Vitamin D: Defending the aging nervous system

Vitamin D: Oxidative Stress, Immunity, and Aging

Volumn , Issue , 2012, Pages 407-431

  Annweiler, Cédric ^a,b  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84883190823     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/b13714     Document Type: Chapter

References (190)

1. American Psychiatric Association. 1994. Diagnostic and statistical manual of mental disorders. In DSM-IV, edited by A. P. P., Inc. Washington, DC.
2. Ankarcrona, M., J. M. Dypbukt, E. Bonfoco, B. Zhivotovsky, S. Orrenius, S. A. Lipton, and P. Nicotera. 1995. Glutamate-induced neuronal death: A succession of necrosis or apoptosis depending on mitochondrial function. Neuron 15(4):961-973.
3. Annweiler, C., G. Allali, P. Allain, S. Bridenbaugh, A. M. Schott, R. W. Kressig, and O. Beauchet. 2009a. Vitamin D and cognitive performance in adults: A systematic review. European Journal of Neurology 16(10):1083-1089.
4. Annweiler, C., A. M. Schott, G. Berrut, and O. Beauchet. 2009b. Vitamine D et cognition, du soleil pour le crépuscule de l’esprit. Annales de Gérontologie 2(4):239-242.
5. Annweiler, C., A. M. Schott, G. Berrut, B. Fantino, and O. Beauchet. 2009c. Vitamin D-related changes in physical performance: A systematic review. The Journal of Nutrition, Health & Aging 13(10):893-898.
6. Annweiler, C., and O. Beauchet. 2010. Vitamin D and bone fracture mechanisms: What about the nonbone ‘D’efense? International Journal of Clinical Practice 64(5):541-543.
7. Annweiler, C., D. Le Gall, B. Fantino, and O. Beauchet. 2010a. Fish consumption and dementia: Keep the vitamin D in memory. European Journal of Neurology e40.
8. Annweiler, C., D. Le Gall, B. Fantino, O. Beauchet, K. L. Tucker, and J. S. Buell. 2010b. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 75(1):95; author reply 95-96.
9. Annweiler, C., M. Montero-Odasso, A. M. Schott, G. Berrut, B. Fantino, and O. Beauchet. 2010c. Fall prevention and vitamin D in the elderly: An overview of the key role of the non-bone effects. Journal of Neuroengineering and Rehabilitation 7:50.
10. Annweiler, C., A. M. Schott, G. Allali, S. A. Bridenbaugh, R. W. Kressig, P. Allain, F. R. Herrmann, and O. Beauchet. 2010d. Association of vitamin D deficiency with cognitive impairment in older women: Cross-sectional study. Neurology 74(1):27-32.
11. Annweiler, C., A. M. Schott, G. Berrut, V. Chauvire, D. Le Gall, M. Inzitari, and O. Beauchet. 2010e. Vitamin D and ageing: Neurological issues. Neuropsychobiology 62(3):139-150.
12. Annweiler, C., A. M. Schott, M. Montero-Odasso, G. Berrut, B. Fantino, F. R. Herrmann, and O. Beauchet. 2010f. Cross-sectional association between serum vitamin D concentration and walking speed measured at usual and fast pace among older women: The EPIDOS Study. Journal of Bone and Mineral Research 25(8):1858-1866.
13. Annweiler, C., A. M. Schott, Y. Rolland, H. Blain, F. R. Herrmann, and O. Beauchet. 2010g. Dietary intakes of vitamin D and cognition in older women: A large population-based study. Neurology 75(20):1810-1816.
14. Annweiler, C., B. Fantino, D. Le Gall, A. M. Schott, G. Berrut, and O. Beauchet. 2011. Severe vitamin D deficiency is associated with advanced-stage dementia amongst geriatric inpatients. Journal of the American Geriatrics Society 59(1):169-171.
15. Annweiler, C., Y. Rolland, A. M. Schott, H. Blain, B. Vellas, and O. Beauchet. 2012a. Serum vitamin D deficiency as a predictor of incident non-Alzheimer dementias: A 7-year longitudinal follow-up. Dementia and Geriatric Cognitive Disorders 32(4):273-278.
16. Annweiler, C., B. Fantino, J. Gautier, M. Beaudenon, S. Thiery, and O. Beauchet. 2012b. Cognitive effects of vitamin D supplementation amongst older outpatients visiting memory clinic: A pre-post study. Journal of the American Geriatrics Society 60(4):793-795.
17. Baas, D., K. Prufer, M. E. Ittel, S. Kuchler-Bopp, G. Labourdette, L. L. Sarlieve, and P. Brachet. 2000. Rat oligodendrocytes express the vitamin D(3) receptor and respond to 1,25-dihydroxyvitamin D(3). Glia 31(1):59-68.
18. Baddeley, A. 1993. La mémoire humaine. Grenoble: Presses Universitaires de Grenoble
19. Baddeley, A., and S. Della Sala. 1996. Working memory and executive control. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 351(1346):1397-1403; discussion 1403-4.
