Relationship between the serotonergic activity and reinforcing effects of a series of amphetamine analogs

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 2, 2005, Pages 848-854

  Wee, S ^a   Anderson, K G ^a,b   Baumann, M H ^c   Rothman, R B ^c   Blough, B E ^d   Woolverton, William L ^a,e  

^a UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d RTI INTERNATIONAL   (United States)

^e UNIVERSITY OF MISSISSIPPI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 FLUOROAMPHETAMINE; 3 METHYLAMPHETAMINE; 4 FLUOROAMPHETAMINE; 4 METHYLAMPHETAMINE; AMPHETAMINE DERIVATIVE; BRAIN MONOAMINE; DOPAMINE; NORADRENALIN; PAL 303; PAL 313; PAL 314; PAL 353; SEROTONIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOPAMINE RELEASE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SELF ADMINISTRATION; IN VITRO STUDY; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; REINFORCEMENT; RHESUS MONKEY; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM;

AMPHETAMINE; ANIMALS; BRAIN; DRUG ADMINISTRATION SCHEDULE; MACACA MULATTA; MALE; REINFORCEMENT SCHEDULE; SELF ADMINISTRATION; SEROTONIN;

EID: 18044380305     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.080101     Document Type: Article

References (39)

1. Bergman J and Johanson CE (1981) The effects of electric shock on responding maintained by cocaine in rhesus monkeys. Pharmacol Biochem Behav 14:423-426.
2. Bergman J, Madras BK, Johnson SE, and Spealman RD (1989) Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther 251:150-155.
3. Birmes P, Coppin D, Schmitt L, and Lauque D (2003) Serotonin syndrome: a brief review. CMAJ 168:1439-1442.
4. Brady JV and Griffiths RR (1976) Behavioral procedures for evaluating the relative abuse potential of CNS drugs in primates. Fed Proc 35:2245-2253.
5. Brauer LH, Johanson CE, Schuster CR, Rothman RB, and de Wit H (1996) Evaluation of phentermine and fenfluramine, alone and in combination, in normal, healthy volunteers. Neuropsychopharmacology 14:233-241.
6. Carroll ME, Lac ST, Asencis M, and Kragh R (1990) Fluoxetine reduces intravenous cocaine self-administration in rats. Pharmacol Biochem Behav 35:237-244.
7. Clark RD, Baumann MH, Blough BE, and Rothman RB (2004) Effects of monoamine releasing agents on extracellular dopamine and serotonin in rat nucleus accumbens: Relationship to locomotor activation (Abstract). College on Problems of Drug Dependence; 2004 June 12-17; San Juan, Puerto Rico. Poster 42.
8. Czoty PW, Ginsburg BC, and Howell LL (2002) Serotonergic attenuation of the reinforcing and neurochemical effects of cocaine in squirrel monkeys. J Pharmacol Exp Ther 300:831-837.
9. Finfgeld DL (2004) Serotonin syndrome and the use of SSRIs. J Psychosoc Nurs Ment Health Serv 42:16-20.
10. Glatz AC, Ehrlich M, Bae RS, Clarke MJ, Quinlan PA, Brown EC, Rada P, and Hoebel BG (2002) Inhibition of cocaine self-administration by fluoxetine or d-fenfluramine combined with phentermine. Pharmacol Biochem Behav 71:197-204.
11. Higgs RA and Glennon RA (1990) Stimulus properties of ring-methyl amphetamine analogs. Pharmacol Biochem Behav 37:835-837.
12. Howell LL and Byrd LD (1995) Serotonergic modulation of the behavioral effects of cocaine in the squirrel monkey. J Pharmacol Exp Ther 275:1551-1559.
13. Howell LL, Hoffman JM, Votaw JR, Landrum AM, Wilcox KM, and Lindsey KP (2002) Cocaine-induced brain activation determined by positron emission tomography neuroimaging in conscious rhesus monkeys. Psychopharmacology 159:154-160.
14. Howell LL and Wilcox KM (2002) Functional imaging and neurochemical correlates of stimulant self-administration in primates. Psychopharmacology 163:352-361.
15. Katz JL and Goldberg SR (1986) Effects of H1-receptor antagonists on responding punished by histamine injection or electric shock presentation in squirrel monkeys. Psychopharmacology 90:461-467.
16. Lile JA, Wang Z, Woolverton WL, France JE, Gregg TC, Davies HM, and Nader MA (2003) The reinforcing efficacy of psychostimulants in rhesus monkeys: the role of pharmacokinetics and pharmacodynamics. J Pharmacol Exp Ther 307:356-366.
