Gender-specific gene-environment interaction in alcohol dependence: The impact of daily life events and GABRA2

Behavior Genetics

Volumn 43, Issue 5, 2013, Pages 402-414

  Perry, Brea L ^a   Pescosolido, Bernice A ^b   Bucholz, Kathleen ^c   Edenberg, Howard ^d   Kramer, John ^e   Kuperman, Samuel ^e   Schuckit, Marc Alan ^f   Nurnberger, John I ^d  

^a UNIVERSITY OF KENTUCKY   (United States)

^b INDIANA UNIVERSITY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF IOWA   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alcohol dependence; Daily hassles and uplifts; Gender; Gene environment interaction; Genetics

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DISINHIBITION THEORY; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; LIFE EVENT; MAJOR CLINICAL STUDY; MALE; PROTECTION; PSYCHOLOGICAL THEORY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM; SOCIAL PSYCHOLOGY;

EID: 84883490262     PISSN: 00018244     EISSN: 15733297     Source Type: Journal    
DOI: 10.1007/s10519-013-9607-9     Document Type: Article

References (84)

1. Agrawal A, Edenberg HJ, Foroud T, Bierut LJ, Dunne G, Hinrichs AL, Nurnberger JI, Crowe R, Kuperman S, Schuckit MA, Begleiter H, Porjesz B, Dick DM (2006) Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36:640-650
2. Allison P (1999) Comparing logit and probit coefficients across groups. Sociol Methods Res 28:186-208
3. Bancroft A (2009) Drugs intoxication and society. Polity, Cambridge
4. Bearman PS, Brückner H (2002) Opposite-sex twins and adolescent same-sex attraction. Am J Sociol 107:1179-1205
5. Begleiter H, Porjesz B (1999) What is inherited in the predisposition toward alcoholism? A proposed model. Alcoholism 23:1125-1135
6. Bird CE, Rieker PP (2008) Gender and health: the effects of contrained choices and social policies. Cambridge University Press, New York
7. Brambor T, Clark WR, Golder M (2006) Understanding interaction models: improving empirical analyses. Polit Anal 14:63-82
8. Brookes ST, Whitely E, Egger M, Smith GD, Mulheran PA, Peters TJ (2004) Subgroup analyses in randomized trials: risks of subgroup-specific analyses: power and sample size for the interaction test. J Clin Epidemiol 57:229-236
9. Caspi A, Moffitt TE, Newman DL, Silva PA (1996) Behavioral observations at age 3 years predict adult psychiatric disorders: longitudinal evidence from a birth cohort. Arch Gen Psychiatry 53:1033-1039
10. Caspi A, Harrington H, Moffitt TE, Begg D, Dickson N, Langley J, Silva PA (1997) Personality differences predict health-risk behaviors in young adulthood: evidence from a longitudinal study. J Pers Soc Psychol 73:1052-1063
11. Caspi A, Hariri AR, Holmes A, Uher R, Moffitt TE (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167(5):509
12. Covault J, Gelernter J et al (2007) Markers in the 5′-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology 33(4):837-848
13. Cross CP, Copping LT, Campbell A (2011) Sex differences in impulsivity: a meta-analysis. Psychol Bull 137:97-130
14. DeLongis A, Coyne JC, Dakof G, Folkman S, Lazarus RS (1982) Relationship of daily hassles, uplifts, and major life events to health status. Health Psychol 1:119-136
15. Dick DM, Rose RJ, Viken RJ, Kaprio J, Koskenvuo M (2001) Exploring gene-environment interactions: socioregional moderation of alcohol use. J Abnorm Psychol 110:625-632
16. Dick D, Bierut L, Hinrichs A, Fox L, Bucholz K, Kramer J, Kuperman S, Hesselbrock V, Schuckit M, Almasy L, Tischfield J, Porjesz B, Begleiter H, Nurnberger J, Xuei X, Edenberg H, Foroud T (2006a) The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 36:577-590
