메뉴 건너뛰기




Volumn 40, Issue 4, 2013, Pages 421-428

The molecular biology of renal cell carcinoma

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; VASCULOTROPIN; VON HIPPEL LINDAU PROTEIN;

EID: 84883195289     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2013.05.006     Document Type: Article
Times cited : (43)

References (76)
  • 2
    • 0035818877 scopus 로고    scopus 로고
    • Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer
    • R.C. Flanigan, S.E. Salmon, and B.A. Blumenstein Nephrectomy followed by interferon alfa-2b compared with interferon alfa-2b alone for metastatic renal-cell cancer N Engl J Med 345 23 2001 1655 1659
    • (2001) N Engl J Med , vol.345 , Issue.23 , pp. 1655-1659
    • Flanigan, R.C.1    Salmon, S.E.2    Blumenstein, B.A.3
  • 3
    • 0035934596 scopus 로고    scopus 로고
    • Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: A randomised trial
    • G.H. Mickisch, A. Garin, H. van Poppel, L. de Prijck, and R. Sylvester Radical nephrectomy plus interferon-alfa-based immunotherapy compared with interferon alfa alone in metastatic renal-cell carcinoma: a randomised trial Lancet 358 9286 2001 966 970
    • (2001) Lancet , vol.358 , Issue.9286 , pp. 966-970
    • Mickisch, G.H.1    Garin, A.2    Van Poppel, H.3    De Prijck, L.4    Sylvester, R.5
  • 4
    • 78650027911 scopus 로고    scopus 로고
    • The impact of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor targeted therapy
    • T.K. Choueiri, W. Xie, and C. Kollmannsberger The impact of cytoreductive nephrectomy on survival of patients with metastatic renal cell carcinoma receiving vascular endothelial growth factor targeted therapy J Urol 185 1 2011 60 66
    • (2011) J Urol , vol.185 , Issue.1 , pp. 60-66
    • Choueiri, T.K.1    Xie, W.2    Kollmannsberger, C.3
  • 5
    • 43249095919 scopus 로고    scopus 로고
    • Tumor angiogenesis
    • R.S. Kerbel Tumor angiogenesis N Engl J Med 358 19 2008 2039 2049
    • (2008) N Engl J Med , vol.358 , Issue.19 , pp. 2039-2049
    • Kerbel, R.S.1
  • 6
    • 77952248366 scopus 로고    scopus 로고
    • Epidemiology and risk factors for kidney cancer. Nature reviews
    • W.H. Chow, L.M. Dong, and S.S. Devesa Epidemiology and risk factors for kidney cancer. Nature reviews Urology 7 5 2010 245 257
    • (2010) Urology , vol.7 , Issue.5 , pp. 245-257
    • Chow, W.H.1    Dong, L.M.2    Devesa, S.S.3
  • 7
    • 0027240519 scopus 로고
    • Identification of the von Hippel-Lindau disease tumor suppressor gene
    • F. Latif, K. Tory, and J. Gnarra Identification of the von Hippel-Lindau disease tumor suppressor gene Science 260 5112 1993 1317 1320
    • (1993) Science , vol.260 , Issue.5112 , pp. 1317-1320
    • Latif, F.1    Tory, K.2    Gnarra, J.3
  • 8
    • 0000020119 scopus 로고
    • Intra-ocular growths (two cases, brother and sister, with peculiar vascular new growth, probably retinal, affecting both eyes)
    • E.T. Collins Intra-ocular growths (two cases, brother and sister, with peculiar vascular new growth, probably retinal, affecting both eyes) Trans Ophthalmol Soc UK 14 1894 141 149
    • (1894) Trans Ophthalmol Soc UK , vol.14 , pp. 141-149
    • Collins, E.T.1
  • 9
    • 34347163881 scopus 로고
    • Ueber eine sehr seltene Erkrankung der Nethaut
    • E. von Hippel Ueber eine sehr seltene Erkrankung der Nethaut Graefe Arch Ophthalmol 59 1904 83 106
    • (1904) Graefe Arch Ophthalmol , vol.59 , pp. 83-106
    • Von Hippel, E.1
  • 10
