Impulsiveness mediates the association between GABRA2 SNPs and lifetime alcohol problems

Genes, Brain and Behavior

Volumn 12, Issue 5, 2013, Pages 525-531

  Villafuerte, S ^a,b   Strumba, V ^a,b,c   Stoltenberg, S F ^a,b,d   Zucker, R A ^b,c   Burmeister, M ^a,b  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF NEBRASKA LINCOLN   (United States)

Author keywords

Alcohol problems; GABRA2; Impulsiveness; Mediation; Single nucleotide polymorphisms

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2;

ADULT; ALCOHOLISM; ARTICLE; EXON; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; HAPLOTYPE; HUMAN; IMPULSIVENESS; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ALCOHOLISM; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; IMPULSIVE BEHAVIOR; INTRONS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GABA-A;

EID: 84879606873     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/gbb.12039     Document Type: Article

References (43)

1. Agrawal, A., Edenberg, H.J., Foroud, T., Bierut, L.J., Dunne, G., Hinrichs, A.L., Nurnberger, J.I., Crowe, R., Kuperman, S., Schuckit, M.A., Begleiter, H., Porjesz, B. & Dick, D.M. (2006) Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Behav Genet 36, 640-650.
2. Barrett, J.C., Fry, B., Maller, J. & Daly, M.J. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21, 263-265.
3. Bauer, L.O. & Hesselbrock, V.M. (1993) EEG, autonomic and subjective correlates of the risk for alcoholism. J Stud Alcohol 54, 577-589.
4. Bauer, L.O., Covault, J., Harel, O., Das, S., Gelernter, J., Anton, R. & Kranzler, H.R. (2007) Variation in GABRA2 predicts drinking behavior in project MATCH subjects. Alcohol Clin Exp Res 31, 1780-1787.
5. Clarke, A.R., Barry, R.J., Mccarthy, R. & Selikowitz, M. (2001) Excess beta activity in children with attention-deficit/hyperactivity disorder: an atypical electrophysiological group. Psychiatr Res 103, 205-218.
6. Costa, P.T.J. & Mccrae, R.R. (1992) Revised NEO Personality Inventory (NEO-PI-R) and NEO Five-Factor Inventory (NEO-FFI) professional manual. Psychological Assessment Resources, Odessa, FL.
7. Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M. & Kranzler, H.R. (2004) Allelic and haplotypic association of GABRA2 with alcohol dependence. Am J Med Genet B 129B, 104-109.
8. Dawe, S., Gullo, M.J. & Loxton, N.J. (2004) Reward drive and rash impulsiveness as dimensions of impulsivity: implications for substance misuse. Addict Behav 29, 1389-1405.
9. Dick, D.M., Bierut, L., Hinrichs, A., Fox, L., Bucholz, K.K., Kramer, J., Kuperman, S., Hesselbrock, V., Schuckit, M., Almasy, L., Tischfield, J., Porjesz, B., Begleiter, H., Nurnberger, J. Jr., Xuei, X., Edenberg, H.J. & Foroud, T. (2006) The role of GABRA2 in risk for conduct disorder and alcohol and drug dependence across developmental stages. Behav Genet 36, 577-590.
10. Dick, D.M., Latendresse, S.J., Lansford, J.E., Budde, J.P., Goate, A., Dodge, K.A., Pettit, G.S. & Bates, J.E. (2009) Role of GABRA2 in trajectories of externalizing behavior across development and evidence of moderation by parental monitoring. Arch Gen Psychiatry 66, 649-657.
11. Dick, D.M., Smith, G., Olausson, P., Mitchell, S.H., Leeman, R.F., O'malley, S.S. & Sher, K. (2010) Understanding the construct of impulsivity and its relationship to alcohol use disorders. Addict Biol 15, 217-226.
12. Edenberg, H.J. & Foroud, T. (2006) The genetics of alcoholism: identifying specific genes through family studies. Addict Biol 11, 386-396.
