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Volumn 13, Issue 4, 2013, Pages 530-540

Aflibercept: A novel VEGF targeted agent to explore the future perspectives of anti-angiogenic therapy for the treatment of multiple tumors

Author keywords

Aflibercept; Angiogenesis; Chemotherapy; VEGF; VEGF Trap

Indexed keywords

AFLIBERCEPT; BEVACIZUMAB; CISPLATIN; DOCETAXEL; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; HYBRID PROTEIN; OXALIPLATIN; PACLITAXEL; PAZOPANIB; PEMETREXED; PLACEBO; PLACENTAL GROWTH FACTOR; PREDNISONE; SORAFENIB; SUNITINIB; TRASTUZUMAB; VASCULOTROPIN; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN C; VASCULOTROPIN D;

EID: 84875339336     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/1389557511313040006     Document Type: Review
Times cited : (34)

References (87)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N Engl J. Med., 1971, 285, 1182-1186.
    • (1971) N Engl J. Med. , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0023157363 scopus 로고
    • Angiogenic factors
    • Folkman, J.; Klagsbrun, M. Angiogenic factors. Science., 1987, 235, 442-447.
    • (1987) Science. , vol.235 , pp. 442-447
    • Folkman, J.1    Klagsbrun, M.2
  • 3
    • 0031969264 scopus 로고    scopus 로고
    • Angiogenesis and tumor metastasis
    • Zetter, BR. Angiogenesis and tumor metastasis. Ann Rev Med., 1998, 49, 407-424.
    • (1998) Ann Rev Med. , vol.49 , pp. 407-424
    • Zetter, B.R.1
  • 4
    • 2542628099 scopus 로고    scopus 로고
    • Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors
    • Tong, RT.; Boucher, Y.; Kozin, SV.; Winkler, F; Hicklin, DJ; Jain, RK. Vascular normalization by vascular endothelial growth factor receptor 2 blockade induces a pressure gradient across the vasculature and improves drug penetration in tumors. Cancer Res., 2004, 64, 3731-3736.5.
    • (2004) Cancer Res. , vol.64 , pp. 3731
    • Tong, R.T.1    Boucher, Y.2    Kozin, S.V.3    Winkler, F.4    Hicklin, D.J.5    Jain, R.K.6
  • 5
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, RK. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science., 2005, 307, 58-62.6.
    • (2005) Science. , vol.307 , pp. 58-62
    • Jain, R.K.1
  • 7
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor basic science and clinical progress
    • Ferrara, N. Vascular endothelial growth factor basic science and clinical progress. Endocr Rev., 2004, 25, 581-611.
    • (2004) Endocr Rev. , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 8
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin, DJ.; Ellis, LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol., 2005, 23, 1011-1127.
    • (2005) J Clin Oncol. , vol.23 , pp. 1011-1127
    • Hicklin, D.J.1    Ellis, L.M.2
  • 9
    • 77957083400 scopus 로고    scopus 로고
    • Clinical Applications of VEGF-Trap (Aflibercept) in Cancer Treatment
    • Li-Song, T.; Ke-Tao, J.; Kui-Feng, He.; Jing, Z.; Hao-Hao, W.; Jiang, Cao. Clinical Applications of VEGF-Trap (Aflibercept) in Cancer Treatment. J Chin Med Assoc., 2010, 73, 449-454.
    • (2010) J Chin Med Assoc. , vol.73 , pp. 449-454
    • Li-Song, T.1    Ke-Tao, J.2    He, K.-F.3    Jing, Z.4    Hao-Hao, W.5    Cao, J.6
  • 10
    • 63749125392 scopus 로고    scopus 로고
    • VEGFs and receptors involved in angiogenesis versus lymphangiogenesis
    • Lohela, M.; Bry, M.; Tammela, T.; Alitalo, K. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr Opin Cell Biol., 2009, 21, 154-165.
    • (2009) Curr Opin Cell Biol. , vol.21 , pp. 154-165
    • Lohela, M.1    Bry, M.2    Tammela, T.3    Alitalo, K.4
  • 11
    • 47949089077 scopus 로고    scopus 로고
    • VEGF-targeted therapy: Mechanisms of anti-tumour
    • Ellis, LM.; Hicklin, DJ. VEGF-targeted therapy: mechanisms of anti-tumour. Rev Cancer., 2008, 8, 579-591.
