Heritability of factors of the insulin resistance syndrome in women twins

Genetic Epidemiology

Volumn 14, Issue 3, 1997, Pages 241-253

  Edwards, Karen L ^a   Newman, Beth ^b   Mayer, Elizabeth ^c   Selby, Joe V ^d   Krauss, Ronald M ^e   Austin, Melissa A ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b IL   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d DIVISION OF RESEARCH   (United States)

^e LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

Factor analysis; Genetic influences; Insulin resistance syndrome

Indexed keywords

GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY FAT; BODY MASS; CONTROLLED STUDY; DIZYGOTIC TWINS; FACTORIAL ANALYSIS; FEMALE; HERITABILITY; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MONOZYGOTIC TWINS; SYNDROME; TWINS;

ADOLESCENT; ADULT; ANALYSIS OF VARIANCE; BLOOD GLUCOSE; BODY CONSTITUTION; CHILD; CHILD, PRESCHOOL; CORONARY DISEASE; DISEASES IN TWINS; FACTOR ANALYSIS, STATISTICAL; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INSULIN; INSULIN RESISTANCE; LIKELIHOOD FUNCTIONS; LIPIDS; MIDDLE AGED; REGRESSION ANALYSIS; RISK FACTORS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC;

EID: 0030976711     PISSN: 07410395     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2272(1997)14:3<241::AID-GEPI3>3.0.CO;2-8     Document Type: Article

References (64)