20. Baddeley, A. D., and B. A. Wilson. 1985. Phonological coding and short-term memory in patients without speech. Journal of Memory and Language 24:490-502.
21. Baksi, S. N., and M. J. Hughes. 1982. Chronic vitamin D deficiency in the weanling rat alters catecholamine metabolism in the cortex. Brain Research 242(2):387-390.
22. Bandler, R. J., Jr. 1969. Facilitation of aggressive behaviour in rat by direct cholinergic stimulation of the hypothalamus. Nature 224(5223):1035-1036.
23. Beauchet, O., C. Annweiler, J. Verghese, B. Fantino, F. R. Herrmann, and G. Allali. 2011a. Biology of gait control: Vitamin D involvement. Neurology 76(19):1617-1622.
24. Beauchet, O., D. Milea, A. Graffe, B. Fantino, and C. Annweiler. 2011b. Association between serum 25-hydroxyvitamin D concentrations and vision: A cross-sectional population-based study of older adults. Journal of the American Geriatrics Society 59(3):568-570.
25. Becker, A., D. W. Eyles, J. J. McGrath, and G. Grecksch. 2005. Transient prenatal vitamin D deficiency is associated with subtle alterations in learning and memory functions in adult rats. Behavioural Brain Research 161(2):306-312.
26. Bemiss, C. J., B. D. Mahon, A. Henry, V. Weaver, and M. T. Cantorna. 2002. Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system. Archives of Biochemistry and Biophysics 402(2):249-254.
27. Benton, A. L., and K. Hamsher. 1976. Multilingual Aphasia Examination. Iowa City: University of Iowa.
28. Bérubé, L. 1991. Terminologie de neuropsychologie et de neurologie du comportement. Montréal: Les Éditions de la Chenelière, Inc.
29. 3-1alpha-hydroxylase in pancreatic islets. The Journal of Steroid Biochemistry and Molecular Biology 89-90(1-5):121-125.
30. Bledowski, C., B. Rahm, and J. B. Rowe. 2009. What “works” in working memory? Separate systems for selection and updating of critical information. Journal of Neuroscience 29(43):13735-13741.
31. Bloch, H. 1994. In Grand dictionnaire de la psychologie, edited by Larousse, Paris.
32. Bonfoco, E., D. Krainc, M. Ankarcrona, P. Nicotera, and S. A. Lipton. 1995. Apoptosis and necrosis: Two distinct events induced, respectively, by mild and intense insults with N-methyl-d-aspartate or nitric oxide/superoxide in cortical cell cultures. Proceedings of the National Academy of Sciences of the United States of America 92(16):7162-7166.
33. Bouvard, B., C. Annweiler, A. Salle, O. Beauchet, D. Chappard, M. Audran, and E. Legrand. 2011. Extraskeletal effects of vitamin D: Facts, uncertainties, and controversies. Joint Bone Spine 78(1):10-16.
34. Brewer, L. D., V. Thibault, K. C. Chen, M. C. Langub, P. W. Landfield, and N. M. Porter. 2001. Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons. Journal of Neuroscience 21(1):98-108.
35. 3 induces nerve growth factor, promotes neurite outgrowth and inhibits mitosis in embryonic rat hippocampal neurons. Neuroscience Letters 343(2):139-143.
36. Buell, J. S., B. Dawson-Hughes, T. M. Scott, D. E. Weiner, G. E. Dallal, W. Q. Qui, P. Bergethon, I. H. Rosenberg, M. F. Folstein, S. Patz, R. A. Bhadelia, and K. L. Tucker. 2009. 25-Hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology 74(1):18-26.
37. Buell, J. S., T. M. Scott, B. Dawson-Hughes, G. E. Dallal, I. H. Rosenberg, M. F. Folstein, and K. L. Tucker. 2009. Vitamin D is associated with cognitive function in elders receiving home health services. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 64(8):888-895.
38. Burne, T. H., A. Becker, J. Brown, D. W. Eyles, A. Mackay-Sim, and J. J. McGrath. 2004. Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats. Behavioural Brain Research 154(2):549-555.
39. Burne, T. H., J. J. McGrath, D. W. Eyles, and A. Mackay-Sim. 2005. Behavioural characterization of vitamin D receptor knockout mice. Behavioural Brain Research 157(2):299-308.
40. Burne, T. H., A. N. Johnston, J. J. McGrath, and A. Mackay-Sim. 2006. Swimming behaviour and post-swimming activity in vitamin D receptor knockout mice. Brain Research Bulletin 69(1):74-78.
41. 3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 93(15):7861-7864.
42. 3 is a positive regulator for the two anti-encephalitogenic cytokines TGF-beta 1 and IL-4. The Journal of Immunology 160(11):5314-5319.
43. Carthy, E. P., W. Yamashita, A. Hsu, and B. S. Ooi. 1989. 1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth. Hypertension 13(6 Pt 2):954-959.
