Structure-activity relationship for the reactivators of acetylcholinesterase inhibited by nerve agent VX

Medicinal Chemistry

Volumn 9, Issue 5, 2013, Pages 689-693

  Kuca, Kamil ^a,b,c   Musilek, Kamil ^a,b,c   Jun, Daniel ^a,b   Karasova, Jana ^a,b   Soukup, Ondrej ^a,b   Pejchal, Jaroslav ^a   Hrabinova, Martina ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c UNIVERSITY OF HRADEC KRALOVE   (Czech Republic)

Author keywords

Acetylcholinesterase; Nerve agent; Oxime; Reactivation; VX

Indexed keywords

1 (3 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1 (4 CARBAMOYLPYRIDINIO) 4 (2 HYDROXYIMINOMETHYLPYRIDINIO) 2 BUTENE DIBROMIDE; 1 (4 CARBAMOYLPYRIDINIO) 4 (4 HYDROXYIMINOMETHYLPYRIDINIO)BUTANE DIBROMIDE; 1 [2,4 BIS(HYDROXYIMINOMETHYL)PYRIDINIO] 1' (4 CARBAMOYLPYRIDINIO)DIMETHYL ETHER DIIODIDE; ANTIDOTE; CHOLINESTERASE REACTIVATOR; H1 (DRUG); H2 (DRUG); H3 (DRUG); K005; K027; K033; K074; K075; METHOXIME; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OBIDOXIME; OXIME DERIVATIVE; PRALIDOXIME; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG STRUCTURE; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; ANIMALS; CHOLINESTERASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MOLECULAR STRUCTURE; ORGANOTHIOPHOSPHORUS COMPOUNDS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84883340970     PISSN: 15734064     EISSN: 18756638     Source Type: Journal    
DOI: 10.2174/1573406411309050008     Document Type: Article

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