17. Dick DM, Agrawal A, Schuckit MA, Bierut L, Hinrichs A, Fox L, Mullaney J, Cloninger CR, Hesselbrock V, Nurnberger JI, Almasy L, Foroud T, Porjesz B, Edenberg H, Begleiter H (2006b) Marital status, alcohol dependence, and GABRA2: evidence for gene-environment correlation and interaction. J Stud Alcohol 67:185-194
18. Dick DM, Latendresse SJ, Lansford JE, Budde JP, Goate A, Dodge KA, Pettit GS, Bates JE (2009) Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Arch Gen Psychiatry 66:649-657
19. Dick DM, Smith G, Olausson P, Mitchell SH, Leeman RF, O'Malley SS, Sher K (2010) Review: understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol 15:217-226
20. Dick DM, Aliev F, Latendresse S, Porjesz B, Schuckit M, Rangaswamy M, Hesselbrock V, Edenberg H, Nurnberger J, Agrawal A, Bierut L, Wang J, Bucholz K, Kuperman S, Kramer J (2013) How phenotype and developmental stage affect the genes we find: GABRA2 and impulsivity. Twin Res Hum Genet 16:661-669
21. Drgon T, D'Addario C et al (2006) Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: candidate gene variants for addictions. Am J Med Genet B 141(8):854-860
22. Duncan LE, Keller MC (2011) A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry. Am J Psychiatry 168(10):1041
23. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li T-K, Nurnberger JI Jr, O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H (2004) Variations in GABRA2, encoding the [alpha]2 subunit of the GABAA receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714
24. Eitle D, Taylor J, Eitle TM (2010) Heavy episodic alcohol use in emerging adulthood: the role of early risk factors and young adult social roles. J Drug Issues 40:295-320
25. Enoch M-A (2008) The role of GABAA receptors in the development of alcoholism. Pharmacol Biochem Behav 90(1):95
26. Enoch M-A, Schwartz L, Albaugh B, Virkkunen M, Goldman D (2006) Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B 141B:599-607
27. Enoch M-A, Hodgkinson CA, Yuan Q, Shen P-H, Goldman D, Roy A (2010) The influence of GABRA2, childhood trauma, and their interaction on alcohol, heroin, and cocaine dependence. Biol Psychiatry 67:20-27
28. Fillmore KM (1987) Women's drinking across the adult life course as compared to men's. Brit J Addict 82(7):801-811
29. Fitzmaurice G, Laird N, Ware J (2004) Applied longitudinal analysis. Wiley, New York
30. Gelernter J, Kranzler HR et al (2009) Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10. Biol Psychiatry 65(2):111-115
31. Gomberg ESL (1997) Alcohol abuse: age and gender differences. In: Wilsnack RW, Wilsnack SC (eds) Gender and alcohol: individual and social perspectives. Rutgers Center of Alcohol Studies, New Brunswick, pp 225-244
32. Grant BF (1997) Prevalence and correlates of alcohol use and DSM-IV alcohol dependence in the United States: results of the National Longitudinal Alcohol Epidemiologic Survey. J Stud Alcohol 58:464-473
33. Guo G (2006) The linking of sociology and biology. Soc Forces 85:145-150
34. Harrison PJ, Tunbridge EM (2007) Catechol-O-methyltransferase (COMT): a gene contributing to sex differences in brain function, and to sexual dimorphism in the predisposition to psychiatric disorders. Neuropsychopharmacology 33:3037-3045
35. Heath AC, Nelson EC (2002) Effects of the interaction between genotype and environment. Research into the genetic epidemiology of alcohol dependence. Alcohol Res Health 26:193-201
36. Hesselbrock M, Easton C, Bucholz KK, Schuckit M, Hesselbrock V (1999) A validity study of the SSAGA-a comparison with the SCAN. Addiction 94:1361-1370
37. Horwitz AV, White HR (1987) Gender role orientations and styles of pathology among adolescents. J Health Soc Behav 28:158-170
38. Huselid RF, Cooper ML (1992) Gender roles as mediators of sex differences in adolescent alcohol use and abuse. J Health Soc Behav 33:348-362
