Fatty-acid binding protein 4 gene variants and childhood obesity: Potential implications for insulin sensitivity and CRP levels

Lipids in Health and Disease

Volumn 9, Issue , 2010, Pages

  Khalyfa, Abdelnaby ^a   Bhushan, Bharat ^a   Hegazi, Mohamed ^a   Kim, Jinkwan ^a   Kheirandish Gozal, Leila ^a   Bhattacharjee, Rakesh ^b   Capdevila, Oscar Sans ^c   Gozal, David ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c HOSPITAL SANT JOAN DE DÉU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; FATTY ACID BINDING PROTEIN 4; GLUCOSE; INSULIN; LIPID; LOW DENSITY LIPOPROTEIN; FABP4 PROTEIN, HUMAN; FATTY ACID BINDING PROTEIN;

ARTICLE; BODY MASS; CHILD; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; GROUPS BY AGE; HUMAN; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; LIPID BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; OBESITY; PRESCHOOL CHILD; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; ALLELE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETICS; HOMEOSTASIS; METABOLIC SYNDROME X; METABOLISM;

ALLELES; BODY MASS INDEX; C-REACTIVE PROTEIN; CHILD; FATTY ACID-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION; GENETIC VARIATION; HOMEOSTASIS; HUMANS; INSULIN; MALE; METABOLIC SYNDROME X; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 77749315602     PISSN: None     EISSN: 1476511X     Source Type: Journal    
DOI: 10.1186/1476-511X-9-18     Document Type: Article

References (30)

