Clinical use of bone marrow, bone marrow concentrate, and expanded bone marrow mesenchymal stem cells in cartilage disease

Stem Cells and Development

Volumn 22, Issue 2, 2013, Pages 181-192

  Veronesi, Francesca ^a   Giavaresi, Gianluca ^a   Tschon, Matilde ^a   Borsari, Veronica ^a   Nicoli Aldini, Nicolò ^a   Fini, Milena ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; FIBRIN; HYALURONIC ACID; TISSUE SCAFFOLD;

ANKLE ARTHRITIS; ARTICULAR CARTILAGE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BIOMECHANICS; BONE DEFECT; BONE MARROW; CHONDROPATHY; CLINICAL TRIAL (TOPIC); ELBOW DISEASE; EVIDENCE BASED MEDICINE; FOLLOW UP; FOOT DISEASE; GROUPS BY AGE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HIP DISEASE; HIP OSTEOARTHRITIS; HISTOLOGY; HUMAN; KNEE OSTEOARTHRITIS; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OSTEOARTHRITIS; OUTCOME ASSESSMENT; PATIENT SAFETY; PRIORITY JOURNAL; REVIEW; STEM CELL EXPANSION; THROMBOCYTE RICH PLASMA; TISSUE REGENERATION;

BONE MARROW; CARTILAGE; CARTILAGE DISEASES; CELL DIFFERENTIATION; CLINICAL TRIALS AS TOPIC; COLLAGEN TYPE II; HUMANS; HYALURONIC ACID; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; OSTEOARTHRITIS; REGENERATION; TISSUE SCAFFOLDS;

EID: 84872479879     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2012.0373     Document Type: Review

References (77)

1. Brittberg M, A Lindahl, A Nilsson, C Ohlsson, O Isaksson and L Peterson. (1994). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889-895. (Pubitemid 24299869)
2. Redman SN, SF Oldfield and CW Archer. (2005). Current strategies for articular cartilage repair. Eur Cell Mat 9:23-32. (Pubitemid 41008175)
3. Clouet J, C Vinatier, C Merceron, M Pot-vaucel, Y Maugars, P Weiss, G Grimandi and J Guicheux. (2009). From osteoarthritis treatment to future regenerative therapies for cartilage. Drug Discov Today 14:913-925.
4. Ulrich-Vinther M, MD Maloney, EM Schwarz, R Rosier and RJ O'Keefe. (2003). Articular cartilage biology. J Am Acad Orthop Surg 11:421-430.
5. Cole BJ, C Pascual-Garrido and RC Grumet. (2009). Surgical management of articular cartilage defects in the knee. J Bone Joint Surg Am 91:1778-1790.
6. Richter W. (2009). Mesenchymal stem cells and cartilage in situ regeneration. J Intern Med 266:390-405.
7. Becerra J, JA Andrades, E Guerado, P Zamora-Navas, JM López-Puertas and AH Reddi. (2010). Articular cartilage: structure and regeneration. Tissue Eng Part B Rev 16:617-627.
8. Kasemkijwattana C, S Kesprayura, K Chaipinyo, C Chanlalit and K Chansiri. (2009). Autologous chondrocytes implantation with three-dimensional collagen scaffold. J Med Assoc Thai 92:1282-1286.
9. Peterson L, T Minas, M Brittberg and A Lindahl. (2003). Treatment of osteochondritis dissecans of the knee with autologous chondrocyte transplantation: results at two to ten years. J Bone Joint Surg Am 85-A (Suppl 2):17-24. (Pubitemid 36535041)
10. Baums MH, G Heidrich, W Schultz, H Steckel, E Kahl and HM Klinger. (2006). Autologous chondrocyte implantation of the ankle: a 2-to 5-year follow-up. J Bone Joint Surg Am 88:303-308.
