The tissue-specific toxicity of methimazole in the mouse olfactory mucosa is partly mediated through target-tissue metabolic activation by CYP2A5

Drug Metabolism and Disposition

Volumn 39, Issue 6, 2011, Pages 947-951

  Xie, Fang ^a   Zhou, Xin ^a   Genter, Mary Beth ^b   Behr, Melissa ^a   Gu, Jun ^a   Ding, Xinxin ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2A5; FLAVIN MONOOXYGENASE; FLAVOPROTEIN; THIAMAZOLE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BASEMENT MEMBRANE; CATALYSIS; CONTROLLED STUDY; CYTOTOXICITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; HISTOPATHOLOGY; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; TIME TO MAXIMUM PLASMA CONCENTRATION; TOXICITY TESTING;

ANIMALS; ANTITHYROID AGENTS; ARYL HYDROCARBON HYDROXYLASES; LIVER; METABOLIC CLEARANCE RATE; METHIMAZOLE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH-FERRIHEMOPROTEIN REDUCTASE; OLFACTORY MUCOSA; ORGAN SPECIFICITY;

MUS;

EID: 79956117400     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.037895     Document Type: Article

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