Contribution of protein binding, Lipid partitioning, and asymmetrical transport to drug transfer into milk in mouse versus human

Pharmaceutical Research

Volumn 30, Issue 9, 2013, Pages 2410-2422

  Ito, Naoki ^a   Ito, Kousei ^a   Koshimichi, Hiroki ^a   Hisaka, Akihiro ^a   Honma, Masashi ^a   Igarashi, Takashi ^b   Suzuki, Hiroshi ^a  

^a UNIVERSITY OF TOKYO HOSPITAL   (Japan)

^b NATIONAL CENTER FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

breastfeeding; lactation; mammary epithelium; species specific differences; transporter

Indexed keywords

ACICLOVIR; ALPRAZOLAM; ATENOLOL; CEFALOTIN; CEFAPIRIN; CEFOTAXIME; CHLORAMPHENICOL; CIMETIDINE; CLINDAMYCIN; DILTIAZEM; DISOPYRAMIDE; FLUCONAZOLE; LABETALOL; METFORMIN; METOPROLOL; METRONIDAZOLE; MILK FAT; MILK PROTEIN; MIRTAZAPINE; MOCLOBEMIDE; NITRAZEPAM; NITROFURANTOIN; PARACETAMOL; PRAZIQUANTEL; PREDNISOLONE; PROPRANOLOL; PROPYLTHIOURACIL; QUETIAPINE; TERBUTALINE;

ANIMAL EXPERIMENT; ARTICLE; BREAST EPITHELIUM; CHEMICAL PARAMETERS; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG MILK LEVEL; DRUG TRANSPORT; FAT CONTENT; FEMALE; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; IN VITRO STUDY; LACTATION; LIPID PARTITIONING; MILK; MILK PLASMA DRUG CONCENTRATION RATIO; MOUSE; NONHUMAN; PHARMACOLOGICAL PARAMETERS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONTENT; SPECIES DIFFERENCE;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD PROTEINS; FEMALE; HUMANS; LIPID METABOLISM; MALE; MICE; MILK; MILK PROTEINS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PROTEIN BINDING;

EID: 84883279808     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1085-5     Document Type: Article

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