44. Cooper, R., and C. Rotimi. 1994. Hypertension in populations of West African origin: Is there a genetic predisposition? Journal of Hypertension 12(3):215-227.
45. 3 regulates the expression of VDR and NGF gene in Schwann cells in vitro. Journal of Neuroscience Research 53(6):742-746.
46. Cowppli-Bony, P., C. Fabrigoule, L. Letenneur, K. Ritchie, A. Alperovitch, J. F. Dartigues, and B. Dubois. 2005. [Validity of the five-word screening test for Alzheimer’s disease in a population based study]. Revue Neurologique 161(12 Pt 1):1205-1212.
47. Cui, X., J. J. McGrath, T. H. Burne, A. Mackay-Sim, and D. W. Eyles. 2007. Maternal vitamin D depletion alters neurogenesis in the developing rat brain. International Journal of Developmental Neuroscience 25(4):227-232.
48. Curtis, C. E., and M. D’Esposito. 2003. Persistent activity in the prefrontal cortex during working memory. Trends in Cognitive Sciences 7(9):415-423.
49. Dawson, V. L., and T. M. Dawson. 1996. Nitric oxide actions in neurochemistry. Neurochemistry International 29(2):97-110.
50. de Viragh, P. A., K. G. Haglid, and M. R. Celio. 1989. Parvalbumin increases in the caudate putamen of rats with vitamin D hypervitaminosis. Proceedings of the National Academy of Sciences of the United States of America 86(10):3887-3890.
51. Deutsch, J. A., and D. Deutsch. 1963. Some theoretical considerations. Psychological Review 70:80-90.
52. Dhesi, J. K., S. H. Jackson, L. M. Bearne, C. Moniz, M. V. Hurley, C. G. Swift, and T. J. Allain. 2004. Vitamin D supplementation improves neuromuscular function in older people who fall. Age and Ageing 33(6):589-595.
53. Dringen, R., J. M. Gutterer, and J. Hirrlinger. 2000. Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. European Journal of Biochemistry 267(16):4912-4916.
54. Duncan, B. B., M. I. Schmidt, J. S. Pankow, C. M. Ballantyne, D. Couper, A. Vigo, R. Hoogeveen, A. R. Folsom, and G. Heiss. 2003. Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study. Diabetes 52(7):1799-1805.
55. Engelhart, M. J., M. I. Geerlings, A. Ruitenberg, J. C. Van Swieten, A. Hofman, J. C. Witteman, and M. M. Breteler. 2002. Diet and risk of dementia: Does fat matter? The Rotterdam Study. Neurology 59(12):1915-1921.
56. Eyles, D., J. Brown, A. Mackay-Sim, J. McGrath, and F. Feron. 2003. Vitamin D3 and brain development. Neuroscience 118(3):641-653.
57. Eyles, D. W., S. Smith, R. Kinobe, M. Hewison, and J. J. McGrath. 2005. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. Journal of Chemical Neuroanatomy 29(1):21-30.
58. Forman, J. P., E. Giovannucci, M. D. Holmes, H. A. Bischoff-Ferrari, S. S. Tworoger, W. C. Willett, and G. C. Curhan. 2007. Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 49(5):1063-1069.
59. Garcion, E., X. D. Thanh, F. Bled, E. Teissier, M. P. Dehouck, F. Rigault, P. Brachet, A. Girault, G. Torpier, and F. Darcy. 1996. 1,25-Dihydroxyvitamin D3 regulates gamma 1 transpeptidase activity in rat brain. Neuroscience Letters 216(3):183-186.
60. Garcion, E., L. Sindji, C. Montero-Menei, C. Andre, P. Brachet, and F. Darcy. 1998. Expression of inducible nitric oxide synthase during rat brain inflammation: Regulation by 1,25-dihydroxyvitamin D3. Glia 22(3):282-294.
61. Garcion, E., L. Sindji, G. Leblondel, P. Brachet, and F. Darcy. 1999. 1,25-dihydroxyvitamin D3 regulates the synthesis of gamma-glutamyl transpeptidase and glutathione levels in rat primary astrocytes. Journal of Neurochemistry 73(2):859-866.
62. Garcion, E., N. Wion-Barbot, C. N. Montero-Menei, F. Berger, and D. Wion. 2002. New clues about vitamin D functions in the nervous system. Trends in Endocrinology and Metabolism 13(3):100-105.
63. Garcion, E., L. Sindji, S. Nataf, P. Brachet, F. Darcy, and C. N. Montero-Menei. 2003. Treatment of experimental autoimmune encephalomyelitis in rat by 1,25-dihydroxyvitamin D3 leads to early effects within the central nervous system. Acta Neuropathologica 105(5):438-448.
64. Gaudino, E. A., M. W. Geisler, and N. K. Squires. 1995. Construct validity in the Trail Making Test: What makes Part B harder? Journal of Clinical and Experimental Neuropsychology 17(4):529-535.