    • (2008) Rev Cancer. , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 12
    • 84855826070 scopus 로고    scopus 로고
    • Has bevacizumab (Avastin) given extra therapeutic gain in metastatic colorectal cancer and malignant brain gliomas? Systematic review answering this question
    • Koukourakis, GV. Has bevacizumab (Avastin) given extra therapeutic gain in metastatic colorectal cancer and malignant brain gliomas? Systematic review answering this question. Recent Pat Inflamm Allergy Drug Discov. 2012, 6, 70-77.
    • (2012) Recent Pat Inflamm Allergy Drug Discov , vol.6 , pp. 70-77
    • Koukourakis, G.V.1
  • 13
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin, DJ.; Ellis, LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol., 2005, 23, 1011-1127.
    • (2005) J Clin Oncol. , vol.23 , pp. 1011-1127
    • Hicklin, D.J.1    Ellis, L.M.2
  • 14
    • 13444278498 scopus 로고    scopus 로고
    • Pharmacology and pharmacodynamits of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies
    • Gerber, HP.; Ferrara, N. Pharmacology and pharmacodynamits of bevacizumab as monotherapy or in combination with cytotoxic therapy in preclinical studies. Cancer Res., 2005, 65, 671-680.
    • (2005) Cancer Res. , vol.65 , pp. 671-680
    • Gerber, H.P.1    Ferrara, N.2
  • 15
    • 3042643346 scopus 로고    scopus 로고
    • Bevacizumab: An angiogenesis inhibitor with efficacy in colorectal and other malignancies
    • Zondor, SD.; Medina, PJ. Bevacizumab: An angiogenesis inhibitor with efficacy in colorectal and other malignancies. Ann Pharmacother., 2004, 38, 1258-1264.
    • (2004) Ann Pharmacother. , vol.38 , pp. 1258-1264
    • Zondor, S.D.1    Medina, P.J.2
  • 16
    • 33846638744 scopus 로고    scopus 로고
    • Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: Systematic review and meta-analysis
    • Zhu, X.; Dahut, WL.; Parikh, CR.; Risks of proteinuria and hypertension with bevacizumab, an antibody against vascular endothelial growth factor: systematic review and meta-analysis. Am J Kidney Dis., 2007, 49, 186-193.
    • (2007) Am J Kidney Dis. , vol.49 , pp. 186-193
    • Zhu, X.1    Dahut, W.L.2    Parikh, C.R.3
  • 17
    • 70349782389 scopus 로고    scopus 로고
    • An overview of smallmolecule inhibitors of VEGFR signaling
    • Ivy, SP.; Wick, JY.; Kaufman, BM. An overview of smallmolecule inhibitors of VEGFR signaling. Nat Rev Clin Oncol., 2009, 6, 569-579.
    • (2009) Nat Rev Clin Oncol. , vol.6 , pp. 569-579
    • Ivy, S.P.1    Wick, J.Y.2    Kaufman, B.M.3
  • 18
    • 79955567607 scopus 로고    scopus 로고
    • Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: A review
    • Keefe, D.; Bowen, J.; Gibson, R.; Tan, T.; Okera, M.; Stringer, A. Noncardiac vascular toxicities of vascular endothelial growth factor inhibitors in advanced cancer: a review. Oncologist., 2011, 16, 432-444.
    • (2011) Oncologist. , vol.16 , pp. 432-444
    • Keefe, D.1    Bowen, J.2    Gibson, R.3    Tan, T.4    Okera, M.5    Stringer, A.6
  • 19
    • 84861190138 scopus 로고    scopus 로고
    • A preclinical and clinical review of aflibercept for the management of cancer
    • Gaya, A.; Tse, V. A preclinical and clinical review of aflibercept for the management of cancer. Cancer Treat. Revi., 2012, 38, 484-493.
    • (2012) Cancer Treat. Revi. , vol.38 , pp. 484-493
    • Gaya, A.1    Tse, V.2
  • 20
    • 0036287302 scopus 로고    scopus 로고
    • Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2
    • Wulff, C.; Wilson, H.; Wiegand, SJ.; Rudge, JS.; Fraser, HM. Prevention of thecal angiogenesis, antral follicular growth, and ovulation in the primate by treatment with vascular endothelial growth factor Trap R1R2. Endocrinology., 2002, 143, 2797-2807.
    • (2002) Endocrinology. , vol.143 , pp. 2797-2807
    • Wulff, C.1    Wilson, H.2    Wiegand, S.J.3    Rudge, J.S.4    Fraser, H.M.5
  • 23
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trapdecreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne, AT.; Ross, L.; Holash, J.; Nakanishi, M.; Hu, L.; Hofmann, JI.; Yancopoulos, GD.; Jaffe, RB. Vascular endothelial growth factor-trapdecreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res., 2003, 9, 5721-5728.
