Autoxidation and oxygen binding properties of recombinant hemoglobins with substitutions at the αval-62 or βval-67 position of the distal heme pocket

Journal of Biological Chemistry

Volumn 288, Issue 35, 2013, Pages 25512-25521

  Tam, Ming F ^a   Rice, Natalie W ^a   Maillett, David H ^a   Simplaceanu, Virgil ^a   Ho, Nancy T ^a   Tam, Tsuey Chyi S ^a   Shen, Tong Jian ^a   Ho, Chien ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME POCKETS; LIGAND BINDING; OXYGEN BINDING; QUATERNARY STRUCTURE; TERTIARY STRUCTURES;

BINDING ENERGY; HEMOGLOBIN; LIGANDS; OXIDATION; PORPHYRINS;

OXYGEN;

GLYCINE; HEME; HEMOGLOBIN A; HISTIDINE; HYDROGEN; ISOLEUCINE; LEUCINE; OXYGEN; PHENYLALANINE; PORPHYRIN; RECOMBINANT HEMOGLOBIN; VALINE;

ALPHA CHAIN; AMINO ACID SUBSTITUTION; ARTICLE; AUTOOXIDATION; BETA CHAIN; BINDING AFFINITY; CONTROLLED STUDY; ESCHERICHIA COLI; GENE MUTATION; HYDROGEN BOND; OXIDATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALLOSTERIC REGULATION; AUTOXIDATION; E11; HEMOGLOBIN; MUTANT; NMR; OXYGEN BINDING;

ADULT; AMINO ACID SUBSTITUTION; BINDING SITES; FEMALE; HEME; HEMOGLOBINS; HUMANS; MALE; OXIDATION-REDUCTION; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; VALINE;

EID: 84883359703     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.474841     Document Type: Article

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