메뉴 건너뛰기




Volumn 36, Issue 4, 2013, Pages 403-411

Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes

Author keywords

Glutathione; Glyoxal; Hepatotoxicity; Methimazole; Mitochondria; N methylthiourea; ROS formation

Indexed keywords

ACETYLCYSTEINE; GLUTATHIONE; GLYOXAL; HYDRALAZINE; METFORMIN; METHYLTHIOUREA; N,N DIMETHYLANILINE; REACTIVE OXYGEN METABOLITE; THIAMAZOLE; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

EID: 84883417924     PISSN: 01480545     EISSN: 15256014     Source Type: Journal    
DOI: 10.3109/01480545.2012.749272     Document Type: Article
Times cited : (45)

References (46)
  • 1
    • 67651102996 scopus 로고    scopus 로고
    • The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion
    • Anoush M, Eghbal MA, Fathiazad F, et al. (2009). The protective effects of garlic extract against acetaminophen-induced oxidative stress and glutathione depletion. Pak J Biol Sci 12:765-71.
    • (2009) Pak J Biol Sci , vol.12 , pp. 765-771
    • Anoush, M.1    Eghbal, M.A.2    Fathiazad, F.3
  • 2
    • 0033105564 scopus 로고    scopus 로고
    • Methimazole toxicity in rodents: Covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb
    • Bergman U, Brittebo, EB. (1999). Methimazole toxicity in rodents: covalent binding in the olfactory mucosa and detection of glial fibrillary acidic protein in the olfactory bulb. Toxicol Appl Pharmacol 155:190-200.
    • (1999) Toxicol Appl Pharmacol , vol.155 , pp. 190-200
    • Bergman, U.1    Brittebo, E.B.2
  • 3
    • 0041805226 scopus 로고    scopus 로고
    • Methimazoleinduced damage in the olfactory mucosa: Effects on ultrastructure and glutathione levels
    • Bergström U, Giovanetti A, Piras E, Brittebo EB. (2003). Methimazoleinduced damage in the olfactory mucosa: effects on ultrastructure and glutathione levels. Toxicol Pathol 31:379-87.
    • (2003) Toxicol Pathol , vol.31 , pp. 379-387
    • Bergström, U.1    Giovanetti, A.2    Piras, E.3    Brittebo, E.B.4
  • 4
    • 0037237973 scopus 로고    scopus 로고
    • Antioxidants, oxidative damage, and oxygen deprivation stress: A review
    • Blokhina O, Virolainen E, Fagerstedt KV. (2003). Antioxidants, oxidative damage, and oxygen deprivation stress: a review. Ann Bot 91:179-94.
    • (2003) Ann Bot , vol.91 , pp. 179-194
    • Blokhina, O.1    Virolainen, E.2    Fagerstedt, K.V.3
  • 5
    • 0028868002 scopus 로고
    • Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa
    • Brittebo EB. (1995). Metabolism-dependent toxicity of methimazole in the olfactory nasal mucosa. Pharmacol Toxicol 76:76-9.
    • (1995) Pharmacol Toxicol , vol.76 , pp. 76-79
    • Brittebo, E.B.1
  • 6
    • 0029920243 scopus 로고    scopus 로고
    • The assessment of flavin-containing monooxygenase activity in intact animals
    • Damani LA, Nnane IP. (1996). The assessment of flavin-containing monooxygenase activity in intact animals. Drug Metabol Drug Interact 13:1-28.
    • (1996) Drug Metabol Drug Interact , vol.13 , pp. 1-28
    • Damani, L.A.1    Nnane, I.P.2
  • 7
    • 0026687088 scopus 로고
    • Metabolism of benzimidazoline-2-thiones by rat hepatic microsomes and dog liver flavincontaining monooxygenase
    • Decker CJ, Doerge DR, Cashman J.R. (1992). Metabolism of benzimidazoline-2-thiones by rat hepatic microsomes and dog liver flavincontaining monooxygenase. Chem Res Toxicol 5:726-33.