    • (2003) Clin Cancer Res. , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6    Yancopoulos, G.D.7    Jaffe, R.B.8
  • 24
    • 3042548695 scopus 로고    scopus 로고
    • Inhibition of vascular endothelialgrowth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    • Inai, T.; Mancuso, M.; Hashizume, H.; Baffert, F.; Haskell, A.; Baluk, P.; Hu-Lowe, DD.; Shalinsky, DR.; Thurston, G.; Yancopoulos, GD.; McDonald, DM. Inhibition of vascular endothelialgrowth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts. Am J Pathol., 2004, 165, 35-52.
    • (2004) Am J Pathol. , vol.165 , pp. 35-52
    • Inai, T.1    Mancuso, M.2    Hashizume, H.3    Baffert, F.4    Haskell, A.5    Baluk, P.6    Hu-Lowe, D.D.7    Shalinsky, D.R.8    Thurston, G.9    Yancopoulos, G.D.10    McDonald, D.M.11
  • 25
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers, G.; Hanahan, D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer., 2008, 8, 592-603.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 26
    • 70450175957 scopus 로고    scopus 로고
    • Targeting angiogenesis progress with anti-VegF treatment with large molecules
    • Grothey, A.; Galanis, E. Targeting angiogenesis progress with anti-VegF treatment with large molecules. Nat Rev Clin Oncol., 2009, 6, 507-518.
    • (2009) Nat Rev Clin Oncol. , vol.6 , pp. 507-518
    • Grothey, A.1    Galanis, E.2
  • 27
    • 69849111795 scopus 로고    scopus 로고
    • Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center
    • Moroney, John W.; Sood, Anil K.; Coleman, Robert L.; Department of Gynecologic Oncology, University of Texas MD Anderson Cancer Center. Future Oncol., 2009, 5, 591-600.
    • (2009) Future Oncol. , vol.5 , pp. 591-600
    • Moroney, J.W.1    Sood, A.K.2    Coleman, R.L.3
  • 28
    • 48749111875 scopus 로고    scopus 로고
    • The discovery of the placental growth factor and its role in angiogenesis: A historical review
    • Ribatti, D. The discovery of the placental growth factor and its role in angiogenesis: a historical review. Angiogenesis., 2008, 11, 215-221.
    • (2008) Angiogenesis. , vol.11 , pp. 215-221
    • Ribatti, D.1
  • 35
    • 84875287758 scopus 로고    scopus 로고
    • Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    • Baffert, F.; Le, T.; Sennino, B.; Thurston, G.; Kuo, CJ.; Hu-Lowe, D.; McDonald, DM. Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling. Epub., 2006, 290, 47-59.
    • (2006) Epub. , vol.290 , pp. 47-59
    • Baffert, F.1    Le, T.2    Sennino, B.3    Thurston, G.4    Kuo, C.J.5    Hu-Lowe, D.6    McDonald, D.M.7
  • 36
    • 33748306057 scopus 로고    scopus 로고
    • VEGF trap abolishes shear stressand overload-dependent angiogenesis in skeletal muscle
    • Williams, JL.; Cartland, D.; Rudge, JS.; Egginton, S. VEGF trap abolishes shear stressand overload-dependent angiogenesis in skeletal muscle. Microcirculation., 2006, 13, 499-509.
    • (2006) Microcirculation. , vol.13 , pp. 499-509
    • Williams, J.L.1    Cartland, D.2    Rudge, J.S.3    Egginton, S.4
  • 37
    • 35148855012 scopus 로고    scopus 로고
    • Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset
    • Taylor, PD.; Wilson, H.; Hillier, SG.; Wiegand, SJ.; Fraser, HM. Effects of inhibition of vascular endothelial growth factor at time of selection on follicular angiogenesis, expansion, development and atresia in the marmoset. Mol Hum Reprod., 2007,13, 729-736.
    • (2007) Mol Hum Reprod. , vol.13 , pp. 729-736
    • Taylor, P.D.1    Wilson, H.2    Hillier, S.G.3    Wiegand, S.J.4    Fraser, H.M.5
  • 38
    • 50449095294 scopus 로고    scopus 로고
    • The role of vascular endothelial growth factor and estradiol in the regulation of endometrial angiogenesis and cell proliferation in the marmoset
    • Fraser HM, Wilson H, Silvestri A, Morris KD, Wiegand SJ. The role of vascular endothelial growth factor and estradiol in the regulation of endometrial angiogenesis and cell proliferation in the marmoset. Endocrinology., 2008, 149, 4413-4420.
