microRNA-224 promotes cell proliferation and tumor growth in human colorectal cancer by repressing PHLPP1 and PHLPP2

Clinical Cancer Research

Volumn 19, Issue 17, 2013, Pages 4662-4672

  Liao, Wen Ting ^a,b,c   Li, Ting Ting ^a,b,c   Wang, Zheng Gen ^d   Wang, Shu Yang ^a,b,c   He, Mei Rong ^a   Ye, Ya Ping ^a,b,c   Qi, Lu ^a,b,c   Cui, Yan Mei ^a,b,c   Wu, Ping ^a,b,c   Jiao, Hong Li ^a,b,c   Zhang, Chi ^a,b,c   Xie, Yi Jun ^a,b,c   Wang, Jun Xian ^a,b,c   Ding, Yan Qing ^a,b,c  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b Basic School of Guangzhou Medical University   (China)

^c SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^d UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MICRORNA; MICRORNA 224; PH DOMAIN LEUCINE RICH REPEATS PROTEIN PHOSPHATASE 1; PH DOMAIN LEUCINE RICH REPEATS PROTEIN PHOSPHATASE 2; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2; TRANSCRIPTION FACTOR FKHRL1; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER PROGNOSIS; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; COLORECTAL CANCER; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHASE TRANSITION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; TUMOR GROWTH; UPREGULATION;

ADULT; AGED; CELL PROLIFERATION; COLORECTAL NEOPLASMS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MICRORNAS; MIDDLE AGED; NUCLEAR PROTEINS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOPROTEIN PHOSPHATASES; SIGNAL TRANSDUCTION;

EID: 84883470363     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-13-0244     Document Type: Article

References (37)

1. Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001;2:533-43. (Pubitemid 33586866)
2. Weitz J, Koch M, Debus J, Hohler T, Galle PR, Buchler MW. Colorectal cancer. Lancet 2005;365:153-65. (Pubitemid 40091806)
3. Harris TJ, McCormick F. The molecular pathology of cancer. Nat Rev Clin Oncol 2010;7:251-65.
4. Kloosterman WP, Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006;11:441-50. (Pubitemid 44430905)
5. He L, Hannon GJ. MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 2004;5:522-31. (Pubitemid 38868508)
6. Aslam MI, Taylor K, Pringle JH, Jameson JS. MicroRNAs are novel biomarkers of colorectal cancer. Br J Surg 2009;96:702-10.
7. Cummins JM, He Y, Leary RJ, Pagliarini R, Diaz LA Jr, SjoblomT, et al. The colorectal microRNAome. Proc Natl Acad Sci U S A 2006;103:3687-92. (Pubitemid 43376616)
8. Hrasovec S, Glavac D. MicroRNAs as novel biomarkers in colorectal cancer. Front Genet 2012;3:180.
9. Tazawa H, Tsuchiya N, Izumiya M, Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad SciUS A 2007;104:15472-7. (Pubitemid 47502941)
10. Nagel R, le Sage C, Diosdado B, van der Waal M, Oude Vrielink JA, Bolijn A, et al. Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancer. Cancer Res 2008;68:5795-802.
11. Asangani IA, Rasheed SA, Nikolova DA, Leupold JH, Colburn NH, Post S, et al. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008;27:2128-36. (Pubitemid 351485639)
12. Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, et al. A reciprocal repression between ZEB1 and members of the miR- 200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008;9:582-9. (Pubitemid 351772923)
13. Liao WT, Jiang D, Yuan J, Cui YM, Shi XW, Chen CM, et al. HOXB7 as a prognostic factor and mediator of colorectal cancer progression. Clin Cancer Res 2011;17:3569-78.
14. Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000;404:782-7. (Pubitemid 30212408)
15. Brognard J, Sierecki E, Gao T, Newton AC. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol Cell 2007;25:917-31. (Pubitemid 46436532)
16. Ambros V. The functions of animal microRNAs. Nature 2004;431:350-5. (Pubitemid 39265675)
17. Shenouda SK, Alahari SK. microRNA function in cancer: oncogene or a tumor suppressor?Cancer Metastasis Rev 2009;28:369-78.
18. Gregory RI, Shiekhattar R. microRNA biogenesis and cancer. Cancer Res 2005;65:3509-12. (Pubitemid 40616320)
19. Calin GA, Croce CM. microRNA signatures in human cancers. Nat Rev Cancer 2006;6:857-66. (Pubitemid 44629897)
20. Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006;6:259-69.
21. Scisciani C, Vossio S, Guerrieri F, Schinzari V, De Iaco R, D'Onorio de Meo P, et al. Transcriptional regulation of miR-224 upregulated in human HCCs by NFkappaB inflammatory pathways. J Hepatol 2012;56:855-61.
22. Huang L, Dai T, Lin X, Zhao X, Chen X, Wang C, et al. MicroRNA-224 targets RKIP to control cell invasion and expression of metastasis genes in human breast cancer cells. Biochem Biophys Res Commun 2012;425:127-33.
23. Mees ST, Mardin WA, Sielker S, Willscher E, Senninger N, Schleicher C, et al. Involvement of CD40 targeting miR-224 and miR-486 on the progression of pancreatic ductal adenocarcinomas. Ann Surg Oncol 2009;16:2339-50.
24. Boguslawska J, Wojcicka A, Piekielko-Witkowska A, Master A, Nauman A. miR-224 targets the 30 UTR of type 1 50-iodothyronine deiodinase possibly contributing to tissue hypothyroidism in renal cancer. PLoS One 2011;6:e24541.
25. Massague J. G1 cell-cycle control and cancer. Nature 2004;432:298-306. (Pubitemid 39551657)
26. Zhang Z, Li J, Zheng H, Yu C, Chen J, Liu Z, et al. Expression and cytoplasmic localization of SAM68 is a significant and independent prognostic marker for renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 2009;18:2685-93.
27. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999;96:857-68. (Pubitemid 29165088)
28. Roy SK, Srivastava RK, Shankar S. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 2010;5:10.
29. Brognard J, Newton AC. PHLiPPing the switch on Akt and protein kinase C signaling. Trends Endocrinol Metab 2008;19:223-30. (Pubitemid 351993013)
30. Richard S, Torabi N, Franco GV, Tremblay GA, Chen T, Vogel G, et al. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet 2005;1:e74.
31. Shimizu K, Mackenzie SM, Storm DR. SCOP/PHLPP and its functional role in the brain. Mol Biosyst. 2010;6:38-43.
32. Qiao M, Wang Y, Xu X, Lu J, Dong Y, Tao W, et al. Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis. Mol Cell 2010;38:512-23.
33. O'Neill AK, Niederst MJ, Newton AC. Suppression of survival signalling pathways by the phosphatase PHLPP. FEBS J 2013;280:572-83.
34. Volinia S, Calin GA, Liu CG, Ambs S, Cimmino A, Petrocca F, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci U S A 2006;103:2257-61. (Pubitemid 43271657)
35. Molina JR, Agarwal NK, Morales FC, Hayashi Y, Aldape KD, Cote G, et al. PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene 2012;31:1264-74.
36. Nitsche C, Edderkaoui M, Moore RM, Eibl G, Kasahara N, Treger J, et al. The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation. Gastroenterology 2012;142:377-87 e1-5.
37. Liu J, Stevens PD, Gao T. mTOR-dependent regulation of PHLPP expression controls the rapamycin sensitivity in cancer cells. J Biol Chem 2011;286:6510-20.