    • (1992) Chem Res Toxicol , vol.5 , pp. 726-733
    • Decker, C.J.1    Doerge, D.R.2    Cashman, J.R.3
  • 8
    • 4444237412 scopus 로고    scopus 로고
    • H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation
    • Eghbal MA, Pennefather PS, O'Brien PJ. (2004). H2S cytotoxicity mechanism involves reactive oxygen species formation and mitochondrial depolarisation. Toxicology 203:69-76.
    • (2004) Toxicology , vol.203 , pp. 69-76
    • Eghbal, M.A.1    Pennefather, P.S.2    O'Brien, P.J.3
  • 9
    • 70350339650 scopus 로고    scopus 로고
    • Thyroid gland: Antithyroid therapy-best choice of drug and dose
    • Franklyn JA. (2009). Thyroid gland: antithyroid therapy-best choice of drug and dose. Nat Rev Endocrinol 5:592-4.
    • (2009) Nat Rev Endocrinol , vol.5 , pp. 592-594
    • Franklyn, J.A.1
  • 10
    • 0037058249 scopus 로고    scopus 로고
    • Idiosyncratic NSAID drug induced oxidative stress
    • Galati G, Tafazoli S, Sabzevari O, et al. (2002). Idiosyncratic NSAID drug induced oxidative stress. Chem Biol Interact 142:25-41.
    • (2002) Chem Biol Interact , vol.142 , pp. 25-41
    • Galati, G.1    Tafazoli, S.2    Sabzevari, O.3
  • 11
    • 73349105618 scopus 로고    scopus 로고
    • Hepatotoxicity induced by methimazole in a previously health patient
    • Gallelli L, Staltari O, Palleria C, et al. (2009). Hepatotoxicity induced by methimazole in a previously health patient. Curr Drug Saf 4:204-6.
    • (2009) Curr Drug Saf , vol.4 , pp. 204-206
    • Gallelli, L.1    Staltari, O.2    Palleria, C.3
  • 12
    • 0029125565 scopus 로고
    • Olfactory toxicity of methimazole: Dose-response and structure-Activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa
    • Genter MB, Deamer NJ, Blake BL, et al. (1995). Olfactory toxicity of methimazole: dose-response and structure-Activity studies and characterization of flavin-containing monooxygenase activity in the Long-Evans rat olfactory mucosa. Toxicol Pathol 23:477-86.
    • (1995) Toxicol Pathol , vol.23 , pp. 477-486
    • Genter, M.B.1    Deamer, N.J.2    Blake, B.L.3
  • 13
    • 72449195814 scopus 로고    scopus 로고
    • Two cases of serious hepatic injury caused by antithyroid drugs. [Article in Polish]
    • Grzywa M, Orlowska-Florek R, Grzywa-Celinska A. (2009). Two cases of serious hepatic injury caused by antithyroid drugs. [Article in Polish]. Endokrynol Pol 60:396-400.
    • (2009) Endokrynol Pol , vol.60 , pp. 396-400
    • Grzywa, M.1    Orlowska-Florek, R.2    Grzywa-Celinska, A.3
  • 14
    • 0022398523 scopus 로고
    • Pharmacokinetics of methimazole in humans
    • Hengstmann JH, Hohn H. (1985). Pharmacokinetics of methimazole in humans. Klin Wochenschr 63:1212-17.
    • (1985) Klin Wochenschr , vol.63 , pp. 1212-1217
    • Hengstmann, J.H.1    Hohn, H.2
  • 15
    • 34447518685 scopus 로고    scopus 로고
    • Cytotoxicity of chloroquine in isolated rat hepatocytes
    • Jamshidzadeh A, Niknahad H, Kashafi H. (2007). Cytotoxicity of chloroquine in isolated rat hepatocytes. J Appl Toxicol 27:322-6.
    • (2007) J Appl Toxicol , vol.27 , pp. 322-326
    • Jamshidzadeh, A.1    Niknahad, H.2    Kashafi, H.3
  • 16
    • 0021995799 scopus 로고
    • Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavincontaining monooxygenase
    • Kedderis GL, Rickert DE. (1985). Loss of rat liver microsomal cytochrome P-450 during methimazole metabolism. Role of flavincontaining monooxygenase. Drug Metab Dispos 13:58-61.
