Neural correlates of altered general emotion processing in social anxiety disorder

Brain Research

Volumn 1378, Issue , 2011, Pages 72-83

  Brühl, Annette B ^a   Rufer, Michael ^b   Delsignore, Aba ^b   Kaffenberger, Tina ^a   Jäncke, Lutz ^c   Herwig, Uwe ^a,d  

^a UNIVERSITY HOSPITAL OF PSYCHIATRY   (Switzerland)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Anticipation; Emotion; Extended amygdala; fMRI; Prefrontal cortex; Social anxiety disorder

Indexed keywords

ADULT; AMBIGUOUS EMOTION; AMYGDALOID NUCLEUS; ANTICIPATORY STIMULUS; ANXIETY; AROUSAL; ARTICLE; ASSOCIATION; BECK DEPRESSION INVENTORY; BRAIN FUNCTION; BRAIN REGION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; EMOTION; EMOTION REGULATION QUESTIONNAIRE; EMOTIONAL STIMULUS; EMOTIONALITY; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HUMAN EXPERIMENT; LIEBOWITZ SOCIAL ANXIETY SCALE; NEGATIVE EMOTION; NEUTRAL EMOTION; OCCIPITAL CORTEX; ORBITAL CORTEX; PARIETAL CORTEX; POSITIVE EMOTION; PRIORITY JOURNAL; PSYCHOLOGICAL RATING SCALE; SOCIAL INTERACTION ANXIETY SCALE; SOCIAL PHOBIA; SOCIAL PHOBIA SCALE; STATE TRAIT ANXIETY INVENTORY; STIMULUS; TEMPORAL CORTEX; THALAMUS; VISUAL STIMULATION;

ADULT; ANXIETY DISORDERS; BRAIN; BRAIN MAPPING; EMOTIONS; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; SOCIAL BEHAVIOR;

EID: 79951954134     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2010.12.084     Document Type: Article

References (92)