65. Ginde, A. A., R. Scragg, R. S. Schwartz, and C. A. Camargo, Jr. 2009. Prospective study of serum 25-hydroxyvitamin D level, cardiovascular disease mortality, and all-cause mortality in older U.S. adults. Journal of the American Geriatrics Society 57(9):1595-1603.
66. Godefroy, O., M. Jeannerod, P. Allain, and D. Le Gall. 2008. [Frontal lobe, executive functions and cognitive control]. Revue Neurologique 164 Suppl 3:S119-127.
67. Grant, W. B. 2009. Does vitamin D reduce the risk of dementia? Journal of Alzheimer’s Disease 17(1):151-159.
68. Grant, W. B. 2011. Vitamin D might reduce some vascular risk factors and, consequently, risk of dementia. The Netherlands Journal of Medicine 69(1):51.
69. Greenspan, S. L., N. M. Resnick, and R. A. Parker. 2005. The effect of hormone replacement on physical performance in community-dwelling elderly women. The American Journal of Medicine 118(11):1232-1239.
70. Grober, E., H. Buschke, H. Crystal, S. Bang, and R. Dresner. 1988. Screening for dementia by memory testing. Neurology 38(6):900-903.
71. Hanninen, T., M. Hallikainen, K. Koivisto, K. Partanen, M. P. Laakso, P. J. Riekkinen, Sr., and H. Soininen. 1997. Decline of frontal lobe functions in subjects with age-associated memory impairment. Neurology 48(1):148-153.
72. Hittmair-Delazer, M., C. Semenza, and G. Denes. 1994. Concepts and facts in calculation. Brain 117 (Pt 4):715-728.
73. Hodkinson, H. M. 1972. Evaluation of a mental test score for assessment of mental impairment in the elderly. Age and Ageing 1(4):233-238.
74. Holick, M. F., L. Y. Matsuoka, and J. Wortsman. 1989. Age, vitamin D, and solar ultraviolet. Lancet 2(8671):1104-1105.
75. Hu, F. B., J. B. Meigs, T. Y. Li, N. Rifai, and J. E. Manson. 2004. Inflammatory markers and risk of developing type 2 diabetes in women. Diabetes 53(3):693-700.
76. 3) against the neurotoxicity of glutamate and reactive oxygen species in mesencephalic culture. Neuropharmacology 40(6):761-771.
77. 3 enhances cerebral clearance of human amyloid-b peptide(1-40) from mouse brain across the blood-brain barrier. Fluids and Barriers of the CNS 8:20.
78. Intersalt Cooperative Research Group. 1988. Intersalt: An international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. BMJ 297(6644):319-328.
79. Jakobson, R. 1960. Closing statements: Linguistics and poetics. In Style in Langage. New York: T.A. Sebeok.
80. 3. II. Chick kidney and brain. Steroids 64(8):541-550.
81. Jorde, R., K. Waterloo, F. Saleh, E. Haug, and J. Svartberg. 2006. Neuropsychological function in relation to serum parathyroid hormone and serum 25-hydroxyvitamin D levels. The Tromso Study. Journal of Neurology 253(4):464-470.
82. Kalmijn, S., L. J. Launer, A. Ott, J. C. Witteman, A. Hofman, and M. M. Breteler. 1997. Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Annals of Neurology 42(5):776-782.
83. Kalra, L., S. H. Jackson, and C. G. Swift. 1993. Effect of antihypertensive treatment on psychomotor performance in the elderly. Journal of Human Hypertension 7(3):285-290.
84. 3). Biochemistry (Mosc) 69(7):738-741.
85. Kalueff, A. V., Y. R. Lou, I. Laaksi, and P. Tuohimaa. 2005a. Abnormal behavioral organization of grooming in mice lacking the vitamin D receptor gene. Journal of Neurogenetics 19(1):1-24.
86. Kalueff, A. V., A. Minasyan, and P. Tuohimaa. 2005b. Anticonvulsant effects of 1,25-dihydroxyvitamin D in chemically induced seizures in mice. Brain Research Bulletin 67(1-2):156-160.
87. Kalueff, A., E. Loseva, H. Haapasalo, I. Rantala, J. Keranen, Y. R. Lou, A. Minasyan, T. Keisala, S. Miettinen, M. Kuuslahti, and P. Tuchimaa. 2006a. Thalamic calcification in vitamin D receptor knockout mice. Neuroreport 17(7):717-721.
88. Kalueff, A. V., T. Keisala, A. Minasyan, M. Kuuslahti, S. Miettinen, and P. Tuohimaa. 2006b. Behavioural anomalies in mice evoked by “Tokyo” disruption of the vitamin D receptor gene. Neuroscience Research 54(4):254-260.
89. Kalueff, A. V., A. Minasyan, T. Keisala, M. Kuuslahti, S. Miettinen, and P. Tuohimaa. 2006c. Increased severity of chemically induced seizures in mice with partially deleted vitamin D receptor gene. Neuroscience Letters 394(1):69-73.