    • (2008) Endocrinology. , vol.149 , pp. 4413-4420
    • Fraser, H.M.1    Wilson, H.2    Silvestri, A.3    Morris, K.D.4    Wiegand, S.J.5
  • 41
    • 0345060442 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model
    • Byrne, AT.; Ross, L.; Holash, J.; Nakanishi, M.; Hu, L.; Hofmann, JI.; Yancopoulos, GD.; Jaffe, RB. Vascular endothelial growth factor-trap decreases tumor burden, inhibits ascites, and causes dramatic vascular remodeling in an ovarian cancer model. Clin Cancer Res., 2003, 9, 5721-5728.
    • (2003) Clin Cancer Res. , vol.9 , pp. 5721-5728
    • Byrne, A.T.1    Ross, L.2    Holash, J.3    Nakanishi, M.4    Hu, L.5    Hofmann, J.I.6    Yancopoulos, G.D.7    Jaffe, R.B.8
  • 42
    • 2542450942 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines
    • Fukasawa, M.; Korc, M. Vascular endothelial growth factor-trap suppresses tumorigenicity of multiple pancreatic cancer cell lines. Clin Cancer Res., 2004, 10, 3327-3332.
    • (2004) Clin Cancer Res. , vol.10 , pp. 3327-3332
    • Fukasawa, M.1    Korc, M.2
  • 43
    • 34547093162 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model
    • Verheul, HM.; Hammers, H.; Van Erp, K.; Wei, Y.; Sanni, T.; Salumbides, B.; Qian, DZ.; Yancopoulos, GD.; Pili, R. Vascular endothelial growth factor trap blocks tumor growth, metastasis formation, and vascular leakage in an orthotopic murine renal cell cancer model. Clin Cancer Res., 2007, 13, 4201-4208.
    • (2007) Clin Cancer Res. , vol.13 , pp. 4201-4208
    • Verheul, H.M.1    Hammers, H.2    van Erp, K.3    Wei, Y.4    Sanni, T.5    Salumbides, B.6    Qian, D.Z.7    Yancopoulos, G.D.8    Pili, R.9
  • 45
    • 26444484355 scopus 로고    scopus 로고
    • Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model
    • Hu, L.; Hofmann, J.; Holash, J.; Yancopoulos, GD.; Sood, AK.; Jaffe, RB. Vascular endothelial growth factor trap combined with paclitaxel strikingly inhibits tumor and ascites, prolonging survival in a human ovarian cancer model. Clin Cancer Res., 2005, 11, 6966-6971.
    • (2005) Clin Cancer Res. , vol.11 , pp. 6966-6971
    • Hu, L.1    Hofmann, J.2    Holash, J.3    Yancopoulos, G.D.4    Sood, A.K.5    Jaffe, R.B.6
  • 46
    • 77958198446 scopus 로고    scopus 로고
    • Aflibercept (VEGF Trap): One moredouble-edged sword of anti-VEGF therapy for cancer?
    • Jin, K.; Shen, Y.; He, K.; Xu, Z.; Li, G.; Teng, L. Aflibercept (VEGF Trap): one moredouble-edged sword of anti-VEGF therapy for cancer? Clin Transl Oncol., 2010, 12, 526-532.
    • (2010) Clin Transl Oncol. , vol.12 , pp. 526-532
    • Jin, K.1    Shen, Y.2    He, K.3    Xu, Z.4    Li, G.5    Teng, L.6
  • 47
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar, F.; Hurwitz, HI.; Fehrenbacher, L.; Meropol, NJ.; Novotny, WF.; Lieberman, G.; Griffing, S.; Bergsland, E. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol., 2003, 21, 60-65.
    • (2003) J Clin Oncol. , vol.21 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3    Meropol, N.J.4    Novotny, W.F.5    Lieberman, G.6    Griffing, S.7    Bergsland, E.8
  • 48
    • 33845490014 scopus 로고    scopus 로고
    • Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
    • Sandler, A.; Gray, R.; Perry, MC. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med., 2006, 355, 2542-2550.
