T-477, a novel Ca2+- and Na+ channel blocker, prevents veratridine-induced neuronal injury

European Journal of Pharmacology

Volumn 398, Issue 2, 2000, Pages 209-216

  Okuyama, Kayoko ^a   Kiuchi, Satoko ^a   Okamoto, Masahito ^a   Narita, Hiroshi ^a   Kudo, Yukitsuka ^a  

^a MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

Ca2+ channel; Death; Hippocampal neuron; Na+ channel; Swelling; Veratridine

Indexed keywords

2 (4 CHLOROPHENYL) 2,3 DIHYDRO 4 DIETHYL AMINOACETYL 4H 1,4 BENZOTHIAZINE HYDROCHLORIDE; 2 (4 CHLOROPHENYL) 4 DIETHYLAMINOACETYL 2,3 DIHYDRO 4H 1,4 BENZOTHIAZINE; AMINO ACID; CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; DILTIAZEM; GLUTAMIC ACID; NEW DRUG; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SODIUM ION; UNCLASSIFIED DRUG; VERATRIDINE;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; CELL SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG MECHANISM; EMBRYO; EMBRYO CELL; HIPPOCAMPUS; NERVE CELL CULTURE; NERVE CELL LESION; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CELL LEVEL; SODIUM TRANSPORT;

AMINO ACIDS; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; CELL DEATH; CELL SIZE; CELL SURVIVAL; CELLS, CULTURED; NEURONS; RATS; SODIUM; TETRODOTOXIN; THIAZINES; TIME FACTORS; VERATRIDINE;

EID: 0034674664     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00305-8     Document Type: Article

References (36)

1. Attwell D., Barbour B., Szatkowski M. Nonvesicular release of neurotransmitter. Neuron. 11:1993;401-407.
2. Berg-Johnsen J., Grøndahl T.Ø., Langmoen I.A., Haugstad T.S., Hegstad E. Changes in amino acid release and membrane potential during cerebral hypoxia and glucose deprivation. Neurol. Res. 17:1995;201-208.
3. Bernath S. Calcium-independent release of amino acid neurotransmitters: fact or artifact? Prog. Neurobiol. 38:1992;57-91.
4. Cheung J.Y., Bonventre J.V., Malis C.D., Leaf A. Calcium and ischemic injury. N. Engl. J. Med. 314:1986;1670-1676.
5. Choi D.W. Glutamate neurotoxicity and diseases of the nervous system. Neuron. 1:1988;623-634.
6. Choi D.W., Koh J.Y., Peters S. Pharmacology of glutamate neurotoxicity in cortical cell culture: attenuation by NMDA antagonists. J. Neurosci. 8:1988;185-196.
7. Goldberg M.P., Choi D.W. Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury. J. Neurosci. 13:1993;3510-3524.
8. 2+ solutions. J. Neurosci. 6:1986;3144-3151.
9. + in individual fibroblasts and lymphocytes. J. Biol. Chem. 264:1989;19458-19467.
10. Haupman M., Nelson D., Wilson D.N., Ereciñska M. Neurotransmitter amino acids in the CNS: Part II. Some changes in amino acid levels in rat brain synaptosomes during and after in vitro anoxia and simulated ischemia. Brain Res. 304:1984;23-35.
11. Hubert J.P., Delumeau J.C., Glowinski J., Prémont J., Doble A. Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action. Br. J. Pharmacol. 113:1994;261-267.
12. + channel blocker, reduces infarct volume following middle cerebral artery occlusion in rats. Jpn. J. Pharmacol. 71(Suppl. 1):1996;175P.
13. Janka Z., Jones D.G. Indirect ultrastructural evidence for lithium uptake by cultured rat cerebral cells through the sodium channel. Brain Res. 273:1982;261-266.
14. Jursky F., Tamura S., Tamura A., Mandiyan S., Nelson H., Nelson N. Structure, function and brain localization of neurotransmitter transporters. J. Exp. Biol. 196:1994;283-295.
15. Kanai Y., Hediger M.A. Primary structure and functional characterization of a high-affinity glutamate transporter. Nature. 360:1992;467-471.
16. Klatzo I. Neuropathological aspects of brain edema. J. Neuropathol. Exper. Neurol. 26:1967;1-14.
17. 2+ channels expressed in Xenopus oocytes. Eur. J. Pharmacol. 332:1997;313-320.
18. 2+ concentration in isolated hippocampal neurones. Br. J. Pharmacol. 89:1986;191-198.
19. Levi G., Raiteri M. Carrier-mediated release of neurotransmitters. Trends Neurosci. 16:1993;415-419.
20. Levi G., Gallo V., Raiteri M. A reevaluation of veratridine as a tool for studying the depolarization-induced release of neurotransmitters from nerve endings. Neurochem. Res. 5:1980;281-295.
21. Lindroth P., Mopper K. High performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluoresence delivatization with o-phthaldialdehyde. Anal. Chem. 51:1979;1667-1674.
22. + channel modulator and glutamate release inhibitor in cultured rat cerebellar neurons and in gerbil global brain ischemia. Stroke. 25:1994;2476-2482.
23. Neal M.J., Cunningham J.R., Hutson P.H., Hogg J. Effects of ischaemia on neurotransmitter release from the isolated retina. J. Neurochem. 62:1994;1025-1033.
24. Nicholls D., Attwell D. The release and uptake of excitatory amino acids. Trends Pharmacol. Sci. 17:1990;359-365.
25. 2+ after exposure to glutamate receptor agonist. Exp. Brain Res. 73:1988;447-458.
26. Ohta M., Narahashi T., Keeler R.F. Effects of veratrum alkaloids on membrane potential and conductance of squid and crayfish giant axons. J. Pharmacol. Exp. Ther. 184:1973;143-154.
27. 2+ channel blocker, T-477, prevents brain edema following microsphere-induced permanent occlusion of cerebral arterioles in rats. Jpn. J. Pharmacol. 1999;. in press.
28. Prenen G.H., Go K.G., Postema F., Zuiderveen F., Korf J. Cerebral cation shifts in hypoxic-ischemic brain damage are prevented by the sodium channel blocker tetrodotoxin. Exp. Neurol. 99:1988;118-132.
29. Ramnath R.R., Strange K., Rosenberg P.A. Neuronal injury evoked by depolarizing agents in rat cortical cultures. Neuroscience. 51:1992;931-939.
30. Rothman S.M., Olney J.W. Glutamate and the pathophysiology of hypoxic-ischemic brain damage. Ann. Neurol. 19:1986;105-111.
31. Sakata K., Sato K., Schloss P., Betz H., Shimada S., Tohyama M. Characterization of glycine release mediated by glycine transporter 1 stably expressed in HEK-293 cells. Brain. Res. Mol. Brain Res. 49:1997;89-94.
32. Smith K.E., Borden L.A., Wang C.H., Hartig P.R., Branchek T.A., Weinshank R.L. Cloning and expression of a high affinity taurine transporter from rat brain. Mol. Pharmacol. 42:1992;563-569.
33. +. J. Neurochem. 59:1992;2271-2277.
34. Szatkowski M., Attwell D. Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms. Trends Neurosci. 16:1993;415-419.
35. +-dependent glutamine transport activity in rat brain neurons. J. Neurochem. 68:1997;954-960.
36. Wahl F., Obrenovitch T.P., Hardy A.M., Plotkine M., Boulu R., Symon L. Extracellular glutamate during focal cerebral ischaemia in rats: time course and calcium dependency. J. Neurochem. 63:1994;1003-1011.