1. Abler, B., Kessler, H., 2009. Emotion regulation questionnaire - Eine deutschsprachige Fassung des ERQ von Gross und John. Diagnostica 55, 144-152.
2. American Psychiatric Association, 2000. Diagnostic and Statistic Manual of Mental Disorders, 4 ed. American Psychiatric Association, Washington, DC.
3. Annett, M., 1970. A classification of hand preference by association analysis. Br. J. Psychol. 61, 303-321.
4. Aron, A.R., Robbins, T.W., Poldrack, R.A., 2004. Inhibition and the right inferior frontal cortex. Trends Cogn. Sci. 8, 170-177.
5. Barlow, D.H., 2000. Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. Am. Psychol. 55, 1247-1263.
6. Beck, A.T., Ward, C.H., Mendelson, M., Mock, J., Erbaugh, J., 1961. An inventory for measuring depression. Arch. Gen. Psychiatry 4, 561-571.
7. Beck, A.T., Emery, G., Greenberg, R.L., 1985. Anxiety Disorders and Phobias. Basic Books, Inc, New York.
8. Bermpohl, F., Pascual-Leone, A., Amedi, A., Merabet, L.B., Fregni, F., Gaab, N., Alsop, D., Schlaug, G., Northoff, G., 2006. Dissociable networks for the expectancy and perception of emotional stimuli in the human brain. Neuroimage 30, 588-600.
9. Birbaumer, N., Grodd, W., Diedrich, O., Klose, U., Erb, M., Lotze, M., Schneider, F., Weiss, U., Flor, H., 1998. fMRI reveals amygdala activation to human faces in social phobics. NeuroReport 9, 1223-1226. (Pubitemid 28266653)
10. Bogels, S.M., Mansell, W., 2004. Attention processes in the maintenance and treatment of social phobia: hypervigilance, avoidance and self-focused attention. Clin. Psychol. Rev. 24, 827-856.
11. Bradley, B.P., Mogg, K., White, J., Groom, C., de Bono, J., 1999. Attentional bias for emotional faces in generalized anxiety disorder. Br. J. Clin. Psychol. 38 (Pt 3), 267-278.
12. Brühl, A.B., Kaffenberger, T., Herwig, U., 2010. Serotonergic and noradrenergic modulation of emotion processing by single dose antidepressants. Neuropsychopharmacology 35, 521-533.
13. Bush, G., Luu, P., Posner, M.I., 2000. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 4, 215-222.
14. Carleton, R.N., Sharpe, D., Asmundson, G.J., 2007. Anxiety sensitivity and intolerance of uncertainty: requisites of the fundamental fears? Behav. Res. Ther. 45, 2307-2316.
15. Chua, P., Krams, M., Toni, I., Passingham, R., Dolan, R., 1999. A functional anatomy of anticipatory anxiety. Neuroimage 9, 563-571. (Pubitemid 29369882)
16. Constans, J.I., Penn, D.L., Ihen, G.H., Hope, D.A., 1999. Interpretive biases for ambiguous stimuli in social anxiety. Behav. Res. Ther. 37, 643-651.
17. Etkin, A., Wager, T.D., 2007. Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am. J. Psychiatry 164, 1476-1488. (Pubitemid 350069724)
18. Fanselow, M.S., Gale, G.D., 2003. The amygdala, fear, and memory. Ann. NY Acad. Sci. 985, 125-134.
19. Furmark, T., Tillfors, M., Marteinsdottir, I., Fischer, H., Pissiota, A., Langstrom, B., Fredrikson, M., 2002. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch. Gen. Psychiatry 59, 425-433.
20. Garner, M., Möhler, H., Stein, D.J., Mueggler, T., Baldwin, D.S., 2009. Research in anxiety disorders: from the bench to the bedside. Eur. Neuropsychopharmacol. 19, 381-390.
21. Ghashghaei, H.T., Hilgetag, C.C., Barbas, H., 2007. Sequence of information processing for emotions based on the anatomic dialogue between prefrontal cortex and amygdala. Neuroimage 34, 905-923. (Pubitemid 46394469)
22. Goebel, R., Esposito, F., Formisano, E., 2006. Analysis of functional image analysis contest (FIAC) data with brainvoyager QX: from single-subject to cortically aligned group general linear model analysis and self-organizing group independent component analysis. Hum. Brain Mapp. 27, 392-401.
23. Goldin, P.R., Manber, T., Hakimi, S., Canli, T., Gross, J.J., 2009. Neural bases of social anxiety disorder: emotional reactivity and cognitive regulation during social and physical threat. Arch. Gen. Psychiatry 66, 170-180.
24. Graeff, F.G., 2004. Serotonin, the periaqueductal gray and panic. Neurosci. Biobehav. Rev. 28, 239-259.