    • 0000768725 scopus 로고
    • Zur Frage der Angiomatosis Retinae und Ihrer Hirncomplikation
    • A. Lindau Zur Frage der Angiomatosis Retinae und Ihrer Hirncomplikation Acta Opthalmol 4 1927 193 226
    • (1927) Acta Opthalmol , vol.4 , pp. 193-226
    • Lindau, A.1
  • 12
    • 0023181644 scopus 로고
    • Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma
    • B. Zbar, H. Brauch, C. Talmadge, and M. Linehan Loss of alleles of loci on the short arm of chromosome 3 in renal cell carcinoma Nature 327 6124 1987 721 724
    • (1987) Nature , vol.327 , Issue.6124 , pp. 721-724
    • Zbar, B.1    Brauch, H.2    Talmadge, C.3    Linehan, M.4
  • 13
    • 0023865666 scopus 로고
    • Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma
    • B.R. Seizinger, G.A. Rouleau, and L.J. Ozelius Von Hippel-Lindau disease maps to the region of chromosome 3 associated with renal cell carcinoma Nature 332 6161 1988 268 269
    • (1988) Nature , vol.332 , Issue.6161 , pp. 268-269
    • Seizinger, B.R.1    Rouleau, G.A.2    Ozelius, L.J.3
  • 14
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • O. Iliopoulos, A. Kibel, S. Gray, and W.G. Kaelin Jr Tumour suppression by the human von Hippel-Lindau gene product Nat Med 1 8 1995 822 826
    • (1995) Nat Med , vol.1 , Issue.8 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin, Jr.W.G.4
  • 15
    • 51749113159 scopus 로고    scopus 로고
    • Germline SDHB mutations and familial renal cell carcinoma
    • C. Ricketts, E.R. Woodward, and P. Killick Germline SDHB mutations and familial renal cell carcinoma J Natl Cancer Inst 100 17 2008 1260 1262
    • (2008) J Natl Cancer Inst , vol.100 , Issue.17 , pp. 1260-1262
    • Ricketts, C.1    Woodward, E.R.2    Killick, P.3
  • 16
    • 79956317112 scopus 로고    scopus 로고
    • Von Hippel-Lindau disease: A clinical and scientific review
    • E.R. Maher, H.P. Neumann, and S. Richard von Hippel-Lindau disease: a clinical and scientific review Eur J Hum Genet 19 6 2011 617 623
    • (2011) Eur J Hum Genet , vol.19 , Issue.6 , pp. 617-623
    • Maher, E.R.1    Neumann, H.P.2    Richard, S.3
  • 17
    • 0033776536 scopus 로고    scopus 로고
    • Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
    • M. Ohh, C.W. Park, and M. Ivan Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein Nature Cell Biol 2 7 2000 423 427
    • (2000) Nature Cell Biol , vol.2 , Issue.7 , pp. 423-427
    • Ohh, M.1    Park, C.W.2    Ivan, M.3
  • 18
    • 0034641615 scopus 로고    scopus 로고
    • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
    • T. Kamura, S. Sato, K. Iwai, M. Czyzyk-Krzeska, R.C. Conaway, and J.W. Conaway Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex Proc Natl Acad Sci U S A 97 19 2000 10430 10435
    • (2000) Proc Natl Acad Sci U S A , vol.97 , Issue.19 , pp. 10430-10435
    • Kamura, T.1    Sato, S.2    Iwai, K.3    Czyzyk-Krzeska, M.4    Conaway, R.C.5    Conaway, J.W.6
  • 19
    • 0034663894 scopus 로고    scopus 로고
    • Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
    • K. Tanimoto, Y. Makino, T. Pereira, and L. Poellinger Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein EMBO J 19 16 2000 4298 4309
    • (2000) EMBO J , vol.19 , Issue.16 , pp. 4298-4309
    • Tanimoto, K.1    Makino, Y.2    Pereira, T.3    Poellinger, L.4
  • 20
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • M.E. Cockman, N. Masson, and D.R. Mole Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein J Biol Chem 275 33 2000 25733 25741
