The amygdala: Inside and out

F1000 Biology Reports

Volumn 3, Issue 1, 2011, Pages

  Hariri, Ahmad R ^a   Whalen, Paul J ^b  

^a DUKE UNIVERSITY   (United States)

^b Dartmouth College   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYGDALOID NUCLEUS; BRAIN FUNCTION; BRAIN REGION; EMOTION; FACIAL EXPRESSION; HUMAN; LEARNING; MENTAL DISEASE; NEUROMODULATION; REVIEW;

EID: 79551712773     PISSN: 17404118     EISSN: 1757594X     Source Type: Journal    
DOI: 10.3410/B3-2     Document Type: Review

References (48)

1. Hariri AR: The neurobiology of individual differences in complex behavioral traits. Annu Rev Neurosci 2009, 32:225-47.
2. Hariri AR, Mattay VS, Tessitore A, Kolachana B, Fera F, Goldman D, Egan MF, Weinberger DR: Serotonin transporter genetic variation and the response of the human amygdala. Science 2002, 297:400-3. (Pubitemid 34790769)
3. Tessitore A, Hariri AR, Fera F, Smith WG, Chase TN, Hyde TM, Weinberger DR, Mattay VS: Dopamine modulates the response of the human amygdala: a study in Parkinson's disease. J Neurosci 2002, 22:9099-103. (Pubitemid 35379080)
4. Bigos KL, Pollock BG, Aizenstein HJ, Fisher PM, Bies RR, Hariri AR: Acute 5-HT reuptake blockade potentiates human amygdala reactivity. Neuropsychopharmacology 2008, 33:3221-5.
5. Murphy SE, Norbury R, O'Sullivan U, Cower PJ, Harmer CJ: Effect of a single dose of citalopram on amygdala response to emotional faces. Br J Psychiatry 2009, 194:535-40.
6. Onur OA, Walter H, Schlaepfer TE, Rehme AK, Schmidt C, Keysers C, Maier W, Hurlemann R: Noradrenergic enhancement of amygdala responses to fear. Soc Cogn Affect Neurosci 2009, 4:119-26.
7. Hurlemann R, Walter H, Rehme AK, Kukolja J, Santoro SC, Schmidt C, Schnell K, Musshoff F, Keysers C, Maier W, Kendrick KM, Onur OA: Human amygdala reactivity is diminished by the beta-noradrenergic antagonist propranolol. Psychol Med 40:1839-48.
8. Paulus MP, Feinstein JS, Castillo G, Simmons AN, Stein MB: Dose-dependent decrease of activation in bilateral amygdala and insula by lorazepam during emotion processing. Arch Gen Psychiatry 2005, 62:282-8.
9. Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H: Cannabinoid modulation of amygdala reactivity to social signals of threat in humans. J Neurosci 2008, 28:2313-9.
10. Kirsch P, Esslinger C, Chen Q, Mier D, Lis S, Siddhanti S, Gruppe H, Mattay VS, Gallhofer B, Meyer-Lindenberg A: Oxytocin modulates neural circuitry for social cognition and fear in humans. J Neurosci 2005, 25:11489-93.
11. Domes G, Heinrichs M, Gläscher J, Büchel C, Braus DF, Herpertz SC: Oxytocin attenuates amygdala responses to emotional faces regardless of valence. Biol Psychiatry 2007, 62:1187-90. (Pubitemid 350029722)
12. van Wingen G, Mattern C, Verkes RJ, Buitelaar J, Fernández G: Testosterone reduces amygdala-orbitofrontal cortex coupling. Psychoneuroendocrinology 2010, 35:105-13.
13. Fisher PM, Meltzer CC, Ziolko SK, Price JC, Moses-Kolko EL, Berga SL, Hariri AR: Capacity for 5-HT1A-mediated autoregulation predicts amygdala reactivity. Nat Neurosci 2006, 9:1362-3.
14. Rhodes RA, Murthy NV, Dresner MA, Selvaraj S, Stavrakakis N, Babar S, Cowen PJ, Grasby PM: Human 5-HT transporter availability predicts amygdala reactivity in vivo. J Neurosci 2007, 27:9233-7. (Pubitemid 47312048)
15. Fisher PM, Meltzer CC, Price JC, Coleman RL, Ziolko SK, Becker C, Moses-Kolko EL, Berga SL, Hariri AR: Medial prefrontal cortex 5-HT(2A) density is correlated with amygdala reactivity, response habituation, and functional coupling. Cereb Cortex 2009, 19:2499-507.
