Antihyperglycemic drug gymnema sylvestre also shows anticancer potentials in human melanoma A375 cells via reactive oxygen species generation and mitochondria-dependent caspase pathway

Integrative Cancer Therapies

Volumn 12, Issue 5, 2013, Pages 433-441

  Chakraborty, Debrup ^a   Ghosh, Samrat ^a   Bishayee, Kausik ^a   Mukherjee, Avinaba ^a   Sikdar, Sourav ^a   Khuda Bukhsh, Anisur Rahman ^a  

^a UNIVERSITY OF KALYANI   (India)

Author keywords

A375 melanoma cells; anticancer potential; apoptosis; DNA damage; Gymnema sylvestre; reactive oxygen species

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ANTINEOPLASTIC AGENT; CASPASE 3; CYTOCHROME C; GYMNEMA SYLVESTRE EXTRACT; LIPOCORTIN 5; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RHODAMINE 123;

ANTIDIABETIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL CYCLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; GYMNEMA SYLVESTRE; HUMAN; HUMAN CELL; LIVER CELL; MELANOMA CELL; MITOCHONDRION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

A375 MELANOMA CELLS; ANTICANCER POTENTIAL; APOPTOSIS; DNA DAMAGE; GYMNEMA SYLVESTRE; REACTIVE OXYGEN SPECIES;

ANTINEOPLASTIC AGENTS; CASPASE 3; CELL SURVIVAL; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GYMNEMA SYLVESTRE; HUMANS; HYPOGLYCEMIC AGENTS; MELANOMA; MITOCHONDRIA; PLANT EXTRACTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SKIN NEOPLASMS;

EID: 84883349245     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735413485419     Document Type: Article

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