Use of Autologous Human mesenchymal Stromal Cell/Fibrin Clot Constructs in Upper Limb Non-Unions: Long-Term Assessment

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Giannotti, Stefano ^a   Trombi, Luisa ^a   Bottai, Vanna ^a   Ghilardi, Marco ^a   D'Alessandro, Delfo ^a   Danti, Serena ^a   Dell'Osso, Giacomo ^a   Guido, Giulio ^a   Petrini, Mario ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARM DISEASE; ARM MOVEMENT; ARTICLE; AUTOLOGOUS MESENCHYMAL STROMA CELL FIBRIN CLOT CONSTRUCT; BONE DEVELOPMENT; BONE GRAFT; BONE INJURY; BONE MARROW; BONE RADIOGRAPHY; CARCINOGENESIS; CELL CULTURE; CELL DIFFERENTIATION; CELL EXPANSION; CELL ISOLATION; CELL MANIPULATION; CLINICAL ARTICLE; EMBEDDING; EX VIVO STUDY; FEMALE; FIBRIN CLOT; FOLLOW UP; FRACTURE HEALING; HUMAN; IMPLANTATION; MALE; MESENCHYMAL STROMA CELL; OUTCOME ASSESSMENT; PSEUDARTHROSIS; RETROSPECTIVE STUDY; TISSUE ENGINEERING; TISSUE GROWTH;

ADOLESCENT; ADULT; AGED; COMPASSIONATE USE TRIALS; FEMALE; FIBRIN; HUMANS; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; PROSTHESES AND IMPLANTS; PSEUDARTHROSIS; STEM CELL TRANSPLANTATION; TIME FACTORS; TRANSPLANTATION, AUTOLOGOUS; YOUNG ADULT;

EID: 84883359911     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0073893     Document Type: Article

References (61)