    • (2006) N Engl J Med. , vol.355 , pp. 2542-2550
    • Sandler, A.1    Gray, R.2    Perry, M.C.3
  • 51
    • 33846148701 scopus 로고    scopus 로고
    • Sorafenib in advanced clearcell renal-cell carcinoma
    • Escudier, B.; Eisen, T.; Stadler, WM. Sorafenib in advanced clearcell renal-cell carcinoma. N Engl J Med., 2007, 356,125-134.
    • (2007) N Engl J Med. , vol.356 , pp. 125-134
    • Escudier, B.1    Eisen, T.2    Stadler, W.M.3
  • 52
    • 33846181370 scopus 로고    scopus 로고
    • Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    • Motzer, RJ.; Hutson, TE.; Tomczak, P. Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med., 2007, 356,115-124.
    • (2007) N Engl J Med. , vol.356 , pp. 115-124
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 55
    • 84863011440 scopus 로고    scopus 로고
    • Aflibercept in the Treatment of Metastatic Colorectal Cancer
    • Wang, T.F.; Lockhart, A. C. Aflibercept in the Treatment of Metastatic Colorectal Cancer. Clin Med Insights Oncol., 2012, 6, 19-30.
    • (2012) Clin Med Insights Oncol. , vol.6 , pp. 19-30
    • Wang, T.F.1    Lockhart, A.C.2
  • 56
    • 84860314303 scopus 로고    scopus 로고
    • Sanofi-Aventis; Regeneron Pharmaceuticals, In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00519285 ClinicalTrials.gov
    • Sanofi-Aventis; Regeneron Pharmaceuticals. Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE). In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00519285. NLM Identifier: NCT00519285.
    • (2000) Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE)
  • 57
    • 79957902010 scopus 로고    scopus 로고
    • Signal transduction by vascular endothelial growth factor receptors
    • Koch, S.; Tugues, S.; Li, X.; Gualandi, L.; Claesson-Welsh, L. Signal transduction by vascular endothelial growth factor receptors. Biochem J. 2011, 437, 169-183.
    • (2011) Biochem J , vol.437 , pp. 169-183
    • Koch, S.1    Tugues, S.2    Li, X.3    Gualandi, L.4    Claesson-Welsh, L.5
  • 60
    • 57349164272 scopus 로고    scopus 로고
    • Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2
    • Le, XF.; Mao, W.; Lu, C.; Thornton, A.; Heymach, JV.; Sood, AK.; Bast, RC Jr. Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2. Cell Cycle., 2008, 7, 3747-3758.
    • (2008) Cell Cycle. , vol.7 , pp. 3747-3758
    • Le, X.F.1    Mao, W.2    Lu, C.3    Thornton, A.4    Heymach, J.V.5    Sood, A.K.6    Bast Jr., R.C.7
  • 62
    • 84859755855 scopus 로고    scopus 로고
    • A phase I study of IV aflibercept (Afl) in combination with R-CHOP in untreated patients (pts) with B-cell lymphoma
    • Kuhnowski, F.; Thieblemont, C.; Jardin, F. A phase I study of IV aflibercept (Afl) in combination with R-CHOP in untreated patients (pts) with B-cell lymphoma. J Clin Oncol., 2010, 28, 1-26.
    • (2010) J Clin Oncol. , vol.28 , pp. 1-26
    • Kuhnowski, F.1    Thieblemont, C.2    Jardin, F.3
  • 63
    • 84875320275 scopus 로고    scopus 로고
    • A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus docetaxel (D) and cisplatin (C) in patients (pts) with advanced solid tumors
    • Freyer, G.; Fumoleau, P.; You, B.; Isambert, N.; Chevalier, P.; Trillet-Lenoir, V. A phase I dose escalation and pharmacokinetic (PK) study of intravenous (iv) aflibercept (VEGF Trap) plus docetaxel (D) and cisplatin (C) in patients (pts) with advanced solid tumors. J Clin Oncol., 2008, 26, 20-50.
    • (2008) J Clin Oncol. , vol.26 , pp. 20-50
    • Freyer, G.1    Fumoleau, P.2    You, B.3    Isambert, N.4    Chevalier, P.5    Trillet-Lenoir, V.6
  • 64
    • 69249228874 scopus 로고    scopus 로고
    • A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: Preliminary results
    • Limentani, SA.; Just, R.; Purdham, A. A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF Trap) plus FOLFOX4 in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol., 2008, 26, 1-17.
