Force Spectroscopy Measurements Show That Cortical Neurons Exposed to Excitotoxic Agonists Stiffen before Showing Evidence of Bleb Damage

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Zou, Shan ^a   Chisholm, Roderick ^a   Tauskela, Joseph S ^a   Mealing, Geoff A ^a   Johnston, Linda J ^a   Morris, Catherine E ^b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; GLUTAMIC ACID; HYPOTONIC SOLUTION; MYOSIN ADENOSINE TRIPHOSPHATASE; N METHYL DEXTRO ASPARTIC ACID; SODIUM CHANNEL; SODIUM ION; SPECTRIN; VERATRIDINE; WATER;

ACTIN MYOSIN INTERACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATOMIC FORCE MICROSCOPY BASED FORCE SPECTROSCOPY; BILAYER MEMBRANE; BLEB DAMAGE; BRAIN CELL; BRAIN INJURY; BRAIN ISCHEMIA; CALCIUM TRANSPORT; CELL DAMAGE; CELL STIFFENING; CELL SWELLING; CELL VOLUME; CONTROLLED STUDY; ELASTICITY; EXCITOTOXICITY; EXPOSURE; FEMALE; HYDROSTATIC PRESSURE; MEASUREMENT; MEMBRANE DAMAGE; NERVE CELL NECROSIS; NONHUMAN; OSMOSIS; POSITIVE FEEDBACK; RAT; SODIUM TRANSPORT; SPECTROSCOPY; TRAUMATIC BRAIN INJURY; WATER TRANSPORT;

ANIMALS; BLISTER; CEREBRAL CORTEX; ELASTICITY; GLUTAMIC ACID; HYPOTONIC SOLUTIONS; MICROSCOPY, ATOMIC FORCE; N-METHYLASPARTATE; NEURONS; NEUROTOXINS; RATS; RATS, SPRAGUE-DAWLEY; SODIUM CHANNELS; SPECTRUM ANALYSIS; TIME FACTORS; VERATRIDINE;

EID: 84883367979     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073499     Document Type: Article

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