Striatal Function in Generalized Social Phobia: A Functional Magnetic Resonance Imaging Study

Biological Psychiatry

Volumn 61, Issue 3, 2007, Pages 396-404

  Sareen, Jitender ^a   Campbell, Darren W ^a   Leslie, William D ^a   Malisza, Krisztina L ^b   Stein, Murray B ^c   Paulus, Martin P ^c   Kravetsky, Laura B ^a   Kjernisted, Kevin D ^a   Walker, John R ^a   Reiss, Jeffrey P ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anxiety; caudate nucleus; functional magnetic resonance imaging; putamen; social phobia; striatum

Indexed keywords

ADULT; ARTICLE; BEHAVIOR; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; CLINICAL ARTICLE; COGNITION; COMPARATIVE STUDY; CONTROLLED STUDY; CORPUS STRIATUM; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INSULA; LEARNING TEST; MALE; PARIETAL LOBE; PRIORITY JOURNAL; RELIABILITY; SOCIAL PHOBIA; STATISTICAL SIGNIFICANCE;

EID: 33846258179     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.05.043     Document Type: Article

References (76)

1. American Psychiatric Association. Diagnostic and Statistical Manual for Mental Disorders. 4th ed. (1994), Author, Washington, DC
2. Amir N., Klumpp H., Elias J., Bedwell J.S., Yanasak N., and Miller L.S. Increased activation of the anterior cingulate cortex during processing of disgust faces in individuals with social phobia. Biol Psychiatry 57 (2005) 975-981
3. Amso D., Davidson M.C., Johnson S.P., Glover G., and Casey B.J. Contributions of the hippocampus and the striatum to simple association and frequency-based learning. Neuroimage 27 (2005) 291-298
4. Argyropoulos S.V., Bell C.J., and Nutt D.J. Brain function in social anxiety disorder. Psychiatr Clin North Am 24 (2001) 707-722
5. Armony J.L., Corbo V., Clement M.H., and Brunet A. Amygdala response in patients with acute PTSD to masked and unmasked emotional facial expressions. Am J Psychiatry 162 (2005) 1961-1963
6. Barnes T.D., Kubota T., Hu D., Jin D.Z., and Graybiel A.M. Activity of striatal neurons reflects dynamic encoding and recoding of procedural memories. Nature 437 (2005) 1158-1161
7. Beck A.T., Ward C.H., Mendelson M., Mock J., and Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 4 (1961) 561-571
8. Biederman J., Hirshfeld-Becker D.R., Rosenbaum J.F., Herot C., Friedman D., Snidman N., et al. Further evidence of association between behavioral inhibition and social anxiety in children. Am J Psychiatry 158 (2001) 1673-1679
9. Birbaumer N., Grodd W., Diedrich O., Klose U., Erb M., Lotze M., et al. fMRI reveals amygdala activation to human faces in social phobics. Neuroreport 9 (1998) 1223-1226
10. Charney D.S. Discovering the neural basis of human social anxiety: A diagnostic and therapeutic imperative. Am J Psychiatry 161 (2004) 1-2
11. Chartier M.J., Walker J.R., and Stein M.B. Social phobia and potential childhood risk factors in a community sample. Psychol Med 31 (2001) 307-315
12. Clark D.M., and McManus F. Information processing in social phobia. Biol Psychiatry 51 (2002) 92-100
13. Cohen M.S., and Dubois R.M. Stability, repeatability, and the expression of signal magnitude in functional magnetic resonance imaging. J Magn Reson Imaging 10 (1999) 33-40
14. Coull J.T., Frith C.D., Frackowiak R.S., and Grasby P.M. A fronto-parietal network for rapid visual information processing: A PET study of sustained attention and working memory. Neuropsychologia 34 (1996) 1085-1095
15. Cox R.W. AFNI: Software for analysis and visualization of functional magnetic resonance neuroimages. Comp Biomed Res 29 (1996) 162-173
16. Deckersbach T., Savage C.R., Curran T., Bohne A., Wilhelm S., Baer L., et al. A study of parallel implicit and explicit information processing in patients with obsessive-compulsive disorder. Am J Psychiatry 159 (2002) 1780-1782