17. Loh EA and Roberts DCS (1990) Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin. Psychopharmacology 101:262-266.
18. Marona-Lewicka D, Rhee G, Sprague JE, and Nichols DE (1995) Psychostimulant-like effects of p-fluoroamphetamine in the rat. Eur J Pharmacol 287:105-113.
19. Monte AP, Waldman SR, Marona-Lewicka D, Wainscott DB, Nelson DL, Sanders-Bush E, and Nichols DE (1997) Dihydrobenzofuran analogues of hallucinogens. 4. Mescaline derivatives. J Med Chem 40:2997-3008.
20. Rea WP, Rothman RB, and Shippenberg TS (1998) Evaluation of the conditioned reinforcing effects of phentermine and fenfluramine in the rat: concordance with clinical studies. Synapse 30:107-111.
21. Ritz MC and Kuhar MJ (1989) Relationship between self-administration of amphetamine and monoamine receptors in brain: comparison with cocaine. J Pharmacol Exp Ther 248:1010-1017.
22. Ritz MC, Lamb RJ, Goldberg SR, and Kuhar MJ (1987) Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science (Wash DC) 237:1219-1223.
23. Roberts DC, Phelan R, Hodges LM, Hodges MM, Bennett B, Childers S, and Davies H (1999) Self-administration of cocaine analogs by rats. Psychopharmacology 144:389-397.
24. Rothman RB and Baumann MH (2002) Serotonin releasing agents. Neurochemical, therapeutic and adverse effects. Pharmacol Biochem Behav 71:825-836.
25. Rothman RB, Lewis B, Dersch CM, Xu H, Radesca L, de Costa BR, Rice KC, Kilburn RB, Akunne HC, and Pert A (1993) Identification of a GBR12935 homolog, LR1111, which is over 4000-fold selective for the dopamine transporter, relative to serotonin and norepinephrine transporters. Synapse 14:34-39.
26. Rothman RB, Vu N, Partilla JS, Roth BL, Hufeisen SJ, Compton-Toth BA, Birkes J, Young R, and Glennon RA (2003) In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptosome reveals selective actions as norepinephrine transporter substrates. J Pharmacol Exp Ther 307:138-145.
27. Smith FL, Yu DS, Smith DG, Leccese AP, and Lyness WH (1986) Dietary tryptophan supplements attenuate amphetamine self-administration in the rat. Pharmacol Biochem Behav 25:849-855.
28. Sternbach H (1991) The serotonin syndrome. Am J Psychiatry 148:705-713.
29. Tessel RE and Woods JH (1975) Fenfluramine and N-ethyl amphetamine: comparison of the reinforcing and rate-decreasing actions in the rhesus monkey. Psychopharmacologia 43:239-244.
30. Vanover KE, Nader MA, and Woolverton WL (1992) Evaluation of the discriminative stimulus and reinforcing effects of sertraline in rhesus monkeys. Pharmacol Biochem Behav 41:789-793.
31. Wee S and Woolverton WL (2004) Evaluation of the reinforcing effects of atomoxetine in monkeys: comparison to methylphenidate and desipramine. Drug Alcohol Depend 75:271-276.
32. Wilcox KM, Rowlett JK, Paul IA, Ordway GA, and Woolverton WL (2000) On the relationship between the dopamine transporter and the reinforcing effects of local anesthetics in rhesus monkeys: practical and theoretical concerns. Psychopharmacology 153:139-147.
33. Wise RA (1978) Catecholamine theories of reward: a critical review. Brain Res 152:215-247.
34. Woolverton WL (1987) Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys. Pharmacol Biochem Behav 26:835-839.
35. Woolverton WL (2003) A novel choice method for studying drugs as punishers. Pharmacol Biochem Behav 76:125-131.
36. Woolverton WL, Hecht GS, Agoston GE, Katz JL, and Newman AH (2001) Further studies of the reinforcing effects of benztropine analogs in rhesus monkeys. Psychopharmacology 154:375-382.
37. Woolverton WL and Johnson KM (1992) Neurobiology of cocaine abuse. Trends Pharmacol Sci 13:193-200.
38. Woolverton WL and Wang Z (2004) Relationship between injection duration, transporter occupancy and reinforcing strength of cocaine. Eur J Pharmacol 486:251-257.
39. Young AM and Herling S (1986) Drugs as reinforcers: studies in laboratory animals, in Behavioral Analysis of Drug Dependence (Goldberg SR and Stolerman IP eds) pp 9-67, Academic Press, New York.