    • (2000) J Biol Chem , vol.275 , Issue.33 , pp. 25733-25741
    • Cockman, M.E.1    Masson, N.2    Mole, D.R.3
  • 21
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • W.G. Kaelin Jr Molecular basis of the VHL hereditary cancer syndrome Nat Rev Cancer 2 9 2002 673 682
    • (2002) Nat Rev Cancer , vol.2 , Issue.9 , pp. 673-682
    • Kaelin, Jr.W.G.1
  • 22
    • 0036883554 scopus 로고    scopus 로고
    • Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney
    • M. Yoshida, M. Yao, and I. Ishikawa Somatic von Hippel-Lindau disease gene mutation in clear-cell renal carcinomas associated with end-stage renal disease/acquired cystic disease of the kidney Genes Chromosomes Cancer 35 4 2002 359 364
    • (2002) Genes Chromosomes Cancer , vol.35 , Issue.4 , pp. 359-364
    • Yoshida, M.1    Yao, M.2    Ishikawa, I.3
  • 23
    • 33644510421 scopus 로고    scopus 로고
    • Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer
    • R.E. Banks, P. Tirukonda, and C. Taylor Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer Cancer Res 66 4 2006 2000 2011
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2000-2011
    • Banks, R.E.1    Tirukonda, P.2    Taylor, C.3
  • 24
    • 0027954044 scopus 로고
    • Mutations of the VHL tumour suppressor gene in renal carcinoma
    • J.R. Gnarra, K. Tory, and Y. Weng Mutations of the VHL tumour suppressor gene in renal carcinoma Nat Genet 7 1 1994 85 90
    • (1994) Nat Genet , vol.7 , Issue.1 , pp. 85-90
    • Gnarra, J.R.1    Tory, K.2    Weng, Y.3
  • 25
    • 16744366213 scopus 로고    scopus 로고
    • VHL alterations in human clear cell renal cell carcinoma: Association with advanced tumor stage and a novel hot spot mutation
    • H. Brauch, G. Weirich, and J. Brieger VHL alterations in human clear cell renal cell carcinoma: association with advanced tumor stage and a novel hot spot mutation Cancer Res 60 7 2000 1942 1948
    • (2000) Cancer Res , vol.60 , Issue.7 , pp. 1942-1948
    • Brauch, H.1    Weirich, G.2    Brieger, J.3
  • 26
    • 51049084870 scopus 로고    scopus 로고
    • Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors
    • M.L. Nickerson, E. Jaeger, and Y. Shi Improved identification of von Hippel-Lindau gene alterations in clear cell renal tumors Clin Cancer Res 14 15 2008 4726 4734
    • (2008) Clin Cancer Res , vol.14 , Issue.15 , pp. 4726-4734
    • Nickerson, M.L.1    Jaeger, E.2    Shi, Y.3
  • 27
    • 24344452947 scopus 로고    scopus 로고
    • The VHL tumor suppressor in development and disease: Functional studies in mice by conditional gene targeting
    • V.H. Haase The VHL tumor suppressor in development and disease: functional studies in mice by conditional gene targeting Semin Cell Dev Biol 16 4-5 2005 564 574
    • (2005) Semin Cell Dev Biol , vol.16 , Issue.45 , pp. 564-574
    • Haase, V.H.1
  • 28
    • 64949107042 scopus 로고    scopus 로고
    • VHL type 2B gene mutation moderates HIF dosage in vitro and in vivo
    • C.M. Lee, M.M. Hickey, and C.A. Sanford VHL type 2B gene mutation moderates HIF dosage in vitro and in vivo Oncogene 28 14 2009 1694 1705
    • (2009) Oncogene , vol.28 , Issue.14 , pp. 1694-1705
    • Lee, C.M.1    Hickey, M.M.2    Sanford, C.A.3
  • 29
    • 0036528246 scopus 로고    scopus 로고
    • Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein
    • K. Kondo, J. Klco, E. Nakamura, M. Lechpammer, and W.G. Kaelin Jr Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein Cancer Cell 1 3 2002 237 246