17. Downar J., Crawley A.P., Mikulis D.J., and Davis K.D. The effect of task relevance on the cortical response to changes in visual and auditory stimuli: An event-related fMRI study. Neuroimage 14 (2001) 1256-1267
18. Fink G.R., Halligan P.W., Marshall J.C., Frith C.D., Frackowiak R.S., and Dolan R.J. Where in the brain does visual attention select the forest and the trees?. Nature 382 (1996) 626-628
19. Frensch P.A., and Runger D. Implicit learning. Curr Dir Psychol Sci 12 (2003) 13-18
20. Fujii N., and Graybiel A.M. Time-varying covariance of neural activities recorded in striatum and frontal cortex as monkeys perform sequential-saccade tasks. Proc Natl Acad Sci U S A 102 (2005) 9032-9037
21. Furmark T., Appel L., Michelgard A., Wahlsteadt K., Ahs F., Zancan S., et al. Cerebral blood flow changes after treatment of social phobia with the neurokinin-1 antagonist GR205171, citalopram, or placebo. Biol Psychiatry 58 (2005) 132-142
22. Furmark T., Tillfors M., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., et al. Common changes in cerebral blood flow in patients with social phobia treated with citalopram or cognitive-behavioral therapy. Arch Gen Psychiatry 56 (2002) 425-433
23. Garavan H., Ross T.J., and Stein E.A. Right hemispheric dominance of inhibitory control: An event-related functional MRI study. Proc Natl Acad Sci U S A 96 (1999) 8301-8306
24. Grafton S.T., Hazeltine E., and Ivry R. Functional mapping of sequence learning in normal humans. J Cogn Neurosci 7 (1995) 497-510
25. Grant K.A., Shively C.A., Nader M.A., Ehrenkaufer R.L., Line S.W., Morton T.E., et al. Effect of social status on striatal dopamine D2 receptor binding characteristics in cynmolgus monkeys assessed with positron emission tomography. Synapse 29 (1998) 80-83
26. Heimberg R.G., Horner K.J., Juster H.R., Safren S.A., Brown E.J., Schneier F.R., et al. Psychometric properties of the Liebowitz Social Anxiety Scale. Psychol Med 29 (1999) 199-212
27. Hettema J.M., Prescott C.A., Myers J.M., Neale M.C., and Kendler K.S. The structure of genetic and environmental risk factors for anxiety disorders in men and women. Arch Gen Psychiatry 62 (2005) 182-189
28. Hopfinger J.B., Buonocore M.H., and Mangun G.R. The neural mechanisms of topdown attentional control. Nature Neurosci 3 (2000) 284-291
29. Jacobi F., Wittchen H.U., Holting C., Hofler M., Pfister H., Muller N., et al. Prevalence, co-morbidity and correlates of mental disorders in the general population: Results from the German Health Interview and Examination Survey (GHS). Psychol Med 34 (2004) 597-611
30. Kessler R.C., Berglund P., Demler O., Jin R., and Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62 (2005) 593-602
31. Kessler R.C., Chiu W.T., Demler O., and Walters E.E. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62 (2005) 617-627
32. Kessler R.C., Stein M.B., and Berglund P.A. Social phobia subtypes in the National Comorbidity Survey. Am J Psychiatry 155 (1998) 613-619
33. Kim J.S., Reading S.A., Brashers-Krug T., Calhoun V.D., Ross C.A., and Pearlson G.D. Functional MRI study of a serial reaction time task in Huntington's disease. Psychiatry Res 131 (2004) 23-30
34. Kumari V., Gray J.A., Honey G.D., Soni W., Bullmore E.T., Williams S.C., et al. Procedural learning in schizophrenia: A functional magnetic resonance imaging investigation. Schizophr Res 57 (2002) 97-101
35. Lorberbaum J.P., Kose S., Johnson M.R., Arana G.W., Sullivan L.K., Hamner M.B., et al. Neural correlates of speech anticipatory anxiety in generalized social phobia. Neuroreport 15 (2004) 2701-2705
36. Lundh L.G., and Ost L.G. Explicit and implicit memory bias in social phobia. The role of subdiagnostic type. Behav Res Ther 35 (1997) 305-317