39. Keefe K (1994) Perceptions of normative social pressure and attitudes toward alcohol use: changes during adolescence. J Stud Alcohol 55:46-54
40. Kessler RC, McGonagle KA, Zhao S, Nelson CB, Hughes M, Eshleman S, Wittchen HU, Kendler KS (1994) Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States. Results from the National Comorbidity Survey. Arch Gen Psychiatry 51:8-19
41. Keyes KM, Grant BF, Hasin DS (2008) Evidence for a closing gender gap in alcohol use, abuse, and dependence in the United States population. Drug Alcohol Depend 93:21-29
42. Koopmans JR, Slutske WS, van Baal GCM, Boomsma DI (1999) The influence of religion on alcohol use initiation: evidence for genotype X environment interaction. Behav Genet 29:445-453
43. Kreek MJ, Nielsen DA, Butelman ER, LaForge KS (2005) Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 8:1450-1457
44. Landrine H, Bardwell S, Dean T (1988) Gender expectations for alcohol use: a study of the significance of the masculine role. Sex Roles 19:703-712
45. Lewis MA, Neighbors C (2004) Gender-specific misperceptions of college student drinking norms. Psychol Addict Behav 18:334-339
46. Long JS (2009) Group comparisons in logit and probit using predicted probabilities. Indiana University, pp 1-25
47. Loscocco K, Spitze G (2007) Gender patterns in provider role attitudes and behavior. J Fam Issues 28(7):934-954
48. Luan J, Wong M et al (2001) Sample size determination for studies of gene-environment interaction. Int J Epidemiol 30(5):1035-1040
49. Martino SC, Collins RL, Ellickson PL (2004) Substance use and vulnerability to sexual and physical aggression: a longitudinal study of young adults. Violence vict 19(5):521-540
50. Martin ER, Monks SA, Warren LL, Kaplan NL (2000) A test for linkage and association in general pedigrees: the pedigree disequilibrium test. Am J Hum Genet 67:146-154
51. Moffitt TE, Caspi A, Rutter M (2006) Measured gene-environment interactions in psychopathology. Perspect Psychol Sci 1:5-27
52. Nilsson KW, Sjöberg RL, Damberg M, Alm PO, Öhrvik J, Leppert J, Lindström L, Oreland L (2005) Role of the serotonin transporter gene and family function in adolescent alcohol consumption. Alcoholism 29:564-570
53. Nolen-Hoeksema S, Hilt L (2006) Possible contributors to the gender differences in alcohol use and problems. J Gen Psychol 133:357-374
54. Nurnberger JI Jr, Wiegand R, Bucholz K, O'Connor S, Meyer ET, Reich T, Rice J, Schuckit M, King L, Petti T, Bierut L, Hinrichs AL, Kuperman S, Hesselbrock V, Porjesz B (2004) A family study of alcohol dependence: coaggregation of multiple disorders in relatives of alcohol-dependent probands. Arch Gen Psychiatry 61:1246-1256
55. Ober C, Loisel DA, Gilad Y (2008) Sex-specific genetic architecture of human disease. Nat Rev Genet 9:911-922
56. Ono H, Shirakawa O, Nushida H, Ueno Y, Maeda K (2004) Association between catechol-O-methyltransferase functional polymorphism and male suicide completers. Neuropsychopharmacology 29:1374-1377
57. Patsopoulos NA, Tatsioni A, Ioannidis JPA (2007) Claims of sex differences. J Am Med Assoc 298:880-893
58. Pescosolido BA, Perry BL, Long JS, Martin JK, Nurnberger JI Jr, Hesselbrock V (2008) Under the influence of genetics: how transdisciplinarity leads us to rethink social pathways to illness. Am J Sociol 114:S171-S201
59. Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A (2008) The relationship of 5HTT (SLC6A4) methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B 147B:543-549
60. Philibert RA, Gunter TD, Beach SRH, Brody GH, Hollenbeck N, Andersen A, Adams W (2009) Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies. Psychiatr Genet 19:91-98. doi: 10.1097/YPG.1090b1013e3283208026