    • (1985) Drug Metab Dispos , vol.13 , pp. 58-61
    • Kedderis, G.L.1    Rickert, D.E.2
  • 17
    • 0026094923 scopus 로고
    • 1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes
    • Khan S, O'Brien PJ. (1991). 1-bromoalkanes as new potent nontoxic glutathione depletors in isolated rat hepatocytes. Biochem Biophys Res Commun 179:436-41.
    • (1991) Biochem Biophys Res Commun , vol.179 , pp. 436-441
    • Khan, S.1    O'Brien, P.J.2
  • 18
    • 0034011876 scopus 로고    scopus 로고
    • Status of glutathione and other thiols and disulfides in human plasma
    • Kleinman WA, Richie Jr JP,. (2000). Status of glutathione and other thiols and disulfides in human plasma. Biochem Pharmacol 60:19-29.
    • (2000) Biochem Pharmacol , vol.60 , pp. 19-29
    • Kleinman, W.A.1    Richie Jr., J.P.2
  • 19
    • 33845977959 scopus 로고    scopus 로고
    • Mitochondrial membrane permeabilization in cell death
    • Kroemer G, Galluzzi L, Brenner C. (2007). Mitochondrial membrane permeabilization in cell death. Physiol Rev 87:99-163.
    • (2007) Physiol Rev , vol.87 , pp. 99-163
    • Kroemer, G.1    Galluzzi, L.2    Brenner, C.3
  • 20
    • 0026554428 scopus 로고
    • Evaluation of the probe 20,70-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress
    • Lebel CP, Ischiropoulos H, Bondy SC. (1992). Evaluation of the probe 20,70-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress. Chem Res Toxicol 5:227-31.
    • (1992) Chem Res Toxicol , vol.5 , pp. 227-231
    • Lebel, C.P.1    Ischiropoulos, H.2    Bondy, S.C.3
  • 21
    • 0018082331 scopus 로고
    • Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases
    • Lee PW, Neal RA. (1978). Metabolism of methimazole by rat liver cytochrome P-450-containing monoxygenases. Drug Metab Dispos 6:591-600.
    • (1978) Drug Metab Dispos , vol.6 , pp. 591-600
    • Lee, P.W.1    Neal, R.A.2
  • 22
    • 77955329997 scopus 로고    scopus 로고
    • Liver failure due to antithyroid drugs: Report of a case and literature review
    • Livadas S, Xyrafis X, Economou F, et al. (2010). Liver failure due to antithyroid drugs: report of a case and literature review. Endocrine 38:24-8.
    • (2010) Endocrine , vol.38 , pp. 24-28
    • Livadas, S.1    Xyrafis, X.2    Economou, F.3
  • 23
    • 79951574562 scopus 로고    scopus 로고
    • Sulfenic acids as reactive intermediates in xenobiotic metabolism
    • Mansuy D, Dansette PM. (2011). Sulfenic acids as reactive intermediates in xenobiotic metabolism. Arch Biochem Biophys 507:174-85.
    • (2011) Arch Biochem Biophys , vol.507 , pp. 174-185
    • Mansuy, D.1    Dansette, P.M.2
  • 24
    • 0036186560 scopus 로고    scopus 로고
    • Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats
    • Masubuchi Y, Nakayama S, Horie T. (2002). Role of mitochondrial permeability transition in diclofenac-induced hepatocyte injury in rats. Hepatology 35:544-51.
    • (2002) Hepatology , vol.35 , pp. 544-551
    • Masubuchi, Y.1    Nakayama, S.2    Horie, T.3
  • 25
    • 0034104597 scopus 로고    scopus 로고
    • Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs
    • Masubuchi Y, Yamada S, Horie T. (2000). Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther 292:982-7.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 982-987
    • Masubuchi, Y.1    Yamada, S.2    Horie, T.3
  • 26
    • 0025219875 scopus 로고
    • Myeloperoxidase catalysed cooxidative metabolism of methimazole: Oxidation of glutathione and NADH by free radical intermediates
    • McGirr LG, Jatoe SD, O'Brien PJ. (1990). Myeloperoxidase catalysed cooxidative metabolism of methimazole: oxidation of glutathione and NADH by free radical intermediates. Chem Biol Interact 73:279-95.
