Nanosuspensions of poorly soluble drugs - Reproducibility of small scale production

International Journal of Pharmaceutics

Volumn 196, Issue 2, 2000, Pages 155-159

  Grau, M J ^a   Kayser, O ^a   Muller R H ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

Author keywords

Drugs; Nanoparticles; Polydispersity index

Indexed keywords

NANOPARTICLE; RMKP 22; UNCLASSIFIED DRUG;

DRUG FORMULATION; DRUG SOLUBILITY; PARTICLE SIZE; PRIORITY JOURNAL; REPRODUCIBILITY; SHORT SURVEY; SUSPENSION;

MORPHOLINES; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; PTERIDINES; REPRODUCIBILITY OF RESULTS; SOLUBILITY; SPECTROPHOTOMETRY; SUSPENSIONS;

EID: 0033964139     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00411-1     Document Type: Article

References (4)

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2. Liversidge G.G., Cundy K.C., Bishop J., Czekai D. Surface modified drug nanoparticles. US Pat. Nr. 5145684:1991.
3. Müller R.H., Peters K., Becker R., Kruss B. Nanosuspensions for the i.v. Administration of poorly soluble drugs - stability during sterilization and long-term storage. Proc. Intern. Symp. Control. Rel. Bioact. Mater. 22:1996;574-575.
4. Müller R.H., Becker R., Kruss B., Peters K. Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution. US Pat. No. 5,858,410:1999.