Enhanced solubility and oral bioavailability of itraconazole by combining membrane emulsification and spray drying technique

International Journal of Pharmaceutics

Volumn 434, Issue 1-2, 2012, Pages 264-271

  Choi, Young Keun ^a   Poudel, Bijay K ^a   Marasini, Nirmal ^a   Yang, Kwan Yeol ^a   Kim, Jeong Whan ^a   Kim, Jong Oh ^a   Choi, Han Gon ^b   Yong, Chul Soon ^a  

^a Yeungnam University   (South Korea)

^b Hanyang University   (South Korea)

Author keywords

Bioavailability; Itraconazole; Membrane emulsification; Solubility; Spray drying

Indexed keywords

DICHLOROMETHANE; DIETHYLENE GLYCOL MONOETHYL ETHER; ITRACONAZOLE;

ANIMAL EXPERIMENT; AQUEOUS SOLUTION; ARTICLE; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG SOLUBILITY; EMULSION; MALE; MEMBRANE EMULSIFICATION; MEMBRANE PERMEABILITY; NANOPORE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SPRAY DRYING; TEMPERATURE; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANIMALS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CRYSTALLIZATION; DEXTRANS; DRUG CARRIERS; EMULSIONS; ETHYLENE GLYCOLS; EXCIPIENTS; HEXOSES; ITRACONAZOLE; MALE; METHYLENE CHLORIDE; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TEMPERATURE;

EID: 84864126060     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.05.039     Document Type: Article

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