Lactation stage-dependent expression of transporters in rat whole mammary gland and primary mammary epithelial organoids

Fundamental and Clinical Pharmacology

Volumn 24, Issue 2, 2010, Pages 205-214

  Gilchrist, Samuel E ^a   Alcorn, Jane ^b  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Lactation; Mammary epithelial organoids; Mammary gland; QRT PCR; Rat; Transporters

Indexed keywords

ABC TRANSPORTER; CARRIER PROTEIN; CONCENTRATIVE NUCLEOSIDE TRANSPORTER 1; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 2; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 3; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1 A; MULTIDRUG RESISTANCE PROTEIN 1 B; NUCLEOBASE TRANSPORTER; NUCLEOBASE TRANSPORTER 1; NUCLEOSIDE TRANSPORTER; OCTAMER TRANSCRIPTION FACTOR 1; ORGANIC CATION TRANSPORTER; PROTEIN MTX1; PROTEIN OCT1; PROTEIN OCTN2; PROTEIN OCTN3; SOLUTE CARRIER PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; BREAST FEEDING; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM CELL; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE LOCATION; ISOLATED ORGAN; LACTATION; MAMMARY GLAND; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUANTITATIVE STUDY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; LACTATION; MAMMARY GLANDS, ANIMAL; MEMBRANE TRANSPORT PROTEINS; ORGANOIDS; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 77949880178     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2009.00760.x     Document Type: Article

References (37)

