    scopus 로고
    • BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy
    • Gottlieb SS, Brater DC, Thomas I, et al.: BG9719 (CVT-124), an A1 adenosine receptor antagonist, protects against the decline in renal function observed with diuretic therapy. Circulation 2002, 105:1348-1353.
    • (2002) Circulation , vol.105 , pp. 1348-1353
    • Gottlieb, S.S.1    Brater, D.C.2    Thomas, I.3
  • 44
    • 0038380612 scopus 로고    scopus 로고
    • Ischaemic tolerance in aged mouse myocardium: The role of adenosine and effects of A1 adenosine receptor overexpression
    • Headrick JP, Willems L, Ashton KJ, et al.: Ischaemic tolerance in aged mouse myocardium: The role of adenosine and effects of A1 adenosine receptor overexpression. J Physiol 2003, 549:823-833.
    • (2003) J Physiol , vol.549 , pp. 823-833
    • Headrick, J.P.1    Willems, L.2    Ashton, K.J.3
  • 45
    • 18144447694 scopus 로고    scopus 로고
    • Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model
    • Liao Y, Takashima S, Asano Y, et al.: Activation of adenosine A1 receptor attenuates cardiac hypertrophy and prevents heart failure in murine left ventricular pressure-overload model. Circ Res 2003, 93:759-766.
    • (2003) Circ Res , vol.93 , pp. 759-766
    • Liao, Y.1    Takashima, S.2    Asano, Y.3
  • 46
    • 33751200636 scopus 로고    scopus 로고
    • Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function
    • Funakoshi H, Chan TO, Good JC, et al.: Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation 2006, 114:2240-2250.
    • (2006) Circulation , vol.114 , pp. 2240-2250
    • Funakoshi, H.1    Chan, T.O.2    Good, J.C.3
  • 47
    • 67651142624 scopus 로고    scopus 로고
    • Cardiac-restricted overexpression of the A2A-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A1-adenosine receptor
    • Chan TO, Funakosji H, Song K, et al.: Cardiac-restricted overexpression of the A2A-adenosine receptor in FVB mice transiently increases contractile performance and rescues the heart failure phenotype in mice overexpressing the A1-adenosine receptor. Clin Trans Sci 2008, 1:126-133.
    • (2008) Clin Trans Sci , vol.1 , pp. 126-133
    • Chan, T.O.1    Funakosji, H.2    Song, K.3
  • 48
    • 40949132561 scopus 로고    scopus 로고
    • The endothelin system as therapeutic target in cardiovascular disease: Great expectations or bleak house?
    • Kirkby NS, Hadoke PWF, Bagnall AJ, Webb DJ: The endothelin system as therapeutic target in cardiovascular disease: Great expectations or bleak house? Br J Pharmacol 2008, 153:1105-1119.
    • (2008) Br J Pharmacol , vol.153 , pp. 1105-1119
    • Kirkby, N.S.1    Hadoke, P.W.F.2    Bagnall, A.J.3    Webb, D.J.4
  • 49
    • 0036710036 scopus 로고    scopus 로고
    • Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology
    • D'Orléans-Juste P, Labonté J, Bkaily G, et al.: Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol Ther 2002, 221-238.
    • (2002) Pharmacol Ther , pp. 221-238
    • D'Orléans-Juste, P.1    Labonté, J.2    Bkaily, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.