-
2
-
-
57349198710
-
Systematic pelvic lymphadenectomy vs no lymphadenectomy in early-stage endometrial carcinoma: Randomized clinical trial
-
Benedetti Panici P, Basile S, et al. Systematic pelvic lymphadenectomy vs. no lymphadenectomy in early-stage endometrial carcinoma: Randomized clinical trial. J Natl Cancer Inst 2008;100: 1707-16
-
(2008)
J Natl Cancer Inst
, vol.100
, pp. 1707-1716
-
-
Benedetti Panici, P.1
Basile, S.2
-
3
-
-
58149191223
-
Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study
-
Kitchener H, Swart AM, Qian Q, et al. Efficacy of systematic pelvic lymphadenectomy in endometrial cancer (MRC ASTEC trial): A randomised study. Lancet 2009;373:125-36
-
(2009)
Lancet
, vol.373
, pp. 125-136
-
-
Kitchener, H.1
Swart, A.M.2
Qian, Q.3
-
5
-
-
84873047904
-
Laparoscopy versus laparotomy for the management of early stage endometrial cancer
-
Galaal K, Bryant A, Fisher AD, et al. Laparoscopy versus laparotomy for the management of early stage endometrial cancer. Cochrane Database Syst Rev 2012;9:CD006655
-
(2012)
Cochrane Database Syst Rev
, vol.9
-
-
Galaal, K.1
Bryant, A.2
Fisher, A.D.3
-
6
-
-
84875428499
-
Recurrence-free and 5-year survival following robotic-Assisted surgical staging for endometrial carcinoma
-
Kilgore JE, Jackson AL, Ko EM, et al. Recurrence-free and 5-year survival following robotic-Assisted surgical staging for endometrial carcinoma. Gynecol Oncol 2013;129:49-53
-
(2013)
Gynecol Oncol
, vol.129
, pp. 49-53
-
-
Kilgore, J.E.1
Jackson, A.L.2
Ko, E.M.3
-
7
-
-
84867281303
-
Analysis of treatment failures and survival of patients with uterine papillary serous carcinoma: A Cooperation Task Force (CTF) Study
-
Gadducci A, Cosio S, Landoni F, et al. Analysis of treatment failures and survival of patients with uterine papillary serous carcinoma: A Cooperation Task Force (CTF) Study. Int J Gynecol Cancer 2012;22: 1355-60
-
(2012)
Int J Gynecol Cancer
, vol.22
, pp. 1355-1360
-
-
Gadducci, A.1
Cosio, S.2
Landoni, F.3
-
9
-
-
84862758072
-
Five-year quality of life of endometrial cancer patients treated in the randomised Post Operative Radiation Therapy in Endometrial Cancer (PORTEC-2) trial and comparison with norm data
-
Nout RA, Putter H, Jürgenliemk-Schulz IM, et al. Five-year quality of life of endometrial cancer patients treated in the randomised Post Operative Radiation Therapy in Endometrial Cancer (PORTEC-2) trial and comparison with norm data. Eur J Cancer 2012;48: 1638-48
-
(2012)
Eur J Cancer
, vol.48
, pp. 1638-1648
-
-
Nout, R.A.1
Putter, H.2
Jürgenliemk-Schulz, I.M.3
-
10
-
-
79953305893
-
The evolving role of adjuvant therapy in endometrial cancer
-
Gadducci A, Greco C. The evolving role of adjuvant therapy in endometrial cancer. Crit Rev Oncol Hematol 2011;78:79-91
-
(2011)
Crit Rev Oncol Hematol
, vol.78
, pp. 79-91
-
-
Gadducci, A.1
Greco, C.2
-
11
-
-
33644836069
-
Randomized phase III trial of whole-Abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: A Gynecologic Oncology Group Study
-
Randall ME, Filiaci VL, Muss H, et al. Randomized phase III trial of whole-Abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: A Gynecologic Oncology Group Study. J Clin Oncol 2006;24:36-44
-
(2006)
J Clin Oncol
, vol.24
, pp. 36-44
-
-
Randall, M.E.1
Filiaci, V.L.2
Muss, H.3
-
12
-
-
33746911931
-
Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: Results of a randomised trial
-
Maggi R, Lissoni A, Spina F, et al. Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: Results of a randomised trial. Br J Cancer 2006;95:266-71
-
(2006)
