Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction

Circulation Research

Volumn 95, Issue 5, 2004, Pages 540-547

  Kokubo, Hiroki ^a,b,e   Miyagawa Tomita, Sachiko ^c   Tomimatsu, Hirofumi ^c   Nakashima, Yasumi ^c   Nakazawa, Makoto ^c   Saga, Yumiko ^a,b   Johnson, Randy L ^d  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

^c TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^d UNIVERSITY OF TEXAS   (United States)

^e NONE   (Japan)

Author keywords

Echocardiography; Heart anomaly; Hesr2, notch signaling pathway; Knockout mouse

Indexed keywords

HELIX LOOP HELIX PROTEIN; NOTCH RECEPTOR; TRANSCRIPTION FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMEGALY; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DELETION MUTANT; DYSPLASIA; GENE; GENE DISRUPTION; GENE TARGETING; HEART ATRIOVENTRICULAR VALVE; HEART ATRIUM SEPTUM DEFECT; HEART DEVELOPMENT; HEART DILATATION; HEART FAILURE; HEART FUNCTION; HEART HEMODYNAMICS; HEART LEFT VENTRICLE CONTRACTILITY; HEART VENTRICLE SEPTUM DEFECT; HESR2 GENE; HOMOZYGOSITY; MITRAL VALVE REGURGITATION; MORPHOLOGY; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; NULL ALLELE; PERINATAL PERIOD; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; TRANSTHORACIC ECHOCARDIOGRAPHY; TRICUSPID VALVE DISEASE; TRICUSPID VALVE REGURGITATION;

EID: 4444312923     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000141136.85194.f0     Document Type: Article

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