    • (2002) Cancer Cell , vol.1 , Issue.3 , pp. 237-246
    • Kondo, K.1    Klco, J.2    Nakamura, E.3    Lechpammer, M.4    Kaelin, Jr.W.G.5
  • 30
    • 2342597973 scopus 로고    scopus 로고
    • Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth
    • K. Kondo, W.Y. Kim, M. Lechpammer, and W.G. Kaelin Jr Inhibition of HIF2alpha is sufficient to suppress pVHL-defective tumor growth PLoS Biol 1 3 2003 E83
    • (2003) PLoS Biol , vol.1 , Issue.3 , pp. 83
    • Kondo, K.1    Kim, W.Y.2    Lechpammer, M.3    Kaelin, Jr.W.G.4
  • 31
    • 56849096837 scopus 로고    scopus 로고
    • HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
    • J.D. Gordan, P. Lal, and V.R. Dondeti HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma Cancer Cell 14 6 2008 435 446
    • (2008) Cancer Cell , vol.14 , Issue.6 , pp. 435-446
    • Gordan, J.D.1    Lal, P.2    Dondeti, V.R.3
  • 32
    • 59949102663 scopus 로고    scopus 로고
    • Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma
    • T. Klatte, P.N. Rao, and M. de Martino Cytogenetic profile predicts prognosis of patients with clear cell renal cell carcinoma J Clin Oncol 27 5 2009 746 753
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 746-753
    • Klatte, T.1    Rao, P.N.2    De Martino, M.3
  • 33
    • 84876015310 scopus 로고    scopus 로고
    • Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma
    • N. Kroeger, T. Klatte, and K. Chamie Deletions of chromosomes 3p and 14q molecularly subclassify clear cell renal cell carcinoma Cancer 119 2013 1547 1554
    • (2013) Cancer , vol.119 , pp. 1547-1554
    • Kroeger, N.1    Klatte, T.2    Chamie, K.3
  • 34
    • 80054771537 scopus 로고    scopus 로고
    • Genetic and functional studies implicate HIF1alpha as a 14q kidney cancer suppressor gene
    • C. Shen, R. Beroukhim, and S.E. Schumacher Genetic and functional studies implicate HIF1alpha as a 14q kidney cancer suppressor gene Cancer Disc 1 3 2011 222 235
    • (2011) Cancer Disc , vol.1 , Issue.3 , pp. 222-235
    • Shen, C.1    Beroukhim, R.2    Schumacher, S.E.3
  • 35
    • 84863393080 scopus 로고    scopus 로고
    • Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
    • M. Gerlinger, A.J. Rowan, and S. Horswell Intratumor heterogeneity and branched evolution revealed by multiregion sequencing N Engl J Med 366 10 2012 883 892
    • (2012) N Engl J Med , vol.366 , Issue.10 , pp. 883-892
    • Gerlinger, M.1    Rowan, A.J.2    Horswell, S.3
  • 36
    • 0034698178 scopus 로고    scopus 로고
    • Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
    • R.C. Osthus, H. Shim, and S. Kim Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc J Biol Chem 275 29 2000 21797 21800
    • (2000) J Biol Chem , vol.275 , Issue.29 , pp. 21797-21800
    • Osthus, R.C.1    Shim, H.2    Kim, S.3
  • 37
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
    • J.W. Kim, I. Tchernyshyov, G.L. Semenza, and C.V. Dang HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia Cell Metab 3 3 2006 177 185
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 38
    • 35448961940 scopus 로고    scopus 로고
    • HIF-1 mediates the Warburg effect in clear cell renal carcinoma
    • G.L. Semenza HIF-1 mediates the Warburg effect in clear cell renal carcinoma J Bioenergetics Biomembranes 39 3 2007 231 234
    • (2007) J Bioenergetics Biomembranes , vol.39 , Issue.3 , pp. 231-234
    • Semenza, G.L.1
  • 39
    • 34249085992 scopus 로고    scopus 로고