90. Kalueff, A. V., and P. Tuohimaa. 2007. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Current Opinion in Clinical Nutrition and Metabolic Care 10(1):12-19.
91. Kendrick, J., G. Targher, G. Smits, and M. Chonchol. 2009. 25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis 205(1):255-260.
92. Krause, R., M. Buhring, W. Hopfenmuller, M. F. Holick, and A. M. Sharma. 1998. Ultraviolet B and blood pressure. Lancet 352(9129):709-710.
93. Kunes, J., J. Tremblay, F. Bellavance, and P. Hamet. 1991. Influence of environmental temperature on the blood pressure of hypertensive patients in Montreal. American Journal of Hypertension 4(5 Pt 1):422-426.
94. Langub, M. C., J. P. Herman, H. H. Malluche, and N. J. Koszewski. 2001. Evidence of functional vitamin D receptors in rat hippocampus. Neuroscience 104(1):49-56.
95. Laurin, D., R. Verreault, J. Lindsay, E. Dewailly, and B. J. Holub. 2003. Omega-3 fatty acids and risk of cognitive impairment and dementia. Journal of Alzheimer’s Disease 5(4):315-322.
96. Lee, D. M., A. Tajar, A. Ulubaev, N. Pendleton, T. W. O’Neill, D. B. O’Connor, G. Bartfai, S. Boonen, R. Bouillon, F. F. Casanueva, J. D. Finn, G. Forti, A. Giwercman, T. S. Han, I. T. Huhtaniemi, K. Kula, M. E. Lean, M. Punab, A. J. Silman, D. Vanderschueren, and F. C. Wu. 2009. Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men. Journal of Neurology, Neurosurgery and Psychiatry 80(7):722-729.
97. Lezak, M. D. 1995. Neuropsychological Assessment. Oxford, UK: Oxford University Press.
98. Li, Y. C., A. E. Pirro, and M. B. Demay. 1998. Analysis of vitamin D-dependent calcium-binding protein messenger ribonucleic acid expression in mice lacking the vitamin D receptor. Endocrinology 139(3):847-851.
99. 3) is a negative endocrine regulator of the renin-angiotensin system. Journal of Clinical Investigation 110(2):229-238.
100. 3. Free Radical Biology & Medicine 34(11):1416-1425.
101. Lind, L., B. Wengle, and S. Ljunghall. 1987. Blood pressure is lowered by vitamin D (alphacalcidol) during long-term treatment of patients with intermittent hypercalcaemia. A double-blind, placebo-controlled study. Acta Medica Scandinavica 222(5):423-427.
102. Lind, L., H. Lithell, E. Skarfors, L. Wide, and S. Ljunghall. 1988. Reduction of blood pressure by treatment with alphacalcidol. A double-blind, placebo-controlled study in subjects with impaired glucose tolerance. Acta Medica Scandinavica 223(3):211-217.
103. Llewellyn, D. J., K. M. Langa, and I. A. Lang. 2009. Serum 25-hydroxyvitamin D concentration and cognitive impairment. Journal of Geriatric Psychiatry and Neurology 22(3):188-195.
104. Llewellyn, D. J., I. A. Lang, K. M. Langa, G. Muniz-Terrera, C. L. Phillips, A. Cherubini, L. Ferrucci, and D. Melzer. 2010. Vitamin D and risk of cognitive decline in elderly persons. Archives of Internal Medicine 170(13):1135-1141.
105. Loonstra, A. S., A. R. Tarlow, and A. H. Sellers. 2001. COWAT metanorms across age, education, and gender. Applied Neuropsychology 8(3):161-166.
106. Luciana, M., and C. A. Nelson. 2002. Assessment of neuropsychological function through use of the Cambridge Neuropsychological Testing Automated Battery: Performance in 4- to 12-year-old children. Developmental Neuropsychology 22(3):595-624.
107. Lui, L. Y., K. Stone, J. A. Cauley, T. Hillier, and K. Yaffe. 2003. Bone loss predicts subsequent cognitive decline in older women: The study of osteoporotic fractures. Journal of the American Geriatrics Society 51(1):38-43.
108. Luria, A. 1969. The Working Brain: An Introduction to Neuropsychology. New York: Basic Books.
109. 3. Journal of Clinical Investigation 76(4):1536-1538.
110. Marsh, R. L., and J. L. Hicks. 1998. Event-based prospective memory and executive control of working memory. Journal of Experimental Psychology. Learning, Memory, and Cognition 24(2):336-349.
111. 3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer’s disease patients. Journal of Alzheimer’s Disease 17(3):703-717.
112. Math, F. 2008. Neurosciences cliniques: De la perception aux troubles du comportement. Paris: De Boeck.
113. Matlin, M. W. 2008. Cognition. 7th revised ed. New York: Wiley-Blackwell.
114. McCann, J. C., and B. N. Ames. 2008. Is there convincing biological or behavioral evidence linking vitamin D deficiency to brain dysfunction? FASEB J 22(4):982-1001.