25. Grefkes, C., Fink, G.R., 2005. The functional organization of the intraparietal sulcus in humans and monkeys. J. Anat. 207, 3-17. (Pubitemid 41025270)
26. Grillon, C., Lissek, S., Rabin, S., McDowell, D., Dvir, S., Pine, D.S., 2008. Increased anxiety during anticipation of unpredictable but not predictable aversive stimuli as a psychophysiologic marker of panic disorder. Am. J. Psychiatry 165, 898-904. (Pubitemid 351948722)
27. Gross, J.J., John, O.P., 2003. Individual differences in two emotion regulation processes: implications for affect, relationships, and well-being. J. Pers. Soc. Psychol. 85, 348-362.
28. Hasler, G., Fromm, S., Alvarez, R.P., Luckenbaugh, D.A., Drevets, W.C., Grillon, C., 2007. Cerebral blood flow in immediate and sustained anxiety. J. Neurosci. 27, 6313-6319. (Pubitemid 46890032)
29. Heimer, L., Van Hoesen, G.W., 2006. The limbic lobe and its output channels: implications for emotional functions and adaptive behavior. Neurosci. Biobehav. Rev. 30, 126-147.
30. Heinrichs, N., Hofmann, S.G., 2001. Information processing in social phobia: a critical review. Clin. Psychol. Rev. 21, 751-770.
31. Herry, C., Bach, D.R., Esposito, F., Di Salle, F., Perrig, W.J., Scheffler, K., Luthi, A., Seifritz, E., 2007. Processing of temporal unpredictability in human and animal amygdala. J. Neurosci. 27, 5958-5966. (Pubitemid 46849758)
32. Herwig, U., Abler, B., Walter, H., Erk, S., 2007a. Expecting unpleasant stimuli - an fMRI study. Psychiatry Res. 154, 1-12. (Pubitemid 46072711)
33. Herwig, U., Kaffenberger, T., Baumgartner, T., Jancke, L., 2007b. Neural correlates of a 'pessimistic' attitude when anticipating events of unknown emotional valence. Neuroimage 34, 848-858.
34. Herwig, U., Brühl, A.B., Kaffenberger, T., Baumgartner, T., Boeker, H., Jäncke, L., 2010. Neural correlates of 'pessimistic' attitude in depression. Psychol. Med. 40, 789-800.
35. Hirsch, C.R., Clark, D.M., 2004. Information-processing bias in social phobia. Clin. Psychol. Rev. 24, 799-825.
36. Hirshfeld-Becker, D.R., Micco, J.A., Simoes, N.A., Henin, A., 2008. High risk studies and developmental antecedents of anxiety disorders. Am. J. Med. Genet. C Semin. Med. Genet. 148, 99-117.
37. John, O.P., Gross, J.J., 2004. Healthy and unhealthy emotion regulation: personality processes, individual differences, and life span development. J. Pers. 72, 1301-1333. (Pubitemid 39558087)
38. Jones, B.E., 2003. Arousal systems. Front. Biosci. 8, s438-s451.
39. Kastner, S., Ungerleider, L.G., 2001. The neural basis of biased competition in human visual cortex. Neuropsychologia 39, 1263-1276. (Pubitemid 32826271)
40. Knutson, B., Fong, G.W., Adams, C.M., Varner, J.L., Hommer, D., 2001. Dissociation of reward anticipation and outcome with event-related fMRI. NeuroReport 12, 3683-3687. (Pubitemid 33105151)
41. Lang, P.J., Bradley, M.M., Cuthbert, B.N., 2005. International Affective Picture System (IAPS): affective ratings of pictures and instruction manual. Technical Report A-6. Center for Research in Psychophysiology, University of Florida, Gainesville, FL.
42. LeDoux, J.E., 2000. Emotion circuits in the brain. Annu. Rev. Neurosci. 23, 155-184.
43. Lee, H.J., Telch, M.J., 2008. Attentional biases in social anxiety: an investigation using the inattentional blindness paradigm. Behav. Res. Ther. 46, 819-835.
44. Levesque, J., Eugene, F., Joanette, Y., Paquette, V., Mensour, B., Beaudoin, G., Leroux, J.-M., Bourgouin, P., Beauregard, M., 2003. Neural circuitry underlying voluntary suppression of sadness. Biol. Psychiatry 53, 502-510. (Pubitemid 36331889)
45. Liebowitz, M.R., 1987. Social phobia. Mod. Probl. Pharmacopsychiatry 22, 141-173.
46. Lorberbaum, J.P., Kose, S., Johnson, M.R., Arana, G.W., Sullivan, L.K., Hamner, M.B., Ballenger, J.C., Lydiard, R.B., Brodrick, P.S., Bohning, D.E., George, M.S., 2004. Neural correlates of speech anticipatory anxiety in generalized social phobia. NeuroReport 15, 2701-2705. (Pubitemid 40070977)
47. Mathews, A., MacLeod, C., 1994. Cognitive approaches to emotion and emotional disorders. Ann. Rev. Psychol. 45, 25-50.