16. Kienast T, Hariri AR, Schlagenhauf F, Wrase J, Sterzer P, Buchholz HG, Smolka MN, Gründer G, Cumming P, Kumakura Y, Bartenstein P, Dolan RJ, Heinz A: Dopamine in amygdala gates limbic processing of aversive stimuli in humans. Nat Neurosci 2008, 11:1381-2.
17. Takahashi H, Takano H, Kodaka F, Arakawa R, Yamada M, Otsuka T, Hirano Y, Kikyo H, Okubo Y, Kato M, Obata T, Ito H, Suhara T: Contribution of dopamine D1 and D2 receptors to amygdala activity in human. J Neurosci 2010, 30:3043-7.
18. Hariri AR, Mattay VS, Tessitore A, Fera F, Smith WG, Weinberger DR: Dextroamphetamine modulates the response of the human amygdala. Neuropsychopharmacology 2002, 27:1036-40. (Pubitemid 35447640)
19. Fakra E, Hyde LW, Gorka A, Fisher PM, Muñoz KE, Kimak M, Halder I, Ferrell RE, Manuck SB, Hariri AR: Effects of HTR1A C(-1019)G on amygdala reactivity and trait anxiety. Arch Gen Psychiatry 2009, 66:33-40.
20. Smolka MN, Schumann G, Wrase J, Grüsser SM, Flor H, Mann K, Braus DF, Goldman D, Büchel C, Heinz A: Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci 2005, 25:836-42.
21. Drabant EM, Hariri AR, Meyer-Lindenberg A, Munoz KE, Mattay VS, Kolachana BS, Egan MF, Weinberger DR: Catechol O-methyl-transferase val158met genotype and neural mechanisms related to affective arousal and regulation. Arch Gen Psychiatry 2006, 63:1396-406. (Pubitemid 44878523)
22. Blasi G, Lo Bianco L, Taurisano P, Gelao B, Romano R, Fazio L, Papazacharias A, Di Giorgio A, Caforio G, Rampino A, Masellis R, Papp A, Ursini G, Sinibaldi L, Popolizio T, Sadee W, Bertolino A: Functional variation of the dopamine D2 receptor gene is associated with emotional control as well as brain activity and connectivity during emotion processing in humans. J Neurosci 2009, 29:14812-9.
23. Rasch B, Spalek K, Buholzer S, Luechinger R, Boesiger P, Papassotiropoulos A, de Quervain DJ: A genetic variation of the noradrenergic system is related to differential amygdala activation during encoding of emotional memories. Proc Natl Acad Sci U S A 2009, 106:19191-6.
24. Hariri AR, Gorka A, Hyde LW, Kimak M, Halder I, Ducci F, Ferrell RE, Goldman D, Manuck SB: Divergent effects of genetic variation in endocannabinoid signaling on human threat- and reward-related brain function. Biol Psychiatry 2009, 66:9-16.
25. Meyer-Lindenberg A, Kolachana B, Gold B, Olsh A, Nicodemus KK, Mattay V, Dean M, Weinberger DR: Genetic variants in AVPR1A linked to autism predict amygdala activation and personality traits in healthy humans. Mol Psychiatry 2009, 14:968-75.
26. Manuck SB, Marsland AL, Flory JD, Gorka A, Ferrell RE, Hariri AR: Salivary testosterone and a trinucleotide (CAG) length polymorphism in the androgen receptor gene predict amygdala reactivity in men. Psychoneuroendocrinology 2010, 35:94-104.
27. Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR: A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Mol Psychiatry 2005, 10:884-8.
28. Neumann SA, Brown SM, Ferrell RE, Flory JD, Manuck SB, Hariri AR: Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function. Biol Psychiatry 2006, 60:1155-62.
29. Zhou Z, Zhu G, Hariri AR, Enoch MA, Scott D, Sinha R, Virkkunen M, Mash DC, Lipsky RH, Hu XZ, Hodgkinson CA, Xu K, Buzas B, Yuan Q, Shen PH, Ferrell RE, Manuck SB, Brown SM, Hauger RL, Stohler CS, Zubieta JK, Goldman D: Genetic variation in human NPY expression affects stress response and emotion. Nature 2008, 452:997-1001.
