Use of a Small Peptide Fragment as an Inhibitor of Insulin Fibrillation Process: A Study by High and Low Resolution Spectroscopy

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Banerjee, Victor ^a   Kar, Rajiv K ^a   Datta, Aritreyee ^a   Parthasarathi, Krupakar ^b   Chatterjee, Subhrangsu ^a   Das, Kali P ^a   Bhunia, Anirban ^a  

^a BOSE INSTITUTE   (India)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARAGINYLISOLEUCYLVALYLASPARAGINYLVALYLSERYLLEUCYLVALYLLYCINE; INSULIN; PEPTIDE FRAGMENT; PHENYLALANINE; THIOFLAVINE; TYROSINE; UNCLASSIFIED DRUG;

ALPHA HELIX; ANALYTIC METHOD; ANISOTROPY; ARTICLE; BINDING SITE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOTOXICITY TEST; FLUORESCENCE ANALYSIS; GEL PERMEATION CHROMATOGRAPHY; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; INFRARED SPECTROSCOPY; INSULIN FIBRILLATION METHOD; LIGHT SCATTERING; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; PEPTIDE ANALYSIS; PH MEASUREMENT; PROTEIN SECONDARY STRUCTURE; RESIDUE ANALYSIS; STRUCTURE ANALYSIS; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; BINDING SITES; CATTLE; CHROMATOGRAPHY, GEL; CIRCULAR DICHROISM; HEMOLYSIS; HUMANS; INSULIN; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PARTICLE SIZE; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS; THIAZOLES;

EID: 84883226851     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0072318     Document Type: Article

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