37. Magee W.J., Eaton W.W., Wittchen H.U., McGonagle K.A., and Kessler R.C. Agoraphobia, simple phobia, and social phobia in the National Comorbidity Survey. Arch Gen Psychiatry 53 (1996) 159-168
38. Martis B., Wright C.I., McMullin K.G., Shin L.M., and Rauch S.L. Functional magnetic resonance imaging evidence for a lack of striatal dysfunction during implicit sequence learning in individuals with animal phobia. Am J Psychiatry 161 (2004) 67-71
39. Mataix-Cols D., Cullen S., Lange K., Zelaya F., Andrew C., Amaro E., et al. Neural correlates of anxiety associated with obsessive-compulsive symptom dimensions in normal volunteers. Biol Psychiatry 53 (2003) 482-493
40. Mathew S.J., Coplan J.D., and Gorman J.M. Neurobiological mechanisms of social anxiety disorder. Am J Psychiatry 158 (2001) 1558-1567
41. Mendlowicz M.V., and Stein M.B. Quality of life in individuals with anxiety disorders. Am J Psychiatry 157 (2000) 669-682
42. Mikkelsen E.J., Detlor J., and Cohen D.J. School avoidance and social phobia triggered by haloperidol in patients with Tourette's disorder. Am J Psychiatry 138 (1981) 1572-1576
43. Nissen M.J., and Bullemer P. Attentional requirement of learning: Evidence from performance measures. Cogn Psychol 19 (1987) 1-32
44. O'Doherty J., Dayan P., Schultz J., Deichmann R., Friston K., and Dolan R.J. Dissociable roles of ventral and dorsal striatum in instrumental conditioning. Science 304 (2004) 452-454
45. Phan K.L., Fitzgerald D.A., Nathan P.J., and Tancer M.E. Association between amygdala hyperactivity faces and severity of social anxiety in generalized social phobia. Biol Psychiatry 59 (2005) 424-429
46. Pineles S.L., and Mineka S. Attentional biases to internal and external sources of potential threat in social anxiety. J Abnorm Psychol 114 (2005) 314-318
47. Rauch S.L., and Savage C.R. Neuroimaging and neuropsychology of the striatum. Bridging basic science and clinical practice. Psychiatr Clin North Am 20 (1997) 741-768
48. Rauch S.L., Savage C.R., Alpert N.M., Dougherty D., Kendrick A., Curran T., et al. Probing striatal function in obsessive-compulsive disorder: A PET study of implicit sequence learning. J Neuropsychiatry Clin Neurosci 9 (1997) 568-573
49. Rauch S.L., Whalen P.J., Curran T., Shin L.M., Coffey B.J., Savage C.R., et al. Probing striato-thalamic function in obsessive-compulsive disorder and Tourette syndrome using neuroimaging methods. Adv Neurol 85 (2001) 207-224
50. Rauch S.L., Whalen P.J., Savage C.R., Curran T., Kendrick A., Brown H.D., et al. Striatal recruitment during an implicit sequence learning task as measured by functional magnetic resonance imaging. Hum Brain Mapp 5 (1997) 124-132
51. Reiss JP, Campbell DW, Leslie WD, Paulus MP, Ryner L, Polimeni JO, Foot BJ, Sareen J (in press): Deficit in schizophrenia to recruit the striatum in implicit learning: A functional magnetic resonance imaging investigation. Schizophrenia Res.
52. Reiss J.P., Campbell D.W., Leslie W.D., Paulus M.P., Stroman P.W., Polimeni J.O., et al. The role of the striatum in implicit learning: A functional magnetic resonance imaging study. Neuroreport 16 (2005) 1291-1295
53. Rodriguez P.F., Aron A.R., and Poldrack R.A. Ventral-striatal/nucleus-accumbens sensitivity to prediction errors during classification learning. Hum Brain Mapp 27 (2005) 306-313
54. Rogan M.T., Leon K.S., Perez D.L., and Kandel E.R. Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron 46 (2005) 309-320
55. Sakai Y., Kumano H., Nishikawa M., Sakano Y., Kaiya H., Imabayashi E., et al. Cerebral glucose metabolism associated with a fear network in panic disorder. Neuroreport 16 (2005) 927-931
56. Schendan H.E., Searl M.M., Melrose R.J., and Stern C.E. An FMRI study of the role of the medial temporal lobe in implicit and explicit sequence learning. Neuron 37 (2003) 1013-1025
