HOXB7 as a prognostic factor and mediator of colorectal cancer progression

Clinical Cancer Research

Volumn 17, Issue 11, 2011, Pages 3569-3578

  Liao, Wen Ting ^a   Jiang, Dan ^a   Yuan, Jian ^a   Cui, Yan Mei ^a   Shi, Xi Wen ^a   Chen, Cui Min ^a   Bian, Xiu Wu ^b   Deng, Yong Jian ^a   Ding, Yan Qing ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN HOXB7; PROTEIN KINASE B; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER STAGING; CANCER SURVIVAL; CARCINOGENESIS; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; COLORECTAL CANCER; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; METASTASIS; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, NUDE; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL;

EID: 79957901659     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2533     Document Type: Article

References (36)

1. Rupnarain C, Dlamini Z, Naicker S, Bhoola K. Colon cancer: genomics and apoptotic events. Biol Chem 2004;385:449-64. (Pubitemid 38967772)
2. Calvert PM, Frucht H. The genetics of colorectal cancer. Ann Intern Med 2002;137:603-12.
3. Weitz J, Koch M, Debus J, Hohler T, Galle PR, Buchler MW. Colorectal cancer. Lancet 2005;365:153-65. (Pubitemid 40091806)
4. Pearson JC, Lemons D, McGinnis W. Modulating Hox gene functions during animal body patterning. Nat Rev Genet 2005;6:893-904.
5. Samuel S, Naora H. Homeobox gene expression in cancer: insights from developmental regulation and deregulation. Eur J Cancer 2005;41:2428-37. (Pubitemid 41540620)
6. Krumlauf R. Hox genes in vertebrate development. Cell 1994;78: 191-201. (Pubitemid 24241088)
7. Beck F, Tata F, Chawengsaksophak K. Homeobox genes and gut development. Bioessays 2000;22:431-41 (Pubitemid 30308269)
8. Yu YY, Pan YS, Zhu ZG. Homeobox genes and their functions on development and neoplasm in gastrointestinal tract. Eur J Surg Oncol 2007;33:129-32. (Pubitemid 46349944)
9. Mallo GV, Rechreche H, Frigerio JM, Rocha D, Zweibaum A, Lacasa M, et al. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. Int J Cancer 1997;74:35-44. (Pubitemid 27157853)
10. Mallo GV, Soubeyran P, Lissitzky JC, André F, Farnarier C, Marvaldi J, et al. Expression of the Cdx1 and Cdx2 homeotic genes leads to reduced malignancy in colon cancer-derived cells. J Biol Chem 1998;273:14030-6. (Pubitemid 28268460)
11. Guo RJ, Huang E, Ezaki T, Patel N, Sinclair K, Wu J, et al. Cdx1 inhibits human colon cancer cell proliferation by reducing beta-catenin/T-cell factor transcriptional activity. J Biol Chem 2004;279: 36865-75. (Pubitemid 39129035)
12. Dang LH, Chen F, Ying C, Chun SY, Knock SA, Appelman HD, et al. CDX2 has tumorigenic potential in the human colon cancer cell lines LOVO and SW48. Oncogene 2006;25:2264-72.
13. Vider BZ, Zimber A, Chastre E, Gespach C, Halperin M, Mashiah P, et al. Deregulated expression of homeobox-containing genes, HOXB6, B8, C8, C9, and Cdx-1, in human colon cancer cell lines. Biochem Biophys Res Commun 2000;272:513-8.
14. De Vita G, Barba P, Odartchenko N, Givel JC, Freschi G, Bucciarelli G, et al. Expression of homeobox-containing genes in primary and metastatic colorectal cancer. Eur J Cancer 1993;29A:887-93. (Pubitemid 23083624)
15. Caré A, Silvani A, Meccia E, Mattia G, Stoppacciaro A, Parmiani G, et al. HOXB7 constitutively activates basic fibroblast growth factor in melanomas. Mol Cell Biol 1996;16:4842-51. (Pubitemid 26272139)
16. Naora H, Yang YQ, Montz FJ, Seidman JD, Kurman RJ, Roden RB. A serologically identified tumor antigen encoded by a homeobox gene promotes growth of ovarian epithelial cells. Proc Natl Acad Sci U S A 2001;98:4060-5. (Pubitemid 32249898)