13. Edenberg, H.J., Dick, D.M., Xuei, X.L., Tian, H.J., Almasy, L., Bauer, L.O., Crowe, R.R., Goate, A., Hesselbrock, V., Jones, K., Kwon, J., Li, T.K., Nurnberger, J.I., O'connor, S.J., Reich, T., Rice, J., Schuckit, M.A., Porjesz, B., Foroud, T. & Begleiter, H. (2004) Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74, 705-714.
14. Enoch, M.A., Schwartz, L., Albaugh, B., Virkkunen, M. & Goldman, D. (2006) Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B 141B, 599-607.
15. Fehr, C., Sander, T., Tadic, A., Lenzen, K.P., Anghelescu, I., Klawe, C., Dahmen, N., Schmidt, L.G. & Szegedi, A. (2006) Confirmation of association of the GABRA2 gene with alcohol dependence by subtype-specific analysis. Psychiatr Genet 16, 9-17.
16. Grobin, A.C., Matthews, D.B., Devaud, L.L. & Morrow, A.L. (1998) The role of GABA(A) receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139, 2-19.
17. Hodgkinson, C.A., Yuan, Q., Xu, K., Shen, P.H., Heinz, E., Lobos, E.A., Binder, E.B., Cubells, J., Ehlers, C.L., Gelernter, J., Mann, J., Riley, B., Roy, A., Tabakoff, B., Todd, R.D., Zhou, Z. & Goldman, D. (2008) Addictions biology: haplotype-based analysis for 130 candidate genes on a single array. Alcohol 43, 505-515.
18. Krystal, J.H., Staley, J., Mason, G., Petrakis, I.L., Kaufman, J., Harris, R.A., Gelernter, J. & Lappalainen, J. (2006) Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch Gen Psychiatry 63, 957-968.
19. Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L.K., Covault, J., Kranzler, H.R., Krystal, J.H. & Gelernter, J. (2005) Association between alcoholism and gamma-amino butyric acid alpha 2 receptor subtype in a Russian population. Alcohol Clin Exp Res 29, 493-498.
20. Lejuez, C.W., Magidson, J.F., Mitchell, S.H., Sinha, R., Stevens, M.C. & De Wit, H. (2010) Behavioral and biological indicators of impulsivity in the development of alcohol use, problems, and disorders. Alcohol Clin Exp Res 34, 1334-1345.
21. Lind, P.A., Macgregor, S., Agrawal, A., Montgomery, G.W., Heath, A.C., Martin, N.G. & Whitfield, J.B. (2008a) The role of GABRA2 in alcohol dependence, smoking, and illicit drug use in an Australian population sample. Alcohol Clin Exp Res 32, 1721-1731.
22. Lind, P.A., Macgregor, S., Montgomery, G.W., Heath, A.C., Martin, N.G. & Whitfield, J.B. (2008b) Effects of GABRA2 variation on physiological, psychomotor and subjective responses in the alcohol challenge twin study. Twin Res Hum Genet 11, 174-182.
23. Low, K., Crestani, F., Keist, R., Benke, D., Brunig, I., Benson, J.A., Fritschy, J.M., Rulicke, T., Bluethmann, H., Mohler, H. & Rudolph, U. (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290, 131-134.
24. Mackinnon, D.P., Fairchild, A.J. & Fritz, M.S. (2007) Mediation analysis. Annu Rev Psychol 58, 593-614.
25. Magid, V. & Colder, C.R. (2007) The UPPS impulsive Behavior scale: factor structure and associations with college drinking. Pers Indiv Differ 43, 1927-1937.
26. Masten, A.S., Faden, V.B., Zucker, R.A. & Spear, L.P. (2008) Underage drinking: a developmental framework. Pediatrics 121 (Suppl. 4), S235-S251.
27. Nyholt, D.R. (2004) A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other. Am J Hum Genet 74, 765-769.
28. Pierucci-Lagha, A., Covault, J., Feinn, R., Nellissery, M., Hernandez-Avila, C., Oncken, C., Morrow, A.L. & Kranzler, H.R. (2005) GABRA2 alleles moderate the subjective effects of alcohol, which are attenuated by finasteride. Neuropsychopharmacology 30, 1193-1203.