1. Almind K, Bjorbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O (1993): Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin dependent diabetes mellitus. Lancet 342:828-832.
2. Austin MA (1991): Plasma triglyceride and coronary heart disease. Arterioscler Thromb 11:2-14.
3. Austin MA (1993): Genetics of low-density lipoprotein subclasses. Curr Opin Lipidol 4:125-132.
4. Austin MA, Kind M-C, Bawol RD, Hulley SB, Friedman GD (1987): Risk factors for coronary heart disease in adult female twins: Genetic heritability and shared environmental influences. Am J Epidemiol 125:308-318.
5. Austin MA Newman B, Selby JV, Edwards K, Mayer EJ, Krauss RM (1993): Genetics of LDL subclass phenotypes in women twins. Concordance, heritability, and commingling analysis. Arterioscler Thromb 13:687-695.
6. Blangero J, Konigsberg LW (1991): Multivariate segregation analysis using the mixed model. Genet Epidemiol 8:299-316.
7. Borecki IB, Rice T, Bouchard C, Rao DC (1991): Commingling analysis of generalized body mass and composition measures: The Quebec family study. Int J Obesity 15:763-773.
8. Bouchard C, Perusse L (1993): Genetics of causes and manifestations of the metabolic syndrome. In Crepaldi G, Tiengo A, Manzato E (eds): "Diabetics, Obesity and the Hyperlipidermas: The Plurimetabolic Syndrome." New York: Elsevier, pp 67-73.
9. Bouchard C, Savard R, Despres JP, Tremblay A, Leblanc C (1985): Body composition in adopted and biological siblings. Hum Biol 57:61-75.
10. Bouchard C, Perusse L, Leblanc C, Tremblay A, Theriault G (1988): Inheritance of the amount and distribution of human body fat. Int J Obesity 12:205-215.
11. Burchfiel CM, Curb JD, Rodriguez BL, Arakaki R, Chyou P-H, Yano K (1995): Distribution and correlates of insulin in elderly men: The Honolulu Heart Program. Arterioscler Thromb Vasc Biol 15:2213-2221.
12. Cardon LR, Carmelli D, Fabsitz RR, Reed T (1994): Genetic and environmental correlations between obesity and body fat distribution in adult male twins. Hum Biol 66:465-479.
13. Carmelli D, Cardon LR, Fabsitz R (1994): Clustering of hypertension, diabetes, and obesity in adult male twins: Same genes or same environment? Am J Hum Genet 55:566-573.
14. Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, DeFreitas P, Fogarty P, Clark AJ (1995): Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest 96:687-692.
15. Cavalli-Sforza LL, Bodmer WF (1971): "The Genetics of Human Populations." San Francisco: W.H. Freeman & Co., pp 585-587.
16. Christian JC, Kang KW, Norton JA (1974): Choice of an estimate of genetic variance from twin data. Am J Hum Genet 26:154-161.
17. Christian JC, Norton JA, Sorbel J, Williams CJ (1995): Comparison of analysis of variance and maximum likelihood based on path analysis of twin data: Partitioning genetic and environmental sources of covariance. Genet Epidemiol 12:27-35.
18. Cook JTE, Hattersley AT, Levy JC, Patel P, Wainscoat JS, Hockaday TDR, Turner RC (1993): The distribution of type 2 diabetes in nuclear families. Diabetes 42:106-112.
19. Cook JTE, Schields DC, Page RCL, Levy JC, Hattersley AT, Shaw JAG, Neil HAW, Wainscoat JS, Turner RC (1994): Segregation analysis of NIDDM in Caucasian families. Diabetologia 37:1231-1240.
20. Cullen P, Farren B, Scott J, Farrall M (1994): Complex segregation analysis provides evidence for a major gene acting on serum triglyceride levels in 55 British families with familial combined hyperlipidemia. Arterioscler Thromb 14:1433-1449.
21. Defronzo RA, Ferrannini E (1991): Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194.
22. Edwards KL, Austin MA, Newman B, Mayer E, Krauss RM, Selby JV (1994): Multivariate analysis of the insulin resistance syndrome in women. Arterioscler Thromb 14:1940-1945.
23. Feinleib M, Garrison RJ, Fabsitz R, Christian JC, Hrubec Z, Borhani NO, Kannel WB, Rosenman R, Schwartz JT, Wagner JO (1977): The NHLBI Twin Study of cardiovascular disease risk factors: Methodology and summary of results. Am J Epidemiol 106:284-295.
24. Ferrannini E, Haffner SM, Mitchell BD, Stern MP (1991): Hyperinsulinaemia: The key feature of a cardiovascular and metabolic syndrome. Diabetologia 34:416-422.
25. Haffner SM, Valdez RA, Hazuda HP, Mitchell BD, Morales PA, Stern MP (1989): Prospective analysis of the insulin resistance syndrome (syndrome X). Arteriosclerosis 9:665-672.
26. Haffner SM, Mykkanene L, Robbins D, Valdez R, Miettinen H, Howard BV, Sterm NP, Bowsher R (1995): A preponderance of small dense LDL is associated with specific insulin, proinsulin and the components of the insulin resistance syndrome in non-diabetic subjects. Diabetologia 38:1328-136.
27. Hamman RF (1992): Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM). Diabetes Metab Rev 8:287-338.
28. Harman HH (1960): "Modern Factor Analysis." Chicago: University of Chicago Press.
29. Heath AC, Neale MC, Hewitt JK, Eaves JL, Fulker DW (1989): Testing structural equation models for twin data using LISREL. Behav Genet 19:9-35.
30. Heller DA, DeFaire U, Pedersen NL, Dahlen G, McClearn GE (1993): Genetic and environmental influences on serum lipid levels in twins. N Engl J Med 328:1150-1156.
31. Hunt SC, Hasstedt SJ, Kuida H, Stults BM, Hopkins PN, Williams RR 91989): Genetic heritability and common environmental components of resting and stressed blood pressures, lipids, and body mass index in Utah pedigrees and twins. Am J Epidemiol 129:625-638.
32. Khoury MJ, Beaty TH, Cohen BH (1993): "Fundamentals of Genetic Epidemiology." New York: Oxford University Press.
33. Krauss RM, Burke DJ (1982): Identification of multiple subclasses of plasma low density lipoprotein in normal humans. J Lipid Res 23:97-104.
34. Laakso M (1993): How good a marker is insulin level for insulin resistance? Am J Epidemiol 137:667-687.
