Neuroanatomical deficits in drug-naïve adult patients with generalized social anxiety disorder: A voxel-based morphometry study

Psychiatry Research - Neuroimaging

Volumn 214, Issue 1, 2013, Pages 9-15

  Meng, Yajing ^a   Lui, Su ^a   Qiu, Changjian ^a   Qiu, Lihua ^a   Lama, Sunima ^a   Huang, Xiaoqi ^a   Feng, Yuan ^a   Zhu, Chunyan ^a   Gong, Qiyong ^a   Zhang, Wei ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Amygdala; DARTEL; Gray matter density; Papez circuit; Social anxiety disorder; Voxel based morphometry

Indexed keywords

ADULT; AMYGDALOID NUCLEUS; ARTICLE; CEREBROSPINAL FLUID; CLINICAL ARTICLE; FEMALE; GENERALIZED ANXIETY DISORDER; GRAY MATTER; HAMILTON ANXIETY SCALE; HUMAN; LIEBOWITZ SOCIAL ANXIETY SCALE; LIMBIC CORTEX; MALE; NEUROANATOMY; NEUROIMAGING; ONSET AGE; OUTPATIENT DEPARTMENT; PRECUNEUS; PRIORITY JOURNAL; SOCIAL PHOBIA; STUDENT T TEST; VOXEL BASED MORPHOMETRY; WHITE MATTER;

AMYGDALA; DARTEL; GRAY MATTER DENSITY; PAPEZ CIRCUIT; SOCIAL ANXIETY DISORDER; VOXEL-BASED MORPHOMETRY;

ADOLESCENT; ADULT; AMYGDALA; BRAIN; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; NERVE FIBERS, MYELINATED; NERVE FIBERS, UNMYELINATED; PHOBIC DISORDERS; THALAMUS;

EID: 84883233776     PISSN: 09254927     EISSN: 18727506     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2013.06.002     Document Type: Article

References (60)