Br J Cancer
, vol.95
, pp. 266-271
-
-
Maggi, R.1
Lissoni, A.2
Spina, F.3
-
13
-
-
77955918294
-
Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer-results from two randomised studies
-
Hogberg T, Signorelli M, de Oliveira CF, et al. Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer-results from two randomised studies. Eur J Cancer 2010;46:2422-31
-
(2010)
Eur J Cancer
, vol.46
, pp. 2422-2431
-
-
Hogberg, T.1
Signorelli, M.2
De Oliveira, C.F.3
-
14
-
-
33646934663
-
Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted therapies
-
Gadducci A, Cosio S, Genazzani AR. Old and new perspectives in the pharmacological treatment of advanced or recurrent endometrial cancer: Hormonal therapy, chemotherapy and molecularly targeted therapies. Crit Rev Oncol Hematol 2006;58:242-56
-
(2006)
Crit Rev Oncol Hematol
, vol.58
, pp. 242-256
-
-
Gadducci, A.1
Cosio, S.2
Genazzani, A.R.3
-
15
-
-
25144454885
-
Epigeneticmediated upregulation of progesterone receptor B gene in endometrial cancer cell lines
-
Xiong Y, Dowdy SC, Gonzalez Bosquet J, et al. Epigeneticmediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. Gynecol Oncol 2005;99:135-41
-
(2005)
Gynecol Oncol
, vol.99
, pp. 135-141
-
-
Xiong, Y.1
Dowdy, S.C.2
Gonzalez Bosquet, J.3
-
16
-
-
34249808191
-
Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells
-
Ren Y, Liu X, Ma D, et al. Down-regulation of the progesterone receptor by the methylation of progesterone receptor gene in endometrial cancer cells. Cancer Genet Cytogenet 2007;175: 107-16
-
(2007)
Cancer Genet Cytogenet
, vol.175
, pp. 107-116
-
-
Ren, Y.1
Liu, X.2
Ma, D.3
-
17
-
-
84859727785
-
Endometrial cancer: Reviving progesterone therapy in the molecular age
-
Yang S, Thiel KW, De Geest K, Leslie KK. Endometrial cancer: Reviving progesterone therapy in the molecular age. Discov Med 2011;12:205-12
-
(2011)
Discov Med
, vol.12
, pp. 205-212
-
-
Yang, S.1
Thiel, K.W.2
De Geest, K.3
Leslie, K.K.4
-
18
-
-
2942657617
-
Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: A Gynecologic Oncology Group Study
-
Fleming GF, Brunetto VL, Cella D, et al. Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: A Gynecologic Oncology Group Study. J Clin Oncol 2004;22:2159-66
-
(2004)
J Clin Oncol
, vol.22
, pp. 2159-2166
-
-
Fleming, G.F.1
Brunetto, V.L.2
Cella, D.3
-
19
-
-
84866769698
-
Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma
-
Vale CL, Tierney J, Bull SJ, Symonds PR. Chemotherapy for advanced, recurrent or metastatic endometrial carcinoma. Cochrane Database Syst Rev 2012;8:CD003915
-
(2012)
Cochrane Database Syst Rev
, vol.8
-
-
Vale, C.L.1
Tierney, J.2
Bull, S.J.3
Symonds, P.R.4
-
20
-
-
59649096025
-
Molecule-targeted agents in endometrial cancer
-
Delmonte A, Sessa C. Molecule-targeted agents in endometrial cancer. Curr Opin Oncol. 2008;20:554-59
-
(2008)
Curr Opin Oncol
, vol.20
, pp. 554-559
-
-
Delmonte, A.1
Sessa, C.2
-
21
-
-
78649592049
-
A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma
-
Slomovitz BM, Lu KH, Johnston T, et al. A phase 2 study of the oral mammalian target of rapamycin inhibitor, everolimus, in patients with recurrent endometrial carcinoma. Cancer 2010;116:5415-19
-
(2010)
Cancer
, vol.116
, pp. 5415-5419
-
-
Slomovitz, B.M.1
Lu, K.H.2
Johnston, T.3
-
22
-
-
80052010923
-
Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group
-
Oza AM, Elit L, Tsao MS, et al. Phase II study of temsirolimus in women with recurrent or metastatic endometrial cancer: A trial of the NCIC Clinical Trials Group. J Clin Oncol 2011;29:3278-85
-