    • Prognostic relevance of the mTOR pathway in renal cell carcinoma: Implications for molecular patient selection for targeted therapy
    • A.J. Pantuck, D.B. Seligson, and T. Klatte Prognostic relevance of the mTOR pathway in renal cell carcinoma: implications for molecular patient selection for targeted therapy Cancer 109 11 2007 2257 2267
    • (2007) Cancer , vol.109 , Issue.11 , pp. 2257-2267
    • Pantuck, A.J.1    Seligson, D.B.2    Klatte, T.3
  • 40
    • 33845309430 scopus 로고    scopus 로고
    • Activation of the mTOR signaling pathway in renal clear cell carcinoma
    • V.A. Robb, M. Karbowniczek, A.J. Klein-Szanto, and E.P. Henske Activation of the mTOR signaling pathway in renal clear cell carcinoma J Urol 177 1 2007 346 352
    • (2007) J Urol , vol.177 , Issue.1 , pp. 346-352
    • Robb, V.A.1    Karbowniczek, M.2    Klein-Szanto, A.J.3    Henske, E.P.4
  • 41
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • R. Zoncu, A. Efeyan, and D.M. Sabatini mTOR: from growth signal integration to cancer, diabetes and ageing Nat Rev Mol Cell Biol 12 1 2011 21 35
    • (2011) Nat Rev Mol Cell Biol , vol.12 , Issue.1 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 42
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • K. Inoki, T. Zhu, and K.L. Guan TSC2 mediates cellular energy response to control cell growth and survival Cell 115 5 2003 577 590
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 43
    • 10044276783 scopus 로고    scopus 로고
    • Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
    • J. Brugarolas, K. Lei, and R.L. Hurley Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex Genes Dev 18 23 2004 2893 2904
    • (2004) Genes Dev , vol.18 , Issue.23 , pp. 2893-2904
    • Brugarolas, J.1    Lei, K.2    Hurley, R.L.3
  • 44
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: A molecular switchboard controlling cell growth
    • J. Huang, and B.D. Manning The TSC1-TSC2 complex: a molecular switchboard controlling cell growth Biochem J. 412 2 2008 179 190
    • (2008) Biochem J. , vol.412 , Issue.2 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 45
    • 0035312747 scopus 로고    scopus 로고
    • Regulation of translation initiation by FRAP/mTOR
    • A.C. Gingras, B. Raught, and N. Sonenberg Regulation of translation initiation by FRAP/mTOR Genes Dev 15 7 2001 807 826
    • (2001) Genes Dev , vol.15 , Issue.7 , pp. 807-826
    • Gingras, A.C.1    Raught, B.2    Sonenberg, N.3
  • 46
    • 67349217986 scopus 로고    scopus 로고
    • Molecular mechanisms of mTOR-mediated translational control
    • X.M. Ma, and J. Blenis Molecular mechanisms of mTOR-mediated translational control Nat Rev Mol Cell Biol 10 5 2009 307 318
    • (2009) Nat Rev Mol Cell Biol , vol.10 , Issue.5 , pp. 307-318
    • Ma, X.M.1    Blenis, J.2
  • 47
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • M.V. Blagosklonny, and M.N. Hall Growth and aging: a common molecular mechanism Aging 1 4 2009 357 362
    • (2009) Aging , vol.1 , Issue.4 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 48
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • S. Wullschleger, R. Loewith, and M.N. Hall TOR signaling in growth and metabolism Cell 124 3 2006 471 484
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 49
    • 80052837898 scopus 로고    scopus 로고
    • Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma
    • B. Kucejova, S. Pena-Llopis, and T. Yamasaki Interplay between pVHL and mTORC1 pathways in clear-cell renal cell carcinoma Mol Cancer Res 9 9 2011 1255 1265
