5-Lipoxygenase plays a pivotal role in endothelial adhesion of monocytes via an increased expression of Mac-1

Cardiovascular Research

Volumn 99, Issue 4, 2013, Pages 724-733

  Lee, Seung Jin ^a,b   Choi, Eun Kyoung ^a,b   Seo, Kyo Won ^a,b   Bae, Jin Ung ^a,b   Kim, Yun Hak ^a,b   Park, So Youn ^a,b   Oh, Sae Ock ^a,b   Kim, Chi Dae ^a,b  

^a Pusan National University School of Medicine   (South Korea)

^b Pusan National University   (South Korea)

Author keywords

5 Lipoxygenase; Mac 1; Monocyte adhesion; TLR4; Vascular inflammation

Indexed keywords

2 (2,6 DIHYDROXYHEXYL) 6 (3 HYDROXY 1,5 UNDECADIENYL)PYRIDINE; ARACHIDONATE 5 LIPOXYGENASE; CD11B ANTIGEN; I KAPPA B; LEUKOTRIENE; LIPOPOLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATHEROSCLEROSIS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MONOCYTE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VASCULAR ENDOTHELIUM; WILD TYPE;

5-LIPOXYGENASE; MAC-1; MONOCYTE ADHESION; TLR4; VASCULAR INFLAMMATION;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CELL ADHESION; CELL LINE, TUMOR; ENDOTHELIUM, VASCULAR; HUMANS; LIPOPOLYSACCHARIDES; MACROPHAGE-1 ANTIGEN; MICE; MICE, INBRED C57BL; MONOCYTES; NF-KAPPA B; RECEPTORS, LEUKOTRIENE B4; SP1 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 4;

EID: 84883246354     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt135     Document Type: Article

References (38)