35. Laws A, Stefanick ML, Reaven GM (1989): Insulin resistance and hypertriglyceridemia in nondiabetic relatives of patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 69:343-347.
36. Mahaney MC, Blangero J, Comuzzie AG, VandeBerg JL, Stern MP, MacCluer JW (1995): Plasma HDL cholesterol, triglycerides, and adiposity: A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study. Circulation 92:3240-3248.
37. Mayer E, Newman B. Austin MA, Zhang D, Quesenberry CP, Edwards K, Selby JV (1996): Genetic and environmental influences on the insulin resistance syndrome: An analysis of women twins. Am J Epidemiol 143:323-332.
38. McCarthy MI, Hitman GA, Shields DC, Morton NE, Snehalatha C, Mohan V, Ramachandran A, Viswanathan M (1994): Family studies on non-insulin-dependent diabetes mcllitus in South Indians. Diabetologia 37:1221-1230.
39. Mitchell BD, Kammerer CM, Hixson JE, Atwood LD, Hackleman S, Blangero J, Haffner SM, Stern MP, MacCluer JW (1995): Evidence for a major gene affecting postchallenge insulin levels in Mexican-Americans. Diabetes 44:284-289.
40. Modan M, Halkin H, Almog S, Lusky A, Eshkol A, Shefi M, Shitrit A, Fuchs Z (1985): Hyperinsulinemia: A link between hypertension, obesity and glucose intolerance. J Clin Invest 75:809-817.
41. Moll PP, Burns TL, Lauer RM (1991): The genetic and environmental sources of body mass index variability: The Muscatine Ponderosity Family Study. Am J Hum Genet 49:1243-1255.
42. Motulsky AG, Burke W, Billings PR, Ward RH (1987): Hypertension and the genetics of red cell membrane abnormalities. In Bock G, Collins G (eds): "Molecular Approaches to Human Polygenic Disease." Chichester: Wiley, Ciba Symposium 130, pp 150-166.
43. Nagele U, Hagele EO, Sauer G, Wiedemann E, Lehmann P, Wahlefeld AW, Gruber W (1984): Reagent for the enzymatic determination of serum total triglycerides with improved lipolytic efficiency. J Clin Chem Clin Biochem 22:165-174.
44. Neel JV (1976): Towards a better understanding of the genetic basis of diabetes mellitus. In Creutzfeldt W, Kobberling J, Neel JV (eds): "The Genetics of Diabetes Mellitus." New York: Springer-Verlag, pp 240-244.
45. Nichols AV, Krauss RM, Muliner TA (1986): Nondenaturing polyacrylamide gradient gel electrophoresis. In Segrest JP, Alberts JJ (eds): "Methods in Enzymology. Vol. 128. Plasma Lipoproteins. Part A: Preparation, Structure and Molecular Biology." Orlando, FL: Academic Press, pp 417-431.
46. Price RA, Ness R, Laskarzewski P (1990): Common major gene inheritance of extreme overweight. Hum Biol 62:747-765.
47. Province MA, Arnqvist P, Keller J, Higgins M, Rao DC (1990): Strong evidence for a major gene for obesity in the large, unselected, total Community Study of Techumseh. Am J Hum Genet Suppl 47:A143.
48. Reaven GM (1988): Role of insulin resistance in human disease. Diabetes 37:1595-1607.
49. Reaven GM, Chen IY-D, Jeppesen J, Maheux P, Krauss RM (1993): Insulin resistance and hyperinsulinemia in individuals with small, dense low density lipoprotein particles. J Clin Invest 92:141-146.
50. Rice T, Borecki IB, Bouchard C, Rao DC (1993): Segregation analysis of fat mass and other body composition measures derived from underwater weighing. Am J Hum Genet 52:967-973.
51. Selby JV, Austin MA, Newman B, Zhang D, Quesenberry CP, Mayer EJ, Krauss RM (1993): LDL subclass phenotypes and the insulin resistance syndrome in women. Circulation 88:381-387.
52. Schumacher MC, Hasstedt SJ, Hunt SC, Williams RR, Elbein SC (1992): Major gene effect for insulin levels in familial NIDDM pedigrees. Diabetes 41:416-423.
53. Sprecher DL, Feigelson HS, Laskarzewski PM (1993): The low HDL cholesterol/high triglyceride trait. Arterioscler Thromb 13:495-504.
54. Sprecher DL, Hein MJ, Laskarzewski PM (1994): Conjoint high triglycerides and low HDL cholesterol across generations. Analysis of proband hypertriglyceridemia and lipid/lipoprotein disorders in first-degree family members. Circulation 90:1177-1184.
55. Stevens J (1986): "Applied Multivariate Statistics for the Social Sciences." Hillsdale, NJ: Lawrence Erlbaum Associates.
56. Stunkard AJ, Foch TT, Hrubec Z (1986a): A twin study of human obesity. JAMA 256:51-54.
57. Stunkard AJ, Sorenson TIA, Hanis C, Teasdale TW, Chakraborty R, Schull WJ, Schulsinger F (1986b): An adoption study of human obesity. N Engl J Med 314:193-198.
58. Taylor SI, Cama A, Accili D, Barbetti F, Quon MJ, Sierra ML, Suzuki Y, Koller E, Levy Toledano R, Wertheimer E, Moncada VY, Kadowaki H, Kadowaki T (1992): Mutations in the insulin receptor gene. Endoc Rev 13:566-595.
59. Towne B, Roche AF, Chumlea WC, Siervogel RM (1995): Quantitative genetics of fasting insulin and body mass index in adults (abstract). Circulation 91:5.
60. U.S. Department of Health, Education, and Welfare (1974): Lipid Research Clinics Manual of Laboratory Operations. Vol 1. Lipid and Lipoprotein Analysis. DHEW Publication no. (NIH)75628. Washington, DC: U.S. Government Printing Office.
61. Williams CJ, Christian JC, Norton JA (1992): TWINAN90: A Fortran program for conducting ANOVA-based and likelihood-based analyses of twin data. Comput Methods Programs Biomed 38:167-176.
62. Williams RR, Hunt SC, Hopkins PN, Wu LL, Hasstedt SJ, Berry TD, Barlow GK, Stults BM, Schumacher MC, Ludwig EH, et al. (1993): Genetic basis of familial dyslipidemia and hypertension: 15-year results from Utah. Am J Hypertens 6:319s-327s.
63. Williams RR, Hunt SC, Hopkins PN, Wu LL, Lalouel JM (1994): Evidence for single gene contributions to hypertension and lipid disturbances: Definition, genetics, and clinical significance. Clin Genet 46:80-87.
64. World Health Organization Expert Committee on Diabetes Mellitus (1980): Second Report: Technical Report Series 646. Geneva: World Health Organization, pp 11-13.