115. McGrath, J. 1999. Hypothesis: Is low prenatal vitamin D a risk-modifying factor for schizophrenia? Schizophrenia Research 40(3):173-177.
116. McGrath, J., F. Feron, D. Eyles, and A. Mackay-Sim. 2001. Vitamin D: The neglected neurosteroid? Trends in Neurosciences 24(10):570-572.
117. 3 level and performance on psychometric tests in NHANES III. Neuroepidemiology 29(1-2):49-54.
118. 3) to suppress experimental autoimmune encephalomyelitis in mice. Archives of Biochemistry and Biophysics 408(2):200-204.
119. Melamed, M. L., P. Muntner, E. D. Michos, J. Uribarri, C. Weber, J. Sharma, and P. Raggi. 2008. Serum 25-hydroxyvitamin D levels and the prevalence of peripheral arterial disease: Results from NHANES 2001 to 2004. Arteriosclerosis, Thrombosis, and Vascular Biology 28(6):1179-1185.
120. Mendall, M. A., P. Patel, M. Asante, L. Ballam, J. Morris, D. P. Strachan, A. J. Camm, and T. C. Northfield. 1997. Relation of serum cytokine concentrations to cardiovascular risk factors and coronary heart disease. Heart 78(3):273-277.
121. 3. Studies in cultured bovine aortic endothelial cells and human dermal capillaries. Journal of Clinical Investigation 83(6):1903-1915.
122. Miller, W. L., and A. A. Portale. 2000. Vitamin D1 alpha-hydroxylase. Trends in Endocrinology and Metabolism 11(8):315-319.
123. Milner, R. D., and C. N. Hales. 1967. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetologia 3(1):47-49.
124. Mitchell, A. J., and M. Shiri-Feshki. 2009. Rate of progression of mild cognitive impairment to dementia- meta-analysis of 41 robust inception cohort studies. Acta Psychiatrica Scandinavica 119(4):252-265.
125. Mitrovic, B., B. A. St Pierre, A. J. Mackenzie-Graham, and J. E. Merrill. 1994. The role of nitric oxide in glial pathology. Annals of the New York Academy of Sciences 738:436-446.
126. Miyake, A., N. P. Friedman, M. J. Emerson, A. H. Witzki, A. Howerter, and T. D. Wager. 2000. The unity and diversity of executive functions and their contributions to complex “frontal lobe” tasks: A latent variable analysis. Cognitive Psychology 41(1):49-100.
127. Morris, M. C. 2009. The role of nutrition in Alzheimer’s disease: Epidemiological evidence. European Journal of Neurology 16 Suppl 1:1-7.
128. Morris, M. C., D. A. Evans, J. L. Bienias, C. C. Tangney, D. A. Bennett, R. S. Wilson, N. Aggarwal, and J. Schneider. 2003. Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease. Archives of Neurology 60(7):940-946.
129. 3 inhibits cytokine production by human blood monocytes at the post-transcriptional level. Cytokine 4(6):506-512.
130. Naveilhan, P., I. Neveu, D. Wion, and P. Brachet. 1996. 1,25-Dihydroxyvitamin D3, an inducer of glial cell line-derived neurotrophic factor. Neuroreport 7(13):2171-2175.
131. Neveu, I., P. Naveilhan, C. Baudet, P. Brachet, and M. Metsis. 1994. 1,25-dihydroxyvitamin D3 regulates NT-3, NT-4 but not BDNF mRNA in astrocytes. Neuroreport 6(1):124-126.
132. Oberauer, K. 2002. Access to information in working memory: Exploring the focus of attention. Journal of Experimental Psychology. Learning, Memory, and Cognition 28(3):411-421.
133. Osterrieth, PA. 1944. Le test de copie d’une figure complexe. Archives de Psychologie 30:206-356.
134. 3 levels are associated with better cognitive test performance in patients with Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders 25(6):539-543.
135. Perl, D. P. 2010. Neuropathology of Alzheimer’s disease. The Mount Sinai Journal of Medicine, New York 77(1):32-42.
136. Petersen, R. C., J. C. Stevens, M. Ganguli, E. G. Tangalos, J. L. Cummings, and S. T. DeKosky. 2001. Practice parameter-Early detection of dementia: Mild cognitive impairment (An evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 56(9):1133-1142.
137. 3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women. The Journal of Clinical Endocrinology and Metabolism 86(4):1633-1637.
138. Pfeiffer, E. 1975. A short portable mental status questionnaire for the assessment of organic brain deficit in elderly patients. Journal of the American Geriatrics Society 23(10):433-441.
139. Pittas, A. G., J. Lau, F. B. Hu, and B. Dawson-Hughes. 2007. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. The Journal of Clinical Endocrinology and Metabolism 92(6):2017-2029.