11. Giannini S, R Buda, B Grigolo, F Vannini, L De Franceschi and A Facchini. (2005). The tedached osteochondral fragment as a source of cells for autologous chondrocyte implantation (ACI) in the ankle joint. Osteoarthritis Cartilage 13:601-607. (Pubitemid 40867859)
12. Marcacci M, M Berruto, D Brocchetta, A Delcogliano, D Ghinelli, A Gobbi, E Kon, L Pederzini, D Rosa, et al. (2005). Articular cartilage engineering with Hyalograft C: 3-year clinical results. Clin Orthop Relat Res 435:96-105. (Pubitemid 40798651)
13. Peterson L, M Brittberg, I Kiviranta, EL Akerlund and A Lindahk. (2002). Autologous chondrocyte transplantation: biomechanics and long-term durability. Am J Sports Med 30:2-12. (Pubitemid 34083708)
14. Oreffo RO, C Cooper, C Mason and M Clements. (2005). Mesenchymal stem cells:lineage, plasticity, and skeletal therapeutic potential. Stem Cell Rev 1:169-178. (Pubitemid 43074202)
15. Jakob RP. (2006). AMIC technique for cartilage repair, a single-step surgical intervention as compared to other methods. Eur Cell Mater 12 (Suppl. 1):26.
16. Wakitani S, T Goto, SJ Pineda, RG Young, JM Mansour, AI Caplan and VM Goldberg. (1994). Mesenchymal cell-based repair of large, full-thickness defects of articular cartilage. J Bone Joint Surg 76-A:579-592. (Pubitemid 24154130)
17. Wakitani S, K Imoto, T Yamamoto, M Saito, N Murata and M Yoneda. (2002). Human autologous culture expanded bone marrow mesenchymal cell transplantation for repair of cartilage defects in osteorthritic knees. Osteoarthritis Cartilage 10:199-206. (Pubitemid 34189569)
18. Varsara AI, MT Nieminen, JS Jurvelin, L Peterson, A Lindahl and I Kiviranta. (2005). Indentation stiffness of repair tissue after autologous chondrocyte transplantation. Clin Orthop Relat Res 233-242. (Pubitemid 40489275)
19. Giannini S, R Buda, F Vannini, M Cavallo and B Grigolo. (2009). One-step bone marrow-derived cell transplantation in talar osteochondral lesions. Clin Orthop Relat Res 467:3307-3320.
20. Cinar BM, E Circi, G Guven, IC Tuncay, MA Hersekli and A Derincek. (2012). Extracorporeal shock waves in articular cartilage defects in the rats. Musculoskelet Surg 96:23-28.
21. Ochi M, Y Uchio, K Kawasaki,S Wakitani and J Iwasa. (2002). Transplantation of cartilage-like tissue made by tissue engineering in the treatment of cartilage defects of the knee. J Bone Joint Surg Br 84:571-578. (Pubitemid 34578510)
22. Bosnakovski D, M Mizuno, G Kim, S Takagi, M Okumura and T Fujinaga. (2006). Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis. Biotechnol Bioeng 93:152-163.
23. Longobardi L, L O'Rear, S Aakula, B Johnstone, K Shimer, A Chytil, WA Horton, HL Moses and A Spagnoli. (2006). Effect of IGF-I in the chondrogenesis of bone marrow mesenchymal stem cells in the presence or absence of TGF-beta signaling. J Bone Miner Res 21:626-636.
24. Xiang Y, O Zheng, BB Jia, GP Huang, YL Xu, JF Wang and ZJ Pan. (2007). Ex vivo expansion and pluripotential differentiation of cryopreserved human bone marrow mesenchymal stem cells. J Zhejiang Univ Sci B 8:136-146.
25. Riccio M, E Resca, T Maraldi, A Pisciotta, A Ferrari, G Bruzzesi and A De Pol. (2010). Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures. Eur J Histochem 54:205-213.
26. Maraldi T, M Riccio, E Resca, A Pisciotta, GB La Sala, A Ferrari, G Bruzzesi and A De Pol. (2011). Human amniotic fluid stem cells seeded in fibroin scaffold produce in vivo mineralized matrix. Tissue Eng Part A 17:2833-2843.
27. Riccio M, T Maraldi, A Pisciotta, GB La Sala, A Ferrari, G Bruzzesi, A Motta and A De Pol. (2012). Fibroin scaffold repairs critical-size bone defects in vivo supported by human amniotic fluid and dental pulp stem cells. Tissue Eng Part A 18:1106-1013.