    • (2008) J Clin Oncol. , vol.26 , pp. 1-17
    • Limentani, S.A.1    Just, R.2    Purdham, A.3
  • 65
    • 69249228874 scopus 로고    scopus 로고
    • A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF Trap) plus weekly gemcitabine (Gem) in patients (pts) with advanced solid tumors: Preliminary results
    • Patnaik, A.; Pipas, M.; Rosen, L. A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF Trap) plus weekly gemcitabine (Gem) in patients (pts) with advanced solid tumors: preliminary results. J Clin Oncol., 2008, 26, 1-32.
    • (2008) J Clin Oncol. , vol.26 , pp. 1-32
    • Patnaik, A.1    Pipas, M.2    Rosen, L.3
  • 66
    • 84875290128 scopus 로고    scopus 로고
    • A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs)
    • Van Cutsem, E.; Khayat, D.; Verslype, C.; Billemont, B.; Tejpar, S.; Meric, JB.; Soussan-Lazard, K.; Assadourian, S.; Cartot-Cotton, S.; Rixe, O. A phase I dose escalation (DE) and pharmacokinetics (PK) study of intravenous aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin (I-LV5FU2) in patients with advanced solid tumors (STs). J Clin Oncol., 2012, 26, 1-8.
    • (2012) J Clin Oncol. , vol.26 , pp. 1-8
    • van Cutsem, E.1    Khayat, D.2    Verslype, C.3    Billemont, B.4    Tejpar, S.5    Meric, J.B.6    Soussan-Lazard, K.7    Assadourian, S.8    Cartot-Cotton, S.9    Rixe, O.10
  • 68
    • 84875285868 scopus 로고    scopus 로고
    • Validation of the selected dose of aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin in a phase I clinical trial of patients (pts) with advanced solid tumors
    • Verslype, C.; Spano, J.; Van Cutsem, E.; Grapin, J. P.; Vandecaveye, V.; Bloch, J.; Soussan Lazard, K.; Assadourian, S.; Tejpar, S.; Khayat, D. Validation of the selected dose of aflibercept (VEGF Trap) plus irinotecan, 5-fluorouracil, and leucovorin in a phase I clinical trial of patients (pts) with advanced solid tumors. J Clin Oncol., 2008, 26, 1-15.
    • (2008) J Clin Oncol. , vol.26 , pp. 1-15
    • Verslype, C.1    Spano, J.2    van Cutsem, E.3    Grapin, J.P.4    Vandecaveye, V.5    Bloch, J.6    Soussan Lazard, K.7    Assadourian, S.8    Tejpar, S.9    Khayat, D.10
  • 70
    • 69549140332 scopus 로고    scopus 로고
    • Aflibercept for advanced epithelial ovarian cancer (EOC) patients with symptomatic malignant ascites: Preliminary results of a pilot study
    • Colombo, N.; Mangili, G.; Mammoliti, S.; Kalling, M.; Tholander, B.; Sternas, L.; Buzenet, G.; Chamberlain, D. Aflibercept for advanced epithelial ovarian cancer (EOC) patients with symptomatic malignant ascites: preliminary results of a pilot study. J Clin Oncol., 2008, 26, 1-15.
    • (2008) J Clin Oncol. , vol.26 , pp. 1-15
    • Colombo, N.1    Mangili, G.2    Mammoliti, S.3    Kalling, M.4    Tholander, B.5    Sternas, L.6    Buzenet, G.7    Chamberlain, D.8
  • 71
    • 77957756488 scopus 로고    scopus 로고
    • Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial
    • Twardowski, P.; Stadler, WM.; Frankel, P.; Lara, PN.; Ruel, C.; Chatta, G.; Heath, E.; Quinn, DI.; Gandara, DR. Phase II study of Aflibercept (VEGF-Trap) in patients with recurrent or metastatic urothelial cancer, a California Cancer Consortium Trial. Urology., 2010, 76, 923-926.
    • (2010) Urology. , vol.76 , pp. 923-926
    • Twardowski, P.1    Stadler, W.M.2    Frankel, P.3    Lara, P.N.4    Ruel, C.5    Chatta, G.6    Heath, E.7    Quinn, D.I.8    Gandara, D.R.9
  • 72
    • 84875287509 scopus 로고    scopus 로고
    • Intravenous aflibercept in advanced ovarian cancer patients with recurrent symptomatic malignant ascites: Key efficacy and safety results of a phase II, randomized, double-blind, placebo-controlled study
    • Gotlieb, WH.; Amant, F.; Advani, S.; Goswami, C.; Hirte, H.; Provencher, D.; Somani, N.; Yamada, SD.; Tamby, JF.; Vergote, I. Intravenous aflibercept in advanced ovarian cancer patients with recurrent symptomatic malignant ascites: key efficacy and safety results of a phase II, randomized, double-blind, placebo-controlled study. Eur Soc Gyne Oncol., 2009, 154-162.
