Effects of viscosity and osmotic stress on the reaction of human butyrylcholinesterase with cresyl saligenin phosphate, a toxicant related to aerotoxic syndrome: Kinetic and molecular dynamics studies

Biochemical Journal

Volumn 454, Issue 3, 2013, Pages 387-399

  Masson, Patrick ^a,b,c   Lushchekina, Sofya ^d   Schopfer, Lawrence M ^a   Lockridge, Oksana ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b CENTRE DE RECHERCHES   (France)

^c INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^d EMANUEL INSTITUTE OF BIOCHEMICAL PHYSICS   (Russian Federation)

Author keywords

Aerotoxic syndrome; Butyrylcholinesterase (BChE); Cresyl saligenin phosphate (CSP); Diffusion control; Organophosphate; Osmotic stress; Viscosity

Indexed keywords

CHOLINESTERASE; CHOLINESTERASE INHIBITOR; CRESYL SALIGENIN PHOSPHATE; GLYCEROL; ORGANOPHOSPHATE; SUCROSE; UNCLASSIFIED DRUG; WATER;

AEROTOXIC SYNDROME; AIRCRAFT; ALCOHOL CONSUMPTION; ARTICLE; AVIATION; CATALYSIS; CHEMICAL STRUCTURE; CHOLINESTERASE INHIBITION; DIFFUSION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; FUME; HUMAN; HYDROGEN BOND; MOLECULAR DYNAMICS; MOLECULE; MUTANT; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; OSMOTIC STRESS; PRIORITY JOURNAL; TOXICOKINETICS; VISCOSITY;

BUTYRYLCHOLINESTERASE; CATALYTIC DOMAIN; CHOLINESTERASE INHIBITORS; GLYCEROL; HUMANS; HYDROGEN BONDING; KINETICS; MOLECULAR DYNAMICS SIMULATION; MUTATION, MISSENSE; ORGANOPHOSPHORUS COMPOUNDS; OSMOTIC PRESSURE; SUCROSE; VISCOSITY; WATER;

EID: 84883378115     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130389     Document Type: Article

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