1. Obesity. DW Haslam WP James, Lancet 2005 366 1197 1209 10.1016/S0140-6736(05)67483-1 16198769
2. The obesity epidemic in the United States - -gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Y Wang MA Beydoun, Epidemiol Rev 2007 29 6 28 10.1093/epirev/mxm007 17510091
3. High body mass index for age among US children and adolescents, 2003 - 2006. CL Ogden MD Carroll KM Flegal, JAMA 2008 299 2401 5 10.1001/jama.299.20. 2401 18505949
4. Low-grade systemic inflammation in overweight children. M Visser LM Bouter GM McQuillan MH Wener TB Harris, Pediatrics 2001 107 1 13 10.1542/peds.107.1.e13 11134477
5. Adipocytokines, body composition, and fitness in children. D Nemet P Wang T Funahashi Y Matsuzawa S Tanaka L Engelman DM Cooper, Pediatr Res 2003 53 148 152 12508095
6. Low-grade systemic inflammation in overweight children: impact of physical fitness. M Halle U Korsten-Reck B Wolfarth A Berg, Exerc Immunol Rev 2004 10 66 74 15633587
7. Endothelial activation and inflammation in prepubertal obese Turkish children. F Süheyl Ezgü A Hasanolu L Tümer F Ozbay C Aybay M Gündüz, Metabolism 2005 54 10 1384 9 10.1016/j.metabol.2005.05.003 16154440
8. Childhood C-reactive protein in predicting CRP and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. M Juonala JS Viikari T Rönnemaa L Taittonen J Marniemi OT Raitakari, Arterioscler Thromb Vasc Biol 2006 26 8 1883 8 10.1161/01.ATV.0000228818.11968.7a 16728658
9. C-reactive protein as an indicator of low intensity inflammation in children and adolescents with and without obesity. AR Brasil RC Norton MB Rossetti E Leo RP Mendes, J Pediatr (Rio J) 2007 83 5 477 80 10.1590/S0021-75572007000600014 17768492
10. Obesity and inflammation: evidence for an elementary lesion. A Sbarbati F Osculati D Silvagni D Benati M Galiè FS Camoglio G Rigotti C Maffeis, Pediatrics 2006 117 1 220 3 10.1542/peds.2004-2854 16396883
11. Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. T Reinehr W Kiess G de Sousa B Stoffel-Wagner R Wunsch, Metabolism 2006 55 1 113 8 10.1016/j.metabol.2005.07. 016 16324929
12. Endothelial dysfunction is related to insulin resistance and inflammatory biomarker levels in obese prepubertal children. M Valle Jiménez RM Estepa RM Camacho RC Estrada FG Luna FB Guitarte, Eur J Endocrinol 2007 156 4 497 502 10.1530/EJE-06-0662 17389466
13. Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. S Lee F Bacha N Gungor S Arslanian, J Pediatr 2008 152 2 177 84 10.1016/j.jpeds.2007.07.053 18206686
14. Obesity and low-grade inflammation: a paediatric perspective. CS Tam K Clément LA Baur J Tordjman, Obes Rev 2009 19845868
15. New insights into the structure and function of fatty acid-binding proteins. AW Zimmerman JH Veerkamp, Cell Mol Life Sci 2002 59 7 1096 116 10.1007/s00018-002-8490-y 12222958
16. Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets. M Furuhashi GS Hotamisligil, Nat Rev Drug Discov 2008 7 6 489 503 10.1038/nrd2589 18511927
17. Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice. M Furuhashi R Fucho CZ Görgün G Tuncman H Cao GS Hotamisligil, J Clin Invest 2008 118 7 2640 50 18551191
18. Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes. K Maeda H Cao K Kono CZ Gorgun M Furuhashi KT Uysal Q Cao G Atsumi H Malone B Krishnan Y Minokoshi BB Kahn RA Parker GS Hotamisligil, Cell Metab 2005 1 2 107 19 10.1016/j.cmet.2004.12.008 16054052
19. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. A Xu AW Tso BM Cheung Y Wang NM Wat CH Fong DC Yeung ED Janus PC Sham KS Lam, Circulation 2007 115 12 1537 43 10.1161/CIRCULATIONAHA.106.647503 17389279
20. Plasma fatty acid binding protein 4 is associated with atherogenic dyslipidemia in diabetes. A Cabré I Lzaro J Girona JM Manzanares F Marimán N Plana M Heras L Masana, J Lipid Res 2008 49 8 1746 51 10.1194/jlr.M800102-JLR200 18421072
21. Adipocyte fatty acid-binding protein in obese children before and after weight loss. T Reinehr B Stoffel-Wagner CL Roth, Metabolism 2007 56 12 1735 41 10.1016/j.metabol.2007.07.019 17998029
22. Association between adipocyte fatty acid-binding protein levels and childhood obesity in Korean children. KE Yun SM Kim KM Choi HS Park, Metabolism 2009 58 6 798 802 10.1016/j.metabol.2009.01.017 19368945
23. Homeostasis model assessment: insulin resistance and -cell function from fasting plasma glucose and insulin concentrations in man. DR Matthews JP Hosker AS Rudenski BA Naylor DF Treacher RC Turner, Diabetologia 1985 28 412 419 10.1007/BF00280883 3899825
24. Child health and nutrition: obesity and high blood cholesterol. ND Ernst E Obarzanek, Prev Med 1994 23 4 427 36 10.1006/pmed.1994.1058 7971869
25. The nutrition transition: worldwide obesity dynamics and their determinants. BM Popkin P Gordon-Larsen, Int J Obes Relat Metab Disord 2004 28 Suppl 3 2 9 10.1038/sj.ijo.0802804 15543214
26. A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease. G Tuncman E Erbay X Hom I De Vivo H Campos EB Rimm GS Hotamisligil, Proc Natl Acad Sci USA 2006 103 18 6970 5 10.1073/pnas.0602178103 16641093
27. Oxidized LDL induces the expression of ALBP/aP2 mRNA and protein in human THP-1 macrophages. Y Fu N Luo MF Lopes-Virella, J Lipid Res 2000 41 12 2017 23 11108735
28. The adipocyte lipid binding protein (ALBP/aP2) gene facilitates foam cell formation in human THP-1 macrophages. Y Fu N Luo MF Lopes-Virella WT Garvey, Atherosclerosis 2002 165 2 259 69 10.1016/S0021-9150(02)00305-2 12417276
29. Adipocyte fatty acid-binding protein (aP2), a newly identified LXR target gene, is induced by LXR agonists in human THP-1 cells. QY Liu E Quinet P Nambi, Mol Cell Biochem 2007 302 1-2 203 13 10.1007/s11010-007-9442-5 17396233
30. Adipocyte fatty acid-binding protein, aP2, alters late atherosclerotic lesion formation in severe hypercholesterolemia. JB Boord K Maeda L Makowski VR Babaev S Fazio MF Linton GS Hotamisligil, Arterioscler Thromb Vasc Biol 2002 22 10 1686 91 10.1161/01.ATV.0000033090.81345.E6 12377750