17. Wu X, Chen H, Parker B, Rubin E, Zhu T, Lee JS, et al. HOXB7, a homeodomain protein, is overexpressed in breast cancer and confers epithelial-mesenchymal transition. Cancer Res 2006;66:9527-34. (Pubitemid 44623651)
18. De Souza Setubal Destro MF, Bitu CC, Zecchin KG, Graner E, Lopes MA, Kowalski LP, et al. Overexpression of HOXB7 homeobox gene in oral cancer induces cellular proliferation and is associated with poor prognosis. Int J Oncol 2010;36: 141-9.
19. Chen KN, Gu ZD, Ke Y, Li JY, Shi XT, Xu GW. Expression of 11 HOX genes is deregulated in esophageal squamous cell carcinoma. Clin Cancer Res 2005;11:1044-9. (Pubitemid 40175752)
20. Chen H, Lee JS, Liang X, Zhang H, Zhu T, Zhang Z, et al. Hoxb7 inhibits transgenic HER-2/neu-induced mouse mammary tumor onset but promotes progression and lung metastasis. Cancer Res 2008; 68:3637-44.
21. Maulbecker CC, Gruss P. The oncogenic potential of deregulated homeobox genes. Cell Growth Differ 1993;4:431-41.
22. Rubin E, Wu X, Zhu T, Cheung JC, Chen H, Lorincz A, et al. A role for the HOXB7 homeodomain protein in DNA repair. Cancer Res 2007;67:1527-35. (Pubitemid 46383376)
23. Carè A, Felicetti F, Meccia E, Bottero L, Parenza M, Stoppacciaro A, et al. HOXB7: a key factor for tumor-associated angiogenic switch. Cancer Res 2001;61:6532-9. (Pubitemid 32783261)
24. Carè A, Valtieri M, Mattia G, Meccia E, Masella B, Luchetti L, et al. Enforced expression of HOXB7 promotes hematopoietic stem cell proliferation and myeloid-restricted progenitor differentiation. Oncogene 1999;18:1993-2001. (Pubitemid 29150086)
25. Care A, Silvani A, Meccia E, Mattia G, Peschle C, Colombo MP. Transduction of the SkBr3 breast carcinoma cell line with the HOXB7 gene induces bFGF expression, increases cell proliferation and reduces growth factor dependence. Oncogene 1998;16: 3285-9. (Pubitemid 28330427)
26. Song LB, Zeng MS, Liao WT, Zhang L, Mo HY, Liu WL, et al. Bmi-1 is a novel molecular marker of nasopharyngeal carcinoma progression and immortalizes primary human nasopharyngeal epithelial cells. Cancer Res 2006;66:6225-32.
27. Liao WT, Wang X, Xu LH, Kong QL, Yu CP, Li MZ, et al. Centromere protein H is a novel prognostic marker for human nonsmall cell lung cancer progression and overall patient survival. Cancer 2009;115: 1507-17.
28. Bostrom K, Tintut Y, Kao SC, Stanford WP, Demer LL. HOXB7 overexpression promotes differentiation of C3H10T1/2 cells to smooth muscle cells. J Cell Biochem 2000;78:210-21. (Pubitemid 30415898)
29. Rinn JL, Bondre C, Gladstone HB, Brown PO, Chang HY. Anatomic demarcation by positional variation in fibroblast gene expression programs. PLoS Genet 2006;2:e119.
30. Rinn JL, Wang JK, Allen N, Brugmann SA, Mikels AJ, Liu H, et al. A dermal HOX transcriptional program regulates site-specific epidermal fate. Genes Dev 2008;22:303-7. (Pubitemid 351214272)
31. Massague J. G1 cell-cycle control and cancer. Nature 2004;432: 298-306. (Pubitemid 39551657)
32. Medema RH, Kops GJ, Bos JL, Burgering BM. AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1. Nature 2000;404:782-7. (Pubitemid 30212408)
33. Pruitt K, Der CJ. Ras and Rho regulation of the cell cycle and oncogenesis. Cancer Lett 2001;171:1-10. (Pubitemid 32727350)
34. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999;398:422-6. (Pubitemid 29180374)
35. Bashir T, Dorrello NV, Amador V, Guardavaccaro D, Pagano M. Control of the SCF(Skp2-Cks1) ubiquitin ligase by the APC/C (Cdh1) ubiquitin ligase. Nature 2004;428:190-3. (Pubitemid 38374316)
36. Roy SK, Srivastava RK, Shankar S. Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer. J Mol Signal 2010;5:10.