(2011)
J Clin Oncol
, vol.29
, pp. 3278-3285
-
-
Oza, A.M.1
Elit, L.2
Tsao, M.S.3
-
23
-
-
52049125733
-
Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148
-
Oza AM, Eisenhauer EA, Elit L, et al. Phase II study of erlotinib in recurrent or metastatic endometrial cancer: NCIC IND-148. J Clin Oncol 2008;26:4319-25
-
(2008)
J Clin Oncol
, vol.26
, pp. 4319-4325
-
-
Oza, A.M.1
Eisenhauer, E.A.2
Elit, L.3
-
24
-
-
74249102857
-
Efficacy and safety of gefitinib (Iressa, ZD1839) and potential prognostic value of soluble EGFR, EGFR mutations and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer
-
abstr e16542
-
Leslie KK, Sill MW, Darcy KM, et al. Efficacy and safety of gefitinib (Iressa, ZD1839) and potential prognostic value of soluble EGFR, EGFR mutations and tumor markers in a Gynecologic Oncology Group phase II trial of persistent or recurrent endometrial cancer. J Clin Oncol 2009;27:abstr e16542
-
(2009)
J Clin Oncol
, vol.27
-
-
Leslie, K.K.1
Sill, M.W.2
Darcy, K.M.3
-
25
-
-
46749152126
-
Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu
-
Santin AD, Bellone S, Roman JJ, et al. Trastuzumab treatment in patients with advanced or recurrent endometrial carcinoma overexpressing HER2/neu. Int J Gynaecol Obstet 2008;102:128-31
-
(2008)
Int J Gynaecol Obstet
, vol.102
, pp. 128-131
-
-
Santin, A.D.1
Bellone, S.2
Roman, J.J.3
-
26
-
-
70749097152
-
Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: A Gynecologic Oncology Group study
-
Fleming GF, Sill MW, Darcy KM, et al. Phase II trial of trastuzumab in women with advanced or recurrent, HER2-positive endometrial carcinoma: A Gynecologic Oncology Group study. Gynecol Oncol 2010;116:15-20
-
(2010)
Gynecol Oncol
, vol.116
, pp. 15-20
-
-
Fleming, G.F.1
Sill, M.W.2
Darcy, K.M.3
-
27
-
-
37549006796
-
Clinical and biological significance of vascular endothelial growth factor in endometrial cancer
-
Kamat AA, Merritt WM, Coffey D, et al. Clinical and biological significance of vascular endothelial growth factor in endometrial cancer. Clin Cancer Res 2007;13:7487-95
-
(2007)
Clin Cancer Res
, vol.13
, pp. 7487-7495
-
-
Kamat, A.A.1
Merritt, W.M.2
Coffey, D.3
-
29
-
-
0035133926
-
Cytosol vascular endothelial growth factor in endometrial carcinoma: Correlation with diseasefree survival
-
Chen CA, Cheng WF, Lee CN, et al. Cytosol vascular endothelial growth factor in endometrial carcinoma: Correlation with diseasefree survival. Gynecol Oncol 2001;80:207-12
-
(2001)
Gynecol Oncol
, vol.80
, pp. 207-212
-
-
Chen, C.A.1
Cheng, W.F.2
Lee, C.N.3
-
30
-
-
0035889939
-
The angiogenic ''vascular endothelial growth factor/flk-1(KDR) receptor'' pathway in patients with endometrial carcinoma: Prognostic and therapeutic implications
-
Giatromanolaki A, Sivridis E, Brekken R, et al. The angiogenic ''vascular endothelial growth factor/flk-1(KDR) receptor'' pathway in patients with endometrial carcinoma: Prognostic and therapeutic implications. Cancer 2001;92:2569-77
-
(2001)
Cancer
, vol.92
, pp. 2569-2577
-
-
Giatromanolaki, A.1
Sivridis, E.2
Brekken, R.3
-
31
-
-
0035136974
-
Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial cancer
-
Hirai M, Nakagawara A, Oosaki T, et al. Expression of vascular endothelial growth factors (VEGF-A/VEGF-1 and VEGF-C/VEGF-2) in postmenopausal uterine endometrial cancer. Gynecol Oncol 2001;80:181-8
-
(2001)
Gynecol Oncol
, vol.80
, pp. 181-188
-
-
Hirai, M.1
Nakagawara, A.2
Oosaki, T.3
-
32
-
-
20444496482
-
VEGF and its receptors (flt-1 and KDR/flk-1) as prognostic indicators in endometrial carcinoma
-
