Loss of Nav1.5 expression and function in murine atria containing the RyR2-P2328S gain-of-function mutation

Cardiovascular Research

Volumn 99, Issue 4, 2013, Pages 751-759

  King, James H ^a   Wickramarachchi, Chandu ^a   Kua, Krystine ^a   Du, Yuan ^b   Jeevaratnam, Kamalan ^c   Matthews, Hugh R ^a   Grace, Andrew A ^a   Huang, Christopher L H ^a   Fraser, James A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^c ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

Atrial fibrillation; Calcium; Catecholaminergic polymorphic ventricular tachycardia; Conduction velocity; Ryanodine receptor

Indexed keywords

CAFFEINE; CALCIUM ION; CONNEXIN 40; CONNEXIN 43; CYCLOPIAZONIC ACID; DYE; PICROSIRIUS RED; PROLINE; RYANODINE RECEPTOR 2; SERINE; SODIUM CHANNEL NAV1.5; SODIUM ION; UNCLASSIFIED DRUG; CALCIUM; GAP JUNCTION PROTEIN; RYANODINE RECEPTOR; SCN5A PROTEIN, MOUSE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; DIASTOLE; ELECTRIC POTENTIAL; EXTRACELLULAR MATRIX; FEMALE; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENOTYPE; HEART; HEART ATRIUM; HEART ATRIUM CONDUCTION; HEART ATRIUM CONDUCTION VELOCITY; HEART DEPOLARIZATION; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE FIBROSIS; IMMUNOBLOTTING; MALE; MEASUREMENT; MICROELECTRODE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN FUNCTION; SODIUM CURRENT; STAINING; WILD TYPE; ANIMAL; ARRHYTHMIAS, CARDIAC; GENETICS; HEART ATRIUM FUNCTION; HEART MUSCLE CONDUCTION SYSTEM; METABOLISM; MUTATION; PHYSIOLOGY; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONDUCTION VELOCITY; HEART ARRHYTHMIA; HEART ATRIUM FIBRILLATION;

ANIMALS; ARRHYTHMIAS, CARDIAC; ATRIAL FUNCTION; CALCIUM; CONNEXIN 43; CONNEXINS; HEART ATRIA; HEART CONDUCTION SYSTEM; MICE; MUTATION; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL;

ATRIAL FIBRILLATION; CALCIUM; CATECHOLAMINERGIC POLYMORPHIC VENTRICULAR TACHYCARDIA; CONDUCTION VELOCITY; RYANODINE RECEPTOR;

EID: 84883225664     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt141     Document Type: Article

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