Nuclear disintegration as a leading step of glutamate excitotoxicity in brain neurons

Journal of Neuroscience Research

Volumn 43, Issue 5, 1996, Pages 613-622

  Ikeda, J ^a   Terakawa, S ^a   Murota, S ^b   Morita, I ^a   Hirakawa, K ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

apoptosis; calcium influx; glutamate neurotoxicity; nitric oxide

Indexed keywords

DIZOCILPINE; DNA FRAGMENT; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL DAMAGE; CELL DEATH; CELL NUCLEUS MEMBRANE; CELL SWELLING; CONTROLLED STUDY; ENZYME ACTIVATION; EXCITABLE MEMBRANE; HEAD INJURY; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT;

ANIMALS; BRAIN; CALCIUM; CELL NUCLEUS; DNA FRAGMENTATION; GLUTAMIC ACID; INTRACELLULAR MEMBRANES; NEURONS; OSMOLAR CONCENTRATION; RATS; TIME FACTORS;

EID: 0029871310     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19960301)43:5<613::AID-JNR11>3.0.CO;2-1     Document Type: Article

References (53)

1. Batistatou A, Greene LA (1991): Aurintricarboxylic acid rescues PC 12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity. J Cell Biol 115:461-471.
2. Choi DW (1987): Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379.
3. Choi DW (1988): Glutamate neurotoxicity and diseases of the nervous system. Neuron 1:623-634.
4. Choi DW (1990): Cerebral hypoxia: Some new approaches and unanswered questions. J Neurosci 10:2493-2501.
5. Choi DW, Koh J-Y, Peters P (1988): Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists. J Neurosci 8:185-196.
6. Clarke PGH (1990): Developmental cell death: Morphological diversity and multiple mechanisms. Anat Embryol 181:195-213.
7. Dawson TM, Bredt DS, Futohi M, Hwang PM, Snyder SH (1991a): Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues. Proc Natl Acad Sci USA 88:7797-7801.
8. Dawson VL, Dawson TM, London ED, Bredt DS, Snyder SH (1991b): Nitric oxide mediates glutamate neurotoxicity in primary cortical cultures. Proc Natl Acad Sci USA 88:6368-6371.
9. Dawson VL, Dawson TM, Hartley DA, Uhl GR, Snyder SH (1993): Mechanisms of nitric oxide neurotoxicity in primary brain cultures. J Neurosci 13:2651-2661.
10. Demerle-Pallardy C, Lonchampt M-O, Chabrier P-E, Braquet P (1991): Absence of implication of L-arginine/nitric oxide pathway on neuronal cell injury induced by L-glutamate or hypoxia. Biochem Biophys Res Commun 181:456-464.
11. Dipasquale B, Marini AM, Youle RJ (1991): Apoptosis and DNA degradation induced by l-methyl-4-phenylpyridinium in neurons. Biochem Biophys Res Commun 181:1442-1448.
12. Dubinsky JM, Rothman SM (1991): Intracellular calcium concentrations during "chemical hypoxia" and excitotoxic neuronal injury. J Neurosci 11:2545-2551.
13. Dux E, Oschlies U, Wiessner C, Hossmann K-A (1992): Glutamate-induced ribosomal disaggregation and ultrastructural changes in rat cortical neuronal culture: Protective effect of horse serum. Neurosci Lett 141:173-176.
14. Ellis RE, Yuan J, Horvitz HR (1991): Mechanisms and functions of cell death. Annu Rev Cell Biol 7:663-698.
15. Faden AI, Demediuk P, Panter SS, Vink R (1989): The role of excitatory amino acids and NMDA receptors in traumatic brain injury. Science 244:798-800.
16. Gavrieli Y, Sherman Y, Ben-Sasson SA (1992): Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 119:493-501.
17. Hewett SJ, Corbett JA, Mcdaniel ML, Choi DW (1993): Inhibition of nitric oxide formation does not protect murine cortical cell cultures from N-methyl-D-aspartate neurotoxicity. Brain Res 625:337-341.
18. 2+ in cultured smooth muscle cells. Am J Physiol 263:C95-C105.
19. Hope BT, Michael GJ, Knigge KM, Vincent SR (1991): Neuronal NADPH diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88:2811-2814.
20. -) in neuronal injury induced by deprivation of oxygen and glucose in vitro. Acta Neurochir Suppl 60:94-97.
21. Ikeda I, Nakajima T, Osborne OC, Mies G, Nowak TS Jr (1994b): Coexpression of c-fos and hsp70 mRNAs in gerbil brain after ischemia: Induction threshold, distribution and time course evaluated by in situ hybridization. Mol Brain Res 26:249-258.
22. Ikeda J, Ochiai K, Monta I, Murota S (1993): Endogenous nitric oxide blocks calcium influx induced by glutamate in neurons containing NADPH diaphorase, Neurosci Lett 158:193-196.
23. Jones DP, McConkey DJ, Nicotera P, Orrenius S (1989): Calcium-activated DNA fragmentation in rat liver nuclei. J Biol Chem 264:6398-6403.