    • (2011) Mol Cancer Res , vol.9 , Issue.9 , pp. 1255-1265
    • Kucejova, B.1    Pena-Llopis, S.2    Yamasaki, T.3
  • 50
    • 34249779568 scopus 로고    scopus 로고
    • Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
    • G. Hudes, M. Carducci, and P. Tomczak Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma N Engl J Med 356 22 2007 2271 2281
    • (2007) N Engl J Med , vol.356 , Issue.22 , pp. 2271-2281
    • Hudes, G.1    Carducci, M.2    Tomczak, P.3
  • 51
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • R.J. Motzer, B. Escudier, and S. Oudard Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial Lancet 372 9637 2008 449 456
    • (2008) Lancet , vol.372 , Issue.9637 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3
  • 53
    • 0028893130 scopus 로고
    • Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas
    • E.P. Henske, H.P. Neumann, B.W. Scheithauer, E.W. Herbst, M.P. Short, and D.J. Kwiatkowski Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas Genes Chromosomes Cancer 13 4 1995 295 298
    • (1995) Genes Chromosomes Cancer , vol.13 , Issue.4 , pp. 295-298
    • Henske, E.P.1    Neumann, H.P.2    Scheithauer, B.W.3    Herbst, E.W.4    Short, M.P.5    Kwiatkowski, D.J.6
  • 55
    • 39649101082 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a therapeutic target in oncology
    • R.T. Abraham, and C.H. Eng Mammalian target of rapamycin as a therapeutic target in oncology Exp Opin Therapeutic Targets 12 2 2008 209 222
    • (2008) Exp Opin Therapeutic Targets , vol.12 , Issue.2 , pp. 209-222
    • Abraham, R.T.1    Eng, C.H.2
  • 56
    • 84876290581 scopus 로고    scopus 로고
    • Everolimus therapy for angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: Results from EXIST-2
    • abstr 356
    • J.J. Bissler, C. Kingswood, and B.A. Zonnenberg Everolimus therapy for angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: results from EXIST-2 J Clin Oncol 30 suppl 2012 abstr 356
    • (2012) J Clin Oncol , vol.30 , Issue.SUPPL.
    • Bissler, J.J.1    Kingswood, C.2    Zonnenberg, B.A.3
  • 58
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • G. van Haaften, G.L. Dalgliesh, and H. Davies Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat Genet 41 5 2009 521 523
    • (2009) Nat Genet , vol.41 , Issue.5 , pp. 521-523
    • Van Haaften, G.1    Dalgliesh, G.L.2    Davies, H.3
  • 59
    • 75149188170 scopus 로고    scopus 로고
    • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
    • G.L. Dalgliesh, K. Furge, and C. Greenman Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes Nature 463 7279 2010 360 363
    • (2010) Nature , vol.463 , Issue.7279 , pp. 360-363
    • Dalgliesh, G.L.1    Furge, K.2    Greenman, C.3
  • 60
    • 45449110185 scopus 로고    scopus 로고
    • Hypoxia upregulates the histone demethylase JMJD1A via HIF-1
    • S. Wellmann, M. Bettkober, and A. Zelmer Hypoxia upregulates the histone demethylase JMJD1A via HIF-1 Biochem Biophys Res Commun 372 4 2008 892 897
    • (2008) Biochem Biophys Res Commun , vol.372 , Issue.4 , pp. 892-897
    • Wellmann, S.1    Bettkober, M.2    Zelmer, A.3
  • 61
    • 73549088729 scopus 로고    scopus 로고
    • Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth
    • A.J. Krieg, E.B. Rankin, D. Chan, O. Razorenova, S. Fernandez, and A.J. Giaccia Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth Mol Cell Biol 30 1 2010 344 353