1. Niedzielski K, Synder M, (2000) The treatment of pseudarthrosis using the Ilizarov method. Ortop traumatol Rehabil 2(3): 46-48.
2. Charles M, Barr T, Clokie CM, Sándor GK, (2007) Fat embolism following posterior iliac graft harvest for jaw reconstruction: managing the complications of major surgery. J Can Dent Assoc 73(1): 67-70.
3. Soucacos PN, Dailiana Z, Beris AE, Johnson EO (2006) Vascularised bone grafts for the management of non-union. Injury 37(1): S41-50. Epub 2006 Apr 11.
4. Bruder SP, Kraus KH, Goldberg VM, Kadiyala S, (1998) The effects of implant loaded with autologous mesenchymal stem cells on the healing of canine segmental bone defects. J Bone Joint Surg Am 80(7): 985-96.
5. Horwitz EM, Le Blanc K, Dominici M, Mueller I, Slaper-Cortenbach I, et al. (2005) Clarification of the nomenclature for MSC: the International Society for Cellular Therapy position statement. Cytotherapy 7: 393-395.
6. Kassem M, Abdallah BM, (2008) Human bone marrow-derived mesenchymal stem cells: biological characteristics and potential role in therapy of degenerative diseases. Cell Tissue Res 331: 157-163.
7. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, et al. (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211-228.
8. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, et al. (2002) Stem Cell Properties of Human Dental Pulp Stem Cells. J of Dental Res 81(8): 531-35.
9. Barachini S, Trombi L, Danti S, D'Alessandro D, Battolla B, et al. (2009) Morpho-functional characterization of human mesenchymal stem cells from umbilical cord blood for potential uses in regenerative medicine. Stem Cells Dev 18(2): 293-305.
10. Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, et al. (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284: 143-47.
11. Minguell JJ, Erices A, Conget P (2001) Mesenchimal stem cells. Exp Biol Med 226(6): 507-20. Review.
12. Bonfield TL, Nolan Koloze MT, Lennon DP, Caplan AI, (2010) Defining human mesenchymal stem cell efficacy in vivo. J Inflamm (Lond) 25(7): 51.
13. Kon E, Muraglia A, Corsi A, Bianco P, Marcacci M, et al. (2000) Autologous bone marrow stromal cells loaded onto porous hydroxiapatite ceramic accelerate bone repair in critical-size defects of sheep long bones. J. Biomed Mater Res 49(3): 328-37.
14. Arinzeh TL, Peter SJ, Archambault MP, Van Den Bos C, Gordon S, et al. (2003) Allogeneic mesenchymal stem cells regenerate bone in a critical-sized canine segmental defect. J. Bone Joint Surg Am 85-A(10): 1927-35.
15. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, et al. (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344(5): 385-86.
16. Muschler GF, Nitto H, Matsukura Y, Boehm C, Valdevit A, et al. (2003) Spine Fusion Using Cell Matrix Composites Enriched in Bone Marrow-Derived Cells. Clin Orthop Relat Res (407): 102-18.
17. Pneumaticos SG, Triantafyllopoulos GK, Chatziioannou S, Basdra EK, Papavassiliou AG (2011) Biomolecular strategies of bone augmentation in spinal surgery. Trends Mol Med 17(4): 215-22. Review.
18. Frank C, Shrive N, Hiraoka H Nakamura N, Kaneda Y, et al. (1999) Optimization of the biology of soft tissue repair. J Sci Med Sport 2(3): 190-210.
19. Shearn JT, Juncosa-Melvin N, Boivin GP, Galloway MT, Goodwin W, et al. (2007) Mechanical stimulation of tendon tissue engineered constructs: effects on construct stiffness, repair biomechanics, and their correlation. J Biomech Eng 129(6): 848-54.
20. Butler DL, Gooch C, Kinneberg KR, Boivin GP, Galloway MT, et al. (2010) The use of mesenchymal stem cells in collagen-based scaffolds for tissue-engineered repair of tendons. Nat Protoc 5(5): 849-63.
21. Pacini S, Spinabella S, Trombi L, Fazzi R, Galimberti S, et al. (2007) Suspension of Bone Marrow-Derived Undifferentiated Mesenchymal Stromal Cells for repair of Superficial Digital Flexor Tendon in Race Horses. Tissue Eng 13(12): 2949-55.
22. Slaughter BV, Khurshid SS, Fisher Oz, Khademhosseini A, Peppas NA, (2009) Hydrogels in Regenerative Medicine. Adv Mater 21: 3307-29.
23. Ahmed TAE, Dare EV, Hincke M, (2008) Fibrin: A versatile scaffold for tissue engineering applications. Tissue Eng B 14(2): 199-215.
24. Jockenhoevel S, Zund G, Hoerstrup SP, Chalabi K, Sachweh JS, et al. (2001) Fibrin gel-advantages of a new scaffold in cardiovascular tissue engineering. Eur J Cardiothorac Surg 19(4): 424-30.
25. Swartz DD, Russell JA, Andreadis ST, (2005) Engineering of fibrin-based functional and implantable small-diameter blood vessels. Am J Physiol Heart Circ Physiol 288(3): H1451-60.
26. Schense JC, Hubbell JA, (1999) Cross-linking exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconjug Chem 10(1): 75-81.
27. Umeda H, Kanemaru S-I, Yamashita M, Kishimoto M, Tamura Y, et al. (2007) Bone regeneration of canine skull using bone marrow derived stromal cells and beta-tricalcium phosphate. Laryngoscope 117(6): 997-1003.
28. Silberstein LE, Williams LJ, Hughlett MA, Magee DA, Weisman RA, (1988) An autologous fibrinogen-based adhesive for use in otologic surgery. Transfusion 28(4): 319-21.
29. Trombi L, Mattii L, Pacini S, D'Alessandro D, Battolla B, et al. (2008) Human autologous plasma-derived clot as a biological scaffold for mesenchymal stem cells in treatment of orthopedic healing. J Orthop Res 26(2): 176-83.
30. Trombi L, D'Alessandro D, Pacini S, Fiorentino B, Scarpellini M, et al. (2008) Good manufacturing practice-grade fibrin gel is useful as a scaffold for human mesenchymal stromal cells and supports in vitro osteogenic differentiation. Transfusion 48: 2246-2251.
