Depletion of the transcriptional coactivators megakaryoblastic leukaemia 1 and 2 abolishes hepatocellular carcinoma xenograft growth by inducing oncogene-induced senescence

EMBO Molecular Medicine

Volumn 5, Issue 9, 2013, Pages 1367-1382

  Hampl, Veronika ^a   Martin, Claudia ^a   Aigner, Achim ^b   Hoebel, Sabrina ^b   Singer, Stephan ^c   Frank, Natalie ^a   Sarikas, Antonio ^d   Ebert, Oliver ^e   Prywes, Ron ^f   Gudermann, Thomas ^a   Muehlich, Susanne ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^d TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^e TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^f Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

DLC1; MKL1; MKL2; MRTF; Senescence

Indexed keywords

MEGAKARYOBLASTIC LEUKEMIA 1 PROTEIN; MEGAKARYOBLASTIC LEUKEMIA 2 PROTEIN; POLYETHYLENEIMINE; RAS PROTEIN; RETINOBLASTOMA PROTEIN; RHO KINASE; SMALL INTERFERING RNA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CONTROLLED STUDY; DRUG TARGETING; GENE DELETION; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; SENESCENCE; TUMOR XENOGRAFT;

DLC1; MKL1; MKL2; MRTF; SENESCENCE;

AGING; ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; DNA-BINDING PROTEINS; GENE KNOCKDOWN TECHNIQUES; HETEROGRAFTS; HUMANS; MICE; MICE, NUDE; ONCOGENE PROTEINS; ONCOGENE PROTEINS, FUSION; TRANSCRIPTION FACTORS;

EID: 84883357114     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201202406     Document Type: Article

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