    • (1990) Chem Biol Interact , vol.73 , pp. 279-295
    • McGirr, L.G.1    Jatoe, S.D.2    O'Brien, P.J.3
  • 27
    • 59049105100 scopus 로고    scopus 로고
    • Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes
    • Mehta R, Wong L, O'Brien PJ. (2009). Cytoprotective mechanisms of carbonyl scavenging drugs in isolated rat hepatocytes. Chem Biol Interact 178:317-23.
    • (2009) Chem Biol Interact , vol.178 , pp. 317-323
    • Mehta, R.1    Wong, L.2    O'Brien, P.J.3
  • 28
    • 1242314244 scopus 로고    scopus 로고
    • Methimazole-induced cholestatic jaundice
    • Mikhail NE. (2004). Methimazole-induced cholestatic jaundice. South Med J 97:178-82.
    • (2004) South Med J , vol.97 , pp. 178-182
    • Mikhail, N.E.1
  • 29
    • 0032946198 scopus 로고    scopus 로고
    • Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione
    • Mizutani T, Murakami M, Shirai M, et al. (1999). Metabolism-dependent hepatotoxicity of methimazole in mice depleted of glutathione. J Appl Toxicol 19:193-8.
    • (1999) J Appl Toxicol , vol.19 , pp. 193-198
    • Mizutani, T.1    Murakami, M.2    Shirai, M.3
  • 30
    • 0034122751 scopus 로고    scopus 로고
    • Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: Structure-toxicity and metabolic studies
    • Mizutani T, Yoshida K, Murakami M, et al. (2000). Evidence for the involvement of N-methylthiourea, a ring cleavage metabolite, in the hepatotoxicity of methimazole in glutathione-depleted mice: structure-toxicity and metabolic studies. Chem Res Toxicol 13:170-6.
    • (2000) Chem Res Toxicol , vol.13 , pp. 170-176
    • Mizutani, T.1    Yoshida, K.2    Murakami, M.3
  • 31
    • 73349136974 scopus 로고    scopus 로고
    • Role of free radicals in liver diseases
    • Muriel P. (2009). Role of free radicals in liver diseases. Hepatol Int 3:526-36.
    • (2009) Hepatol Int , vol.3 , pp. 526-536
    • Muriel, P.1
  • 32
    • 0016259426 scopus 로고
    • S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase
    • Poulsen LL, Hyslop RM, Ziegler DM. (1974). S-oxidation of thioureylenes catalyzed by a microsomal flavoprotein mixed-function oxidase. Biochem Pharmacol 23:3431-40.
    • (1974) Biochem Pharmacol , vol.23 , pp. 3431-3440
    • Poulsen, L.L.1    Hyslop, R.M.2    Ziegler, D.M.3
  • 33
    • 0035451601 scopus 로고    scopus 로고
    • Mechanism of clofibrate hepatotoxicity: Mitochondrial damage and oxidative stress in hepatocytes
    • Qu B, Li QT, Wong KP, et al. (2001). Mechanism of clofibrate hepatotoxicity: mitochondrial damage and oxidative stress in hepatocytes. Free Radic Biol Med 31:659-69.
    • (2001) Free Radic Biol Med , vol.31 , pp. 659-669
    • Qu, B.1    Li, Q.T.2    Wong, K.P.3
  • 34
    • 0036318194 scopus 로고    scopus 로고
    • Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,40-dithiodipyridine
    • Riener CK, Kada G, Gruber HJ. (2002). Quick measurement of protein sulfhydryls with Ellman's reagent and with 4,40-dithiodipyridine. Anal Bioanal Chem 373:266-76.
    • (2002) Anal Bioanal Chem , vol.373 , pp. 266-276
    • Riener, C.K.1    Kada, G.2    Gruber, H.J.3
  • 35
    • 73449143152 scopus 로고    scopus 로고
    • Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-Acetylcysteine
    • Saito C, Zwingmann C, Jaeschke H. (2010). Novel mechanisms of protection against acetaminophen hepatotoxicity in mice by glutathione and N-Acetylcysteine. Hepatology 51:246-54.