28. Mizuno H, M Tobita and AC Uysal. (2012). Concise review: adipose-derived stem cells as a novel tool for future regenerative medicine. Stem Cells 30:804-810.
29. Jäger M, C Zilkens, B Bittersohl and R Krauspe. (2009). Cord blood-an alternative source for bone regeneration. Stem Cell Rev 5:266-277.
30. Hass R, C Kasper, S Bohm and R Jacobs. (2011). Different populations and sources of human mesenchymal stem cells (MSC): a comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 9:12.
31. Valero MC, HD Huntsman, J Liu, K Zou and MD Boppart. (2012). Eccentric exercise facilitates mesenchymal stem cell appearance in skeletal muscle. PLoS One 7:1-11.
32. Kuroda R, K Ishida, T Matsumoto, T Akisue, H Fujioka, K Mizuno, H Ohgushi, S Wakitani and M Kurosaka. (2007). Treatment of a full-thickness articular cartilage defect in the femoral condyle of an athlete with autologous bone marrowstromal cells. Osteoarthritis Cartilage 15:226-231. (Pubitemid 46132105)
33. Wakitani S, T Mitsuoka, N Nakamura, Y Toritsuka, Y Nakamura and S Horibe. (2004). Autologous bone marrow stromal cell transplantation for repair of full-thickness atricular cartilage defects in human patellae: two case reports. Cell Transplant 13:595-600. (Pubitemid 39557438)
34. Wakitani S, M Nawata, K Tensho, T Okabe, H Machida and H Ohgushi. (2007). Repair of articular cartilage defects in the patella-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med 1:74-79.
35. Kasemkijwattana C, S Hongeng, S Kesprayura, V Rungsinaporn, K Chaipinyo and K Chansiri. (2011). Autologous bone marrow mesenchymal stem cells implantation for cartilage defects: two cases report. J Med Assoc Thai 94:395-400.
36. Venkataramana NK, SKV Kumar, S Balaraju, RC Radhakrishnan, A Bansal, A Dixit, DK Rao, M Das, M Jan, PK Gupta and SM Totey. (2010). Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Transl Res 155:62-70.
37. Mazzini L, I Ferrero, V Luparello, D Rustichelli, M Gunetti, K Mareschi, L Testa, A Stecco, R Tarletti, et al. (2010). Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: a Phase I clinical trial. Exp Neurol 223:229-237.
38. Dash NR, SN Dash, P Routray, S Mohapatra and PC Mohapatra. (2009). Targeting nonhealing ulcers of lower extremity in human through autologous bone marrow-derived mesenchymal stem cells. Rejuvenation Res 12:359-366.
39. Yoshikawa T, H Mitsuno, I Nonaka, Y Sen, K Kawanishi, Y Inada, Y Takakura, K Okuchi and A Nonomura. (2008). Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg 121:860-877. (Pubitemid 351642820)
40. Katritsis DG, P Sotiropoulou, E Giazitzoglou, E Karvouni and M Papamichail. (2007). Electrophysiological effects of intracoronary transplantation of autologous mesenchymal and endothelial progenitor cells. Europace 9:167-171. (Pubitemid 46404162)
41. Hare JM, JH Traverse, TD Henry, N Dib, RK Strumpf, SP Schulman, G Gerstenblith, AN DeMaria, AE Denktas, et al. (2009). A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol 54:2277-2286.
42. Le Blanc K, F Frassoni, L Ball, F Locatelli, H Roelofs, I Lewis, E Lanino, B Sundberg, ME Bernardo, et al. (2008). Developmental Committee of the European Group for Blood and Marrow Transplantation. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 371:1579-1586. (Pubitemid 351626841)
43. Kebriaei P and S Robinson. (2011). Mesenchymal stem cell therapy in the treatment of acute and chronic graft versus host disease. Front Oncol 1:1-8.
44. Wang D, H Zhang, M Cao, Y Tang, J Liang, X Feng, H Wang, B Hua, B Liu and L Sun. (2011). Efficacy of allogeneic mesenchymal stem cell transplantation in patients with drug-resistant polymyositis and dermatomyositis. Ann Rheum Dis 70:1285-1288.