Talvensaari-Mattila A, Soini Y, Santala M. VEGF and its receptors (flt-1 and KDR/flk-1) as prognostic indicators in endometrial carcinoma. Tumour Biol 2005;26:81-7
-
(2005)
Tumour Biol
, vol.26
, pp. 81-87
-
-
Talvensaari-Mattila, A.1
Soini, Y.2
Santala, M.3
-
33
-
-
84855511518
-
Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma
-
Pengchong H, Tao H. Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma. Eur J Gynaecol Oncol 2011;32:660-4
-
(2011)
Eur J Gynaecol Oncol
, vol.32
, pp. 660-664
-
-
Pengchong, H.1
Tao, H.2
-
34
-
-
80053989552
-
Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer
-
Gadducci A, Cosio S, Genazzani AR. Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer. Crit Rev Oncol Hematol 2011;80:181-92
-
(2011)
Crit Rev Oncol Hematol
, vol.80
, pp. 181-192
-
-
Gadducci, A.1
Cosio, S.2
Genazzani, A.R.3
-
35
-
-
76449094050
-
Understanding the molecular-based mechanism of action of the tyrosine kinase inhibitor: Sunitinib
-
Mena AC, Pulido EG, Guillen-Ponce C. Understanding the molecular-based mechanism of action of the tyrosine kinase inhibitor: Sunitinib. Anticancer Drugs 2010;21:S3-11
-
(2010)
Anticancer Drugs
, vol.21
-
-
Mena, A.C.1
Pulido, E.G.2
Guillen-Ponce, C.3
-
36
-
-
78650446898
-
A phase II study of sunitinib in recurrent or metastatic endometrial carcinoma: A trial of the Princess Margaret Hospital, The
-
University of Chicago, and California Cancer Phase II Consortia abstr 5038
-
Correa R, Mackay H, Hirte HW, et al. A phase II study of sunitinib in recurrent or metastatic endometrial carcinoma: A trial of the Princess Margaret Hospital, The University of Chicago, and California Cancer Phase II Consortia. J Clin Oncol 2010;28: Abstr 5038
-
(2010)
J Clin Oncol
, vol.28
-
-
Correa, R.1
Mackay, H.2
Hirte, H.W.3
-
37
-
-
4944249117
-
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
-
Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the Raf/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004;64:7099-109
-
(2004)
Cancer Res
, vol.64
, pp. 7099-7109
-
-
Wilhelm, S.M.1
Carter, C.2
Tang, L.3
-
38
-
-
71049186531
-
Sorafenib (SOR) in patients (pts) with advanced/recurrent uterine carcinoma (UCA) or carcinosarcoma (CS): A phase II trial of the
-
University of Chicago, PMH, and California Phase II Consortia abstr 5585
-
Nimeiri HS, Oza AM, Morgan RJ, et al. Sorafenib (SOR) in patients (pts) with advanced/recurrent uterine carcinoma (UCA) or carcinosarcoma (CS): A phase II trial of the University of Chicago, PMH, and California Phase II Consortia. J Clin Oncol 2008;26:abstr 5585
-
(2008)
J Clin Oncol
, vol.26
-
-
Nimeiri, H.S.1
Oza, A.M.2
Morgan, R.J.3
-
39
-
-
0033980850
-
Continuous low dose Thalidomide: A phase II study in advanced melanoma, renal cell, ovarian and breast cancer
-
Eisen T, Boshoff C, Mak I, et al. Continuous low dose Thalidomide: A phase II study in advanced melanoma, renal cell, ovarian and breast cancer. Br J Cancer 2000;82:812-17
-
(2000)
Br J Cancer
, vol.82
, pp. 812-817
-
-
Eisen, T.1
Boshoff, C.2
Mak, I.3
-
41
-
-
34247128217
-
A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: A Gynecologic Oncology Group study
-
McMeekin DS, Sill MW, Benbrook D, et al. A phase II trial of thalidomide in patients with refractory endometrial cancer and correlation with angiogenesis biomarkers: A Gynecologic Oncology Group study. Gynecol Oncol 2007;105:508-16
-
(2007)
Gynecol Oncol
, vol.105
, pp. 508-516
-
-
McMeekin, D.S.1
Sill, M.W.2
Benbrook, D.3
-
42
-
-
84867404688
-
A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: A Gynecologic Oncology Group study
