Enhanced antiviral activity of Acyclovir loaded into β-cyclodextrin-poly(4-acryloylmorpholine) conjugate nanoparticles

Journal of Controlled Release

Volumn 137, Issue 2, 2009, Pages 116-122

  Cavalli, Roberta ^a   Donalisio, Manuela ^b   Civra, Andrea ^b   Ferruti, Paolo ^c   Ranucci, Elisabetta ^c   Trotta, Francesco ^a   Lembo, David ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b SAN LUIGI GONZAGA HOSPITAL   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

cyclodextrin; cyclodextrin poly(4 acryloylmorpholine) conjugate; Acyclovir; Amphiphilic polymers; Antiviral activity; Polymer nanoparticles

Indexed keywords

ACYCLOVIR; AMPHIPHILIC; AMPHIPHILIC POLYMERS; ANTIVIRAL ACTIVITIES; ANTIVIRAL ACTIVITY; CELL UPTAKE; CLINICAL ISOLATES; CONFOCAL LASER MICROSCOPY; COUMARIN 6; DRUG LOADING; FLUORESCENT NANOPARTICLES; HYDROPHILIC HEADS; IN-CELL; IN-VITRO; INCLUSION COMPLEX; POLYMER NANOPARTICLES; POLYMERIC NANOPARTICLES; SOLVENT INJECTION;

DATA STORAGE EQUIPMENT; POLYMERS; ZETA POTENTIAL;

NANOPARTICLES;

ACICLOVIR; BETA CYCLODEXTRIN; COUMARIN; MORPHOLINE DERIVATIVE; NANOPARTICLE; POLY(4 ACRYLOYLMORPHOLINE); SOLVENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL NUCLEUS; CELL TRANSPORT; CHEMICAL STRUCTURE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG RELEASE; HERPES SIMPLEX VIRUS 1; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; IN VITRO STUDY; INTERNALIZATION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ULTRAVIOLET SPECTROSCOPY; VERO CELL; ZETA POTENTIAL;

ACRYLAMIDES; ACYCLOVIR; ANIMALS; ANTIVIRAL AGENTS; BETA-CYCLODEXTRINS; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COUMARINS; DRUG CARRIERS; HERPESVIRUS 1, HUMAN; MORPHOLINES; NANOPARTICLES; PARTICLE SIZE; POLYMERS; THIAZOLES; VERO CELLS;

EID: 67349085245     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.04.004     Document Type: Article

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