Genetic susceptibility to obesity and metabolic syndrome in childhood;Susceptibilidad genética de obesidad y síndrome metabólico en la infancia

Nutricion Hospitalaria

Volumn 28, Issue SUPPL.5, 2013, Pages 44-55

  Aguilera, Concepción M ^a   Olza, Josune ^a   Gil, Ángel ^a  

^a UNIVERSITY OF GRANADA   (Spain)

Author keywords

Gene variants; Genes; Metabolic syndrome; Obesity; Single nucleotide polymorphisms

Indexed keywords

CHILD; CHILDHOOD OBESITY; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HUMAN; METABOLIC SYNDROME X; PREVALENCE; REVIEW; SPAIN;

CHILD; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HUMANS; METABOLIC SYNDROME X; PEDIATRIC OBESITY; PREVALENCE; SPAIN;

EID: 84883179453     PISSN: 02121611     EISSN: 16995198     Source Type: Journal    
DOI: 10.3305/nh.2013.28.sup5.6917     Document Type: Article

References (48)

1. International Association for the Study of Obesity. Obesity the global epidemic. [Accessed March 1st 2013]. Available in URL: http://www.iaso.org/iotf/obesity/obesitytheglobalepidemic/
2. Freedman DS, Dietz WH, Tang R, Mensah GA, Bond MG, Urbina EM, et al. The relation of obesity through-out life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study. Int J Obes 2004; 28: 159-66.
3. Lauer RM, Lee J, Clarke WR. Factors affecting the relationship between childhood and adult cholesterol levels: the Muscatine Study. Pediatrics 1988; 82: 309-18.
4. Bremer AA, Mietus-Snyder M, Lustig RH. Toward a unifying hypothesis of metabolic syndrome. Pediatrics 2012; 129: 557-70.
5. International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome. [Accessed March 3rd 2013]. Available in URL: http://www.idf.org/webdata/ docs/IDF_Meta_def_final.pdf
6. Olza J, Gil-Campos M, Leis R, Bueno G, Aguilera CM, Valle M, et al. Presence of the metabolic syndrome in obese children at prepubertal age. Ann Nutr Metab 2011; 58: 343-50.
7. Weiss R, Bremer AA, Lustig RH. What is metabolic syndrome, and why are children getting it? Ann NY AcadSci 2013; doi: 10.1111/nyas.12030.
8. D'Adamo E, Santoro N, Caprio S. Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed. Endocrinol Metab Clin North Am 2009; 38: 549-63.
9. Friend A, Craig L, Turner S. The Prevalence of Metabolic Syndrome in Children: A Systematic Review of the Literature. Metab Syndr Relat Disord 2013 DOI: 10.1089/met.2012.0122.
10. Ginsberg HN, Zhang YL, Hernández-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 2005; 36: 232-40.
11. Ouchi N, Parker JL, Lugus J, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol 2011; 11: 85-97.
12. Petersen KF, Dufour S, Savage DB, Bilz S, Solomon G, Yonemitsu S, et al. The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome. Proc Natl Acad Sci 2007; 104: 12587-94.
13. Maes HH, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 1997; 27: 325-51.
14. Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med 1997; 337: 869-73.
15. Carmelli D, Cardon LR, Fabsitz R. Clustering of hypertension, diabetes, and obesity in adult male twins: same genes or same environments? Am J Hum Genet 1994; 55: 566-73.
16. Edwards KL, Newman B, Mayer E, Selby JV, Krauss RM, Austin MA. Heritability of factors of the insulin resistance syndrome in women twins. Genet Epidemiol 1997; 14: 241-53.
17. Lin HF, Boden-Albala B, Juo SH, Park N, Rundek T, Sacco RL. Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia 2005; 48: 2006-12.
18. Rankinen T, Zuberi A, Chagnon YC, Weisnagel SJ, Argyropoulos G, Walts B et al. The human obesity gene map: the 2005 update. Obesity (Silver Spring) 2006; 14: 529-644.
19. Vimaleswaran KS, Tachmazidou I, Zhao JH, Hirschhorn JN, Dudbridge F, Loos RJ. Candidate genes for obesity-susceptibility show enriched association within a large genome-wide association study for BMI. Hum Mol Genet 2012; 21: 4537-42.
20. Fall T, Ingelsson E. Genome-wide association studies of obesity and metabolic syndrome. Mol Cell Endocrinol 2012 Sep 3. doi:pii: S0303-7207(12)00413.
21. Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. Wellcome Trust Case Control Consortium; Genetic Investigation of Anthropometric Traits Consortium. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41: 25-34.
22. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genomewide association studies. Diabetes 2010; 59: 2980-8.
23. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316: 889-94.
24. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao JH, Sharp SJ, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genomewide association studies. Diabetes 2010; 59: 2980-8.
25. Zabaneh D, Balding DJ. A genome-wide association study of the metabolic syndrome in Indian Asian men. PLoS One 2010; 5, e11961.