-
McMeekin DS, Sill MW, Darcy KM, et al. A phase II trial of thalidomide in patients with refractory uterine carcinosarcoma and correlation with biomarkers of angiogenesis: A Gynecologic Oncology Group study. Gynecol Oncol. 2012;127:356-61
-
(2012)
Gynecol Oncol
, vol.127
, pp. 356-361
-
-
McMeekin, D.S.1
Sill, M.W.2
Darcy, K.M.3
-
43
-
-
2442621619
-
Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer
-
Ferrara N, Hillan KJ, Gerber HP, Novotny W. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nat Rev Drug Discov 2004;3:391-400
-
(2004)
Nat Rev Drug Discov
, vol.3
, pp. 391-400
-
-
Ferrara, N.1
Hillan, K.J.2
Gerber, H.P.3
Novotny, W.4
-
44
-
-
36849019301
-
Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study
-
Burger RA, Sill MW, Monk BJ, et al. Phase II trial of bevacizumab in persistent or recurrent epithelial ovarian cancer or primary peritoneal cancer: A Gynecologic Oncology Group Study. J Clin Oncol 2007;25:5165-71
-
(2007)
J Clin Oncol
, vol.25
, pp. 5165-5171
-
-
Burger, R.A.1
Sill, M.W.2
Monk, B.J.3
-
45
-
-
36849056497
-
Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer
-
Cannistra SA, Matulonis UA, Penson RT, et al. Phase II study of bevacizumab in patients with platinum-resistant ovarian cancer or peritoneal serous cancer. J Clin Oncol 2007;25:5180-6
-
(2007)
J Clin Oncol
, vol.25
, pp. 5180-5186
-
-
Cannistra, S.A.1
Matulonis, U.A.2
Penson, R.T.3
-
46
-
-
79951576333
-
Clinical predictors of bevacizumab-Associated gastrointestinal perforation
-
Tanyi JL, McCann G, Hagemann AR, et al. Clinical predictors of bevacizumab-Associated gastrointestinal perforation. Gynecol Oncol 2011;120:464-9
-
(2011)
Gynecol Oncol
, vol.120
, pp. 464-469
-
-
Tanyi, J.L.1
McCann, G.2
Hagemann, A.R.3
-
47
-
-
84855425106
-
Incorporation of bevacizumab in the primary treatment of ovarian cancer
-
Burger RA, Brady MF, Bookman MA, et al. Incorporation of bevacizumab in the primary treatment of ovarian cancer. N Engl J Med 2011;365:2473-83
-
(2011)
N Engl J Med
, vol.365
, pp. 2473-2483
-
-
Burger, R.A.1
Brady, M.F.2
Bookman, M.A.3
-
48
-
-
84855466019
-
A phase 3 trial of bevacizumab in ovarian cancer
-
Perren TJ, Swart AM, Pfisterer J, et al. A phase 3 trial of bevacizumab in ovarian cancer. N Engl J Med 2011;365:2484-96
-
(2011)
N Engl J Med
, vol.365
, pp. 2484-2496
-
-
Perren, T.J.1
Swart, A.M.2
Pfisterer, J.3
-
49
-
-
84861736119
-
OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer
-
Aghajanian C, Blank SV, Goff BA, et al. OCEANS: A randomized, double-blind, placebo-controlled phase III trial of chemotherapy with or without bevacizumab in patients with platinum-sensitive recurrent epithelial ovarian, primary peritoneal, or fallopian tube cancer. J Clin Oncol 2012;30:2039-45
-
(2012)
J Clin Oncol
, vol.30
, pp. 2039-2045
-
-
Aghajanian, C.1
Blank, S.V.2
Goff, B.A.3
-
50
-
-
84866493383
-
AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC
-
abstr LBA 5002
-
Pujade-Lauraine E, Hilpert F, Weber B, et al. AURELIA: A randomized phase III trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum (PT)-resistant recurrent ovarian cancer (OC). J Clin Oncol 2012;30:abstr LBA 5002
-
(2012)
J Clin Oncol
, vol.30
-
-
Pujade-Lauraine, E.1
Hilpert, F.2
Weber, B.3
-
51
-
-
79957949444
-
Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study
-
Aghajanian C, Sill MW, Darcy KM, et al. Phase II trial of bevacizumab in recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study. J Clin Oncol 2011;29:2259-65
-
(2011)
J Clin Oncol
, vol.29