1. US Food and Drug Administration Content and format of labeling for human prescription drug and biological products; requirements for pregnancy and lactation labeling. Federal Register (2008) 73 30831 30868.
2. Ito S., Alcorn J. Xenobiotic transporter expression and function in the human mammary gland. Adv. Drug Deliv. Rev. (2003) 55 653 665.
3. Jonker J.W., Merino G., Musters S. et al. The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk. Nat. Med. (2005) 11 127 129.
4. US Food and Drug Administration : 3763s2 02 selen. Drug transfer into breast milk: Nonclinical and clinical methods. http://www.scribd.com/doc/ 1081814/US-Food-and-Drug-Administration-3763s2-02-selen. 2001.
5. McManaman J.L., Neville M.C. Mammary physiology and milk secretion. Adv. Drug Deliv. Rev. (2003) 55 629 641.
6. Shennan D.B., Peaker M. Transport of milk constituents by the mammary gland. Physiol. Rev. (2000) 80 925 951.
7. Groneberg D.A., Doring F., Theis S., Nickolaus M., Fischer A., Daniel H. Peptide transport in the mammary gland: expression and distribution of PEPT2 mRNA and protein. Am J Physiol Endocrinol Metab. (2002) 282 E1172 E1179.
8. Kelleher S.L., Lonnerdal B. Molecular regulation of milk trace mineral homeostasis. Mol. Aspects Med. (2005) 26 328 339.
9. Rudolph M.C., McManaman J.L., Phang T. et al. Metabolic regulation in the lactating mammary gland: a lipid synthesizing machine. Physiol. Genomics (2007) 28 323 336.
10. Ling B., Alcorn J. Acute administration of cefepime lowers L-carnitine concentrations in early lactation stage rat milk. J. Nutr. (2008) 138 1317 1322.
11. Ito S., Lee A. Drug excretion into breast milk - overview. Adv. Drug Deliv. Rev. (2003) 55 617 627.
12. McNamara P.J., Abbassi M. Neonatal exposure to drugs in breast milk. Pharm. Res. (2004) 21 555 566.
13. Hewitt N.J., Lechon M.J., Houston J.B. et al. Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism, enzyme induction, transporter, clearance, and hepatotoxicity studies. Drug Metab. Rev. (2007) 39 159 234.
14. Alcorn J., McNamara P.J. Acyclovir, ganciclovir, and zidovudine transfer into rat milk. Antimicrob. Agents Chemother. (2002) 46 1831 1836.
15. Edwards J.E., Alcorn J., Savolainen J., Anderson B.D., McNamara P.J. Role of P-glycoprotein in distribution of nelfinavir across the blood-mammary tissue barrier and blood-brain barrier. Antimicrob. Agents Chemother. (2005) 49 1626 1628.
16. Darcy K.M., Black J.D., Hahm H.A., Ip M.M. Mammary organoids from immature virgin rats undergo ductal and alveolar morphogenesis when grown within a reconstituted basement membrane. Exp. Cell Res. (1991) 196 49 65.
17. Wojcik S.F., Capen C.C., Rosol T.J. Expression of PTHrP and the PTH/PTHrP receptor in purified alveolar epithelial cells, myoepithelial cells, and stromal fibroblasts derived from the lactating rat mammary gland. Exp. Cell Res. (1999) 248 415 422.
18. Whitehead Institute for Medical Research. Primer 3. (Last accessed 7 February 2007) http://frodo.wi.mit.edu, 2008.
19. Huggett J., Dheda K., Bustin S., Zumla A. Real-time RT-PCR normalisation; strategies and considerations. Genes Immun. (2005) 6 279 284.
20. Kendziorski C.M., Zhang Y., Lan H., Attie A.D. The efficiency of pooling mRNA in microarray experiments. Biostatistics (2003) 4 465 477.
21. Kelleher S.L., Lonnerdal B. Marginal maternal Zn intake in rats alters mammary gland Cu transporter levels and milk Cu concentration and affects neonatal Cu metabolism. J. Nutr. (2003) 133 2141 2148.
22. Petrovic V., Teng S., Piquette-Miller M. Regulation of drug transporters during infection and inflammation. Mol. Interv. (2007) 7 99 111.
23. Kelleher S.L., Lonnerdal B. Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells. J. Nutr. (2003) 133 3378 3385.
24. Leong W.I., Lonnerdal B. Iron transporters in rat mammary gland: effects of different stages of lactation and maternal iron status. Am. J. Clin. Nutr. (2005) 81 445 453.
25. Zhao F.Q., Keating A.F. Expression and regulation of glucose transporters in the bovine mammary gland. J. Dairy Sci. (2007) 90 (Suppl 1) E76 E86.
26. Liuzzi J.P., Bobo J.A., Cui L., McMahon R.J., Cousins R.J. Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation. J. Nutr. (2003) 133 342 351.
27. Gerk P.M., Oo C.Y., Paxton E.W., Moscow J.A., McNamara P.J. Interactions between cimetidine, nitrofurantoin, and probenecid active transport into rat milk. J. Pharmacol. Exp. Ther. (2001) 296 175 180.
28. Oo C.Y., Paxton E.W., McNamara P.J. Active transport of nitrofurantoin into rat milk. Adv. Exp. Med. Biol. (2001) 501 547 552.
29. Dils R.R. Explants and disaggregated tissue preparations as model systems in nutritional research: advantages and pitfalls. Proc. Nutr. Soc. (1984) 43 133 140.
30. Ip M.M., Darcy K.M. Three-dimensional mammary primary culture model systems. J. Mammary Gland Biol. Neoplasia (1996) 1 91 110.
31. Augustine L.M., Markelewicz R.J. Jr., Boekelheide K., Cherrington N.J. Xenobiotic and endobiotic transporter mRNA expression in the blood-testis barrier. Drug Metab. Dispos. (2005) 33 182 189.
32. Luttringer O., Theil F.P., Lave T. et al. Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes. Biochem. Pharmacol. (2002) 64 1637 1650.
33. Nakhasi H.L., Quasba P.K. Quantitation of milk proteins and their mRNAs in rat mammary gland at various stages of gestation and lactation. J. Biol. Chem. (1979) 254 6016 6025.
34. Streuli C.H., Bailey N., Bissell M.J. Control of mammary epithelial differentiation: basement membrane induces tissue-specific gene expression in the absence of cell-cell interaction and morphological polarity. J. Cell Biol. (1991) 115 1383 1395.
35. Streuli C.H., Schmidhauser C., Bailey N. et al. Laminin mediates tissue-specific gene expression in mammary epithelia. J. Cell Biol. (1995) 129 591 603.
36. Roskelley C.D., Srebrow A., Bissell M.J. A hierarchy of ECM-mediated signalling regulates tissue-specific gene expression. Curr. Opin. Cell Biol. (1995) 7 736 747.
37. Schuetz J.D., Schuetz E.G. Extracellular matrix regulation of multidrug resistance in primary monolayer cultures of adult rat hepatocytes. Cell Growth Differ. (1993) 4 31 40.