    • (2010) Mol Cell Biol , vol.30 , Issue.1 , pp. 344-353
    • Krieg, A.J.1    Rankin, E.B.2    Chan, D.3    Razorenova, O.4    Fernandez, S.5    Giaccia, A.J.6
  • 62
    • 63249087504 scopus 로고    scopus 로고
    • SWI/SNF regulates the cellular response to hypoxia
    • N.S. Kenneth, S. Mudie, P. van Uden, and S. Rocha SWI/SNF regulates the cellular response to hypoxia J Biol Chem 284 7 2009 4123 4131
    • (2009) J Biol Chem , vol.284 , Issue.7 , pp. 4123-4131
    • Kenneth, N.S.1    Mudie, S.2    Van Uden, P.3    Rocha, S.4
  • 63
    • 79960197509 scopus 로고    scopus 로고
    • A phase II trial of panobinostat, a histone deacetylase inhibitor, in the treatment of patients with refractory metastatic renal cell carcinoma
    • J.D. Hainsworth, J.R. Infante, D.R. Spigel, E.R. Arrowsmith, R.V. Boccia, and H.A. Burris A phase II trial of panobinostat, a histone deacetylase inhibitor, in the treatment of patients with refractory metastatic renal cell carcinoma Cancer Invest 29 7 2011 451 455
    • (2011) Cancer Invest , vol.29 , Issue.7 , pp. 451-455
    • Hainsworth, J.D.1    Infante, J.R.2    Spigel, D.R.3    Arrowsmith, E.R.4    Boccia, R.V.5    Burris, H.A.6
  • 64
    • 84862988411 scopus 로고    scopus 로고
    • BAP1 loss defines a new class of renal cell carcinoma
    • S. Pena-Llopis, S. Vega-Rubin-de-Celis, and A. Liao BAP1 loss defines a new class of renal cell carcinoma Nat Genet 44 7 2012 751 759
    • (2012) Nat Genet , vol.44 , Issue.7 , pp. 751-759
    • Pena-Llopis, S.1    Vega-Rubin-De-Celis, S.2    Liao, A.3
  • 65
    • 79955934205 scopus 로고    scopus 로고
    • An emerging model for BAP1's role in regulating cell cycle progression
    • Z.M. Eletr, and K.D. Wilkinson An emerging model for BAP1's role in regulating cell cycle progression Cell Biochem Biophysics 60 1-2 2011 3 11
    • (2011) Cell Biochem Biophysics , vol.60 , Issue.12 , pp. 3-11
    • Eletr, Z.M.1    Wilkinson, K.D.2
  • 66
    • 78649700287 scopus 로고    scopus 로고
    • Frequent mutation of BAP1 in metastasizing uveal melanomas
    • J.W. Harbour, M.D. Onken, and E.D. Roberson Frequent mutation of BAP1 in metastasizing uveal melanomas Science 330 6009 2010 1410 1413
    • (2010) Science , vol.330 , Issue.6009 , pp. 1410-1413
    • Harbour, J.W.1    Onken, M.D.2    Roberson, E.D.3
  • 67
    • 84873081430 scopus 로고    scopus 로고
    • Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: A retrospective analysis with independent validation
    • P. Kapur, S. Pena-Llopis, and A. Christie Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation Lancet Oncol 14 2 2013 159 167
    • (2013) Lancet Oncol , vol.14 , Issue.2 , pp. 159-167
    • Kapur, P.1    Pena-Llopis, S.2    Christie, A.3
  • 68
    • 0141988692 scopus 로고    scopus 로고
    • Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: Evidence for a cytogenetic evolution of type 2 from type 1 tumors
    • B. Gunawan, A. von Heydebreck, and T. Fritsch Cytogenetic and morphologic typing of 58 papillary renal cell carcinomas: evidence for a cytogenetic evolution of type 2 from type 1 tumors Cancer Res 63 19 2003 6200 6205
    • (2003) Cancer Res , vol.63 , Issue.19 , pp. 6200-6205
    • Gunawan, B.1    Von Heydebreck, A.2    Fritsch, T.3
  • 69
    • 50049106969 scopus 로고    scopus 로고
    • Prognostic factors in a prospective series of papillary renal cell carcinoma
    • P. Gontero, G. Ceratti, and S. Guglielmetti Prognostic factors in a prospective series of papillary renal cell carcinoma BJU Int 102 6 2008 697 702
