Effects of methcathinone and 3-Cl-methcathinone (PAL-434) in cocaine discrimination or self-Administration in rhesus monkeys

International Journal of Neuropsychopharmacology

Volumn 16, Issue 9, 2013, Pages 1985-1998

  Kohut, Stephen J ^a   Fivel, Peter A ^a   Blough, Bruce E ^b   Rothman, Richard B ^c   Mello, Nancy K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b RTI INTERNATIONAL   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

Cocaine; discrimination; dopamine; self Administration; serotonin

Indexed keywords

3 CHLOROMETHCATHINONE; AMINOKETONE; COCAINE; DEXAMPHETAMINE; METHCATHINONE; PAL 434; SEROTONIN; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG DISCRIMINATION; DRUG EFFECT; DRUG POTENCY; DRUG SELF ADMINISTRATION; DRUG STRUCTURE; MALE; NONHUMAN; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY; SEROTONIN RELEASE;

ANIMALS; BEHAVIOR, ADDICTIVE; BEHAVIOR, ANIMAL; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; COCAINE-RELATED DISORDERS; DISCRIMINATION (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; MACACA MULATTA; MALE; PROPIOPHENONES; REINFORCEMENT (PSYCHOLOGY); SELF ADMINISTRATION; SEROTONIN; TIME FACTORS;

EID: 84883426979     PISSN: 14611457     EISSN: 14695111     Source Type: Journal    
DOI: 10.1017/S146114571300059X     Document Type: Article

References (57)