29. Rangaswamy, M., Porjesz, B., Chorlian, D.B., Wang, K., Jones, K.A., Bauer, L.O., Rohrbaugh, J., O'connor, S.J., Kuperman, S., Reich, T. & Begleiter, H. (2002) Beta power in the EEG of alcoholics. Biol Psychiatry 52, 831-842.
30. Rangaswamy, M., Porjesz, B., Chorlian, D.B., Wang, K., Jones, K.A., Kuperman, S., Rohrbaugh, J., O'connor, S.J., Bauer, L.O., Reich, T. & Begleiter, H. (2004) Resting EEG in offspring of male alcoholics: beta frequencies. Int J Psychophysiol 51, 239-251.
31. Soyka, M., Preuss, U.W., Hesselbrock, V., Zill, P., Koller, G. & Bondy, B. (2008) GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res 42, 184-191.
32. Tian, H., Chen, H.J., Cross, T.H. & Edenberg, H.J. (2005) Alternative splicing and promoter use in the human GABRA2 gene. Brain Res Mol Brain Res 137, 174-183.
33. Uhart, M., Weerts, E.M., Mccaul, M.E., Guo, X., Yan, X., Kranzler, H.R., Li, N. & Wand, G.S. (2013) GABRA2 markers moderate the subjective effects of alcohol. Addict Biol 18, 357-369.
34. Villafuerte, S., Heitzeg, M.M., Foley, S., Wendy Yau, W.Y., Majczenko, K., Zubieta, J.K., Zucker, R.A. & Burmeister, M. (2012) Impulsiveness and insula activation during reward anticipation are associated with genetic variants in GABRA2 in a family sample enriched for alcoholism. Mol Psychiatry 17, 511-519.
35. Whiteside, S.P. & Lynam, D.R. (2001) The Five Factor Model and impulsivity: using a structural model of personality to understand impulsivity. Pers Indiv Differ 30, 669-689.
36. Whiteside, S.P., Lynam, D.R., Miller, J.D. & Reynolds, S.K. (2005) Validation of the UPPS impulsive behaviour scale: a four-factor model of impulsivity. Eur J Personality 19, 559-574.
37. Zucker, R. A. (1990). The concept of risk and the etiology of alcoholism: a probabilistic developmental perspective. D. J. Pittman & H.R. White Society, Culture and Drinking Patterns Re Examined, Piscataway, NJ: Rutgers Center of Alcohol Studies.
38. Zucker, R.A. (1991) Scaling the developmental momentum of alcoholic process via the lifetime alcohol problems score. Alcohol 1, 505-510.
39. Zucker, R.A., Ellis, D.A., Bingham, C.R., Fitzgerald, H.E. & Sanford, K.P. (1996) Other evidence for at least two alcoholisms, II: life course variation in antisociality and heterogeneity of alcoholic outcome. Dev Psychopathol 8, 831-848.
40. Zucker, R.A., Davies, W.H., Kincaid, S.B., Fitzgerald, H.E. & Reider, E.E. (1997) Conceptualizing and scaling the developmental structure of behavior disorder: the lifetime alcohol problems score as an example. Dev Psychopathol 9, 453-471.
41. Zucker R. A., Fitzgerald H.E., Refior S.K., Puttler L.I., Pallas D.M. & Ellis D.A. (2000) The clinical and social ecology of childhood for children of alcoholics: description and implications for a differentiated social policy. In Fitzgerald, H.E., Lester, B.M. & Zuckerman, B.S. (eds), Children of Addiction: Research, Health and Policy Issues, Routledge/Falmer, New York, pp. 109-141.
42. Zucker, R.A., Donovan, J.E., Masten, A.S., Mattson, M.E. & Moss, H.B. (2008) Early developmental processes and the continuity of risk for underage drinking and problem drinking. Pediatrics 121 (Suppl. 4), S252-S272.
43. Zucker, R.A., Heitzeg, M.M. & Nigg, J.T. (2011) Parsing the undercontrol/disinhibition pathway to substance use disorders: a multilevel developmental problem. Child Dev Perspect 5, 248-255.