The Age-dependence of atrial arrhythmogenicity in Scn5a +/-murine hearts reflects alterations in action potential propagation and recovery

Clinical and Experimental Pharmacology and Physiology

Volumn 39, Issue 6, 2012, Pages 518-527

  Guzadhur, Laila ^a   Jiang, Wenhui ^c   Pearcey, Sarah M ^a   Jeevaratnam, Kamalan ^a,d   Duehmke, Rudy M ^a   Grace, Andrew A ^a   Lei, Ming ^b   Huang, Christopher L H ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MEDICAL SCHOOL OF XI AN JIAOTONG UNIVERSITY   (China)

^d PERDANA UNIVERSITY   (Malaysia)

Author keywords

Age; Atrial arrhythmia; Brugada syndrome; Na+ channel; Remodelling; Scn5a +

Indexed keywords

SODIUM CHANNEL NAV1.5;

ACTION POTENTIAL; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARRHYTHMOGENESIS; ARTICLE; ATRIAL ARRHYTHMOGENICITY; BRUGADA SYNDROME; ELECTRIC ACTIVITY; ELECTROSTIMULATION; EXTRASYSTOLE; GENOTYPE; HEART; HEART ATRIUM ARRHYTHMIA; HEART ATRIUM PACING; HEART ELECTROPHYSIOLOGY; HEART RATE; HEART REPOLARIZATION; ISOLATED HEART; LOSS OF FUNCTION MUTATION; MOUSE; NONHUMAN;

ACTION POTENTIALS; AGE FACTORS; AGING; ANIMALS; BRUGADA SYNDROME; HEART; MICE; MICE, 129 STRAIN; MICE, TRANSGENIC; NAV1.5 VOLTAGE-GATED SODIUM CHANNEL; ORGAN CULTURE TECHNIQUES; RECOVERY OF FUNCTION;

EID: 84861656136     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2012.05706.x     Document Type: Article

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