Association between catechol-O-methyltransferase functional polymorphism and male suicide completers

Neuropsychopharmacology

Volumn 29, Issue 7, 2004, Pages 1374-1377

  Ono, Hisae ^a   Shirakawa, Osamu ^a   Nushida, Hideyuki ^a   Ueno, Yasuhiro ^a   Maeda, Kiyoshi ^a  

^a KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Association study; Catecholaminergic dysfunction; COMT 158Val Met polymorphism; Gender differences; Suicide

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; VALINE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENOTYPE; HUMAN; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RISK; SEX DIFFERENCE; SUICIDE;

ADULT; AGED; CATECHOL O-METHYLTRANSFERASE; CHI-SQUARE DISTRIBUTION; FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; MALE; METHIONINE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; SEX CHARACTERISTICS; SUICIDE; VALINE;

EID: 2942640246     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1300470     Document Type: Article

References (24)

1. Arango V, Ernsberger P, Sved AF, Mann JJ (1993). Quantitative autoradiography of alpha 1- and alpha 2-adrenergic receptors in the cerebral cortex of controls and suicide victims. Brain Res 30: 271-282.
2. Asberg M, Traskman L, Thoren P (1976). 5-HIAA in the cerebrospinal fluid. A biochemical suicide predictor? Arch Gen Psychiatry 33: 1193-1197.
3. Balthazart J, Foidart A, Absil P, Harada N (1996). Effects of testosterone and its metabolites on aromatase-immunoreactive cells in the quail brain: relationship with the activation of male reproductive behavior. J Steroid Biochem Mol Biol 48: 185-200.
4. Daniels JK, Williams NM, Williams J, Jones LA, Cardno AG, Murphy KC et al (1996). No evidence for allelic association between schizophrenia and a polymorphism determining high or low catechol-O-methyltransferase activity. Am J Psychiatry 153: 268-270.
5. Dauvilliers Y, Neidhart E, Lecendreux M, Billiard M, Tafti M (2001). MAO-A and COMT polymorphisms and gene effects in narcolepsy. Mol Psychiatry 6: 367-372.
6. Frisch A, Postilnick D, Rockah R, Michaelovsky E, Postilnick S, Birman E et al (1999). Association of unipolar major depressive disorder with genes of the serotonergic and dopaminergic pathways. Mol Psychiatry 4: 389-392.
7. Jones JS, Stanley B, Mann JJ, Frances AJ, Guido JR, Traskman-Bendz L et al (1990). CSF 5-HIAA and HVA concentrations in elderly depressed patients who attempted suicide. Am J Psychiatry 147: 1225-1227.
8. Karayiorgou M, Sobin C, Blundell ML, Galke BL, Malinova L, Goldberg P et al (1999). Family-based association studies support a sexually dimorphic effect of COMT and MAOA on genetic susceptibility to obsessive-compulsive disorder. Biol Psychiatry 45: 1178-1189.
9. Katoh T, Mano S, Ikuta T, Munkhbat B, Tounai K, Ando H et al (2002). Genetic isolates in East Asia: a study of linkage disequilibrium in the X chromosome. Am J Hum Genet 71: 395-400.
10. Kotler M, Barak P, Cohen H, Averbuch IE, Grinshpoon A, Gritsenko I et al (1999). Homicidal behavior in schizophrenia associated with a genetic polymorphism determining low catechol-O-methyltransferase (COMT) activity. Am J Med Genet 88: 628-633.
11. Kunugi H, Nanko S, Ueki A, Otsuka E, Hattori M, Hoda F et al (1997a). High and low activity alleles of catechol-O-methyltransferase gene: ethnic difference and possible association with Parkinson's disease. Neurosci Lett 221: 202-204.
12. Kunugi H, Vallada HP, Hoda F, Kirov G, Gill M, Aitchison KJ et al (1997b). No evidence for an association of affective disorders with high- or low-activity allele of catechol-O-methyltransferase gene. Biol Psychiatry 42: 282-285.
13. Lachman HM, Nolan KA, Mohr P, Saito T, Volavka J (1998). Association between catechol-O-methyltransferase genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 155: 835-837.
14. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM (1996). Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6: 243-250.
15. Lester D (1995). The concentration of neurotransmitter metabolites in the cerebrospinal fluid of suicidal individuals: a metaanalysis. Pharmacopsychiatry 28: 45-50.
16. Nolan KA, Volavka J, Czobor P, Cseh A, Lachman H, Saito T et al (2000). Suicidal behavior in patients with schizophrenia is related to COMT polymorphism. Psychiatr Genet 10: 117-124.
17. Ohara K, Nagai M, Suzuki Y, Ohara K (1998). Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression. Neuroreport 9: 1305-1308.
18. Ohmori O, Shinkai T, Kojima H, Terao T, Suzuki T, Mita T et al (1998). Association study of a functional catechol-O-methyltransferase gene polymorphism in Japanese schizophrenics. Neurosci Lett 243: 109-112.
19. Palmatier MA, Kang AM, Kidd KK (1999). Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol Psychiatry 46: 557-567.
20. Qian Q, Wang Y, Zhou R, Li J, Wang B, Glatt S et al (2003). Family-based and case-control association studies of catechol-O-methyltransferase in attention deficit hyperactivity disorder suggest genetic sexual dimorphism. Am J Med Genet 118B: 103-109.
21. Roy A, Agren H, Pickar D, Linnoila M, Doran AR, Cutler NR et al (1986). Reduced CSF concentrations of homovanillic acid and homovanillic acid to 5-hydroxyindoleacetic acid ratios in depressed patients: relationship to suicidal behavior and dexamethasone nonsuppression. Am J Psychiatry 143: 1539-1545.
22. Roy A, Rylander G, Sarchiapone M (1997). Genetics of suicides: family studies and molecular genetics. Ann NY Acad Sci 836: 135-157.
23. Shifman S, Bronstein M, Sternfeld M, Pisante-Shalom A, Lev-Lehman E, Weizman A et al (2002). A highly significant association between a COMT haplotype and schizophrenia. Am J Hum Genet 71: 1296-1302.
24. Strous RD, Bark N, Parsia SS, Volavka J, Lachman HM (1997). Analysis of a functional catechol-O-methyltransferase gene polymorphism in schizophrenia: evidence for association with aggressive and antisocial behavior. Psychiatry Res 69: 71-77.