The inclusion complex of 4-hydroxynonenal with a polymeric derivative of β-cyclodextrin enhances the antitumoral efficacy of the aldehyde in several tumor cell lines and in a three-dimensional human melanoma model

Free Radical Biology and Medicine

Volumn 65, Issue , 2013, Pages 765-777

  Pizzimenti, Stefania ^a   Ciamporcero, Eric ^a   Pettazzoni, Piergiorgio ^a,d   Osella Abate, Simona ^b   Novelli, Mauro ^b   Toaldo, Cristina ^a   Husse, Miriam ^a   Daga, Martina ^a   Minelli, Rosalba ^a   Bisazza, Agnese ^a   Ferruti, Paolo ^c   Ranucci, Elisabetta ^c   Grazia Bernengo, Maria ^b   Dianzani, Chiara ^a   Biasi, Fiorella ^a   Cavalli, Roberta ^b   Barrera, Giuseppina ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d UNIVERSITY OF TEXAS   (United States)

Author keywords

Cyclodextrin poly(4 acryloylmorpholine) conjugate; 4 Hydroxynonenal; Free radicals; Nanotechnology; Three dimensional human melanoma model; Tumor cell lines

Indexed keywords

4 HYDROXYNONENAL; BETA CYCLODEXTRIN DERIVATIVE; BETA CYCLODEXTRIN POLY(4 ACRYLOYLMORPHOLINE); NANOCARRIER; PROTEIN S 100; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; ALDEHYDE; ANTINEOPLASTIC AGENT; DRUG CARRIER;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG STABILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; INTERNALIZATION; MALE; MELANOMA; NONHUMAN; PRIORITY JOURNAL; CELL PROLIFERATION; CELL SURVIVAL; CULTURE TECHNIQUE; DRUG EFFECTS; DRUG SCREENING; IC50; TUMOR CELL LINE;

ALDEHYDES; ANTINEOPLASTIC AGENTS; BETA-CYCLODEXTRINS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DRUG CARRIERS; DRUG SCREENING ASSAYS, ANTITUMOR; DRUG STABILITY; HUMANS; INHIBITORY CONCENTRATION 50; MELANOMA;

EID: 84883464368     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.06.035     Document Type: Article

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