    • (2009) Eur Soc Gyne Oncol. , pp. 154-162
    • Gotlieb, W.H.1    Amant, F.2    Advani, S.3    Goswami, C.4    Hirte, H.5    Provencher, D.6    Somani, N.7    Yamada, S.D.8    Tamby, J.F.9    Vergote, I.10
  • 73
    • 78651394951 scopus 로고    scopus 로고
    • A phase II study of VEGF trap (aflibercept) in patients with radioactive iodine refractory, positron emission tomography (PET) positive thyroid carcinoma
    • Sherman, E. J.; Ho A, L.; Haque, S.; Ghossein, R. A.; Lisa, D. M.; Schöder, H.; Baum, M. S.; Shaha A. R.; Tuttle, R. M.; Pfister, D. G. A phase II study of VEGF trap (aflibercept) in patients with radioactive iodine refractory, positron emission tomography (PET) positive thyroid carcinoma. J Clin Oncol., 2010, 28, 1-20.
    • (2010) J Clin Oncol. , vol.28 , pp. 1-20
    • Sherman, E.J.1    Ho, A.L.2    Haque, S.3    Ghossein, R.A.4    Lisa, D.M.5    Schöder, H.6    Baum, M.S.7    Shaha, A.R.8    Tuttle, R.M.9    Pfister, D.G.10
  • 77
    • 84875288029 scopus 로고    scopus 로고
    • Eastern Cooperative Oncology Group; National Cancer Institute (NCI), In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00357760 ClinicalTrials.gov
    • Eastern Cooperative Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with metastatic or unresectable kidney cancer. In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00357760. NLM Identifier: NCT00357760.
    • (2000) VEGF Trap in treating patients with metastatic or unresectable kidney cancer
  • 78
    • 84875307404 scopus 로고    scopus 로고
    • Gynecologic Oncology Group; National Cancer Institute (NCI), In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00462826 ClinicalTrials.gov
    • Gynecologic Oncology Group; National Cancer Institute (NCI). VEGF Trap in treating patients with recurrent or persistent endometrial cancer. In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00462826. NLM Identifier: NCT00462826.
    • (2000) VEGF Trap in treating patients with recurrent or persistent endometrial cancer
  • 79
    • 84875329676 scopus 로고    scopus 로고
    • Weill Medical College of Cornell University; National Cancer Institute (NCI), In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00437034 ClinicalTrials.gov
    • Weill Medical College of Cornell University; National Cancer Institute (NCI). VEGF Trap in treating patients with stage II or stage III multiple myeloma that has relapsed or not responded to previous treatment. In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00437034. NLM Identifier: NCT00437034.
    • (2000) VEGF Trap in treating patients with stage II or stage III multiple myeloma that has relapsed or not responded to previous treatment
  • 80
    • 84875334707 scopus 로고    scopus 로고
    • California Cancer Consortium; National Cancer Institute (NCI), In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00509249 ClinicalTrials.gov
    • California Cancer Consortium; National Cancer Institute (NCI), Aflibercept in treating patients with myelodysplastic syndromes. In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00509249. NLM Identifier: NCT00509249.
    • (2000) Aflibercept in treating patients with myelodysplastic syndromes
  • 81
    • 84860314303 scopus 로고    scopus 로고
    • Sanofi-Aventis; Regeneron Pharmaceuticals, In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00519285 ClinicalTrials.gov
    • Sanofi-Aventis; Regeneron Pharmaceuticals. Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE). In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00519285. NLM Identifier: NCT00519285.
    • (2000) Aflibercept in combination with docetaxel in metastatic androgen independent prostate cancer (VENICE)
  • 82
    • 85019778046 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled randomized phase III trial of aflibercept (A) plus gemcitabine (G) versus placebo (P) plus gemcitabine (G) in patients with metastatic pancreatic cancer: Final results
    • In:, June 30-July 3, 2010; Barcelona, Spain. Abstract O-0006
    • Riess H, Manges R, Karasek P. Double-blind, placebo-controlled randomized phase III trial of aflibercept (A) plus gemcitabine (G) versus placebo (P) plus gemcitabine (G) in patients with metastatic pancreatic cancer: Final results. In: Proceedings from the 12th world congress on gastrointestinal cancer. June 30-July 3, 2010; Barcelona, Spain. Abstract O-0006.