    • (2010) Hepatology , vol.51 , pp. 246-254
    • Saito, C.1    Zwingmann, C.2    Jaeschke, H.3
  • 36
    • 0022966847 scopus 로고
    • Methimazoleassociated cholestatic liver injury: Case report and brief literature review
    • Schmidt G, Borsch G, Muller KM, Wegener M. (1986). Methimazoleassociated cholestatic liver injury: case report and brief literature review. Hepatogastroenterology 33:244-6.
    • (1986) Hepatogastroenterology , vol.33 , pp. 244-246
    • Schmidt, G.1    Borsch, G.2    Muller, K.M.3    Wegener, M.4
  • 37
    • 4444260621 scopus 로고    scopus 로고
    • The cytotoxic mechanism of glyoxal involves oxidative stress
    • Shangari N, O'Brien PJ. (2004). The cytotoxic mechanism of glyoxal involves oxidative stress. Biochem Pharmacol 68:1433-42.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1433-1442
    • Shangari, N.1    O'Brien, P.J.2
  • 38
    • 0019730383 scopus 로고
    • The metabolism of [2-14C]methimazole in the rat
    • Skellern GG, Steer S. (1981). The metabolism of [2-14C]methimazole in the rat. Xenobiotica 11:627-34.
    • (1981) Xenobiotica , vol.11 , pp. 627-634
    • Skellern, G.G.1    Steer, S.2
  • 39
  • 40
    • 18744364709 scopus 로고    scopus 로고
    • Oxidative stress mediated idiosyncratic drug toxicity
    • Tafazoli S, Spehar DD, O'Brien PJ. (2005). Oxidative stress mediated idiosyncratic drug toxicity. Drug Metab Rev 37:311-25.
    • (2005) Drug Metab Rev , vol.37 , pp. 311-325
    • Tafazoli, S.1    Spehar, D.D.2    O'Brien, P.J.3
  • 41
    • 0015231922 scopus 로고
    • The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450
    • Tephly TR, Hibbeln P. (1971). The effect of cobalt chloride administration on the synthesis of hepatic microsomal cytochrome P-450. Biochem Biophys Res Commun 42:589-95.
    • (1971) Biochem Biophys Res Commun , vol.42 , pp. 589-595
    • Tephly, T.R.1    Hibbeln, P.2
  • 42
    • 67649742556 scopus 로고    scopus 로고
    • Idiosyncratic drug-induced agranulocytosis: Possible mechanisms and management
    • Tesfa D, Keisu M, Palmblad J. (2009). Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management. Am J Hematol 84:428-34.
    • (2009) Am J Hematol , vol.84 , pp. 428-434
    • Tesfa, D.1    Keisu, M.2    Palmblad, J.3
  • 43
    • 33749986298 scopus 로고    scopus 로고
    • Free radicals and antioxidants in normal physiological functions and human disease
    • Valko M, Leibfritz D, Moncol J, et al. (2007). Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol 39:44-84.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 44-84
    • Valko, M.1    Leibfritz, D.2    Moncol, J.3
  • 44
    • 0036001059 scopus 로고    scopus 로고
    • Methimazole-induced hepatotoxicity
    • Woeber KA. (2002). Methimazole-induced hepatotoxicity. Endocr Pract 8:222-4.
    • (2002) Endocr Pract , vol.8 , pp. 222-224
    • Woeber, K.A.1
  • 45
    • 0036471379 scopus 로고    scopus 로고
    • Identification of a-dicarbonyl scavengers for cellular protection against carbonyl stress
    • Wondrak GT, Cervantes-Laurean D, Roberts MJ, et al. (2002). Identification of a-dicarbonyl scavengers for cellular protection against carbonyl stress. Biochem Pharmacol 63:361-73.
    • (2002) Biochem Pharmacol , vol.63 , pp. 361-373
    • Wondrak, G.T.1    Cervantes-Laurean, D.2    Roberts, M.J.3
  • 46
    • 79956117400 scopus 로고    scopus 로고
    • The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5
    • Xie F, Zhou X, Genter MB, et al. (2011). The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5. Drug Metab Dispos 39:947-51.
    • (2011) Drug Metab Dispos , vol.39 , pp. 947-951
    • Xie, F.1    Zhou, X.2    Genter, M.B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.