1. Aderka I.M., Nickerson A., Hofmann S.G. Hofmann admixture analysis of the diagnostic subtypes of social anxiety disorder: implications for the DSM-V. Journal of Behavior Therapy and Experimental Psychiatry 2012, 43:752-757.
2. Adolphs R. Cognitive neuroscience of human social behaviour. Nature Reviews Neuroscience 2003, 4:165-178.
3. Amaral D.G. The primate amygdala and the neurobiology of social behavior: implications for understanding social anxiety. Biological Psychiatry 2002, 51:11-17.
4. Ashburner J., Friston K.J. Voxel-based morphometry-the methods. NeuroImage 2000, 11:805-821.
5. Ashburner J., Friston K.J. Why voxel-based morphometry should be used. NeuroImage 2001, 14:1238-1243.
6. Ashburner J. A fast diffeomorphic image registration algorithm. NeuroImage 2007, 38:95-113.
7. Baas D., Aleman A., Kahn R.S. Lateralization of amygdala activation: a systematic review of functional neuroimaging studies. Brain Research Reviews 2004, 45:96-103.
8. Baker K.B., Kim J.J. Amygdalar lateralization in fear conditioning: evidence for greater involvement of the right amygdala. Behavioral Neuroscience 2004, 118:15-23.
9. Bear M.F., Connors B., Paradiso M. Neuroscience: Exploring the Brain (Neuroscience) 2006, Lippincott/Williams & Wilkins, Philadelphia.
10. Bergouignan L., Chupin M., Czechowska Y., Kinkingnéhun S., Lemogne C., Le Bastard G., Lepage M., Garnero L., Colliot O., Fossati P. Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?. NeuroImage 2009, 45:29-37.
11. Brühl A.B., Rufer M., Delsignore A., Kaffenberger T., Jancke L., Herwig U. Neural correlates of altered general emotion processing in Social Anxiety Disorder. Brain Research 2011, 1378:72-83.
12. Carey P.D., Warwick J., Niehaus D., van der Linden G., van Heerden B.B., Harvey B.H., Seedat S., Stein D.J. Single photon emission computed tomography (SPECT) of anxiety disorders before and after treatment with citalopram. BMC Psychiatry 2004, 4:30.
13. Clark D.M., McManus F. Information processing in social phobia. Biological Psychiatry 2002, 51:92-100.
14. Cooney R.E., Atlas L.Y., Joormann J., Eugene F., Gotlib I.H. Amygdala activation in the processing of neutral faces in social anxiety disorder: is neutral really neutral?. Psychiatry Research: Neuroimaging 2006, 148:55-59.
15. Dalrymple K.L., Zimmerman M. Age of onset of social anxiety disorder in depressed outpatients. Journal of Anxiety Disorders 2007, 25:131-137.
16. Damsa C., Kosel M, Moussally J. Current status of brain imaging in anxiety disorders. Current Opinion in Psychiatry 2009, 22:96-110.
17. Davidson J.R.T., Bose A., Korotzer A., Zheng H. Escitalopram in the treatment of generalized anxiety disorder: double-blind, placebo-controlled flexible dose study. Depression and Anxiety 2004, 19:234-240.
18. den Ouden H.E.M., Frith U., Frith C., Blakemore S.J. Thinking about intentions. NeuroImage 2005, 28:787-796.
19. Ding J., Chen H., Qiu C., Liao W., Warwick J.M., Duan X., Zhang W., Gong Q. Disrupted functional connectivity in social anxiety disorder: a resting-state fMRI study. Magnetic Resonance Imaging 2011, 29:701-711.
20. Engel K., Bandelow B., Gruber O., Wedekind D. Neuroimaging in anxiety disorders. Journal of Neural Transmission 2009, 116:703-716.
21. Etkin A., Prater K.E., Schatzberg A.F., Menon V., Greicius M.D. Disrupted amygdalar subregion functional connectivity and evidence of a compensatory network in generalized anxiety disorder. Archives of General Psychiatry 2009, 66:1361-1372.
22. Etkin A., Wager T.D. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. American Journal of Psychiatry 2007, 164:1476-1488.
23. Feinstein J.S., Adolphs R., Damasio A., Tranel D. The human amygdala and the induction and experience of fear. Current Biology 2010, 21:34-38.
24. Ferrari M.C.F., Busatto G.F., McGuire P.K., Crippa J.A.S. Structural magnetic resonance imaging in anxiety disorders: an update of research findings. Revista Brasileira de Psiquiatria-Sao Paulo, Brazil 2008, 30:251-264.
25. Furmark T., Tillfors M., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., Fredrikson M. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Archives of General Psychiatry 2002, 59:425-433.
26. Gentili C., Gobbini M.I., Ricciardi E., Vanello N., Pietrini P., Haxby J.V., Guazzelli M. Differential modulation of neural activity throughout the distributed neural system for face perception in patients with social phobia and healthy subjects. Brain Research Bulletin 2008, 77:286-292.
27. Gentili C., Ricciardi E., Gobbini M.I., da Santarelli M.F., Haxby J.V., Pietrini P., Guazzelli M. Beyond amygdala: default mode network activity differs between patients with social phobia and healthy controls. Brain Research Bulletin 2009, 79:409-413.
28. Giuliani N.R., Calhoun V.D., Pearlson G.D., Francis A., Buchanan R.W. Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophrenia Research 2005, 74:135-147.
29. Glascher J., Adolphs R. Processing of the arousal of subli-minal and supraliminal emotional stimuli by the human amygdala. Journal of Neuroscience 2003, 23:10274-10282.
30. Gong Q.Y., Sluming V., Mayes A., Keller S., Barrick T., Cezayirli E., Roberts N. Voxel-based morphometry and stereology provide convergent evidence of the importance of medial prefrontal cortex for fluid intelligence in healthy adults. NeuroImage 2005, 25:1175-1186.
31. Good C.D., Johnsrude I.S., Ashburner J., Henson R.N.A., Friston K.J., Frackowiak R.S.J. A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage 2001, 14:21-36.
32. Hahn A., Stein P., Windischberger C., Weissenbacher A., Spindelegger C., Moser E., Kasper S., Lanzenberger R. Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder. NeuroImage 2011, 56:881-889.