    • Proceedings from the 12th world congress on gastrointestinal cancer
    • Riess, H.1    Manges, R.2    Karasek, P.3
  • 83
    • 84875363572 scopus 로고    scopus 로고
    • Sanofi-Aventis; Regeneron Pharmaceuticals, In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00532155 ClinicalTrials.gov
    • Sanofi-Aventis; Regeneron Pharmaceuticals. A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or metastatic non-small-cell lung cancer (VITAL). In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00532155. NLM Identifier: NCT00532155.
    • (2000) A study of aflibercept versus placebo in patients with second-line docetaxel for locally advanced or metastatic non-small-cell lung cancer (VITAL)
  • 84
    • 84861185664 scopus 로고    scopus 로고
    • Aflibercept in combination with docetaxel for second-line treatment of locally advanced or metastatic nonsmall-cell lung cancer (NSCLC): Final results of a multinational placebo controlled phase III trial (EFC10261-VITAL)
    • In:, July 3-7, Amsterdam, The Netherlands. Abstract O43.06
    • Novello S, Ramlay R, Gorbunova VA. Aflibercept in combination with docetaxel for second-line treatment of locally advanced or metastatic nonsmall-cell lung cancer (NSCLC): Final results of a multinational placebo controlled phase III trial (EFC10261-VITAL). In: Proceedings from the international association for the study of lung cancer. July 3-7, 2011; Amsterdam, The Netherlands. Abstract O43.06.
    • (2011) Proceedings from the international association for the study of lung cancer
    • Novello, S.1    Ramlay, R.2    Gorbunova, V.A.3
  • 85
    • 84875357105 scopus 로고    scopus 로고
    • Sanofi-Aventis; Regeneron Pharmaceuticals, National Surgical Adjuvant Breast and Bowel Project (NSABP), In:, Internet. Bethesda (MD): National Library of Medicine (US), [cited 2011 October 7]. Available from:, NLM Identifier: NCT00561470 ClinicalTrials.gov
    • Sanofi-Aventis; Regeneron Pharmaceuticals, National Surgical Adjuvant Breast and Bowel Project (NSABP). Aflibercept versus placebo in combination with irinotecan and 5-FU in the treatment of patients with metastatic colorectal cancer after failure of an oxaliplatin based regimen (VELOUR). In: ClinicalTrials. gov Internet. Bethesda (MD): National Library of Medicine (US); 2000 [cited 2011 October 7]. Available from: http://www.clinicaltrials.gov/ct2/show/NCT00561470. NLM Identifier: NCT00561470.
    • (2000) Aflibercept versus placebo in combination with irinotecan and 5-FU in the treatment of patients with metastatic colorectal cancer after failure of an oxaliplatin based regimen (VELOUR)
  • 86
    • 84861382251 scopus 로고    scopus 로고
    • Intravenous Aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (mCRC): Results of a multinational Phase III trial (EFC10262-VELOUR)
    • abstract O-0024
    • Van Cutsem E, Tabernero J, Lakomy R. Intravenous Aflibercept versus placebo in combination with irinotecan/5-FU (FOLFIRI) for second-line treatment of metastatic colorectal cancer (mCRC): results of a multinational Phase III trial (EFC10262-VELOUR). Ann Oncol., 2011, 22(s5) abstract O-0024.
    • (2011) Ann Oncol. , vol.22 , Issue.S5
    • van Cutsem, E.1    Tabernero, J.2    Lakomy, R.3
  • 87
    • 84875306411 scopus 로고    scopus 로고
    • Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: A phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen
    • abstract 3505
    • Carmen, JA.; Radek, L.; Josep, T.; Jana, P.; Paul, R.; Guy, VH.; Vladimir, MM.; David, RF.; Joseph, JM.; Eric, VC. Effects of prior bevacizumab (B) use on outcomes from the VELOUR study: A phase III study of aflibercept (Afl) and FOLFIRI in patients (pts) with metastatic colorectal cancer (mCRC) after failure of an oxaliplatin regimen. J Clin Oncol., 30, 2012 abstract 3505.
    • (2012) J Clin Oncol. , vol.30
    • Carmen, J.A.1    Radek, L.2    Josep, T.3    Jana, P.4    Paul, R.5    Guy, V.H.6    Vladimir, M.M.7    David, R.F.8    Joseph, J.M.9    Eric, V.C.10


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