45. Mohamadnejad M, B Pournasr, M Bagheri, N Aghdami, M Shahsavani, LA Hosseini, E Taghiabadi, H Azizi, I Heidari, et al. (2010). Transplantation of allogeneic bone marrow mesenchymal stromal cell-derived hepatocyte-like cells in homozygous familial hypercholesterolemia. Cytotherapy 12:566-568.
46. Kim SJ, GJ Moon, YH Cho, HY Kang, NK Hyung, D Kim, JH Lee, JY Nam and OY Bang. (2012). Circulating mesenchymal stem cells microparticles in patients with cerebrovascular disease. PLoS One 7:e37036.
47. Ball LM, ME Bernardo, F Locatelli and RM Egeler. (2008). Potential role of mesenchymal stromal cells in pediatric hematopoietic SCT. BoneMarrow Transplant 42 Suppl 2:S60-S66.
48. Nejadnik H, JH Hui, EP Feng Choong, BC Tai and EH Lee. (2010). Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med 38:1110-1116.
49. Giannini S, R Buda, M Cavallo, A Ruffilli, A Cenacchi, C Cavallo and F Vannini. (2010). Cartilage repair evolution in post-traumatic osteochondral lesions of the talus: from open field autologous chondrocyte to bone-marrow-derived cells transplantation. Injury 41:1196-1203.
50. Buda R, F Vannini, M Cavallo, B Grigolo, A Cenacchi and S Giannini. (2010). Osteochondral lesions of the knee: a new one-step repair technique with bone-marrow-derived cells. J Bone Joint Surg Am 92:2-11.
51. Centeno CJ, J Kisiday, M Freeman and JR Schultz. (2006). Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: a case study. Pain Physician 9:253-256. (Pubitemid 44227398)
52. Centeno CJ, D Busse, J Kisiday, C Keohan, M Freeman and D Karli. (2008). Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. Med Hypotheses 71:900-908.
53. Centeno CJ, D Busse, J Kisiday, C Keohan, M Freeman and D Karli. (2008). Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343-353. (Pubitemid 351959424)
54. Slynarski K, J Deszczynski and J Karpinski. (2006). Fresh bone marrow and periosteum transplantation for cartilage defects of the knee. Transplant Proc 38:318-319.
55. Pascarella A, R Ciatti, F Pascarella, C Latte, M Giuseppe Di Salvatore, L Liguori and G Iannella. (2010). Treatment of articular cartilage lesions of the knee joint using a modified AMIC technique. Knee Surg Sports Traumatol Arthrosc 18:509-513.
56. Gigante A, S Calcagno, S Cecconi, D Ramazzotti, S Manzotti and D Enea. (2011). Use of collagen scaffold and autologous bone marrow concentrate as a one-step cartilage repair in the knee: histological results of second-look biopsies at 1 year follow-up. Int J Immunopathol Pharmacol 24:69-72.
57. Wakitani S, T Okabe, S Horibe, T Mitsuoka, M Saito, T Koyama, M Nawata, K Tensho, H Kato, et al. (2011). Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med 5:146-150.
58. Shino K, S Nakagawa, M Inoue, S Horibe and M Yoneda. (1993). Deterioration of patellofemoral articular surfaces after amterior cruciate ligament reconstruction. Am J Sports Med 21:206-211. (Pubitemid 23096800)
59. O'Driscoll SW, DB Saris, Y Ito and JS Fitzimmons. (2001). The chondrogenic potential of periosteum decreases with age. J Orthop Res 19:95-103. (Pubitemid 32288641)
60. Kacena MA, CM Gundberg and MC Horwitz. (2006). A reciprocal regulatory interaction between megacaryocytes, bone cells and hematopoietic stem cells. Bone 39:978-984. (Pubitemid 44528390)
61. Steinwachs MR, Th Guggi and PC Kreuz. (2008). Marrow stimulation techniques. Injury 39:26-31. (Pubitemid 351296054)
62. Nair MB, HK Varma and A John. (2009). Platelet-rich plasma and fibrin glue-coated bioactive ceramics enhance growth and differentiation of goat bone marrow-derived stem cells. Tissue Eng 15:1-13.