57. Scherer H., Stip E., Paquet F., and Bedard M.A. Mild procedural learning disturbances in neuroleptic-naive patients with schizophrenia. J Neuropsychiatry Clin Neurosci 15 (2003) 58-63
58. Schneider F., Weiss U., Kessler C., Muller-Gartner H.-W., Posse S., Salloum J.B., et al. Subcortical correlates of differential classical conditioning of aversive emotional reactions in social phobia. Biol Psychiatry 45 (1999) 863-871
59. Schneier F.R., Liebowitz M.R., Abi-Dargham A., Zea-Ponce Y., Lin S.H., and Laruelle M. Low dopamine D(2) receptor binding potential in social phobia. Am J Psychiatry 157 (2000) 457-459
60. Sheehan D.V., Lecrubier Y., Sheehan K.H., Amorim P., Janavs J., Weiller E., et al. The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry 59 suppl 20 (1998) 22-33
61. Shin L.M., Wright C.I., Cannisstraro P.A., Wedig M.M., McMullin K., Martis B., et al. A functional magnetic resonance imaging study of amygdala and medial prefrontal cortex responses to overtly presented fearful faces in posttraumatic stress disorder. Arch Gen Psychiatry 62 (2005) 273-281
62. Spielberger C.D., Gorsuch R.L., and Lushene R.E. Manual for the State-Trait Anxiety Inventory (1970), Consulting Psychologist Press, Palo Alto, CA
63. SPSS 10th edition (1999). Chicago, IL: SPSS.
64. Stein M.B., Chartier M.J., Hazen A.L., Kozak M.V., Tancer M.E., Lander S., et al. A direct-interview family study of generalized social phobia. Am J Psychiatry 155 (1998) 90-97
65. Stein M.B., Goldin P.R., Sareen J., Zorrilla L.T., and Brown G.G. Increased amygdala activation to angry and contemptuous faces in generalized social phobia. Arch Gen Psychiatry 59 (2002) 1027-1034
66. Stein M.B., Heuser I.J., Juncos J.L., and Uhde T.W. Anxiety disorders in patients with Parkinson's disease. Am J Psychiatry 147 (1990) 217-220
67. Stein M.B., and Kean Y.M. Disability and quality of life in social phobia: Epidemiologic findings. Am J Psychiatry 157 (2000) 1606-1613
68. Stein M.B., Torgrud L.J., and Walker J.W. Social phobia symptoms, subtypes, and severity: Findings from a community survey. Arch Gen Psychiatry 57 (2000) 1046-1052
69. Straube T., Kolassa I.T., Glauer M., Mentzel H.J., and Miltner W.H. Effect of task conditions on brain responses to threatening faces in social phobics: An event-related functional magnetic resonance imaging study. Biol Psychiatry 56 (2004) 921-930
70. Straube T., Mentzel H.J., and Miltner W.H. Common and distinct brain activation to threat and safety signals in social phobia. Neuropsychobiology 52 (2005) 163-168
71. Thomas K.M., Hunt R.H., Vizuetta N., Sommer T., Durston S., Yang Y., et al. Evidence of developmental differences in implicit sequence learning: an fMRI study of children and adults. J Cogn Neurosci 16 (2004) 1339-1351
72. Thomas S.A., Friedmann E., Wimbush F., and Schron E. Psychological factors and survival in the cardiac arrhythmia suppression trial (CAST): A reexamination. Am J Clin Care 6 (1997) 116-126
73. Tiihonen J., Kuikka J., Bergstrom K., Lepola U., Koponen H., and Leinonen E. Dopamine reuptake site densities in patients with social phobia. Am J Psychiatry 154 (1997) 239-242
74. Tillfors M., Furmark T., Marteinsdottir I., Fischer H., Pissiota A., Langstrom B., et al. Cerebral blood flow during anticipation of public speaking in social phobia: A PET study. Biol Psychiatry 52 (2002) 1113-1119
75. van den Heuvel O.A., Veltman D.J., Groenewegen H.J., Dolan R.J., Cath D.C., Boellaard R., et al. Amygdala activity in obsessive-compulsive disorder with contamination fear: A study with oxygen-15 water positron emission tomography. Psychiatry Res 132 (2004) 225-237
76. Willingham D.B., Nissen M.J., and Bullemer P. On the development of procedural knowledge. J Exp Psychol Learn Mem Cogn 15 (1989) 1047-1060