31. Bensaid W, Triffit JT, Blanchat C, Oudina K, Sedel L, et al. (2003) A biodegradable scaffold for mesenchymal stem cell transplantation. Biomaterials 24(14): 2497-502.
32. Wu X, Ren J, Li J (2012) Fibrin glue as the cell-delivery vehicle for mesenchymal stromal cells in regenerative medicine. Cytotherapy 14(5): 555-62. Review.
33. Danti S, Serino LP, D'Alessandro D, Moscato S, Danti S, et al. (2013) Growing bone tissue-engineered niches with graded osteogenicity: an in vitro method for biomimetic construct assembly. Tissue Eng C Methods. Apr 30. [Epub ahead of print].
34. Mu{double acute}ller ME, Koch P, Nazarian S, Schatzker J (1990) The comprehensive classification of fractures of long bones. Berlin: Springer-Verlag. 53.
35. Calori GM, Albisetti W, Agus A, Lori S, Tagliabue L (2007) Risks factors contributing to fracture non union. Injury 38(2): S11-18. Review.
36. Heary RF, Schlenk RP, Sacchieri TA, Barone D, Brotea C, (2002) Persistent iliac crest donor site pain: independent outcome assessment. Neurosurgery 50(3): 510-6.
37. Schwartz CE, Martha JF, Kowalski P, Wang DA, Bode R, et al. (2009) Prospective evaluation of chronic pain associated with posterior autologous iliac crest bone graft harvest and its effect on postoperative outcome. Health Qual Life Outcomes 29(7): 49.
38. Kanakaris NK, Giannoudis PV (2007) The health economics of the treatment of long bone non-unions. Injury 38(2): S77-84. Review.
39. Schmitt A, van Griensven M, Imhoff AB, Buchmann S (2007) Application of Stem Cells in Orthopedics. Stem Cells International 2012: 1-11. Review.
40. Cancedda R, Bianchi G, Derubeis A, Quarto R, (2003) Cell Therapy for bone disease: a review of current status. Stem Cells 21: 610-619.
41. Veronesi F, Giavaresi G, Tschon M, Borsari V, Nicoli Aldini N, et al. (2013) Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease. Stem Cells Dev 22(2): 181-92.
42. Xiang Y, Zheng O, Jia BB, Huang GP, Xu YL, et al. (2007) Ex vivo expansion and pluripotential differentiation of cryopreserved human bone marrow mesenchymal stem cells. J Zhejiang Univ Sci B 8: 136-146.
43. Vulcano E, Murena L, Cherubino P, Falvo DA, Rossi A, et al. (2012) Treatment of severe post-traumatic bone defects with autologous stem cells loaded on allogeneic scaffolds. Surg Technol Int Sep 30;XXII. [Epub ahead of print].
44. Gómez-Barrena E, Rosset P, Müller I, GiordanoR, Bunu C, et al. (2011) Bone regeneration: stem cell therapies and clinical studies in orthopaedics and traumatology. J Cell Mol Med 15(6): 1266-86.
45. Jäger M, Jelinek EM, Wess KM, Scharfstädt A, Jacobson M, et al. (2009) Bone marrow concentrate: a novel strategy for bone defect treatment. Curr Stem Cell Res Ther 28(4): 34-43.
46. Kitoh H, Kawasumi M, Kaneko H, Ishiguro N, (2009) Differential effects of culture-expanded bone marrow cells on the regeneration of bone between the femoral and the tibial lengthenings. J Pediatr Orthop 29(6): 643-9.
47. Kim SJ, Shin YW, Yang KH, Kim SB, Yoo MJ, et al. (2009) A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast (Ossron) injection to treat fractures. BMC Musculoskelet Disord 10: 20.
48. Bajada S, Harrison PE, Ashton BA, Cassar-Pullicino VN, Ashammakhi N, et al. (2007) Successful treatment of refractory tibial nonunion using calcium sulphate and bone marrow stromal cell implantation. J Bone Joint Surg Br 89(10): 1382-6.
49. Marcacci M, Kon E, Moukhachev V, Lavroukov A, Kutepov S, et al. (2007) Stem cells associated with macroporous bioceramics for long bone repair: 6- to 7-year outcome of a pilot clinical study. Tissue Eng 13(5): 947-55.
50. Bonab MM, Alimoghaddam K, Talebian F, Ghaffari SH, Ghavamzadeh A, et al. (2006) Aging of mesenchymal stem cell in vitro. BMC Cell Biology 7: 14.
51. Lynch JR, Taitsman LA, Barei DP, Nork SE, (2008) Femoral non union: risk factors and treatment options. J Am. Acad Orthop Surg 16: 88-97.
52. Greco SJ, Rameshwar P, (2012) Mesenchymal stem cells in drug/gene delivery: implications for cell therapy. Ther deliv 3(8): 997-1004.
53. Castano-Izquierdo H, Alvarez-Barreto J, van den Dolder J, Jansen JA, Mikos AG, et al. (2007) Pre-culture period of mesenchymal stem cells in osteogenic media influences their in vivo bone forming potential. J Biomed Mater Res A 82(1): 129-38.
54. Petrini M, Pacini S, Trombi L, Fazzi R, Montali M, et al. (2009) Identification and purification of mesodermal progenitor cells from human adult bone marrow. Stem Cells Dev 18(6): 857-866.
55. Trombi L, Pacini S, Montali M, Fazzi R, Chiellini F, et al. (2009) Selective culture of mesodermal progenitor cells. Stem Cells Dev 18(8): 1227-34.
56. Pacini S, Carnicelli V, Trombi L, Montali M, Fazzi R, et al. (2010) Constitutive expression of pluripotency-associated genes in mesodermal progenitor cells (MPCs). PloSOne 5(3): e9861.
57. Harris MT, Butler DL, Boivin GP, Florer JB, Schantz EJ, et al. (2004) Mesenchymal stem cells used for rabbit tendon repair can form ectopic bone and express phosphatase activity in constructs. J Orthop Res 22(5): 998-1003.
58. Montaln H, Schichor C, Lah TT (2010) Human mesenchymal stem cells and their use in cell-based therapies. Cancer 116(11): 2519-30. Review.
59. Seebach C, Schultheiss J, Wilhelm K, Frank J, Henrich D, (2010) Comparison of six bone-graft substitutes regarding to cell seeding efficiency, metabolism and growth behaviour of human mesenchymal stem cells (MSC) in vitro. Injury 41(7): 731-8.
60. Siggers K, Frei H, Fernlund G, Rossi F, (2010) Effect of bone graft substitute on marrow stromal cell proliferation and differentiation. J Biomed Mater Res A 94(3): 877-85.
61. Giannoudis PV, Einhorn TA, Marsh D (2007) Fracture healing: the diamond concept. Injury 38(4): S3-6. Review.