Eight new bispyridinium oximes in comparison with the conventional oximes pralidoxime and obidoxime: In vivo efficacy to protect from diisopropylfluorophosphate toxicity

Journal of Applied Toxicology

Volumn 28, Issue 7, 2008, Pages 920-928

  Lorke, D E ^a,b   Nurulain, S M ^a   Hasan, M Y ^a   Kuca K ^c   Musilek, K ^c   Petroianu, G A ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Cox analysis; DFP; Fluorophosphates; K oxime; Organophosphate; Rat

Indexed keywords

ACETYLCHOLINESTERASE; BIS(PYRIDINIUM OXIME) DERIVATIVE; DYFLOS; K 107; K 108; K 113; K 27; K 48; K 53; K 74; K 75; OBIDOXIME; PRALIDOXIME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; IN VITRO STUDY; IN VIVO STUDY; INTOXICATION; LD 50; MALE; MORTALITY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; TOXICITY TESTING;

ANIMALS; ANTIDOTES; CHOLINESTERASE INHIBITORS; DRUG ANTAGONISM; INJECTIONS, INTRAPERITONEAL; ISOFLUROPHATE; LETHAL DOSE 50; LONGEVITY; OBIDOXIME CHLORIDE; PRALIDOXIME COMPOUNDS; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; RATTUS;

EID: 55449117133     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.1359     Document Type: Article

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