1. Banks ML, Blough BE, Negus SS (2011) Effects of monoamine releasers with varying selectivity for releasing dopamine/ norepinephrine vs serotonin on choice between cocaine and food in rhesus monkeys. Behav Pharmacol 22:824-836
2. Baumann MH, Ayestas MA, Dersch CM, Brockington A, Rice KC, Rothman RB (2000) Effects of phentermine and fenfluramine on extracellular dopamine and serotonin in rat nucleus accumbens: therapeutic implications. Synapse 36:102-113
3. Baumann MH, Williams Z, Zolkowska D, Rothman RB (2011a) Serotonin (5-HT) precursor loading with 5-hydroxy-L-Tryptophan (5-HTP) reduces locomotor activation produced by (+)-Amphetamine in the rat. Drug Alc Depend 114:147-152
4. Baumann MH, Clark RD, Woolverton WL, Wee S, Blough BE, Rothman RB (2011b) In vivo effects of amphetamine analogs reveal evidence for serotonergic inhibition of mesolimbic dopamine transmission in the rat. J Pharmacol Exp Ther 337:218-225
5. Bendotti C, Borsini F, Zanini MG, Samanin R, Garattini S (1980) Effect of fenfluramine and norfenfluramine stereoisomers on stimulant effects of d-Amphetamine and apomorphine in the rat. Pharmacol Res Commun 12:567-574
6. Czoty PM, Ginsburg BC, Howell LL (2002) Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 300:831-837
7. Czoty PM, Martelle JL, Nader MA (2010) Effects of chronic d-Amphetamine administration on the reinforcing strength of cocaine in rhesus monkeys. Psychopharmacology 209:375-382
8. Czoty PM, Gould RW, Martelle JL (2011) Prolonged attenuation of the reinforcing strength of cocaine by chronic d-Amphetamine in rhesus monkeys. Neuropsychopharmacology 36:539-547
9. Desai RI, Paronis CA, Martin J, Desai R, Bergman J (2010) Monoaminergic psychomotor stimulants: discriminative stimulus effects and dopamine efflux. J Pharmacol Exp Ther 333:834-843
10. Fivel PA (2011) Computer-controlled drug doses for IV drug self-Administration. Exp Clin Psychopharmacol 19:131-133
11. Glatz AC, Ehrlich M, Clarke MJ, Quinlan PA, Brown EC, Rada P, Hoebel BG (2002) Inhibition of cocaine self-Administration by fluoxetine or D-fenfluramine combined with phentermine. Pharmacol Biochem Behav 71:197-204
12. Glennon RA, Yousif M, Naiman N, Kalix P (1987) Methcathinone: a new and potent amphetamine-like agent. Pharmacol Biochem Behav 26:547-551
13. Glowa JR, Rice KC, Matecka D, Rothman RB (1997) Phentermine/fenfluramine decreases cocaine selfadministration in rhesus monkeys. Neuroreport 14:1347-1351
14. Grabowski J, Rhoades H, Schmitz J, Stotts A, Daruzska LA, Creson D, Moeller FG (2001) Dextroamphetamine for cocaine-dependence treatment: a double-blind randomized clinical trial. J Clin Psychopharmacol 21:522-526
15. Henningfield JE (1995) Nicotine medications for smoking cessation. N Engl J Med 333:1196-1203
16. Herin DV, Rush CR, Grabowski J (2010) Agonist-like pharmacotherapy for stimulant dependence: preclinical, human laboratory, and clinical studies. Ann NY Acad Sci 1187:76-100
17. Howell LL, Byrd LD (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. J Pharmacol Exp Ther 275:1551-1559
18. Howell LL, Carroll FI, Votaw JR, Goodman MM, Kimmel HL (2007) Effects of combined dopamine and serotonin transporter inhibitors on cocaine self-Administration in rhesus monkeys. J Pharmacol Exp Ther 320:757-765
19. ILAR-NRC (1996) Guide for the care and use of laboratory animals, p125. Washington, DC: National Academy Press.
20. Kaminski BJ, Griffiths RR (1994) Intravenous self-injection of methcathinone in the baboon. Pharmacol Biochem Behav 47:981-983
21. Kreek MJ (1996) Opiates, opioids, and addiction. Mol Psychiatry 1:232-254
22. Li SM, Campbell BL, Katz JL (2006) Interactions of cocaine with dopamine uptake inhibitors or dopamine releasers in rats discriminating cocaine. J Pharmacol Exp Ther 317:1088-1096
23. Line SW (1987) Environmental enrichment for laboratory primates. J Am Vet Med Assoc 190:854-859
24. Mello NK (2005) Evaluation of drug abuse treatment medications: concordance between clinical and preclinical studies. NIDA Res Monogr 185:82-104
25. Mello NK, Mendelson JH (1995) Buprenorphine treatment of cocaine and heroin abuse. In: Buprenorphine: combatting Drug Abuse with a unique opioid (Cowan A, Lewis J, eds), pp. 241-287 New York: John Wiley and Sons, Inc.
26. Mello NK, Negus SS (1996) Preclinical evaluation of pharmacotherapies for treatment of cocaine and opioid abuse using drug self-Administration procedures. Neuropsychopharmacology 14:375-424
27. Mello NK, Fivel PA, Kohut SJ, Bergman J (2013a) Effects of chronic buspirone treatment on cocaine self-Administration. Neuropsychopharmacology 38:455-467
28. Mello NK, Fivel PA, Kohut SJ (2013b) Effects of chronic buspirone treatment on nicotine and concurrent nicotine+ cocaine self-Administration. Neuropsychopharmacology. Advance online publication. doi: 10.1038/npp.2013.25
29. Mendelson JH, Mello NK (1996) Management of cocaine abuse and dependence. N Engl J Med 334:965-972
30. Negus SS, Mello NK (2003a) Effects of chronic d-Amphetamine treatment on cocaine- and food-maintained responding under a second-order schedule in rhesus monkeys. Drug Alcohol Depend 70:39-52
