Expression of Pirh2, a p27 Kip1 ubiquitin ligase, in hepatocellular carcinoma: Correlation with p27 Kip1 and cell proliferation

Human Pathology

Volumn 42, Issue 4, 2011, Pages 507-515

  Huang, Xiaodong ^a   Qian, Xiaoli ^b   Cheng, Chun ^a   He, Song ^a   Sun, Linlin ^b   Ke, Qing ^b   Zhang, Li ^b   Pan, Xia ^b   He, Fei ^b   Wang, Qiuhong ^b   Meng, Jie ^b   Ni, Runzhou ^a   Shen, Aiguo ^a  

^a NANTONG UNIVERSITY   (China)

^b NANTONG MEDICAL COLLEGE   (China)

Author keywords

Cell proliferation; Hepatocellular carcinoma; p27 Kip1; Pirh2

Indexed keywords

ALPHA FETOPROTEIN; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HEPATITIS B SURFACE ANTIGEN; P53 INDUCED RING H2 PROTEIN; UBIQUITIN PROTEIN LIGASE; UNCLASSIFIED DRUG;

ADULT; ANTIGEN DETECTION; ARTICLE; CANCER CELL CULTURE; CANCER GRADING; CANCER INVASION; CANCER SIZE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; KAPLAN MEIER METHOD; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; WESTERN BLOTTING;

ADULT; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P27; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; KAPLAN-MEIER ESTIMATE; LIVER NEOPLASMS; MALE; MIDDLE AGED; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL; UBIQUITIN-PROTEIN LIGASES;

EID: 79952989230     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.04.021     Document Type: Article

References (19)

1. Wang X.M., Yang L.Y., Guo L., Fan C., and Wu F. p53-induced RING-H2 protein, a novel marker for poor survival in hepatocellular carcinoma after hepatic resection Cancer 115 2009 4554 4563
2. Makuuchi M., Imamura H., Sugawara Y., and Takayama T. Progress in surgical treatment of hepatocellular carcinoma Oncology 62 Suppl 1 2002 74 81 (Pubitemid 34702024)
3. Hung J.H., Lu Y.S., and Wang Y.C. FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling Cancer Res 68 2008 1204 1212
4. Leng R.P., Lin Y., and Ma W. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation Cell 112 2003 779 791 (Pubitemid 36378882)
5. Corcoran C.A., Montalbano J., Sun H., He Q., Huang Y., and Sheikh M.S. Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains J Biol Chem 284 2009 21955 21970
6. Duan W., Gao L., and Druhan L.J. Expression of Pirh2, a newly identified ubiquitin protein ligase, in lung cancer J Natl Cancer Inst 96 2004 1718 1721 (Pubitemid 39585640)
7. Logan I.R., Gaughan L., McCracken S.R., Sapountzi V., Leung H.Y., and Robson C.N. Human PIRH2 enhances androgen receptor signaling through inhibition of histone deacetylase 1 and is overexpressed in prostate cancer Mol Cell Biol 26 2006 6502 6510 (Pubitemid 44277889)
8. Weinstein I.B. Disorders in cell circuitry during multistage carcinogenesis: the role of homeostasis Carcinogenesis 21 2000 857 864 (Pubitemid 30265126)
9. Hulit J., Lee R.J., and Li Z. p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling Cancer Res 66 2006 8529 8541 (Pubitemid 44449166)
10. Chen Q., Xie W., and Kuhn D.J. Targeting the p27 E3 ligase SCF(Skp2) results in p27- and Skp2-mediated cell-cycle arrest and activation of autophagy Blood 111 2008 4690 4699
11. Hattori T., Isobe T., and Abe K. Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1 Cancer Res 67 2007 10789 10795 (Pubitemid 350145907)
12. Lim M.S., Adamson A., and Lin Z. Expression of Skp2, a p27(Kip1) ubiquitin ligase, in malignant lymphoma: correlation with p27(Kip1) and proliferation index Blood 100 2002 2950 2956
13. Carrano A.C., Eytan E., Hershko A., and Pagano M. SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27 Nat Cell Biol 1 1999 193 199 (Pubitemid 129500937)
14. Sutterluty H., Chatelain E., and Marti A. p45SKP2 promotes p27Kip1 degradation and induces S phase in quiescent cells Nat Cell Biol 1 1999 207 214 (Pubitemid 129500939)
15. Harper J.W. Protein destruction: adapting roles for Cks proteins Curr Biol 11 2001 R431 R435
16. Ganoth D., Bornstein G., and Ko T.K. The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27 Nat Cell Biol 3 2001 321 324 (Pubitemid 32201330)
17. Shimada M., Kitagawa K., and Dobashi Y. High expression of Pirh2, an E3 ligase for p27, is associated with low expression of p27 and poor prognosis in head and neck cancers Cancer Sci 100 2009 866 872
18. Voorhees P.M., Dees E.C., O'Neil B., and Orlowski R.Z. The proteasome as a target for cancer therapy Clin Cancer Res 9 2003 6316 6325 (Pubitemid 38031815)
19. Duan W., Gao L., Wu X., Zhang Y., Otterson G.A., and Villalona-Calero M.A. Differential response between the p53 ubiquitin-protein ligases Pirh2 and MdM2 following DNA damage in human cancer cells Exp Cell Res 312 2006 3370 3378 (Pubitemid 44380235)