140. Plassman, B. L., K. M. Langa, G. G. Fisher, S. G. Heeringa, D. R. Weir, M. B. Ofstedal, J. R. Burke, M. D. Hurd, G. G. Potter, W. L. Rodgers, D. C. Steffens, J. J. McArdle, R. J. Willis, and R. B. Wallace. 2008. Prevalence of cognitive impairment without dementia in the United States. Annals of Internal Medicine 148(6):427-434.
141. Postle, B. R. 2006. Working memory as an emergent property of the mind and brain. Neuroscience 139(1):23-38.
142. Pradhan, A. D., J. E. Manson, N. Rifai, J. E. Buring, and P. M. Ridker. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA 286(3):327-334.
143. 3 receptor immunoreactivity in the rat brain and spinal cord. Journal of Chemical Neuroanatomy 16(2):135-145.
144. Przybelski, R. J., and N. C. Binkley. 2007. Is vitamin D important for preserving cognition? A positive correlation of serum 25-hydroxyvitamin D concentration with cognitive function. Archives of Biochemistry and Biophysics 460(2):202-205.
145. Przybelski, R., S. Agrawal, D. Krueger, J. A. Engelke, F. Walbrun, and N. Binkley. 2008. Rapid correction of low vitamin D status in nursing home residents. Osteoporosis International 19(11):1621-1628.
146. 3) as novel inhibitors of renin biosynthesis. The Journal of Steroid Biochemistry and Molecular Biology 96(1):59-66.
147. Rabbit, P. 1997. Methodology of Frontal and Executive Functions. Hove, UK: Psychology Press.
148. Reitan, R. M. 1958. Validity of the Trail Making Test as an indicator of organic brain damage. Perceptual and Motor Skills 8:271-276.
149. 3) derivative (CB1093) induces nerve growth factor and prevents neurotrophic deficits in streptozotocin-diabetic rats. Diabetologia 42(11):1308-1313.
150. Rondanelli, M., R. Trotti, A. Opizzi, and S. B. Solerte. 2007. Relationship among nutritional status, pro/antioxidant balance and cognitive performance in a group of free-living healthy elderly. Minerva Medica 98(6):639-645.
151. Rostand, S. G. 1997. Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension 30(2 Pt 1):150-156.
152. Sabouraud, O. 1995. Le langage et ses maux. Paris: Ed. Odile Jacob.
153. Sackett, D. L. 1979. Bias in analytic research. Journal of Chronic Diseases 32(1-2):51-63.
154. Salthouse, T. A. 2001. Attempted decomposition of age-related influences on two tests of reasoning. Psychology and Aging 16(2):251-263.
155. 3) increases striatal GDNF mRNA and protein expression in adult rats. Brain Research. Molecular Brain Research 108(1-2):143-146.
156. Saporito, M. S., H. M. Wilcox, K. C. Hartpence, M. E. Lewis, J. L. Vaught, and S. Carswell. 1993. Pharmacological induction of nerve growth factor mRNA in adult rat brain. Experimental Neurology 123(2):295-302.
157. Sato, Y., T. Asoh, and K. Oizumi. 1998. High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer’s disease. Bone 23(6):555-557.
158. Scarmeas, N., J. A. Luchsinger, N. Schupf, A. M. Brickman, S. Cosentino, M. X. Tang, and Y. Stern. 2009. Physical activity, diet, and risk of Alzheimer disease. JAMA 302(6):627-637.
159. Scragg, R. 1981. Seasonality of cardiovascular disease mortality and the possible protective effect of ultra-violet radiation. International Journal of Epidemiology 10(4):337-341.
160. Seamans, K. M., T. R. Hill, L. Scully, N. Meunier, M. Andrillo-Sanchez, A. Polito, I. Hininger-Favier, D. Ciarapica, E. E. Simpson, B. J. Stewart-Knox, J. M. O’Connor, C. Coudray, and K. D. Cashman. 2010. Vitamin D status and measures of cognitive function in healthy older European adults. European Journal of Clinical Nutrition 64(10):1172-1178.
161. Shagam, J. Y. 2009. The many faces of dementia. Radiologic Technology 81(2):153-168.
162. 3) on cultured mesencephalic dopaminergic neurons to the combined toxicity caused by l-buthionine sulfoximine and 1-methyl-4-phenylpyridine. Journal of Neuroscience Research 62(3):374-382.
163. Singer, R. N. 1980. Cognitive processes, learner strategies, and skilled motor behaviors. Canadian Journal of Applied Sport Sciences 5(1):25-32.
164. Slinin, Y., M. L. Paudel, B. C. Taylor, H. A. Fink, A. Ishani, M. T. Canales, K. Yaffe, E. Barrett-Connor, E. S. Orwoll, J. M. Shikany, E. S. Leblanc, J. A. Cauley, and K. E. Ensrud. 2010. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology 74(1):33-41.