1. Ley K, Miller YI, Hedrick CC. Monocyte and macrophage dynamics during atherogenesis. Arterioscler Thromb Vasc Biol 2011;31:1506-1516.
2. Badimon L, Storey RF, Vilahur G. Update on lipids, inflammation and atherothrombosis. Thromb Haemost 2011;105:S34-S42.
3. Mestas J, Ley K. Monocyte-endothelial cell interactions in the development of atherosclerosis. Trends Cardiovasc Med 2008;18:228-232.
4. van Gils JM, Zwaginga JJ, Hordijk PL. Molecular and functional interactions among monocytes, platelets, and endothelial cells and their relevance for cardiovascular diseases. J Leukoc Biol 2009;85:195-204.
5. Daub K, Seizer P, Stellos K, Krämer BF, Bigalke B, SchallerMet al. Oxidized LDL-activated platelets induce vascular inflammation. Semin Thromb Hemost 2010;36:146-156.
6. Zhao L, Moos MP, Gräbner R, Pédrono F, Fan J, Kaiser B et al. The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm. Nat Med 2004;10:966-973.
7. De Caterina R, Zampolli A. From asthma to atherosclerosis-5-lipoxygenase, leukotrienes, and inflammation. N Engl J Med 2004;350:4-7.
8. Jawień J. The putative role of leukotrienes in experimental atherogenesis. Pol Arch Med Wewn 2009;119:90-93.
9. Poeckel D, Funk CD. The 5-lipoxygenase/leukotriene pathway in preclinical models of cardiovascular disease. Cardiovasc Res 2010;86:243-253.
10. Osterud B, Bjorklid E. Role of monocytes in atherogenesis. Physiol Rev 2003;83: 1069-1112.
11. Pamukcu B, Lip GY, Devitt A, Griffiths H, Shantsila E. The role of monocytes in atherosclerotic coronary artery disease. Ann Med 2010;42:394-403.
12. Woollard KJ, Geissmann F. Monocytes in atherosclerosis: subsets and functions. Nat Rev Cardiol 2010;7:77-86.
13. Saha P, Modarai B, Humphries J, Mattock K,Waltham M, Burnand KG et al. The monocyte/macrophage as a therapeutic target in atherosclerosis. Curr Opin Pharmacol 2009;9: 109-118.
14. Zarbock A, Singbartl K, Ley K. Complete reversal of acid-induced acute lung injury by blocking of platelet-neutrophil aggregation. J Clin Invest 2006;116:3211-3219.
15. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM et al. CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol 2011;31: 160-166.
16. Kellersch B, KolanusW. Membrane-proximal signaling events in beta-2 integrin activation. Results Probl Cell Differ 2006;43:245-257.
17. Takahashi Y, Zhu H, Yoshimoto T. Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis. Antioxid Redox Signal 2005;7:425-431.
18. Doran AC, Meller N, McNamara CA. Role of smooth muscle cells in the initiation and early progression of atherosclerosis. Arterioscler Thromb Vasc Biol 2008;28:812-819.
19. Guo YL, Bai R, Chen CX, Liu DQ, Liu Y, Zhang CY et al. Role of junctional adhesion molecule-like protein in mediating monocyte transendothelial migration. Arterioscler Thromb Vasc Biol 2009;29:75-83.
20. Mehrabian M, Allayee H,Wong J, ShiW,Wang XP, Shaposhnik Z et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 2002;91:120-126.
21. Jawien J, Gajda M, Rudling M, Mateuszuk L, Olszanecki R, Guzik TJ et al. Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice. Eur J Clin Invest 2006;36:141-146.
22. Back M, Sultan A, Ovchinnikova O, Hansson GK. 5-Lipoxygenase-activating protein: a potential link between innate and adaptive immunity in atherosclerosis and adipose tissue inflammation. Circ Res 2007;100:946-949.
23. Hagihara H,Nomoto A, Mutoh S, Yamaguchi I,OnoT. Role of inflammatory responses in initiation of atherosclerosis: effects of anti-inflammatory drugs on cuff-induced leukocyte accumulation and intimal thickening of rabbit carotid artery. Atherosclerosis 1991; 91:107-116.
24. Lee SJ, Kim CE, Yun MR, Seo KW, Park HM, Yun JW et al. 4-Hydroxynonenal enhances MMP-9 production in murine macrophages via 5-lipoxygenase-mediated activation of ERK and p38MAPK. Toxicol Appl Pharmacol 2010;242:191-198.
25. Kim CE, Lee SJ, Seo KW, Park HM, Yun JW, Bae JU et al. Acrolein increases 5-lipoxygenase expression in murine macrophages through activation of ERK pathway. Toxicol Appl Pharmacol 2010;245:76-82.
26. Seo KW, Lee SJ, Kim CE, Yun MR, Park HM, Yun JW et al. Participation of 5-lipoxygenase-derived LTB(4) in 4-hydroxynonenal-enhanced MMP-2 production in vascular smooth muscle cells. Atherosclerosis 2010;208:56-61.
27. YunMR, ParkHM,SeoKW, Lee SJ, Im DS, KimCD. 5-Lipoxygenase playsan essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase. Free Radic Res 2010;44:742-750.
28. Lee SJ, Kim CE, Seo KW, Kim CD. HNE-induced 5-LO expression is regulated by NF-{kappa}B/ERK and Sp1/p38 MAPK pathways via EGF receptor in murine macrophages. Cardiovasc Res 2010;88:352-359.
29. Ma CY, Shi GY, Shi CS, Kao YC, Lin SW,Wu HL. Monocyticthrombomodulin triggers LPS-and gram-negative bacteria-induced inflammatory response. J Immunol 2012;188: 6328-6337.
30. Guzzo C, Ayer A, Basta S, Banfield BW, Gee K. IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes. J Immunol 2012;188:864-873.
31. Surette ME, Nadeau M, Borgeat P, Gosselin J. Priming of human peripheral blood mononuclear cells with lipopolysaccharides for enhanced arachidonic acid release and leukotriene synthesis. J Leukoc Biol 1996;59:709-715.
32. Qiu H, GabrielsenA, Agardh HE,WanM,Wetterholm A,WongCHet al. Expression of 5-lipoxygenase and leukotriene A4 hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability. Proc Natl Acad Sci USA 2006;103:8161-8166.
33. Cipollone F, Mezzetti A, Fazia ML, Cuccurullo C, Iezzi A, Ucchino S et al. Association between 5-lipoxygenase expression and plaque instability in humans. Arterioscler Thromb Vasc Biol 2005;25:1665-1670.
34. Bäck M. Inhibitors of the 5-lipoxygenase pathway in atherosclerosis. Curr Pharm Des 2009;15:3116-3132.
35. Osher E,Weisinger G, Limor R, Tordjman K, Stern N. The 5 lipoxygenase system in the vasculature: emerging role in health and disease. Mol Cell Endocrinol 2006;252:201-206.
36. Aiello RJ, Bourassa PA, Lindsey S,WengW, Freeman A, Showell HJ. Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler Thromb Vasc Biol 2002;22:443-449.
37. Galkina E, Ley K. Vascular adhesion molecules in atherosclerosis. Arterioscler Thromb Vasc Biol 2007;27:2292-2301.
38. Serio KJ, Reddy KV, Bigby TD. Lipopolysaccharide induces 5-lipoxygenase-activating protein gene expression in THP-1 cells via a NF-kappaB and C/EBP-mediated mechanism. Am J Physiol Cell Physiol 2005;288:C1125-C1133.