61. Porjesz B, Rangaswamy M (2007) Neurophysiological endophenotypes, CNS disinhibition, and risk for alcohol dependence and related disorders. ScientificWorldJournal 7:131-141
62. Rabe-Hesketh S, Skrondal A (2008) Multilevel and longitudinal modeling using stata. Stata, College Station
63. Reich T (1996) A genomic survey of alcohol dependence and related phenotypes: results from the Collaborative Study on the Genetics of Alcoholism (COGA). Alcoholism 20:133a-137a
64. Ricciardelli LA, Connor JP, Williams RJ, Young RM (2001) Gender stereotypes and drinking cognitions as indicators of moderate and high risk drinking among young women and men. Drug Alcohol Depend 61:129-136
65. Rose RJ, Dick DM, Viken RJ, Kaprio J (2001) Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use. Alcoholism 25:637-643
66. Rutledge PC, Sher KJ (2001) Heavy drinking from the freshman year into early young adulthood: the roles of stress, tension-reduction drinking motives, gender and personality. J Stud Alcohol 62:457-466
67. Rutter M, Moffitt TE, Caspi A (2006) Gene-environment interplay and psychopathology: multiple varieties but real effects. J Child Psychol Psychiatry 47:226-261
68. Schmidt C, Klee L, Ames G (1990) Review and analysis of literature on indicators of women's drinking problems. Br J Addict 85:179-192
69. Schulte MT, Ramo D, Brown SA (2009) Gender differences in factors influencing alcohol use and drinking progression among adolescents. Clin Psychol Rev 29:535-547
70. Shanahan MJ, Hofer SM (2005) Social context in gene-environment interactions: retrospect and prospect. J Gerontol B 60:65-76
71. Shanahan Michael J, Vaisey S, Erickson Lance D, Smolen A (2008) Environmental contingencies and genetic propensities: social capital, educational continuation, and dopamine receptor gene DRD2. Am J Sociol 114:S260-S286
72. Sher KJ, Grekin ER, Williams NA (2005) The development of alcohol use disorders. Annu Rev Clin Psychol 1:493-523
73. Simon RW (1992) Parental role strains, salience of parental identity and gender differences in psychological distress. J Health Soc Behav 33(1):25-35
74. Simon RW (1995) Gender, multiple roles, role meaning, and mental health. J Health Soc Behav 36(2):182-194
75. Singer BH, Ryff CD (2001) New horizons in health: an Integrative approach. National Academy Press, Washington
76. StataCorp (2011) Stata Statistical Software: Release 12. StataCorp LP, College Station
77. Stein MB, Fallin MD, Schork NJ, Gelernter J (2005) COMT polymorphisms and anxiety-related personality traits. Neuropsychopharmacology 30:2092-2102
78. Umberson D, Crosnoe R, Reczek C (2010) Social relationships and health behavior across life course. Annu Rev Sociol 36:139-157
79. Villafuerte S, Heitzeg MM, et al (2012) Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Mol Psychiatry 17(5):511-519
80. Villafuerte S, Strumba V, Stoltenberg SF, Zucker RA, Burmeister M (2013) Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems. Genes Brain Behav 12:525-531
81. Waldman ID, Robinson BF, Rhee SH (1999) A logistic regression extension of the transmission disequilibrium test for continuous traits: application to linkage disequilibrium between alcoholism and the candidate genes DRD2 and ADH3. Genet Epidemiol 17(Suppl 1):S379-S384
82. Young-Wolff KC, Enoch MA, et al (2011) The influence of gene-environment interactions on alcohol consumption and alcohol use disorders: a comprehensive review. Clin Psychol Rev 31(5):800-816
83. Zucker RA, Heitzeg MM, Nigg JT (2011) Parsing the undercontrol- disinhibition pathway to substance use disorders: a multilevel developmental problem. Child Dev Perspect 5:248-255
84. Zuckerman M, Kuhlman DM (2000) Personality and risk-taking: common bisocial factors. J Pers 68:999-1029