Role of GABRA2 on risk for alcohol, nicotine, and cannabis dependence in the Iowa Adoption Studies

Psychiatric Genetics

Volumn 19, Issue 2, 2009, Pages 91-98

  Philibert, Robert A ^a,b,e   Gunter, Tracy D ^a   Beach, Steven R H ^d   Brody, Gene H ^d   Hollenbeck, Nancy ^a   Andersen, Allan ^c   Adams, William ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

^c GEORGETOWN UNIVERSITY   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

^e Psychiatry Research/MEB   (United States)

Author keywords

Alcohol dependence; Cannabis dependence; GABRA2; Nicotine dependence

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; CANNABIS ADDICTION; FEMALE; GENE LOCUS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TOBACCO DEPENDENCE; UNITED STATES;

ALCOHOLISM; BASE SEQUENCE; DEMOGRAPHY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; IOWA; LINKAGE DISEQUILIBRIUM; MALE; MARIJUANA ABUSE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A; REGRESSION ANALYSIS; TOBACCO USE DISORDER;

CANNABIS;

EID: 63149174272     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/YPG.0b013e3283208026     Document Type: Article

References (29)

1. Agrawal A, Edenberg HJ, Foroud T, Laura JB, Bierut U, Dunne G, et al. (2006). Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36:640-650.
2. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorder, Fourth Edition. Washington, DC: American Psychiatric Association.
3. Barrett JC, Fry B, Mailer J, Daly MJ (2005). Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
4. Bucholz KK, Cadoret R, Cloninger CR, Dinwiddie SH, Hesselbrock VM, Nurnberger Jl Jr, et al. (1994). A new, semi-structured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55:149-158.
5. Cadoret RJ, Yates WR, Troughton E, Woodworth G, Stewart MA (1995). Adoption study demonstrating two genetic pathways to drug abuse. Arch Gen Psychiatry 52:42-52.
6. Covault J, Gelernter J, Hesselbrock V, Nellissery M, Kranzler HR (2004). Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B Neuropsychiatr Genet 129:104-109.
7. Covault J, Gelernter J, Jensen K, Anton R, Kranzler HR (2007). Markers in the 5[prime]-region of GABRG1 associate to alcohol dependence and are in linkage disequilibrium with markers in the adjacent GABRA2 gene. Neuropsychopharmacology 33:837-848.
8. Cutrona CE, Cadoret RJ, Suhr JA, Richards CC, Troughton E, Schutte K, Woodworth G. (1994). Interpersonal variables in the prediction of alcoholism among adoptees: evidence for gene-environment interactions. ComprPsychiatry 35:171-179.
9. Dick D, Bierut L, Hinrichs A, Fox L, Bucholz K, Kramer J, et al. (2006). The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 36:577-590.
10. Drgon T, D'Addario C, Uhl G (2006). Linkage disequilibrium, haplotype and association studies of a chromosome 4 GABA receptor gene cluster: Candidate gene variants for addictions. Am J Med Genet B Neuropsychiatr GeneM41B:854-860.
11. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, et al. (2004). Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
12. Fehr C, Sander T, Tadic A, Lenzen KP, Anghelescu I, Klawe C, et al. (2006). Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet 16:9-17.
13. Kandel D, Chen K, Warner LA, Kessler RC, Grant B (1997). Prevalence and demographic correlates of symptoms of last year dependence on alcohol, nicotine, marijuana and cocaine in the U.S. population. Drug Alcohol Depend 44:11-29.
14. Kendler KS, Jacobson KC, Prescott CA, Neale MC (2003). Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins. Am J Psychiatry 160:687-695.
15. Lahiri DK, Nurnberger Jl Jr (1991). A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 19:5444.
16. Lee JC, Weissglas-Volkov D, Kyttala M, Sinsheimer JS, Jokiaho A, de Bruin T, et al. (2007). USF1 contributes to high serum lipid levels in Dutch FCHL families and U.S. Whites with coronary artery disease. Arterioscler Thromb Vase Biol 27:2222-2227.
17. Lynskey MT, Heath AC, Nelson EC, Bucholz KK, Madden PA, Slutske WS, et al. (2002). Genetic and environmental contributions to cannabis dependence in a national young adult twin sample. Psychol Med 32:195-207.
18. Matthews AG, Hoffman EK, Zezza N, Stiffler S, Hill SY (2007). The role of the GABRA2 polymorphism in multiplex alcohol dependence families with minimal comorbidity: within-family association and linkage analyses. J Stud Alcohol Drugs 68:625-633.
19. Nyholt DR (2004). A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74:765-769.
20. Philibert RA, Gershenfeld HK (2007). Therapeutic potential of targeting gene variants in schizophrenia. Expert Rev Neurother 7:757-760.
21. Philibert R, Madan A, Andersen A, Cadoret R, Packer H, Sandhu H (2007a). Serotonin transporter mRNA levels are associated with the methylation of an upstream CpG island. Am J Med Genet B Neuropsychiatr Genet 144: 101-105.
22. Philibert RA, Ryu GY, Yoon JG, Sandhu H, Hollenbeck N, GunterT, et a/. (2007b). Transcriptional profiling of subjects from the Iowa adoption studies. Am J Med Genet B Neuropsychiatr Genet 144:683-690.
23. Philibert RA, Sandhu H, Hollenbeck N, Gunter T, Adams W, Madan A (2007c). The relationship of 5HTT methylation and genotype on mRNA expression and liability to major depression and alcohol dependence in subjects from the Iowa Adoption Studies. Am J Med Genet B Neuropsychiatr Genet [Epub ahead of print]
24. Schooling CM (2007). Growth environment and sex differences in lipids, body shape and diabetes risk. PLoS ONE 2:e1070.
25. Soyka M, Preuss UW, Hesselbrock V, Zill P, Koller G, Bondy B (2008). GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res 42:184-191.
26. Stephens M, Smith NJ, Donnelly P (2001). A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68:978-989.
27. Tsuang MT, Bar JL, Harley RM, Lyons MJ (2001). The Harvard Twin Study of Substance Abuse: what we have learned. Harv Rev Psychiatry 9:267-279.
28. Xu K, Yaunl Q, Hodgkinson CA, Shen P, Neuhold L, Ren Z, et al. (2006). A large scale approach for identifying vulnerability genes to alcoholism: a 1536 SNP Array. Alcohol Clin Exp Res 30:11 A.
29. Yates W, Cadoret R, Troughton E (1998). The Iowa Adoption Studies Methods and Results. In: LaBuda M, Grigorenko E, editors. On the way to individuality: methodological issues in behavioral genetics. Hauppauge, New York: Nova Science Publishers, pp. 95-125.