63. Veronesi F, P Torricelli, V Borsari, M Tschon, L Rimondini and M Fini. (2011). Mesenchymal stem cells in the aging and osteoporotic population. Crit Rev Eukaryot Gene Expr 21:363-377.
64. Ohgushi H, N Kotobuki, H Funaoka, H Machida, M Hirose, Y Tanaka and Y Takakura. (2005). Tissue engineering ceramic artificial joint-ex vivo osteogenic differentiation of patient mesenchymal cells on total ankle joints for treatment of osteoarthritis. Biomaterials 26:4654-4661. (Pubitemid 40269282)
65. Toubai T, S Paczesny, Y Shono, J Tanaka, KP Lowler, CT Malter, M Kasai and M Imamura. (2009). Mesenchymal stem cells for treatment and prevention of graft-versus-host disease after allogenic hematopoietic cell transplantation. Curr Stem Cell Res Ther 4:252-259.
66. Rubio D, J Garcia-Castro, MC Martin, R de la Fuente, JC Cigudosa, AC Lloyd and A Bernad. (2005). Spontaneous human adult stem cell transformation. Cancer Res 65:3035-3039. (Pubitemid 40524580)
67. Wang Y, DLH uso, J Harrington, J Kellner, DK Jeong, J Turney and IK McNiece.(2005). Outgrowth of a transformed cell population derived from normal human BM mesenchymal stem cell culture. Cytotherapy 7:509-519. (Pubitemid 43078081)
68. Rosland GV, A Svendsen, A Torsvik, E Sobala, E McCormack, H Immervoll, J Mysliwietz, JC Tonn, R Goldbrunner, et al. (2009). Long-term cultures of bone marrow-derived human mesenchymal stem cells frequently undergo spontaneous malignant transformation. Cancer Res 69:5331-5339.
69. Bernardo ME, N Zaffaroni, F Novara, AM Cometa, MA Avanzini, A Moretta, D Montagna, R Maccario, R Villa, et al. (2007). Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 67:9142-9149. (Pubitemid 47535900)
70. Tarte K, J Gaillard, JJ Lataillade, L Fouillard, M Becker, H Mossafa, A Tchirkov, H Rouard, C Henry, et al. (2010). Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood 115:1549-1553.
71. Tolar J, AJ Nauta, MJ Osborn, A Panoskaltsis Mortari, RT McElmurry, S Bell, L Xia, N Zhou, M Riddle, et al. (2007). Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 25:371-379. (Pubitemid 46232791)
72. Zhou YF, M Bosch-Marce, H Okuyama, B Krishnamachary, H Kimura, L Zhang, DL Huso and GL Semenza. (2006). Spontaneous transformation of cultured mouse bone marrow-derived stromal cells. Cancer Res 66:10849-10854. (Pubitemid 44876981)
73. Parekkadan B, D van Poll, K Suganuma, EA Carter, F Berthiaume, AW Tilles and ML Yarmush. (2007). Mesenchymal stem cell-derived molecules reverse fulminant hepatic failure. PLoS One 2:e941.
74. Yabana T, Y Arimura, H Tanaka, A Goto, M Hosokawa, K Nagaishi, K Yamashita, H Yamamoto, Y Adachi, et al. (2009). Enhancing epithelial engraftment of rat mesenchymal stem cells restores epithelial barrier integrity. J Pthol 218: 350-359.
75. Bernardo ME and WE Fibbie. (2012). Safety and efficacy of mesenchymal tromal cell therapy in autoimmune disorders. Ann NY Acad Sci 1266:107-117.
76. van Buul GM, WLM Koevoet, N Kops, PK Bos, JAN Verhaar, H Weinans, MR Bernsen and GJVM van Osch. (2011). Platelet-Rich Plasma Releasate Inhibits Inflammatory Processes in Osteoarthritic Chondrocytes. AJSM 20:1-9.
77. Lima EG, AR Tan, T Tai, L Bian, AM Stoker, GA Ateshian, JL Cook and CT Hung. (2008). Differences in interleukin-1 response between engineered and native cartilage. Tissue Eng Part A 14:1721-1730.