48. Mathews, A., MacLeod, C., 2005. Cognitive vulnerability to emotional disorders. Annu. Rev. Clin. Psychol. 1, 167-195.
49. Mattick, R.P., Clarke, J.C., 1998. Development and validation of measures of social phobia scrutiny fear and social interaction anxiety. Behav. Res. Ther. 36, 455-470.
50. Mesulam, M.M., 1998. From sensation to cognition. Brain 121 (Pt 6), 1013-1052.
51. Milad, M.R., Rauch, S.L., 2007. The role of the orbitofrontal cortex in anxiety disorders. Ann. NY Acad. Sci. 1121, 546-561.
52. Mineka, S., Ohman, A., 2002. Phobias and preparedness: the selective, automatic, and encapsulated nature of fear. Biol. Psychiatry 52, 927-937. (Pubitemid 35356351)
53. Mogg, K., Bradley, B.P., de Bono, J., Painter, M., 1997. Time course of attentional bias for threat information in non-clinical anxiety. Behav. Res. Ther. 35, 297-303.
54. Mogg, K., Philippot, P., Bradley, B.P., 2004. Selective attention to angry faces in clinical social phobia. J. Abnorm. Psychol. 113, 160-165.
55. Mueller, E.M., Hofmann, S.G., Santesso, D.L., Meuret, A.E., Bitran, S., Pizzagalli, D.A., 2009. Electrophysiological evidence of attentional biases in social anxiety disorder. Psychol. Med. 39, 1141-1152.
56. Nakao, T., Sanematsu, H., Yoshiura, T., Togao, O., Murayama, K., Tomita, M., Masuda, Y., Kanba, S., 2011. fMRI of patients with social anxiety disorder during a social situation task. Neurosci. Res. 69, 67-72.
57. Nitschke, J.B., Sarinopoulos, I., Mackiewicz, K.L., Schaefer, H.S., Davidson, R.J., 2006. Functional neuroanatomy of aversion and its anticipation. Neuroimage 29, 106-116. (Pubitemid 41828035)
58. Nitschke, J.B., Sarinopoulos, I., Oathes, D.J., Johnstone, T., Whalen, P.J., Davidson, R.J., Kalin, N.H., 2009. Anticipatory activation in the amygdala and anterior cingulate in generalized anxiety disorder and prediction of treatment response. Am. J. Psychiatry 166, 302-310.
59. Ochsner, K.N., Gross, J.J., 2005. The cognitive control of emotion. Trends Cogn. Sci. 9, 242-249.
60. Ochsner, K.N., Bunge, S.A., Gross, J.J., Gabrieli, J.D.E., 2002. Rethinking feelings: an fMRI study of the cognitive regulation of emotion. J. Cogn. Neurosci. 14, 1215-1229.
61. Paquette, V., Levesque, J., Mensour, B., Leroux, J.M., Beaudoin, G., Bourgouin, P., Beauregard, M., 2003. "Change the mind and you change the brain": effects of cognitive-behavioral therapy on the neural correlates of spider phobia. Neuroimage 18, 401-409.
62. Paxinos, G. (Ed.), 1990. The Human Nervous System. Academic Press, Inc., San Diego, California.
63. Pessoa, L., 2008. On the relationship between emotion and cognition. Nat. Rev. Neurosci. 9, 148-158.
64. Pessoa, L., Adolphs, R., 2010. Emotion processing and the amygdala: from a 'low road' to 'many roads' of evaluating biological significance. Nat. Rev. Neurosci. 11, 773-783.
65. Pessoa, L., Kastner, S., Ungerleider, L.G., 2003. Neuroimaging studies of attention: from modulation of sensory processing to top-down control. J. Neurosci. 23, 3990-3998. (Pubitemid 36958415)
66. Pezze, M.A., Feldon, J., 2004. Mesolimbic dopaminergic pathways in fear conditioning. Prog. Neurobiol. 74, 301-320.
67. Phan, K.L., Fitzgerald, D.A., Nathan, P.J., Tancer, M.E., 2006. Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalized social phobia. Biol. Psychiatry 59, 424-429. (Pubitemid 43289221)
68. Phelps, E.A., LeDoux, J.E., 2005. Contributions of the amygdala to emotion processing: from animal models to human behavior. Neuron 48, 175-187. (Pubitemid 41476352)
69. Phillips, M.L., Drevets, W.C., Rauch, S.L., Lane, R., 2003. Neurobiology of emotion perception I: the neural basis of normal emotion perception. Biol. Psychiatry 54, 504-514. (Pubitemid 37289437)
70. Pujol, J., Harrison, B.J., Ortiz, H., Deus, J., Soriano-Mas, C., Lopez-Sola, M., Yucel, M., Perich, X., Cardoner, N., 2009. Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety. Psychol. Med. 39, 1177-1187.
71. Rapee, R.M., Spence, S.H., 2004. The etiology of social phobia: empirical evidence and an initial model. Clin. Psychol. Rev. 24, 737-767.