24. Koh JY, Choi DW (1987): Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20:83-90.
25. Kure S, Tominaga T, Yoshiraoto T, Tada K, Narisawa K (1991): Glutamate triggers internucleosomal DNA cleavage in neuronal cells. Biochem Biophys Res Commun 179:39-45.
26. Linnik MD, Zobrist RH, Hatfield MD (1993): Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2009.
27. Lipton SA, Rosenberg PA (1994): Mechanisms of disease: Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330:613-622.
28. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman CW (1993): Apoptosis is induced by b-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90: 7951-7955.
29. Macaya A, Munell F, Gubits RM, Burke RE (1994): Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc Natl Acad Sci USA 91:8117-8121.
30. McConkey DJ, Hartzell P, Nicotera P, Orrenius S (1989a): Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J 115:461-471.
31. 2+ concentration. Arch Biochem Biophys 269:365-370.
32. Michaels RL, Rothman SM (1990): Glutamate neurotoxicity in vitro: Antagonist pharmacology and intracellular calcium concentrations. J Neurosci 10:283-292.
33. Moncada S, Higgs A (1993): Mechanisms of disease: The L-argininenitric oxide pathway. N Engl J Med 329:2002-2012.
34. 2+ after exposure to glutamate receptor agonist. Exp Brain Res 73:447-458.
35. Ojcius DM, Zychlinsky A, Zheng LM, Young JD-E (1991): lonophore-induced apoptosis: Role of DNA fragmentation and calcium fluxes. Exp Cell Res 197:43-49.
36. Olney JW, Labruyere J, Price MT (1989): Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360-1362.
37. Pauwels PJ, Leysen JE (1992): Blockade of nitric oxide formation does not prevent glutamate-induced neurotoxicity in neuronal cultures from rat hippocampus. Neurosci Lett 143:27-30.
38. Pittman RN, Wang S, DiBenedetto AJ, Mills JC (1993): A system for characterizing cellular and molecular events in programmed neuronal cell death. J Neurosci 13:3669-3680.
39. Randall RD, Thayer SA (1992): Glutamate-induced calcium transient triggers delayed calcium overload and neurotoxicity in rat hippocampal neurons. J Neurosci 12:1882-1895.
40. Ratan RR, Murphy TH, Baraban JM (1994a): Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. J Neurosci 14:4385-4392.
41. Ratan RR, Murphy TH, Baraban JM (1994b): Oxidative stress induces apoptosis in embryonic cortical neurons. J Neurochem 62:376-379.
42. Roberts-Lewis JM, Marcy VR, Zhao Y, Vaught JL, Siman R, Lewis ME (1993): Aurintricarboxylic acid protects hippocampal neurons from NMDA- and ischemia-induced toxicity in vivo. J Neurochem 61:378-381.
43. Samples SD, Dubinsky JM (1993): Aurintricarboxylic acid protects hippocampal neurons from glutamate excitotoxicity in vitro. J Neurochem 61:382-385.
44. Schuier FJ, Hossmann KA (1980): Experimental brain infarcts in cats. II. Ischemic brain edema. Stroke 11:593-601.
45. Shigeno T, Yamasaki Y, Kato G, Kusaka K, Mima T, Takakura K, Graham DI, Furukawa S (1990): Reduction of delayed neuronal death by inhibition of protein synthesis. Neurosci Lett 120:117-119.
46. Smeyne RJ, Vendrell M, Hayward M, Baker SJ, Miao GG, Schilling K, Robertson LM, Curran T, Morgan JI (1993): Continuous c-fos expression precedes programmed cell death in vivo. Nature 363:166-199.
47. Terakawa S, Fan J-H, Kumakura K, Ohara-Imaizumi M (1991): Quantitative analysis of exocytosis directly visualized in living chromaffin cells. Neurosci Lett 123:82-86.
48. Tominaga T, Kure S, Narisawa K, Yoshimoto T (1993): Endonuclease activation following focal ischemic injury in the rat brain. Brain Res 608:21-26.
49. Wyllie AH (1980): Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 284:555-556.
50. Wyllie AH, Morris RG, Smith AL, Dunlop D (1984): Chromatin cleavage in apoptosis: Association with condensed chromatin morphology and dependence on macromolecular synthesis. J Pathol 142:67-77.
51. Zeevalk CD, Schoepp D, Nicklas WJ (1993): Aurintricarboxylic acid prevents NMDA-mediated excitotoxicity: Evidence for its action as an NMDA receptor antagonist. J Neurochem 61:386-389.
52. Zhang J, Dawson VL, Dawson TM, Snyder SH (1994): Nitric oxide activation of poly (ADP-ribose) synthetase in neurotoxicity. Science 263:687-689.
53. Zhong L-T, Kane DJ, Bredesen DE (1993): BCL-2 blocks glutamate toxicity in neural cell lines. Mol Brain Res 19:353-355.