, pp. 2259-2265
-
-
Aghajanian, C.1
Sill, M.W.2
Darcy, K.M.3
-
52
-
-
0035836697
-
Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer
-
Kuo CJ, Farnebo F, Yu EY, et al. Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer. Proc Natl Acad Sci U S A 2001;98:4605-10
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 4605-4610
-
-
Kuo, C.J.1
Farnebo, F.2
Yu, E.Y.3
-
53
-
-
0037143764
-
VEGF-Trap: A VEGF blocker with potent antitumor effects
-
Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA. 2002;99:11393-8
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11393-11398
-
-
Holash, J.1
Davis, S.2
Papadopoulos, N.3
-
54
-
-
74949101370
-
Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors
-
Tew WP, Gordon M, Murren J, et al. Phase 1 study of aflibercept administered subcutaneously to patients with advanced solid tumors. Clin Cancer Res 2010;16:358-66
-
(2010)
Clin Cancer Res
, vol.16
, pp. 358-366
-
-
Tew, W.P.1
Gordon, M.2
Murren, J.3
-
55
-
-
36749040908
-
VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade
-
Rudge JS, Holash J, Hylton D, et al. VEGF Trap complex formation measures production rates of VEGF, providing a biomarker for predicting efficacious angiogenic blockade. Proc Natl Acad Sci USA. 2007;104:18363-70
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 18363-18370
-
-
Rudge, J.S.1
Holash, J.2
Hylton, D.3
-
56
-
-
56749174211
-
FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-Angiogenic therapy?
-
Fischer C, Mazzone M, Jonckx B, Carmeliet P. FLT1 and its ligands VEGFB and PlGF: Drug targets for anti-Angiogenic therapy? Nat Rev Cancer 2008;8:942-56
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 942-956
-
-
Fischer, C.1
Mazzone, M.2
Jonckx, B.3
Carmeliet, P.4
-
57
-
-
0345060442
-
Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
-
Byrne AT, Ross L, Holash J, et al. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res 2003;9:5721-8
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5721-5728
-
-
Byrne, A.T.1
Ross, L.2
Holash, J.3
-
58
-
-
84856509199
-
Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A phase 2, randomised, double-blind, placebo-controlled study
-
Gotlieb WH, Amant F, Advani S, et al. Intravenous aflibercept for treatment of recurrent symptomatic malignant ascites in patients with advanced ovarian cancer: A phase 2, randomised, double-blind, placebo-controlled study. Lancet Oncol 2012;13:154-62
-
(2012)
Lancet Oncol
, vol.13
, pp. 154-162
-
-
Gotlieb, W.H.1
Amant, F.2
Advani, S.3
-
59
-
-
84869465976
-
North central cancer treatment group (NCCTG) N0537: Phase II trial of VEGF-trap in patients with metastatic breast cancer previously treated with an anthracycline and/or a taxane
-
Sideras K, Dueck AC, Hobday TJ, et al. North central cancer treatment group (NCCTG) N0537: Phase II trial of VEGF-trap in patients with metastatic breast cancer previously treated with an anthracycline and/or a taxane. Clin Breast Cancer 2012;12: 387-91
-
(2012)
Clin Breast Cancer
, vol.12
, pp. 387-391
-
-
Sideras, K.1
Dueck, A.C.2
Hobday, T.J.3
-
60
-
-
84867047384
-
Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen
-
Van Cutsem E, Tabernero J, Lakomy R, et al. Addition of aflibercept to fluorouracil, leucovorin, and irinotecan improves survival in a phase III randomized trial in patients with metastatic colorectal cancer previously treated with an oxaliplatin-based regimen. J Clin Oncol 2012;30:3499-506
-
(2012)
J Clin Oncol
, vol.30
, pp. 3499-3506
-
-
Van Cutsem, E.1
Tabernero, J.2
Lakomy, R.3
-
61
-
-
84858339404
-