26. Kraja AT, Vaidya D, Pankow JS, Goodarzi MO, Assimes TL, Kullo IJ, et al. A bivariate genome-wide approach to metabolic syndrome: STAMPEED consortium. Diabetes 2011; 60: 1329-39.
27. Avery CL, He Q, North KE, Ambite JL, Boerwinkle E, Fornage M, et al. A phenomics-based strategy identifies loci on APOC1, BRAP, and PLCG1 associated with metabolic syndrome phenotype domains. PLoS Genet 2011; 7: e1002322.
28. Kristiansson K, Perola M, Tikkanen E, Kettunen J, Surakka I, Havulinna AS et al. Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits. CircCardiovasc Genet 2012; 5: 242-9.
29. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet 2010; 42: 105-16.
30. Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet 2012; 44: 659-69.
31. Povel CM, Boer JM, Onland-Moret NC, Dollé ME, Feskens EJ, van der Schouw YT. Single nucleotide polymorphisms (SNPs) involved in insulin resistance, weight regulation, lipid metabolism and inflammation in relation to metabolic syndrome: an epidemiological study. CardiovascDiabetol 2012; 11: 133.
32. Kaisaki PJ, Delepine M, Woon PY, Sebag-Montefiore L, Wilder SP, Menzel S et al. Polymorphisms in type II SH2 domaincontaining inositol 5-phosphatase (INPPL1, SHIP2) are associated with physiological abnormalities of the metabolic syndrome. Diabetes 2004; 53: 1900-4.
33. Hyvönen ME, Ihalmo P, Forsblom C, Thorn L, Sandholm N, Lehtonen S et al. INPPL1 is associated with the metabolic syndrome in men with Type 1 diabetes, but not with diabetic nephropathy. Diabet Med 2012 Dec; 29 (12): 1589-95. doi: 10.1111/ j.1464-5491.2012.03668.x.
34. Joy T, Lahiry P, Pollex RL, Hegele RA. Genetics of metabolic syndrome. CurrDiab Rep 2008; 8: 141-8.
35. Tonjes A, Scholz M, Loeffler M, Stumvoll M. Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor gamma with Pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals. Diabetes Care 2006; 29: 2489-97.
36. Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J. Association between peroxisome proliferator-activated receptor gamma haplotypes and the metabolic syndrome in French men and women. Diabetes 2005; 54: 3043-8.
37. Robitaille J, Brouillette C, Houde A, Lemieux S, Pérusse L, Tchernof A, et al. Association between the PPARalpha-L162 V polymorphism and components of the metabolic syndrome. J Hum Genet 2004; 49: 482-9.
38. Yu Z, Han S, Cao X, Zhu C, Wang X, Guo X. Genetic polymorphisms in adipokine genes and the risk of obesity: a systematic review and meta-analysis. Obesity 2012; 20: 396-406.
39. Yang WS, Yang YC, Chen CL, Wu IL, Lu JY, Lu FH, et al. Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J ClinNutr 2007; 86: 509-13.
40. Norata GD, Ongari M, Garlaschelli K, Tibolla G, Grigore L, Raselli S, et al. Effect of the-420C/G variant of the resistin gene promoter on metabolic syndrome, obesity, myocardial infarction and kidney dysfunction. J Intern Med 2007; 262: 104-12.
41. Peters KE, Beilby J, Cadby G, Warrington NM, Bruce DG, Davis WA, et al. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. BMC Med Genet 2013; 14: 1.
42. Santoro N, Cirillo G, Lepore MG, Palma A, Amato A, Savarese P, et al. Effect of the rs997509 polymorphism on the association between ectonucleotidepyrophosphatasephosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity. J Clin Endocrinol Metab 2009; 94: 300-5.
43. Santoro N, Cirillo G, Amato A, Luongo C, Raimondo P, D'Aniello A, et al. Insulin gene variable number of tandem repeats (INS VNTR) genotype and metabolic syndrome in childhood obesity. J ClinEndocrinolMetab 2006; 91: 4641-4.
44. Juárez-Meavepeña M, Carreón-Torres E, López-Osorio C, García-Sánchez C, Gamboa R, Torres-Tamayo M, et al. The Srb1+1050T allele is associated with metabolic syndrome in children but not with cholesteryl ester plasma concentrations of high-density lipoprotein subclasses Metab Syndr Relat Disord 2012; 10: 110-6.
45. Khalyfa A, Bhushan B, Hegazi M, Kim J, Kheirandish-Gozal L, Bhattacharjee R et al. Fatty-acid binding protein 4 gene variants and childhood obesity: potential implications for insulin sensitivity and CRP levels. Lipids Health Dis 2010; 9: 18.
46. Deram S, Nicolau CY, Pérez-Martínez P, Guazzelli I, Halpern A, Wajchenberg BL, et al. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. J Clin Endocrinol Metab 2008; 93: 4933-40.
47. Pyrzak B, Wisniewska A, Popko K, Demkow U, Kucharska AM. 7. Association between anthropometric measures of obesity, metabolic disturbances and polymorphism G-308A of the tumor necrosis factor-alpha gene in children. Eur J Med Res 2010; 15 (Suppl 2): 141-6.
48. Pyrzak B, Wisniewska A, Majcher A, Popko K, Wasik M, Demkow U. Association between metabolic disturbances and G-174C polymorphism of interleukin-6 gene in obese children. Eur J Med Res 2009; 14 (Suppl 4): 196-200.