165. 3-1alpha-hydroxylase is expressed in human vascular smooth muscle cells and is upregulated by parathyroid hormone and estrogenic compounds. Circulation 111(13):1666-1671.
166. Sonnenberg, J., V. N. Luine, L. C. Krey, and S. Christakos. 1986. 1,25-Dihydroxyvitamin D3 treatment results in increased choline acetyltransferase activity in specific brain nuclei. Endocrinology 118(4):1433-1439.
167. Stroop, J. R. 1935. Studies of interference in serial verbal reactions. Journal of Experimental Psychology 18:643-662.
168. 3. Science 215(4538):1403-1405.
169. 3 (soltriol) levels influence serotonin levels in the hypothalamus of the rat. Abstracts-Society for Neuroscience 17:498.
170. Stein, M.S., S. C. Scherer, K. S. Ladd, and L. C. Harrisson. 2011. A randomized controlled trial of high-dose vitamin D2 followed by intranasal insulin in Alzheimer’s disease. Journal of Alzheimer’s Disease 26(3):477-484.
171. Sutherland, M. K., M. J. Somerville, L. K. Yoong, C. Bergeron, M. R. Haussler, and D. R. McLachlan. 1992. Reduction of vitamin D hormone receptor mRNA levels in Alzheimer as compared to Huntington hippocampus: Correlation with calbindin-28k mRNA levels. Brain Research. Molecular Brain Research 13(3):239-250.
172. Sutra Del Galy, A., M. Bertrand, F. Bigot, P. Abraham, R. Thomlinson, M. Paccalin, O. Beauchet, and C. Annweiler. 2009. Vitamin D insufficiency and acute care in geriatric inpatients. Journal of the American Geriatrics Society 57(9):1721-1723.
173. Van Lente, F. 2000. Markers of inflammation as predictors in cardiovascular disease. Clinica Chimica Acta 293(1-2):31-52.
174. 3 receptors in the central nervous system of the rat embryo. Brain Research 804(2):193-205.
175. 3 receptor immunoreactivity in the limbic system of the rat. Hormone and Metabolic Research 33(9):525-531.
176. 3) attenuates cortical infarction induced by middle cerebral arterial ligation in rats. Neuropharmacology 39(5):873-880.
177. 3) attenuates 6-hydroxydopamine-induced neurotoxicity in rats. Brain Research 904(1):67-75.
178. Warrington, E. K. 1966. The Camden Memory Tests Manual. Hove: UK: Psychology Press.
179. Wechsler, D. 1987. Wechsler Memory Scale-Revised. Manual. New York: The Psychological Corporation.
180. Wechsler, D. 1997. Manual for the Wechsler Memory Scale-Third Edition (WMS-III), 3rd ed. San Antonio, TX: The Psychological Corporation.
181. Wilkins, C. H., Y. I. Sheline, C. M. Roe, S. J. Birge, and J. C. Morris. 2006. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. The American Journal of Geriatric Psychiatry 14(12):1032-1040.
182. Wilkins, C. H., S. J. Birge, Y. I. Sheline, and J. C. Morris. 2009. Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans. Journal of the National Medical Association 101(4):349-354.
183. Wilson, J. M., and Y. G. Jungner. 1968. [Principles and practice of mass screening for disease]. Boletín de la Oficina Sanitaria Panamericana 65(4):281-393.
184. Woodhouse, P. R., K. T. Khaw, and M. Plummer. 1993. Seasonal variation of blood pressure and its relationship to ambient temperature in an elderly population. Journal of Hypertension 11(11):1267-1274.
185. World Health Organization. 2000. The World Health Report 2000. Health systems: Improving performance. Geneva, Switzerland.
186. Yoshizawa, T., Y. Handa, Y. Uematsu, S. Takeda, K. Sekine, Y. Yoshihara, T. Kawakami, K. Arioka, H. Sato, Y. Uchiyama, S. Masushige, A. Fukamizu, T. Matsumoto, and S. Kato. 1997. Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nature Genetics 16(4):391-396.
187. Yu, J., M. Gattoni-Celli, H. Zhu, N. R. Bat, K. Sambamurti, S. Gattoni-Celli, M. S. Kindy. 2011. Vitamin D3-enriched diet correlates with a decrease of amyloid plaques in the brain of AbetaPP transgenic mice. Journal of Alzheimer’s Disease 25(2):295-307.
188. 3) by human endothelial cells is regulated by inflammatory cytokines: A novel autocrine determinant of vascular cell adhesion. Journal of the American Society of Nephrology 13(3):621-629.
189. Zittermann, A. 2003. Vitamin D in preventive medicine: Are we ignoring the evidence? The British Journal of Nutrition 89(5):552-572.
190. Zou, J., A. Minasyan, T. Keisala, Y. Zhang, J. H. Wang, Y. R. Lou, A. Kalueff, I. Pyykko, and P. Tuohimaa. 2008. Progressive hearing loss in mice with a mutated vitamin D receptor gene. Audiology & Neuro-Otology 13(4):219-230.