72. Rushworth, M.F., Paus, T., Sipila, P.K., 2001. Attention systems and the organization of the human parietal cortex. J. Neurosci. 21, 5262-5271. (Pubitemid 32622951)
73. Saalmann, Y.B., Kastner, S., 2009. Gain control in the visual thalamus during perception and cognition. Curr. Opin. Neurobiol. 19, 408-414.
74. Schienle, A., Schafer, A., Hermann, A., Rohrmann, S., Vaitl, D., 2007. Symptom provocation and reduction in patients suffering from spider phobia: an fMRI study on exposure therapy. Eur. Arch. Psychiatry Clin. Neurosci. 257, 486-493.
75. Schneider, F., Weiss, U., Kessler, C., Muller-Gartner, H.W., Posse, S., Salloum, J.B., Grodd, W., Himmelmann, F., Gaebel, W., Birbaumer, N., 1999. Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol. Psychiatry 45, 863-871. (Pubitemid 29185477)
76. Schneier, F.R., Kent, J.M., Star, A., Hirsch, J., 2009. Neural circuitry of submissive behavior in social anxiety disorder: a preliminary study of response to direct eye gaze. Psychiatry Res. 173, 248-250.
77. Shah, S.G., Klumpp, H., Angstadt, M., Nathan, P.J., Phan, K.L., 2009. Amygdala and insula response to emotional images in patients with generalized social anxiety disorder. J. Psychiatry Neurosci. 34, 296-302.
78. Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., Hergueta, T., Baker, R., Dunbar, G.C., 1998. The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J. Clin. Psychiatry 59, 22-33. (Pubitemid 29001829)
79. Shin, L.M., Liberzon, I., 2009. The neurocircuitry of fear, stress, and anxiety disorders. Neuropsychopharmacology 35, 169-191.
80. Silver, M.A., Ress, D., Heeger, D.J., 2005. Topographic maps of visual spatial attention in human parietal cortex. J. Neurophysiol. 94, 1358-1371. (Pubitemid 41061370)
81. Simmons, A., Strigo, I., Matthews, S.C., Paulus, M.P., Stein, M.B., 2006. Anticipation of aversive visual stimuli is associated with increased insula activation in anxiety-prone subjects. Biol. Psychiatry 60, 402-409. (Pubitemid 44215851)
82. Spielberger, C.D., Gorsuch, R.L., Lushene, R.E., 1970. State-Trait Anxiety Inventory, Manual for the State-Trait-Anxiety Inventory. Consulting Psychologist Press, Palo Alto, CA.
83. Stangier, U., Heidenreich, T., Berardi, A., Golbs, U., Hoyer, J., 1999. Die Erfassung sozialer Phobie durch die Social Interaction Anxiety Scale (SIAS) und die Social Phobia Scale (SPS). Z. Klin. Psychol. 28, 28-36.
84. Stein, M.B., Goldin, P.R., Sareen, J., Zorrilla, L.T.E., Brown, G.G., 2002. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch. Gen. Psychiatry 59, 1027-1034.
85. Stein, M.B., Simmons, A.N., Feinstein, J.S., Paulus, M.P., 2007. Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. Am. J. Psychiatry 164, 318-327.
86. Straube, T., Mentzel, H.J., Miltner, W.H., 2007. Waiting for spiders: brain activation during anticipatory anxiety in spider phobics. Neuroimage 37, 1427-1436. (Pubitemid 47385286)
87. Summerfield, C., Egner, T., 2009. Expectation (and attention) in visual cognition. Trends Cogn. Sci. 13, 403-409.
88. Talairach, J., Tournoux, P., 1988. Co-planar Stereotaxic Atlas of the Human Brain: Three-dimensional Proportional System. Thieme Medical, New York.
89. Tillfors, M., Furmark, T., Marteinsdottir, I., Fischer, H., Pissiota, A., Langstrom, B., Fredrikson, M., 2001. Cerebral blood flow in subjects with social phobia during stressful speaking tasks: a PET study. Am. J. Psychiatry 158, 1220-1226. (Pubitemid 32717694)
90. Tillfors, M., Furmark, T., Marteinsdottir, I., Fredrikson, M., 2002. Cerebral blood flow during anticipation of public speaking in social phobia: a PET study. Biol. Psychiatry 52, 1113-1119. (Pubitemid 35379968)
91. Ueda, K., Okamoto, Y., Okada, G., Yamashita, H., Hori, T., Yamawaki, S., 2003. Brain activity during expectancy of emotional stimuli: an fMRI study. NeuroReport 14, 51-55. (Pubitemid 36160741)
92. Yoon, K.L., Zinbarg, R.E., 2007. Threat is in the eye of the beholder: social anxiety and the interpretation of ambiguous facial expressions. Behav. Res. Ther. 45, 839-847.