A phase II study single agent of aflibercept (vegf trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma a trial of the princess margaret hospital chicago and california cancer phase ii consortia
-
Mackay HJ, Buckanovich RJ, Hirte H, et al. A phase II study single agent of aflibercept (VEGF Trap) in patients with recurrent or metastatic gynecologic carcinosarcomas and uterine leiomyosarcoma. A trial of the Princess Margaret Hospital, Chicago and California Cancer Phase II Consortia. Gynecol Oncol 2012;125: 136-40
-
(2012)
Gynecol Oncol
, vol.125
, pp. 136-140
-
-
Mackay, H.J.1
Buckanovich, R.J.2
Hirte, H.3
-
62
-
-
84875339336
-
Aflibercept: A novel VEGF targeted agent to explore the future perspectives of anti-Angiogenic therapy for the treatment of multiple tumors
-
Sharma T, Dhingra R, Singh S, et al. Aflibercept: A novel VEGF targeted agent to explore the future perspectives of anti-Angiogenic therapy for the treatment of multiple tumors. Mini Rev Med Chem 2013;13:530-40
-
(2013)
Mini Rev Med Chem
, vol.13
, pp. 530-540
-
-
Sharma, T.1
Dhingra, R.2
Singh, S.3
-
63
-
-
84868588283
-
A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study
-
Coleman RL, Sill MW, Lankes HA, et al. A phase II evaluation of aflibercept in the treatment of recurrent or persistent endometrial cancer: A Gynecologic Oncology Group study. Gynecol Oncol 2012; 127:538-43
-
(2012)
Gynecol Oncol
, vol.127
, pp. 538-543
-
-
Coleman, R.L.1
Sill, M.W.2
Lankes, H.A.3
-
64
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature 2001;411:355-65
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
65
-
-
34250829395
-
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
-
Pollock PM, Gartside MG, Dejeza LC, et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 2007;26:7158-62
-
(2007)
Oncogene
, vol.26
, pp. 7158-7162
-
-
Pollock, P.M.1
Gartside, M.G.2
Dejeza, L.C.3
-
66
-
-
47249122523
-
Drug-sensitive FGFR2 mutations in endometrial carcinoma
-
Dutt A, Salvesen HB, Chen TH, et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc Natl Acad Sci USA 2008; 105:8713-17
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8713-8717
-
-
Dutt, A.1
Salvesen, H.B.2
Chen, T.H.3
-
67
-
-
65349087952
-
FGFR2 as a molecular target in endometrial cancer
-
Byron SA, Pollock PM. FGFR2 as a molecular target in endometrial cancer. Future Oncol 2009;5:27-32
-
(2009)
Future Oncol
, vol.5
, pp. 27-32
-
-
Byron, S.A.1
Pollock, P.M.2
-
68
-
-
77952828838
-
Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis
-
Dey JH, Bianchi F, Voshol J, et al. Targeting fibroblast growth factor receptors blocks PI3K/AKT signaling, induces apoptosis, and impairs mammary tumor outgrowth and metastasis. Cancer Res 2010;70:4151-62
-
(2010)
Cancer Res
, vol.70
, pp. 4151-4162
-
-
Dey, J.H.1
Bianchi, F.2
Voshol, J.3
-
69
-
-
84862145477
-
A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma
-
Sivanand S, Penä-Llopis S, Zhao H, et al. A validated tumorgraft model reveals activity of dovitinib against renal cell carcinoma. Sci Transl Med 2012;4:137-75
-
(2012)
Sci Transl Med
, vol.4
, pp. 137-175
-
-
Sivanand, S.1
Penä-Llopis, S.2
Zhao, H.3
-
70
-
-
82555173128
-
Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma
-
Kim KB, Chesney J, Robinson D, et al. Phase I/II and pharmacodynamic study of dovitinib (TKI258), an inhibitor of fibroblast growth factor receptors and VEGF receptors, in patients with advanced melanoma. Clin Cancer Res 2011;17:7451-61
-
(2011)
Clin Cancer Res
, vol.17
, pp. 7451-7461
-
-
Kim, K.B.1
Chesney, J.2
Robinson, D.3
|