33. Hariri, B.A.R., Whalen, P.J., 2011. Face to face with the emotional brain. F1000 Biology Reports 3, 2, http://dx.doi.org/10.3410/B3-2.
34. He Y., Chen Z.J., Evans A.C. Small-world anatomical networks in the human brain revealed by cortical thickness from MRI. Cerebral Cortex 2007, 17:2019-2407.
35. Irle E. Reduced amygdalar and hippocampal size in adults with generalized social phobia. Journal of Psychiatry and Neuroscience 2010, 35:126-131.
36. Johnson S. Emotions and the brain: fear. Discover Magazine 2003, March 1st, online. 〈http:/discovermagazine.com/2003/mar/cover〉.
37. Li D., Chokka P., Tibbo P. Toward an integrative understanding of social phobia. Psychiatry Neuroscience 2001, 26:190-202.
38. Liao W., Chen H., Feng Y., Mantini D., Gentili C., Pan Z., Ding J., Duan X., Qiu C., Lui S., Gong Q., Zhang W. Selective aberrant functional connectivity of resting state networks in social anxiety disorder. NeuroImage 2010, 52:1549-1558.
39. Liao W., Qiu C., Gentili C., Walter M., Pan Z., Ding J., Zhang W., Gong Q., Chen H. Altered effective connectivity network of the amygdala in social anxiety disorder: a resting-state FMRI study. PloS One 2010, 5:e15238.
40. Liao W., Xu Q., Mantini D., Ding J., Machado-de-Sousa J.P., Hallak J.E.C., Trzesniak C., Qiu C., Zen L., Zhang W., Crippa J.A.S., Gong Q., Chen H. Altered gray matter morphometry and resting-state functional and structural connectivity in social anxiety disorder. Brain Research 2011, 1388:167-177.
41. Lui S., Deng W., Huang X., Jiang L., Ouyang L. Neuroanatomical differences between familial and sporadic schizophrenia and their parents: an optimized voxel-based morphometry study. Psychiatry Research: Neuroimaging 2009, 171:71-81.
42. Mather A.A., Stein M.B., Sareen J. Social anxiety disorder and social fears in the Canadian military: prevalence, comorbidity, impairment, and treatment-seeking. Journal of Psychiatric Research 2010, 44:887-893.
43. Mathew S.J., Coplan J.D., Gorman J.M. Neurobiological mechanisms of social anxiety disorder. American Journal of Psychiatry 2001, 158:1558-1567.
44. Nakao T., Sanematsu H., Yoshiura T., Togao O., Murayama K., Tomita M., Masuda Y., Kanba S. fMRI of patients with social anxiety disorder during a social situation task. Neuroscience Research 2011, 69:67-72.
45. Potts N.L., Davidson J.R., Krishnan K.R., Doraiswamy P.M. Magnetic resonance imaging in social phobia. Psychiatry Research: Neuroimaging 1994, 52:35-42.
46. Ruby P., Decety J. Effect of subjective perspective taking during simulation of action: a PET investigation of agency. Nature Neuroscience 2001, 4:546-550.
47. Rytwinski N.K., Fresco D.M., Heimberg R.G., Coles M.E., Liebowitz M.R., Cissell S., Stein M.B., Hofmann S.G. Screening for social anxiety disorder with the self-report version of the Liebowitz Social Anxiety Scale. Depression and Anxiety 2009, 26:34-38.
48. Sareen J., Campbell D.W., Leslie W.D., Malisza K.L., Stein M.B., Paulus M.P., Kravetsky L.B., Kjernisted K.D., Walker J.R., Reiss J.P. Striatal function in generalized social phobia: a functional magnetic resonance imaging study. Biological Psychiatry 2007, 61:396-404.
49. Stein M.B., Goldin P.R., Sareen J., Zorrilla L.T.E., Brown G.G. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Archives of General Psychiatry 2002, 59:1027-1034.
50. Straube T., Kolassa I.T., Glauer M., Mentzel H.J., Miltner W.H.R. Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study. Biological Psychiatry 2004, 56:921-930.
51. Syal S., Hattingh C.J., Fouché J.P., Spottiswoode B., Carey P.D., Lochner C., Stein D.J. Grey matter abnormalities in social anxiety disorder: a pilot study. Metabolic Brain Disease 2012, 27:299-309.
52. Talati A., Pantazatos S.P., Schneier F.R., Weissman M.M., Hirsch J. Gray matter abnormalities in social anxiety disorder: primary, replication, and specificity studies. Biological Psychiatry 2013, 73(1):75-84.
53. Tapp P.D., Head K., Head E., Milgram N.W., Muggenburg B., Su M.Y. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. NeuroImage 2006, 29:234-244.
54. Tillfors M., Furmark T., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., Fredrikson M. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study. American Journal of Psychiatry 2001, 158:1220-1226.
55. Warwick J.M., Carey P., Jordaan G.P., Dupont P., Stein D.J. Resting brain perfusion in social anxiety disorder: a voxel-wise whole brain comparison with healthy control subjects. Progress in Neuro-Psychopharmacology & Biological Psychiatry 2008, 32:1251-1256.
56. Wang X., Cui D., Wang Z., Fan Q., Xu H., Qiu J., Chen J., Zhang H., Jiang K., Xiao Z. Cross-sectional comparison of the clinical characteristics of adults with early-onset and late-onset obsessive compulsive disorder. Journal of Affective Disorders 2012, 136:498-504.
57. Woon F.L., Hedges D.W. Amygdala volume in adults with posttraumatic stress disorder: a meta-analysis. Journal of Neuropsychiatry and Clinical Neurosciences 2009, 21:5-12.
58. Wright P., Liu Y. Neutral faces activate the amygdala during identity matching. NeuroImage 2006, 29:628-636.
59. Wilke M., Keller S.S., Wieshmann U.C., Sluming V.A., Roberts N. Comparison of standard and optimized voxel-based morphometry for analysis of brain changes associated with temporal lobe epilepsy. NeuroImage 2004, 23:860-868.
60. Zou K., Deng W., Li T., Zhang B., Jiang L., Huang C., Sun X., Sun X. Changes of brain morphometry in first-episode, drug-naïve, non-late-life adult patients with major depression: an optimized voxel-based morphometry study. Biological Psychiatry 2010, 67:186-188.