31. Negus SS, Mello NK (2003b) Effects of chronic d-Amphetamine treatment on cocaine- and food-maintained responding under a progressive ratio schedule in rhesus monkeys. Psychopharmacology 167:324-332
32. Negus SS, Mello NK, Blough BE, Baumann MH, Rothman RB (2007) Monoamine releasers with varying selectivity for dopamine/norepinephrine vs serotonin release as candidate 'agonist' medications for cocaine dependence: studies in assays of cocaine discrimination and cocaine selfadministration in rhesus monkeys. J Pharmacol Exp Ther 320:627-636
33. Negus SS, Baumann MH, Rothman RB, Mello NK, Blough BE (2009a) Selective suppression of cocaine- vs foodmaintained responding by monoamine releasers in rhesus monkeys: benzylpiperazine, (+)phenmetrazine, and 4-benzylpiperidine. J Pharmacol Exp Ther 329:272-281
34. Negus SS, Mello NK, Kimmel HL, Howell LL, Carroll FI (2009b) Effects of the monoamine uptake inhibitors RT1-112 and RT1-113 on cocaine- and food- maintained responding in rhesus monkeys. Pharmacol Biochem Behav 91:333-338
35. Newman JL, Negus SS, Lozama A, Prisinzano TE, Mello NK (2010) Behavioral evaluation of modafinil and the abuse-related effects of cocaine in rhesus monkeys. Exp Clin Psychopharm 18:395-408
36. Ricaurte GA (1989) Studies of MDMA-induced neurotoxicity in nonhuman primates: a basis for evaluating long-Term effects in humans. NIDA Res Monogr 94:306-322
37. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-Administration of cocaine. Science 237:1219-1223
38. Roberts DCS, Phelan R, Hodges LM, Hodges MM, Bennett B, Childers S, Davies H (1999) Self-Administration of cocaine analogs by rats. Psychopharmacology 144:389-397
39. Rothman RB (1990) High affinity dopamine reuptake inhibitors as potential cocaine antagonists: a strategy for drug development. Life Sci 46:PL17-PL21
40. Rothman RB, Baumann MH, Dersch CM, Romero DV, Rice KC, Carroll FI, Partilla JS (2001) Amphetamine-Type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Synapse 39:32-41
41. Rothman RB, Blough BE, Woolverton WL, Anderson KG, Negus SS, Mello NK, Roth BL, Baumann MH (2005) Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-Administration. J Pharmacol Exp Ther 313:1361-1369
42. Rothman RB, Blough BE, Baumann MH (2006) Dual dopamine-5-HT releasers: potential treatment agents for cocaine addiction. Trends Pharmacol Sci 27:612-618
43. Rothman RB, Blough BE, Baumann MH (2008) Dopamine/ serotonin releasers as medications for stimulant addictions. Prog Brain Res 172:385-406
44. SAMHSA (ed.) (2011) National Survey on Drug Use and Health (NSDUH), Substance Abuse and Mental Health Services Administration (SAMHSA), US Department of Health and Human Services
45. Sidman M (1980) A note on the measurement of conditional discrimination. J Exp Anal Behav 33:285-289
46. Sparago M, Wios J, Yuan J, Hatzidimitriou G, Tolliver J, Dal Cason TA, Katz JL, Ricaurte G (1996) Neurotoxic and pharmacologic studies on enantiomers of the N-methylated analog of cathinone (methcathinone): a new drug of abuse. J Pharmacol Exp Ther 279:1043-1052
47. Tolliver JM (1995) Methcathinone: a new amphetamine-like drug of abuse. NIDA Res Monogr 153:406. UNODC (2011) World Drug Report 2011. United Nations Publication, Sales No. E.11.XI.10
48. Volkow ND, Wang GJ, Fowler JS, Gatley SJ, Ding YS, Logan J, Dewey SL, Hitzemann R, Lieberman J (1996) Relationship between psychostimulant-induced 'high' and dopamine transporter occupancy. Proc Natl Acad Sci USA 93:10388-10392
49. Volkow ND, Wang GJ, Fischman MW, Foltin RW, Fowler JS, Abumrad NN, Vitkun S, Logan J, Gatley SJ, Pappas N, Hitzemann R, Shea CE (1997) Relationship between subjective effects of cocaine and dopamine transporter occupancy. Nature 386:827-830
50. Walsh SL, Preston KL, Sullivan JT, Fromme R, Bigelow GE (1994) Fluoxetine alters the effects of intravenous cocaine in humans. J Clin Psychopharmacol 14:396-407
51. Wee S, Woolverton WL (2006) Self-Administration of mixtures of fenfluramine and amphetamine by rhesus monkeys. Pharmacol Biochem Behav 84:337-343
52. Wee S, Anderson KG, Baumann MH, Rothman RB, Blough BE, Woolverton WL (2005) Relationship between serotoninergic activity and reinforcing effects of a series of amphetamine analogs. J Pharmacol Exp Ther 313:848-854
53. Weerts EM, Goodwin AE, Fantegrossi WE (2007) The value of nonhuman primates in drug abuse research. Exp Clin Psychopharmacology 15:309-327
54. Woods JH, Tessel RE (1974) Fenfluramine: amphetamine congener that fails to maintain drug-Taking behavior in the rhesus monkey. Science 185:1067-1069
55. Woolverton WL, Johnson KM (1992) Neurobiology of cocaine abuse. Trends Pharmacol Sci 13:193-200
56. Young R, Glennon RA (1993) Cocaine-stimulus generalization to two new designer drugs: methcathinone and 4-methylaminorex. Pharmacol Biochem Behav 45:229-231
57. Young R, Glennon RA (1998) Discriminative stimulus effects of S(-)-methcathinone (CAT): a potent stimulant drug of abuse. Psychopharmacology 140:250-256.