30. LeDoux J: The emotional brain. The mysterious underpinnings of emotional life. New York: Simon & Schuster; 1996.
31. Kapp BS, Whalen PJ, Supple WF, Pascoe JP: Amygdaloid contributions to conditioned arousal and sensory information processing. In The Amygdala: Neurobiological Aspects of Emotion, Memory, and Mental Dysfunction. Edited by Aggelton JP. New York: Wiley-Liss; 1992, 229-54.
32. Gallagher M, Holland PC: The amygdala complex: Multiple roles in associative learning and attention. Proc Natl Acad Sci U S A 1994, 91:11771-6.
33. Whalen PJ: Fear, vigilance, and ambiguity: Initial neuroimaging studies of the human amygdala. Curr Dir Psychol Sci 1998, 7:177-88.
34. Weisz DJ, Harden DG, Xiang Z: Effects of amygdala lesions on reflex facilitation and conditioned response acquisition during nictitating membrane response conditioning in rabbit. Behav Neurosci 1992, 106:262-73.
35. Phillips ML, Drevets WC, Rauch SL, Lane R: Neurobiology of emotion perception II: Implications for major psychiatric disorders. Biol Psychiatry 2003, 54:515-28.
36. Etkin A, Wager TD: Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 2007, 164:1476-88. (Pubitemid 350069724)
37. Whalen PJ, Johnstone T, Somerville LH, Nitschke JB, Polis S, Alexander AL, Davidson RJ, Kalin NH: A functional magnetic resonance imaging predictor of treatment response to venlafaxine in generalized anxiety disorder. Biol Psychiatry 2008, 63:858-63.
38. Nitschke JB, Sarinopoulos I, Oathes DJ, Johnstone T, Whalen PJ, Davidson RJ, Kalin NH: Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am J Psychiatry 2009, 166:302-10.
39. Morris JS, Ohman A, Dolan RJ: Conscious and unconscious emotional learning in the human amygdala. Nature 1998, 393:467-70.
40. Whalen PJ, Rauch SL, Etcoff NL, McInerney SC, Lee MB, Jenike MA: Masked presentations of emotional facial expressions modulate amygdala activity without explicit knowledge. J Neurosci 1998, 18:411-8.
41. Esteves F, Ohman A: Masking the face: recognition of emotional facial expressions as a function of the parameters of backward masking. Scand J Psychol 1993, 34:1-18.
42. Esteves F, Parra C, Dimberg U, Ohman A: Nonconscious associative learning: Pavlovian conditioning of skin conductance responses to masked fear-relevant facial stimuli. Psychophysiology 1994, 31:375-85.
43. Williams MA, Morris AP, McGlone F, Abbott DF, Mattingley JB: Amygdala responses to fearful and happy facial expressions under conditions of binocular suppression. J Neurosci 2004, 24:2898-904.
44. Amting JM, Greening SG, Mitchell DG: Multiple mechanisms of consciousness: the neural correlates of emotional awareness. J Neurosci 2010, 30:10039-47.
45. Demos KE, Kelley WM, Ryan SL, Davis FC, Whalen PJ: Human amygdala sensitivity to the pupil size of others. Cereb Cortex 2008, 18:2729-34.
46. Mujica-Parodi LR, Strey HH, Frederick B, Savoy R, Cox D, Botanov Y, Tolkunov D, Rubin D, Weber J: Chemosensory cues to conspecific emotional stress activate amygdala in humans. PLoS One 2009, 4:e6415.
47. Engell AD, Haxby JV, Todorov A: Implicit trustworthiness decisions: automatic coding of face properties in the human amygdala. J Cogn Neurosci 2007, 19:1508-19.
48. Said CP, Baron SG, Todorov A: Nonlinear amygdala response to face trustworthiness: contributions of high and low spatial frequency information. J Cogn Neurosci 2009, 21:519-28.