    • (2008) BJU Int , vol.102 , Issue.6 , pp. 697-702
    • Gontero, P.1    Ceratti, G.2    Guglielmetti, S.3
  • 70
    • 64549110213 scopus 로고    scopus 로고
    • Renal papillary carcinoma classification into subtypes may be reproduced by nuclear morphometry
    • K. Okon, A. Sinczak-Kuta, and J. Stachura Renal papillary carcinoma classification into subtypes may be reproduced by nuclear morphometry Analytic Quantitative Cytol Histol 31 2 2009 109 117
    • (2009) Analytic Quantitative Cytol Histol , vol.31 , Issue.2 , pp. 109-117
    • Okon, K.1    Sinczak-Kuta, A.2    Stachura, J.3
  • 71
    • 77952753366 scopus 로고    scopus 로고
    • Cytogenetic features, clinical significance and prognostic impact of type 1 and type 2 papillary renal cell carcinoma
    • A. Antonelli, R. Tardanico, and P. Balzarini Cytogenetic features, clinical significance and prognostic impact of type 1 and type 2 papillary renal cell carcinoma Cancer Genet Cytogenet 199 2 2010 128 133
    • (2010) Cancer Genet Cytogenet , vol.199 , Issue.2 , pp. 128-133
    • Antonelli, A.1    Tardanico, R.2    Balzarini, P.3
  • 72
    • 0000939691 scopus 로고    scopus 로고
    • Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome
    • M.L. Nickerson, M.B. Warren, and J.R. Toro Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome Cancer Cell 2 2 2002 157 164
    • (2002) Cancer Cell , vol.2 , Issue.2 , pp. 157-164
    • Nickerson, M.L.1    Warren, M.B.2    Toro, J.R.3
  • 73
    • 33750293584 scopus 로고    scopus 로고
    • Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
    • M. Baba, S.B. Hong, and N. Sharma Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling Proc Natl Acad Sci U S A 103 42 2006 15552 15557
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.42 , pp. 15552-15557
    • Baba, M.1    Hong, S.B.2    Sharma, N.3
  • 74
    • 66749104378 scopus 로고    scopus 로고
    • High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas
    • M.V. Yusenko, R.P. Kuiper, T. Boethe, B. Ljungberg, A.G. van Kessel, and G. Kovacs High-resolution DNA copy number and gene expression analyses distinguish chromophobe renal cell carcinomas and renal oncocytomas BMC Cancer 9 2009 152
    • (2009) BMC Cancer , vol.9 , pp. 152
    • Yusenko, M.V.1    Kuiper, R.P.2    Boethe, T.3    Ljungberg, B.4    Van Kessel, A.G.5    Kovacs, G.6
  • 75
    • 42549085633 scopus 로고    scopus 로고
    • Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors
    • F.A. Monzon, J.M. Hagenkord, and M.A. Lyons-Weiler Whole genome SNP arrays as a potential diagnostic tool for the detection of characteristic chromosomal aberrations in renal epithelial tumors Mod Pathol 21 5 2008 599 608
    • (2008) Mod Pathol , vol.21 , Issue.5 , pp. 599-608
    • Monzon, F.A.1    Hagenkord, J.M.2    Lyons-Weiler, M.A.3
  • 76
    • 84879843091 scopus 로고    scopus 로고
    • Clinicopathological, genetic, ultrastructural characterizations and prognostic factors of papillary renal cell carcinoma: New diagnostic and prognostic information
    • W. Yu, W. Zhang, and Y. Jiang Clinicopathological, genetic, ultrastructural characterizations and prognostic factors of papillary renal cell carcinoma: new diagnostic and prognostic information Acta Histochem 115 2012 452 459
    • (2012) Acta Histochem , vol.115 , pp. 452-459
    • Yu, W.1    Zhang, W.2    Jiang, Y.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.